Jon Casey presents the results of the PREPARE II trial at CCR22
Welcome to the 556th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are the one year outcomes of the COCA trial, investigating calcium for out-of-hospital cardiac arrest; systematic reviews and meta analyses on survival with extracorporeal life support during cardiac arrest & therapeutic hypothermia for children with traumatic brain injury; and observational studies on psychological distress and morbidity of family members experiencing virtual visiting in intensive care during COVID-19 & refractory status epilepticus.
There are also guidelines on reducing pollution from inhalational anaesthetics & core outcome measures for clinical effectiveness trials of nutritional and metabolic interventions in critical illness; narrative reviews on COVID-19-associated fungal infections & extracorporeal membrane oxygenation in children; editorials on gene-expression-based diagnostics for the presymptomatic diagnosis of hospital-acquired infections & real-time therapeutic drug monitoring; and commentaries on timing of early mobilization to optimize outcomes in mechanically ventilated ICU patients & restrictive fluid therapy and high-dose vitamin C in sepsis.
If you only have time to read one review article this week, try this one on POCUS shock management.
CCR22 Presentations
The videos from CCR22 are now being released. This week we posted the recording of the PREPARE II trial, evaluating the efficacy of a fluid bolus for the prevention of cardiovascular collapse in patients receiving emergency intubation. LOVIT, FIRST-ABC and CLASSIC have already been released. Jakub Fronczek has also produced a superb visual abstract on the PREPAREII trial.
CCR Blog
The Blog has been quiet for the past year. We've restarted it by reposting a great article from Dr Ed Palmer on the Fragility Index. Just how useful a concept is it?
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Research
Randomised Controlled Trials
- Vallentin. Effect of Calcium vs. Placebo on Long-Term Outcomes in Patients with Out-of-hospital Cardiac Arrest A Randomized Clinical Trial. Resuscitation 2022;epublished July 30th
- Coulson. A double-blind randomised feasibility trial of angiotensin-2 in cardiac surgery. Anaesthesia 2022;77(9):999-1009
- Wagener. A randomized, placebo-controlled, double-blinded pilot study of angiotensin 1–7 (TXA-127) for the treatment of severe COVID-19. Crit Care 2022;26:229
- Boeschoten. Efficacy of a loading dose of IV salbutamol in children with severe acute asthma admitted to a PICU: a randomized controlled trial. Eur J Pediatr 2022;epublished August 3rd
Systematic Review & Meta Analyses
- Kok. POCUS in dyspnea, nontraumatic hypotension, and shock; a systematic review of existing evidence. Eur J Intern Med 2022;epublished August 1st
- Battaglini. Tracheostomy outcomes in critically ill COVID-19 patients: a systematic review, meta-analysis, and meta-regression. Br J Anaesth 2022;epublished August 3rd
- Yang. Target Temperature Management Versus Normal Temperature Management for Cardiac Arrest After Traumatic Brain Injury Patient: A Meta-Analysis and Systemic Review. Ther Hypothermia Temp Manag 2022;epublished August 1st
- Panagides. Survival and Factors Associated with Survival with Extracorporeal Life Support During Cardiac Arrest: A Systematic Review and Meta-Analysis. ASAIO J 2022;68(8):987-995
- Verhoeff. Relationship between anti-Xa level achieved with prophylactic low-molecular weight heparin and venous thromboembolism in trauma patients: A systematic review and meta-analysis. J Trauma Acute Care Surg 2022;93(2):e61-e70
- Cortegiani. Empiric treatment of patients with sepsis and septic shock and place in therapy of cefiderocol: a systematic review and expert opinion statement. J Anesth Analg Crit Care 2022;2:34
- Du. Effect of Hypothermia Therapy on Children with Traumatic Brain Injury: A Meta-Analysis of Randomized Controlled Trials. Brain Sci 2022;12:1009
Observational Studies
- Rose. Psychological distress and morbidity of family members experiencing virtual visiting in intensive care during COVID-19: an observational cohort study. Intensive Care Med 2022;epublished August 1st
- Chiu. Management Of Refractory Status Epilepticus: An International COhort stuDy (MORSE CODe) Analysis of Patients Managed in the ICU. Neurology 2022epublished August 2nd
- Tsai. National Estimates of Increase in US Mechanical Ventilator Supply During the COVID-19 Pandemic. JAMA Netw Open 2022;5(8):e2224853
- Zhang. Efficacy of low-dose corticosteroids in patients with acute respiratory distress syndrome: a prospective observational study. J Thorac Dis 2022;14(7):2511-2521
- Tachino. Development of clinical phenotypes and biological profiles via proteomic analysis of trauma patients. Crit Care 2022;26:241
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Guidelines
- Davies. Core outcome measures for clinical effectiveness trials of nutritional and metabolic interventions in critical illness: an international modified Delphi consensus study evaluation (CONCISE). Crit Care 2022;26(1):240
- Devlin-Hegedus. Action guidance for addressing pollution from inhalational anaesthetics. Anaesthesia 2022;77(9):1023-1029
- Pandit. The effect of overlapping surgical scheduling on operating theatre productivity: a narrative review. Anaesthesia 2022;77(9):1030-1038
