Hot Trials 2023

• Stefan. Effectiveness of Lumbar Cerebrospinal Fluid Drain Among Patients With Aneurysmal Subarachnoid Hemorrhage: A Randomized Clinical Trial. JAMA Neurol epublished June 18th
• Olthuis. Endovascular treatment versus no endovascular treatment after 6–24 h in patients with ischaemic stroke and collateral flow on CT angiography (MR CLEAN-LATE) in the Netherlands: a multicentre, open-label, blinded-endpoint, randomised, controlled, phase 3 trial. Lancet 2023;401:1371-1380
• Sarraj. Trial of Endovascular Thrombectomy for Large Ischemic Strokes. N Engl J Med 2023;388:1259-1271.
• Huo. Trial of Endovascular Therapy for Acute Ischemic Stroke with Large Infarct. N Engl J Med 2023;388:1272-1283.
• Wang. Tenecteplase versus alteplase in acute ischaemic cerebrovascular events (TRACE-2): a phase 3, multicentre, open-label, randomised controlled, non-inferiority trial. Lancet 2023;epublished February 9th
• Chen. Effect of Argatroban Plus Intravenous Alteplase vs Intravenous Alteplase Alone on Neurologic Function in Patients With Acute Ischemic Stroke. The ARAIS Randomized Clinical Trial. JAMA 2023;epublished February 9th
• Sharshar. Valproic acid as adjuvant treatment for convulsive status epilepticus: a randomised clinical trial. Crit Care 2023;27:8
• Soukup. Prolonged sedation with sevoflurane in comparison to intravenous sedation in critically ill patients - A randomized controlled trial. J Crit Care 2023;74:154251

• Thiele. Extracorporeal Life Support in Infarct-Related Cardiogenic Shock. N Engl J Med 2023;epublished August 26th
• Biscaglia. Complete or Culprit-Only PCI in Older Patients with Myocardial Infarction. N Engl J Med 2023;epublished August 26th
• Diletti. Immediate versus staged complete revascularisation in patients presenting with acute coronary syndrome and multivessel coronary disease (BIOVASC): a prospective, open-label, non-inferiority, randomised trial. Lancet 2023;epublished March 5th
• Bollaert. Fluid balance control in critically ill patients: results from POINCARE-2 stepped wedge cluster-randomized trial. Crit Care 2023;27:66

• Eastwood. Mild Hypercapnia or Normocapnia after Out-of-Hospital Cardiac Arrest. N Engl J Med 2023;epublished June 15th
• Suverein. Early Extracorporeal CPR for Refractory Out-of-Hospital Cardiac Arrest (INCEPTION). N Engl J Med 2023;388:299-309

• Prekker. Video versus Direct Laryngoscopy for Tracheal Intubation of Critically Ill Adults. N Engl J Med 2023;epublished June 16th
• Bandyopadhyay. Peri-Intubation Hypoxia After Delayed Versus Rapid Sequence Intubation in Critically Injured Patients on Arrival to Trauma Triage: A Randomized Controlled Trial. Anesth Analg 2023;136(5):913-919
• Badovinac. Tranexamic Acid vs Adrenaline for Controlling Iatrogenic Bleeding During Flexible Bronchoscopy: A Double-Blind Randomized Controlled Trial. Chest. 2023;163(4):985-993
• Kriege. A multicentre randomised controlled trial of the McGrath Mac videolaryngoscope versus conventional laryngoscopy. Anaesthesia 2023;epublished March 16th
• Landais. Continued enteral nutrition until extubation compared with fasting before extubation in patients in the intensive care unit: an open-label, cluster-randomised, parallel-group, non-inferiority trial (AMBROISIE). Lancet Respir Med 2023;epublished January 21st
• Grillot. Effect of Remifentanil vs Neuromuscular Blockers During Rapid Sequence Intubation on Successful Intubation Without Major Complications Among Patients at Risk of Aspiration. A Randomized Clinical Trial. JAMA 2023;329(1):28-38

• Svenningsen. Effects of Dupilumab on Mucus Plugging and Ventilation Defects in Patients with Moderate-to-Severe Asthma: A Randomized, Double-Blind, Placebo-controlled Trial. Am J Respir Crit Care Med 2023;epublished August 18th
• Dequin. Hydrocortisone in Severe Community-Acquired Pneumonia. N Engl J Med 2023;epublished March 21st
• Bowdish. A Randomized Trial of Mesenchymal Stromal Cells for Moderate to Severe Acute Respiratory Distress Syndrome from COVID-19. Am J Respir Crit Care Med 2023;207(3):61–270
• De Jong. Effect of non-invasive ventilation after extubation in critically ill patients with obesity in France: a multicentre, unblinded, pragmatic randomised clinical trial (EXTUB-OBESE). Lancet Respir Med 2023;epublished January 21st

Observational

• Pham. Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study. Lancet Respir Med 2023;epublished January 21st

• de Wijkerslooth. 2 days versus 5 days of postoperative antibiotics for complex appendicitis: a pragmatic, open-label, multicentre, non-inferiority randomised trial. Lancet 2023;401(10374):366-376

• Reignier. Low versus standard calorie and protein feeding in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group trial (NUTRIREA-3). Lancet Respir Med 2023;epublished March 20th
• Heyland. The effect of higher protein dosing in critically ill patients with high nutritional risk (EFFORT Protein): an international, multicentre, pragmatic, registry-based randomised trial. Lancet 2023;epublished January 25th

