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Critical Care Reviews Newsletter

Newsletter 599  |  June 4th, 2023

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Just a Week to CCR23

Welcome to the 599th Critical Care Reviews Newsletter and the end of an era for us. Sadly, after 11 years and 599 consecutive issues, this will be our last free newsletter. If you wish to continue receiving it, please subscribe - the cost is relatively low and will help fund our work. If you are from a low or low-middle income country, please This email address is being protected from spambots. You need JavaScript enabled to view it. to request your complimentary access. If you would like to enquire about a unit level subscription for a group in your ICU, ED or elsewhere, again please This email address is being protected from spambots. You need JavaScript enabled to view it..


The highlights of this week's edition are randomised controlled trials on thoracic epidural analgesia in ICU patients with acute pancreatitis & nangibotide, a TREM-1 inhibitor, in patients with septic shock; systematic reviews and meta analyses on high-normal versus low-normal mean arterial pressure thresholds in critically ill patients & the efficacy of CytoSorb; and observational studies on ventilator-associated pneumonia in neurocritically ill patients & clinical outcomes of intensive inpatient blood pressure management in hospitalized older adults.

There are also guidelines on mechanical circulatory support & acute heart failure and valvular heart disease; narrative reviews on right ventricular dysfunction in patients with ARDS receiving venovenous ECMO & fluid management in patients with septic shock; editorials on veno-pulmonary arterial ECMO in severe ARDS & how could ChatGPT impact my practice as an intensivist?; and commentaries on adjunctive vasopressors in distributive shock & normothermic regional perfusion in organ transplantation.

If you only have time to read one review article this week, try this one on hemodynamic and respiratory support in pulmonary embolism.

Critical Care Reviews Meeting 2023

There is just over a week until the Critical Care Reviews Meeting 2023 in Titanic Belfast, Northern Ireland. There is still room for late registrations. If you can't make it to Belfast, you can watch online for free, or take the paid option for 18 CPD/CME points. With no fewer than 7 major trial results presentations, 6 reviews of some of the best trials of the past year, two panel discussions and the John Hinds Lecture, it promises to be a superb event.


Randomised Controlled Trials

Systematic Review & Meta Analyses

Observational Studies





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Until next week