- Sindone. Consensus statement on the current pharmacological prevention and management of heart failure. Med J Aust 2022;epublished July 31st
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Reviews
Clinical
COVID-19
- Giacobbe. Herpes Simplex Virus 1 (HSV-1) Reactivation in Critically Ill COVID-19 Patients: A Brief Narrative Review. Infect Dis Ther 2022;epublished August 1st
- Amini. Pharmacotherapy consideration of thrombolytic medications in COVID-19-associated ARDS. J Intensive Care 2022;10:38
- Chan. Contemporary Concise Review 2021: COVID‐19 and other respiratory infections. Respirology 2022;27(8):661–668
- Hoenigl. COVID-19-associated fungal infections. Nat Microbiol 2022;epublished August 2nd
Neurological
- Mosconi. Treatments in Ischemic Stroke: Current and Future. Eur Neurol 2022;epublished August 2nd
- Hawryluk. Rationale and Methods for Updated Guidelines for the Management of Penetrating Traumatic Brain Injury. Neurotrauma Rep 2022;3(1):240-247
- Moss. Demystifying the Black Box: The Importance of Interpretability of Predictive Models in Neurocritical Care. Neurocrit Care 2022;37:185–191
Circulatory
Respiratory
- Whitney. Evolution of multiple omics approaches to define pathophysiology of pediatric acute respiratory distress syndrome. Elife 2022;11:e77405
- Balonov. Intraoperative protective lung ventilation strategies in patients with morbid obesity. Saudi J Anaesth 2022;16(3):327-331
- Yang. An Updated Review of Driving-Pressure Guided Ventilation Strategy and Its Clinical Application. BioMed Research International 2022;6236438
- Kim. Ventilation through a straw. Anesth Pain Med 2022;17(3):249-255
Hepatobiliary
Sepsis
- Wu. Sepsis prognosis related scoring standards: a comprehensive review. Biotarget 2022;5:3
- Ewoldt. The impact of sepsis on hepatic drug metabolism in critically ill patients: a narrative review. Expert Opin Drug Metab Toxicol 2022;epublished August 3rd
Paediatrics
Perioperative
Miscellaneous
- dos Santos. Ethics in the use of prognostic scores in intensive care units: an integrative review. Rev Bioét 2022;30(2):391-404
- Gravesteijn. Modern Learning from Big Data in Critical Care: Primum Non Nocere. Neurocrit Care 2022;37:174–184
Non-Clinical
Pre-Clinical
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Editorials
- Moita. A new possibility: gene-expression-based diagnostics for presymptomatic diagnosis of hospital-acquired infections. Intensive Care Med 2022;epublished August 2nd
- Martin-Loeches. Therapeutic drug monitoring (TDM) in real-time: a need for the present future. Expert Rev Anti Infect Ther 2022;epublished August 3rd
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Commentaries
- Kleinveld. Trauma-induced coagulopathy. Intensive Care Med 2022;epublished August 4th
- Schweickert. Timing of early mobilization to optimize outcomes in mechanically ventilated ICU patients. Intensive Care Med 2022;epublished August 4th
- Malbrain. Continuous intra-abdominal pressure: is it ready for prime time?. Intensive Care Med 2022;epublished August 4th
- Malbrain. Everything you need to know about deresuscitation. Intensive Care Med 2022;epublished August 6th
- Nieman. Unshrinking the baby lung to calm the VILI vortex. Crit Care 2022;26:242
- Kleinveld. Trauma-induced coagulopathy. Intensive Care Med 2022;epublished August 4th
- Schweickert. Timing of early mobilization to optimize outcomes in mechanically ventilated ICU patients. Intensive Care Med 2022;epublished August 4th
- Malbrain. Continuous intra-abdominal pressure: is it ready for prime time?. Intensive Care Med 2022;epublished August 4th
- Plummer. Restrictive fluid therapy and high-dose vitamin C in sepsis. Nat Rev Nephrol 2022;epublished August 1st
- Stoppe. Intravenous vitamin C in adults with sepsis in the intensive care unit: still LOV’IT?. Crit Care 2022;26:230
- Chen. Decoding Artificial Intelligence to Achieve Diagnostic ExcellenceLearning From Experts, Examples, and Experience. JAMA 2022;epublished August 1st
- Bleed. Lunchroom Revolution. JAMA 2022;328(5):423-424
- Weinfurt. Patient-Reported Outcome Measures in Clinical Research. JAMA 2022;328(5):472-473
- Charlesworth. How to disseminate clinical research. Anaesthesia 2022;77(9):1051-1054
- Sanghavi. Not So Fast: Kidney Replacement Therapy for Critically Ill Patients with AKI. Kidney360 2022;3(7):1281-1284
- Grieco. Why compliance and driving pressure may be inappropriate targets for PEEP setting during ARDS. Crit Care 2022;26:234
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Correspondence
- Desai. The need for caution in interpretation of network meta-analyses. Anaesthesia 2022;77(9):1060-1061
- Pasquier. Outcome prediction for hypothermic patients in cardiac arrest. J Intensive Care 2022;10:37
- Dudoignon. Multiplex bacterial PCR for antibiotic stewardship in pneumonia. Lancet Respir Med 2022;epublished August 1st
- Knox. Comparison of radiographic pneumothorax and pneumomediastinum in COVID-19 vs. non-COVID-19 acute respiratory distress syndrome. Intensive Care Med 2022;epublished August 5th
- Snow. Clarithromycin as an immunomodulator in sepsis: still a (IN)CLASS act. Crit Care 2022;26:238
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Case Reports
I hope you find this newsletter useful.
Until next week
Rob
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