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Latest Trial Summaries & Critiques

ARISE FLUIDS

Restricted fluids and early vasopressors or a larger initial intravenous fluid volume and later vasopressors in septic shock

SNAP - Benzylpenicillin Trial

Benzylpenicillin versus flucloxacillin or cloxacillin for the treatment of penicillin-susceptible Staphylococcus aureus bacteraemia

Added June 19th

SNAP - Cephazolin Trial

Consevative vs liberal oxygenation in patients post cardiac arrest witht suspected hypoxic-ischaemic encephalopathy

Added June 18th

LOGICAL Trial

Consevative vs liberal oxygenation in patients post cardiac arrest witht suspected hypoxic-ischaemic encephalopathy

Added June 18th

Hypertonic saline box

MARCH Trial

Mucoactive agents in acute respiratory failure

Added June 18th

Vitamin C ampoule surrounded by oranges

VICTORY Trial

High dose vitamin C in severe burns

Added June 18th

Tele-Rehab Trial

Integrated multicomponent telehealth-based rehabilitation intervention in patients with acute hypoxemic respiratory failure requiring invasive mechanical ventilation

Added June 18th

BIHCA Trial

Bicarbonate in cardiac arrest

Added June 18th

Person mobilising with a physiotherapist at home

ACCOMPLISH Trial

Remote patient monitoring for preventing hospital readmission following infection and sepsis

Added June 18th

Nurse working with CRRT machine

SODa-BIC Trial

Sodium bicarbonate for severe metabolic acidosis

Added June 18th

GASTRIC-PICU Trial

Residual gastric volume monitoring in critically ill pchildren

Added June 18th

CCR Meeting Talks

After 16 meetings, we have a huge collection of superb presentations. We'll showcase them here, one at a time.

CCR26  |  BIHCA Trial

Asger Grenfeldt (Aarhus) and Lars Wiuff Andersen (Aarhus) present the results of the BIHCA trial at the Critical Care Reviews Meeting 2026 in Titanic Belfast. BIHCA investigates the efficacy of sodium bicarbonate in cardiac arrest. Ary Serpa Neto (Melbourne) gives an independent editorial. Aryelly Rodriguez (Edinburgh), Kathy Rowan (London) and Angela Jerath (Toronto) contribute to a panel discussion. The session is chaired by Peter McGuigan (Belfast). BIHCA was simultaneously published in JAMA.

Added June 19th

Trialists Summary

Dr Padmanabhan Ramnarayan (London) and Mr Alvin Richards-Belle (London) present the results of the FIRST-ABC (Step Down) trial, comparing high flow nasal oxygen with continuous positive airway pressure in recently extubated children. This was presented during a Critical Care Reviews Livestream event.

Papers

JAMA Paper

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Foundational Trials Collection

After many months of preparation, we're delighted to release our Foundational Trials Collection.

250 critical care contemporary trials are summarised and critiqued in depth.

If you are new to the field, are undertaking exams, or just want to refresh your knowledge, this is an excellent place to start.

added February 17th

COVID-ICU

Sample Summaries

CCR Content

Left MCA stroke

Paper of the Day

Marelli. Magnesium in Neurocritical Care: Clinical Relevance, Status Assessment, and Practical Implications for Outcomes—A Narrative Review. Nutrients 2026;18(9):1359

added Saturday June 20th

CCR Newsletter icon

Latest Newsletter

Newsletter 755

(subscription required)

added May 31st

Ventilated patient in bed in the ICU

Highlighted Guideline

Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2026. Crit Care Med 2026;epublished March 23rd

added March 24th