Matthew Semler presents the PILOT Trial Results
Welcome to the 568th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. The highlight of this week's edition is the presentation of the PILOT randomised controlled trial, which we held as a livestream on Monday night. This was simultaneously published in the New England Journal of Medicine. The other big news of the week was the presentation and publication of several major trials at the ESICM 2022 Congress in Paris. These trials have been collated in a supplemental newsletter sent on Wednesday night. The SuDDICU trial was presented during this session and was published in JAMA, in combination with a systematic review and meta analysis on selective digestive decontamination, also published in JAMA. We have now released the video of the SuDDICU trial results presentation from CCR22.
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Research
Randomised Controlled Trials
- Semler. Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation. N Engl J Med 2022;epublished October 24th
- Jiang. Volatile Versus Total Intravenous Anesthesia on Postoperative Delirium in Adult Patients Undergoing Cardiac Valve Surgery: A Randomized Clinical Trial. Anesth Analg 2022;epublished October 27th
- Vatter. Invasive Diagnostic and Therapeutic Management of Cerebral VasoSpasm after Aneurysmal Subarachnoid Hemorrhage (IMCVS)—A Phase 2 Randomized Controlled Trial. J Clin Med 2022;11(20):6197
- Hong. Nelonemdaz for Patients With Acute Ischemic Stroke Undergoing Endovascular Reperfusion Therapy: A Randomized Phase II Trial. Stroke 2022;53:3250–3259
- Karampitsakos. Tocilizumab versus baricitinib in hospitalized patients with severe COVID-19: an open label, randomized controlled trial. Clin Microbiol Infect 2022;epublished October 20th
Systematic Review & Meta Analyses
- Tamme. Incidence and outcomes of acute mesenteric ischaemia: a systematic review and meta-analysis. BMJ Open 2022;12(10):e062846
- Bolther. Ventilation Strategies During General Anesthesia for Noncardiac Surgery: A Systematic Review and Meta-Analysis. Anesth Analg 2022;135(5):971-985
- Heffernan. Comparison of continuous versus intermittent enteral feeding in critically ill patients: a systematic review and meta-analysis. Crit Care 2022;26:325
- García-Pérez-de-Sevilla. Effectiveness of physical exercise and neuromuscular electrical stimulation interventions for preventing and treating intensive care unit-acquired weakness: A systematic review of randomized controlled trials. Intensive Crit Care Nursing 2022;epublished October 22nd
- Quispe-Cornejo. Effects of rapid fluid infusion on hemoglobin concentration: a systematic review and meta-analysis. Crit Care 2022;26(1):324
Observational Studies
- Flaatten. Consent is a confounding factor in a prospective observational study of critically ill elderly patients. PLoS One 2022;17(10):e0276386
- Masse. The evolution of mean arterial pressure in critically ill patients on vasopressors before and during a trial comparing a specific mean arterial pressure target to usual care. BMC Anesthesiol 2022;22:6
- Hawchar. Hemoadsorption in the critically ill—Final results of the International CytoSorb Registry. PLoS One 2022;17(10):e0274315
- Robba. Oxygen targets and 6-month outcome after out of hospital cardiac arrest: a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial. Crit Care 2022;26(1):323
- Adrian. Mechanical complications after central venous catheterisation in the ultrasound-guided era: a prospective multicentre cohort study. Br J Anaesth 2022;epublished October 21st
- Cacioppo. Association of Intravenous Potassium and Magnesium Administration With Spontaneous Conversion of Atrial Fibrillation and Atrial Flutter in the Emergency Department. JAMA Netw Open 2022;5(10):e2237234
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Guidelines
- ESPNIC clinical practice guidelines: intravenous maintenance fluid therapy in acute and critically ill children- a systematic review and meta-analysis. Intensive Care Med 2022;epublished October 26th
- Japan Stroke Society Guideline 2021 for the Treatment of Stroke. Int J Stroke. 2022;17(9):1039–1049
- Messina. Head to toe ultrasound: a narrative review of experts’ recommendations of methodological approaches. J Anesth Analg Crit Care 2022;2:44
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Reviews
Clinical
COVID-19
- Leither. Care of the Seriously Ill Patient with SARS-CoV-2. Med Clin North Am 2022;106(6):949-960
- Thandassery. COVID-19 and the liver: a narrative review of the present state of knowledge. Transl Gastroenterol Hepatol. 2022 Oct 25;7:40
- Shen. COVID-19 and Gut Injury. Nutrients 2022;14(20):4409
- Diamantopoulos. Endocrine Aspects of ICU-Hospitalized COVID-19 Patients. J Pers Med 2022;12(10):1703
Neurological
- Yu. Endovascular Thrombectomy for Acute Basilar Artery Occlusion: Latest Findings and Critical Thinking on Future Study Design. Transl Stroke Res 2022;13:913–922
- Song. The BE COOL Treatments (Batroxobin, oxygEn, Conditioning, and cOOLing): Emerging Adjunct Therapies for Ischemic Cerebrovascular Disease. J Clin Med 2022;11(20):6193
Circulatory
- Upadhrasta. Early Mechanical Circulatory Support for Cardiogenic Shock. Cardiol Rev 2022;epublished October 25th
