Latest Trial Summaries & Critiques

ARISE FLUIDS

Restricted fluids and early vasopressors or a larger initial intravenous fluid volume and later vasopressors in septic shock

SNAP - Benzylpenicillin Trial

Benzylpenicillin versus flucloxacillin or cloxacillin for the treatment of penicillin-susceptible Staphylococcus aureus bacteraemia

Added June 19th

SNAP - Cephazolin Trial

Consevative vs liberal oxygenation in patients post cardiac arrest witht suspected hypoxic-ischaemic encephalopathy

Added June 18th

LOGICAL Trial

Consevative vs liberal oxygenation in patients post cardiac arrest witht suspected hypoxic-ischaemic encephalopathy

Added June 18th

MARCH Trial

Mucoactive agents in acute respiratory failure

Added June 18th

VICTORY Trial

High dose vitamin C in severe burns

Added June 18th

Tele-Rehab Trial

Integrated multicomponent telehealth-based rehabilitation intervention in patients with acute hypoxemic respiratory failure requiring invasive mechanical ventilation

Added June 18th

BIHCA Trial

Bicarbonate in cardiac arrest

Added June 18th

Person mobilising with a physiotherapist at home

ACCOMPLISH Trial

Remote patient monitoring for preventing hospital readmission following infection and sepsis

Added June 18th

SODa-BIC Trial

Sodium bicarbonate for severe metabolic acidosis

Added June 18th

GASTRIC-PICU Trial

Residual gastric volume monitoring in critically ill pchildren

Added June 18th

CCR Meeting Talks

After 16 meetings, we have a huge collection of superb presentations. We'll showcase them here, one at a time.

CCR26 | BIHCA Trial

Asger Grenfeldt (Aarhus) and Lars Wiuff Andersen (Aarhus) present the results of the BIHCA trial at the Critical Care Reviews Meeting 2026 in Titanic Belfast. BIHCA investigates the efficacy of sodium bicarbonate in cardiac arrest. Ary Serpa Neto (Melbourne) gives an independent editorial. Aryelly Rodriguez (Edinburgh), Kathy Rowan (London) and Angela Jerath (Toronto) contribute to a panel discussion. The session is chaired by Peter McGuigan (Belfast). BIHCA was simultaneously published in JAMA.

Added June 19th

Trialists Summary

Asger Granfeldt and Lars Andersen summarise the results of the BIHCA trial.

Papers

JAMA Paper

Journal Watch Latest

Journal Watch

Newsletter

RCT

Neyra. Polymyxin B haemoadsorption in endotoxic septic shock (Tigris): a multicentre, open-label, Bayesian, randomised, controlled, phase 3 trial. Lancet Respir Med 2026;epublished March 23rd

added March 24th

image: Shutterstock / KILO LUX

RCT

Todd. Procalcitonin testing combined with NEWS2 evaluation compared with usual care based on NEWS2 for identification of sepsis and antibiotic initiation in the emergency department in England and Wales (PRONTO): a multicentre, randomised, controlled, open-label, phase 3 trial. Lancet Respir Med 2026;epublished March 22nd

added March 24th

image: Shutterstock / Saiful52

RCT

Semple. Endotracheal surfactant for infants with life-threatening bronchiolitis (BESS): a randomised, blinded, sham-controlled, phase 2 trial. Lancet Respir Med 2026;epublished March 21st

added March 24th

image: Shutterstock / mindfullness

Observational Study

Reddy. Bedside identification of subphenotypes in acute respiratory failure (PHIND): a multicentre, observational cohort study. Lancet Respir Med 2026;epublished March 23rd

added March 24th

image: Shutterstock / kalewa

Guideline

Clinical criteria for the definition of refractory septic shock: a joint Delphi consensus from the Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM). Intensive Care Med 2026;epublished March 24th

added March 24th

image: Shutterstock / Retrofernz

Guideline

Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2026. Crit Care Med 2026;epublished March 23rd

added March 24th

image: SSC logo

Guideline

Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026. Intensive Care Med 2026;epublished March 23rd

