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Hot Trials

Hot Trials 2023

The best critical care trials published in 2023

Other Years: 2021 | 2022

Neuro
- Sharshar. Valproic acid as adjuvant treatment for convulsive status epilepticus: a randomised clinical trial. Crit Care 2023;27:8
- Soukup. Prolonged sedation with sevoflurane in comparison to intravenous sedation in critically ill patients - A randomized controlled trial. J Crit Care 2023;74:154251
Resuscitation
- Suverein. Early Extracorporeal CPR for Refractory Out-of-Hospital Cardiac Arrest (INCEPTION). N Engl J Med 2023;388:299-309
Airway
- Landais. Continued enteral nutrition until extubation compared with fasting before extubation in patients in the intensive care unit: an open-label, cluster-randomised, parallel-group, non-inferiority trial (AMBROISIE). Lancet Respir Med 2023;epublished January 21st
- Grillot. Effect of Remifentanil vs Neuromuscular Blockers During Rapid Sequence Intubation on Successful Intubation Without Major Complications Among Patients at Risk of Aspiration. A Randomized Clinical Trial. JAMA 2023;329(1):28-38
Respiratory
- Dequin. Hydrocortisone in Severe Community-Acquired Pneumonia. N Engl J Med 2023;epublished March 21st
- De Jong. Effect of non-invasive ventilation after extubation in critically ill patients with obesity in France: a multicentre, unblinded, pragmatic randomised clinical trial (EXTUB-OBESE). Lancet Respir Med 2023;epublished January 21st
Observational
- Pham. Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study. Lancet Respir Med 2023;epublished January 21st
Nutrition
- Reignier. Low versus standard calorie and protein feeding in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group trial (NUTRIREA-3). Lancet Respir Med 2023;epublished March 20th
- Heyland. The effect of higher protein dosing in critically ill patients with high nutritional risk (EFFORT Protein): an international, multicentre, pragmatic, registry-based randomised trial. Lancet 2023;epublished January 25th
Sepsis
- Annane. Intravenous ravulizumab in mechanically ventilated patients hospitalised with severe COVID-19: a phase 3, multicentre, open-label, randomised controlled trial. Lancet Respir Med 2023;epublished March 20th
- The National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Clinical Trials Network. Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension. N Engl J Med 2023;epublished January 21st
COVID-19
- Trøseid. Efficacy and safety of baricitinib in hospitalized adults with severe or critical COVID-19 (Bari-SolidAct): a randomised, double-blind, placebo-controlled phase 3 trial. Crit Care 2023;27:9
Paediatrics
- Franklin. Effect of Early High-Flow Nasal Oxygen vs Standard Oxygen Therapy on Length of Hospital Stay in Hospitalized Children With Acute Hypoxemic Respiratory Failure. The PARIS-2 Randomized Clinical Trial. JAMA 2023;329(3):224-234
Miscellaneous
Rehabilitation
- Patel. Effect of early mobilisation on long-term cognitive impairment in critical illness in the USA: a randomised controlled trial. Lancet Respir Med 2023;epublished January 21st
Perioperative
- Stoppe. Effect of High-Dose Selenium on Postoperative Organ Dysfunction and Mortality in Cardiac Surgery Patients: The SUSTAIN CSX Randomized Clinical Trial. JAMA Surg 2023;epublished January 11th
Trauma
- Bouzat. Efficacy and Safety of Early Administration of 4-Factor Prothrombin Complex Concentrate in Patients With Trauma at Risk of Massive TransfusionThe PROCOAG Randomized Clinical Trial. JAMA 2023;epublished March 21st

Last updated January 30th, 2023

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