- Tavazzi. Mechanical circulatory support in ventricular arrhythmias. Front Cardiovasc Med 2022;epublished October 11th
- Dini. Right ventricular failure in left heart disease: from pathophysiology to clinical manifestations and prognosis. Heart Fail Rev 2022;epublished October 26th
- Ball. Technical considerations in the management of penetrating cardiac injury. Can J Surg 2022;65(5):E580-E592
- Ștefan. Volatile Anaesthesia versus Total Intravenous Anaesthesia for Cardiac Surgery—A Narrative Review. J Clin Med 2022;11(20):6031
- Flachskampf. The Role of Novel Cardiac Imaging for Contemporary Management of Heart Failure. J Clin Med 2022;11(20):6201
Resuscitation
- Lüsebrink. Targeted Temperature Management in Postresuscitation Care After Incorporating Results of the TTM2 Trial. J American Heart Assoc 2022;epublished October 26th
- Hooper. Drug routes in out-of-hospital cardiac arrest: a summary of current evidence. Resuscitation 2022;epublished October 26th
Respiratory
- Humayun. Mechanical ventilation in acute brain injury patients with acute respiratory distress syndrome. Front Med 2022;9:999885
- Bejjani. Pulmonary Embolism Response Teams: Theory, Implementation, and Unanswered Questions. J Clin Med 2022;11(20):6129
- Wyatt. Recent advances in the use of high flow nasal oxygen therapies. Front Med 2022;9:1017965
- Sams. Adult ECMO in the En Route Care Environment: Overview and Practical Considerations of Managing ECMO Patients During Transport. Curr Trauma Rep 2022;epublished October 20th
Haematological
Sepsis
Trauma
Neonatology
- Boel. Non-invasive respiratory support in preterm infants. Paediatr Respir Rev 2022 Sep;43:53-59
- Sankaran. Role of Volume Replacement during Neonatal Resuscitation in the Delivery Room. Children 2022;9(10):1484
Obstetrics
- Griffin. Obstetric Disorders and Critical Illness. Clin Chest Med 2022;43(3):471–488
- Bain. Postoperative systemic inflammatory dysregulation and corticosteroids: a narrative review. 2022;epublished October 29th
Miscellaneous
Non-Clinical
Revista Española de Quimioterapia
- Perea. Optimization of antimicrobial treatment in sepsis. Rev Esp Quimioter 2022;35(Suppl 3):30-33
- Suberviola. Management of hyperinflammation in COVID-19 patients. Rev Esp Quimioter 2022;35(Suppl 3):6-9
- Aiello. Antiviral drugs against SARS-CoV-2. Rev Esp Quimioter 2022;35(Suppl 3):10-15
- Berenguer. Neutralizing antibodies for SARS-CoV-2 infection. Rev Esp Quimioter 2022;35(Suppl 3):16-19
- Plata-Menchaca. Current treatment of nosocomial pneumonia and ventilator-associated pneumonia. Rev Esp Quimioter 2022;35(Suppl 3):25-29
- Maseda. Controversies in the management of ESBL-producing Enterabacterales. Clinical Implications. Rev Esp Quimioter 2022;35(Suppl 3):41-45
- Íñigo. Treatment of infections caused by carbapenemase-producing Enterobacterales. Rev Esp Quimioter 2022;35(Suppl 3):46-50
- Chumbita. New treatments for multidrug-resistant non-fermenting Gram-negative bacilli Infections. Rev Esp Quimioter 2022;35(Suppl 3):51-53
- Rosas. Global strategy in the treatment of HIV infection in 2022. Rev Esp Quimioter 2022;35(Suppl 3):34-36
- García-Bustos. Current management of CMV infection in cancer patients (solid tumors). Epidemiology and therapeutic strategies. Rev Esp Quimioter 2022;35(Suppl 3):74-79
- Merino. Treatment of Clostridioides difficile infection: from guidelines to clinical practice. Rev Esp Quimioter 2022;35(Suppl 3):97-101
- Cercenado. Rapid techniques for therapeutic optimization. Diagnostic stewardship. Rev Esp Quimioter 2022;35(Suppl 3):80-83
- Pasquau-Liaño. Timing in antibiotic therapy: when and how to start, de-escalate and stop antibiotic therapy. Proposals from a stablished antimicrobial stewardship program. Rev Esp Quimioter 2022;35(Suppl 3):102-107
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Editorials
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Commentaries
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Study Critiques
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Correspondence
- Lemieux. Standardising corticosteroid use in acute respiratory distress syndrome. Lancet respir Med 2022;epublished October 21st
- Colaianni-Alfonso. ROX index to predict CPAP outcome in hypoxemic respiratory failure due to COVID-19. Intensive Care Med 2022;epublished October 21st
- Lauridsen. Full resuscitation or no resuscitation attempt: Should we have a third option? Resuscitation 2022;epublished October 27th
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Case Reports
- Pradhan. Inadvertent extravasations of norepinephrine. Clin Case Rep 2022 Oct;10(10):e6516
- Yap. A rare cause of narrow QRS complex tachycardia: the tortoise and the hare. Neth Heart J 2022;30:536–537
- Ruwanpathirana. Clinical manifestations of wasp stings: a case report and a review of literature. Trop Med Health 2022;50:82
- Kojima. Clostridium perfringens bacteremia and intravascular hemolysis. QJM 2022;epublished October 12th
- Ivek. Methemoglobinemia – a case report and literature review. Acta Clin Croat 2022;61(Suppl 1):93-98
- Delalić. Can’t intubate, can’t oxygenate: a rare case of a difficult airway due to nonhereditary angioedema. Acta Clin Croat 2022;61(Suppl 1):99-103
I hope you find this newsletter useful.
Until next week
Rob