• Louvet. Effect of Prophylactic Antibiotics on Mortality in Severe Alcohol-Related Hepatitis. A Randomized Clinical Trial. JAMA 2023;329(18):1558-1566

• Collins. Balanced crystalloid solution versus saline in deceased donor kidney transplantation (BEST-Fluids): a pragmatic, double-blind, randomised, controlled trial. Lancet 2023;epublished June 18th
• Blankestijn. Effect of Hemodiafiltration or Hemodialysis on Mortality in Kidney Failure. N Engl J Med 2023;epublished June 16th

• Monti. Continuous vs Intermittent Meropenem Administration in Critically Ill Patients With SepsisThe MERCY Randomized Clinical Trial. JAMA 2023;epublished June 16th
• Roquilly. Interferon gamma-1b for the prevention of hospital-acquired pneumonia in critically ill patients: a phase 2, placebo-controlled randomized clinical trial. Intensive Care Med 2023;epublished April 18th
• Annane. Intravenous ravulizumab in mechanically ventilated patients hospitalised with severe COVID-19: a phase 3, multicentre, open-label, randomised controlled trial. Lancet Respir Med 2023;epublished March 20th
• Varghese. Intravenous Doxycycline, Azithromycin, or Both for Severe Scrub Typhus. N Engl J Med 2023;388(9):792-803
• The National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Clinical Trials Network. Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension. N Engl J Med 2023;epublished January 21st

COVID-19

• Nay. Prone position versus usual care in hypoxemic COVID-19 patients in medical wards: a randomised controlled trial. Crit Care 2023;27(1):240
• Brown. Intravenous aviptadil and remdesivir for treatment of COVID-19-associated hypoxaemic respiratory failure in the USA (TESICO): a randomised, placebo-controlled trial. Lancet Respir Med;epublished June 19th
• Writing Committee for the REMAP-CAP Investigators. Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support-Free Days in Patients Hospitalized With COVID-19: A Randomized Clinical Trial. JAMA 2023;329(14):1183-1196
• Self. Renin-Angiotensin System Modulation With Synthetic Angiotensin (1-7) and Angiotensin II Type 1 Receptor-Biased Ligand in Adults With COVID-19: Two Randomized Clinical Trials. JAMA 2023;329(14):1170-1182
• RECOVERY Collaborative Group. Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial. Lancet 2023;epublished April 12th
• Trøseid. Efficacy and safety of baricitinib in hospitalized adults with severe or critical COVID-19 (Bari-SolidAct): a randomised, double-blind, placebo-controlled phase 3 trial. Crit Care 2023;27:9

• Hayakawa. The Restrictive Red Blood Cell Transfusion Strategy for Critically Injured Patients (RESTRIC) trial: a cluster-randomized, crossover, non-inferiority multicenter trial of restrictive transfusion in trauma. J Intensive Care 2023;11:34
• The PATCH-Trauma Investigators and the ANZICS Clinical Trials Group. Prehospital Tranexamic Acid for Severe Trauma. N Engl J Med 2023;epublished June 14th
• Wang. The effectiveness of early surgical stabilization for multiple rib fractures: a multicenter randomized controlled trial. J Cardiothorac Surg 2023;18(1):118
• Bouzat. Efficacy and Safety of Early Administration of 4-Factor Prothrombin Complex Concentrate in Patients With Trauma at Risk of Massive TransfusionThe PROCOAG Randomized Clinical Trial. JAMA 2023;epublished March 21st

• Hansen. Cerebral Oximetry Monitoring in Extremely Preterm Infants. N Engl J Med 2023; 388:1501-1511
• Roca. Effect of Intrapartum Azithromycin vs Placebo on Neonatal Sepsis and Death. A Randomized Clinical Trial. JAMA 2023;329(9):716-724
• Welzel. Methylprednisolone versus intravenous immunoglobulins in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS): an open-label, multicentre, randomised trial. Lancet Child Adolesc Health 2023;epublished February 3rd
• Franklin. Effect of Early High-Flow Nasal Oxygen vs Standard Oxygen Therapy on Length of Hospital Stay in Hospitalized Children With Acute Hypoxemic Respiratory Failure. The PARIS-2 Randomized Clinical Trial. JAMA 2023;329(3):224-234

Rehabilitation

• Schweickert. Structured Mobilization for Critically Ill Patients: A Pragmatic Cluster-Randomized Trial. Am J Respir Crit Care Med 2023;epublished March 30th
• Patel. Effect of early mobilisation on long-term cognitive impairment in critical illness in the USA: a randomised controlled trial. Lancet Respir Med 2023;epublished January 21st

Perioperative

• The TRACE Study Investigators. Routine Postsurgical Anesthesia Visit to Improve 30-day Morbidity and Mortality. A Multicenter, Stepped-wedge Cluster Randomized Interventional Study (The TRACE Study). Ann Surg 2023;277(3):375-380
• Stoppe. Effect of High-Dose Selenium on Postoperative Organ Dysfunction and Mortality in Cardiac Surgery Patients: The SUSTAIN CSX Randomized Clinical Trial. JAMA Surg 2023;epublished January 11th

End-of-Life

• Curtis. Intervention to Promote Communication About Goals of Care for Hospitalized Patients With Serious Illness. A Randomized Clinical Trial. JAMA 2023;329(23):2028-2037