Welcome to the 584th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are randomised controlled trials comparing tenecteplase with alteplase in acute ischaemic cerebrovascular events & ultrasound-guided and clinically-guided fluid management in children with septic shock; systematic reviews and meta analyses on general anesthesia compared to non-general anesthesia in endovascular thrombectomy for ischemic stroke & insulin infusion dosing in pediatric diabetic ketoacidosis; and observational studies on protocolized care of patients with severe traumatic brain injury without intracranial pressure monitoring & lung ultrasound prediction for acute respiratory distress syndrome.
There are also guidelines on anesthetic care of the pregnant patient with cardiovascular disease & extracorporeal treatment for ethylene glycol poisoning; narrative reviews on noninvasive methods to monitor intracranial pressure & challenges in ARDS definition, management, and identification of effective personalized therapies; as well as commentaries on recent advances in critical care & five new realities in critical care for patients with cancer.
If you only have time to read one review article this week, try this one on how to manage coagulopathies in critically ill patients.
We've started to announce the trials to be presented at CCR23. So far, on the programme we have CLOVERS, comparing early restrictive with liberal fluid management for sepsis-induced hypotension; AID-ICU, investigating haloperidol for delirium in the ICU; DEVICE, comparing video with direct laryngoscopy for emergency intubation in the critically ill; and the UK REBOA trial, the first randomised trial evaluating REBOA in trauma patients with uncontrolled torso haemorrhage. We have another two great trials to add this week. If you're planning on attending CCR23, don't be slow to book either the meeting or your accommodation, or you'll miss out!
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I hope you find this newsletter useful.
Until next week