Critical Care Reviews Newsletter

Welcome to the 564th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.

The highlights of this week's edition are randomised controlled trials on temperature control after in-hospital cardiac arrest & high-flow nasal cannula oxygen vs standard oxygen therapy in patients with respiratory failure due to COVID-19; systematic reviews and meta analyses on early versus late tracheostomy & tissue penetration of antimicrobials; and observational studies on the incidence of death or disability at 6 months after extracorporeal membrane oxygenation & hemodynamic and clinical performance of hearts donated after circulatory death.

There are also guidelines on acute kidney injury in children & mass shootings; narrative reviews on osmotherapy for severe traumatic brain injuries & hemodynamic monitoring; editorials on long-term consequences of pediatric traumatic brain injury: & cerebral autoregulation and neurovascular coupling in brain disorders; and commentaries on bronchoscopy for the diagnosis of ventilator-associated pneumonia & four principles of hemodynamic monitoring.

If you only have time to read one review article this week, try this one on albumin administration in patients with cirrhosis.

This week's visual abstract from Jakub Fronczek is on the PRAGUE OHCA study trial. You can follow us on Instagram to stay current with these superb infographics.

PILOT Trial Results Livestream - Monday, October 24th

We're delighted to announce our next livestream will be the results presentation of the PILOT trial, a 2,250-patient cluster-randomized cluster-crossover trial comparing a lower SpO2 target (90%; range 88-92%), an intermediate SpO2 target (94%; range 92-96%), and a higher SpO2 target (98%; range 96-100%) with regard to the outcome of days alive and free of invasive mechanical ventilation. As usual, this will be a full, free livestream including results, independent editorial, viewers questions and expert panel discussion. It is scheduled to start at 20:00 UTC+1. More details will follow over the coming days.

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