added March 23rd

image: Shutterstock / BelezaPoy

RCT

Tavoulareas. Efficacy of anakinra in reducing progression to organ dysfunction in patients with pneumonia (INSPIRE): a randomised, double-blind, placebo-controlled, phase IIa trial. Lancet Reg Health Eur 2026;62:101573

added February 18th

image: Shutterstock / Karan Bunjean

CT brain showing a large intra cerebral haemorrhage

Commentary

Sekhon. Hyperoxaemia in acute brain injured patients: too much of a good thing?. Intensive Care Med 2026;epublished February 17th

added February 17th

image: Shutterstock / Yok_onepiece

Narrative Reviews

Joosten. Intraoperative blood pressure management in noncardiac surgery: a narrative review based on current evidence. Intensive Care Med 2026;epublished February 17th

added February 17th

image: Shutterstock /

Foundational Trials Collection

After many months of preparation, we're delighted to release our Foundational Trials Collection.

250 critical care contemporary trials are summarised and critiqued in depth.

If you are new to the field, are undertaking exams, or just want to refresh your knowledge, this is an excellent place to start.

added February 17th

Sample Summaries

ARMA

Low tidal volume ventilation
HEMOTION

Transfusion thresholds in TBI
IABP-SHOCK II

Intraaortic balloon pump for myocardial infarction with cardiogenic shock
SAFE

Albumin vs Saline in ICU
ADRENAL

Hydrocortisone for septic shock
REVISE

PPI for gastric ulcer prophylaxis
RSI

Ketamine vs etomidate for rapid sequence intubation
BLING III

Beta lactam infusions in sepsis

CCR Content

Paper of the Day

Hughes. Hyperangulated videolaryngoscopy. BJA Education 2025;25(6):248-255

added Monday June 22nd

Foundational Trial Summary & Critique

Semler. Balanced Crystalloids versus Saline in Critically Ill Adults (SMART). N Engl J Med 2018;378:829-839

added March 24th

Empty operating room, in a blurred focus

Major Trial Summary & Critique

Sonneville R, Couffignal C, Sigaud F, et al; R2D2-ICU Investigator Study Group. Restrictive vs liberal physical restraint strategies in critically ill patients: the R2D2-ICU randomized clinical trial. JAMA 2026;epublished March 17th

added March 24th

Latest Trial Summaries & Critiques

ARISE FLUIDS

Restricted fluids and early vasopressors or a larger initial intravenous fluid volume and later vasopressors in septic shock

SNAP - Benzylpenicillin Trial

Benzylpenicillin versus flucloxacillin or cloxacillin for the treatment of penicillin-susceptible Staphylococcus aureus bacteraemia

SNAP - Cephazolin Trial

Consevative vs liberal oxygenation in patients post cardiac arrest witht suspected hypoxic-ischaemic encephalopathy

LOGICAL Trial

Consevative vs liberal oxygenation in patients post cardiac arrest witht suspected hypoxic-ischaemic encephalopathy

MARCH Trial

Mucoactive agents in acute respiratory failure

VICTORY Trial

High dose vitamin C in severe burns

Tele-Rehab Trial

Integrated multicomponent telehealth-based rehabilitation intervention in patients with acute hypoxemic respiratory failure requiring invasive mechanical ventilation

BIHCA Trial

Bicarbonate in cardiac arrest

ACCOMPLISH Trial

Remote patient monitoring for preventing hospital readmission following infection and sepsis

SODa-BIC Trial

Sodium bicarbonate for severe metabolic acidosis

GASTRIC-PICU Trial

Residual gastric volume monitoring in critically ill pchildren

CCR Meeting Talks

After 16 meetings, we have a huge collection of superb presentations. We'll showcase them here, one at a time.

CCR26 | BIHCA Trial

Trialists Summary

Papers

Journal Watch Latest

RCT

RCT

RCT

Observational Study

Guideline

Guideline

Guideline

RCT

Commentary

Narrative Reviews

Foundational Trials Collection

Sample Summaries

CCR Content

Paper of the Day

Latest Newsletter

Highlighted Guideline

Foundational Trial Summary & Critique

Major Trial Summary & Critique

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