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About
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Support CCR
Latest Evidence
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Subscribe
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PILOT
NITRIC
FIRST-ABC
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PLUS
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RECOVERY-RS
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Major Trials
Liver
Albumin
Cirrhosis
Spontaneous Bacterial Peritonitis
Infections
Fluids
Albumin
Cirrhosis
China. A Randomized Trial of Albumin Infusions in Hospitalized Patients with Cirrhosis. N Engl J Med 2021;384:808-817
Spontaneous Bacterial Peritonitis
Sort. Effect of intravenous albumin on renal impairment and mortality in patients with cirrhosis and spontaneous bacterial peritonitis. N Engl J Med 1999;341:403–409
Infections
Guevara. Albumin for bacterial infections other than spontaneous bacterial peritonitis in cirrhosis. A randomized, controlled study. J Hepatol 2012;57:759–765
Hepatorenal Syndrome
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Albumin
Wong. Terlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome. N Engl J Med 2021; 384:818-828
Extracorporeal Support
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Prometheus
Kribben. Effects of Fractionated Plasma Separation and Adsorption on Survival in Patients With Acute-on-Chronic Liver Failure (HELIOS study). Gastroenterology 2012;142(4)782-789
N-Acetylcysteine
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Paracetamol Liver Injury
Keays. Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial. BMJ 1991;303:1026-1029
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Non-Paracetamol Liver Injury
Darweesh. Effect of N-Acetylcysteine on Mortality and Liver Transplantation Rate in Non-Acetaminophen-Induced Acute Liver Failure: A Multicenter Study. Clin Drug Investig 2017;37:473–482
Hypothermia
Acute Liver Failure
Bernal. A multicentre randomized controlled trial of moderate hypothermia to prevent intracranial hypertension in acute liver failure. J Hepatol 2016;65:273-279
Antibiotics
Alcoholic Hepatitis
Louvet. Effect of Prophylactic Antibiotics on Mortality in Severe Alcohol-Related Hepatitis. A Randomized Clinical Trial. JAMA 2023;329(18):1558-1566