Critical Care Reviews Newsletter

Newsletter 583  |  February 12th, 2023

Please support our work to share science

The Trials to be Presented at CCR23 Are Now Being Announced

Welcome to the 583rd Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.

The highlights of this week's edition are randomised controlled trials comparing methylprednisolone with intravenous immunoglobulins in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 & closed with open endotracheal tube suction in mechanically ventilated neonates; systematic reviews and meta analyses on brain tissue oxygenation monitoring in subarachnoid hemorrhage for the detection of delayed ischemia & the association between hypocholesterolemia and mortality in critically ill patients with sepsis; and observational studies on hospital-acquired bloodstream infections in intensive care unit patients & prehospital ultrasound in undifferentiated dyspnea.

There are also guidelines on acute mechanical circulatory support & pediatric coma and disorders of consciousness; narrative reviews on advanced point-of-care bedside monitoring for acute respiratory failure & sequential extracorporeal therapy in sepsis; editorials on early mobilization in the ICU & methylprednisolone for heart surgery in infants; and commentaries on the uncertain future of the determination of brain death & the top 10 papers in acute cardiac care and ischaemic heart disease in 2022.

If you only have time to read one review article this week, try this one on selective prehospital advanced resuscitative care to prevent prehospital deaths from noncompressible torso hemorrhage.


We've started to announce the trials to be presented at the Critical Care Reviews Meeting 2023, in Titanic Belfast. Our first trial is the long anticipated CLOVERS trial, comparing an early vasopressor with early fluids strategy in patients with sepsis-induced hypotension. Co-chief investigator Ivor Douglas, from Colorado, USA, will present the trial. Our second trial is AID-ICU, a fascinating trial evaluating haloperidol in ICU patients with delirium. Nina Christine Andersen-Ranberg, the co-ordinating investigator, from Copenhagen, Denmark, will present the trial. We have two massive trials to announce this week - watch this space!

Support CCR

Many thanks to those who responded to our call for support last week - your donations are gratefully received and help fund our work. Unfortunately, even after last week, this remains a tiny fraction (<1%) of those who use our platform. You can support Critical Care Reviews, from as little as the price of a cup of coffee per month or make a one-off donation. We are not-for-profit and make all our content free to view. Our aim is to share science for the benefit of all - please join us in this mission.

I hope you find this newsletter useful.

Until next week





Disseminating Evidence for over a Decade

© All rights reserved.

Back to Top