Skip to main content

Critical Care Reviews Newsletter

Newsletter 595  |  May 7th, 2023

Please support our work to share science

MERCY Trial Results Presentation at CCR23

Welcome to the 595th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.

The highlights of this week's edition are systematic reviews and meta analyses on lower vs higher fluid volumes in adult patients with sepsis & autoresuscitation after circulatory arrest; and observational studies on intraarrest transport, extracorporeal cardiopulmonary resuscitation, and early invasive management in refractory out-of-hospital cardiac arrest & intensivist physician-to-patient ratios and mortality in the intensive care unit.

There are also guidelines on the differential diagnosis of suspected chronic obstructive pulmonary disease exacerbations in the acute care setting & a brain-based definition of death and criteria for its determination after arrest of circulation or neurologic function in Canada; narrative reviews on the role of hormones in sepsis & microcirculatory dysfunction in cardiogenic shock; editorials on clinical practice guidelines for acute-on-chronic liver failure & personalized noninvasive respiratory support for acute hypoxemic respiratory failure; and commentaries on vasopressor weaning in sepsis & why anticoagulant studies on sepsis fail frequently ––– start with SCARLET.

If you only have time to read one review article this week, try this one on artificial intelligence in critical illness.

Critical Care Reviews Meeting 2023

We have completed the programme for the Critical Care Reviews Meeting 2023 with the addition of the MERCY Trial. This international randomised controlled trial compares the continuous infusion of meropenem with its bolus administration in critically ill patients with sepsis and septic shock. The results will be presented by Giacomo Monti and Giovanni Landoni (Milan, Italy). The full programme is now available. There are 7 major trial result sessions, 6 trials reviews, 2 panel discussions and the John Hinds Lecture. Join us in Titanic Belfast for the best critical care trials in the world.

Support CCR

You can support Critical Care Reviews, from as little as the price of a cup of coffee per month or make a one-off donation. We are not-for-profit and make all our content free to view. Our aim is to share science for the benefit of all - please join us in this mission.


Systematic Review & Meta Analyses

Observational Studies


Canadian Journal of Anesthesia Issue on Organ Donation





Canadian Journal of Anesthesia Issue on Organ Donation

I hope you find this newsletter useful.

Until next week