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The Nothing-to-Lose Fallacy

When everything seems lost, the temptation is to do more. More drugs. More interventions. More physiology. But is that instinct always right?

Drawing on Chris Hadfield's remarkable spacewalk aboard the International Space Station and the landmark COCA trial, we explore a dangerous cognitive trap in critical care: the belief that a patient in cardiac arrest has "nothing to lose." Perhaps the opposite is true—they have everything to lose. In the highest-stakes emergencies, the discipline to trust evidence—not desperation—may be the intervention that matters most.

Added July 25th


CCR Meeting Talks


After 16 meetings, we have a huge collection of superb presentations. We'll showcase them here, one at a time.


CCR26  |  VICTORY Trial

Christian Stoppe (Berlin) presents the results of the VICTORY trial at the Critical Care Reviews Meeting 2026 in Titanic Belfast. VICTORY investigates the efficacy of high dose vitamin C in patients with severe burns. Kathryn Puxty (Glasgow) delivers an independent editorial. Aryelly Rodriguez (Edinburgh), Sandra Peake (Adelaide) and Danny McAuley (Belfast) contribute to a panel discussion. Christopher Seymour (Pittsburgh) chairs the session.

Added June 29th

Trialists Summary

Christian Stoppe summarises the results of the VICTORY trial.

Papers


Foundational Trials Collection


After many months of preparation, we're delighted to release our Foundational Trials Collection.

250 critical care contemporary trials are summarised and critiqued in depth.

If you are new to the field, are undertaking exams, or just want to refresh your knowledge, this is an excellent place to start.

added February 17th

COVID-ICU