Welcome to the 556th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are the one year outcomes of the COCA trial, investigating calcium for out-of-hospital cardiac arrest; systematic reviews and meta analyses on survival with extracorporeal life support during cardiac arrest & therapeutic hypothermia for children with traumatic brain injury; and observational studies on psychological distress and morbidity of family members experiencing virtual visiting in intensive care during COVID-19 & refractory status epilepticus.
There are also guidelines on reducing pollution from inhalational anaesthetics & core outcome measures for clinical effectiveness trials of nutritional and metabolic interventions in critical illness; narrative reviews on COVID-19-associated fungal infections & extracorporeal membrane oxygenation in children; editorials on gene-expression-based diagnostics for the presymptomatic diagnosis of hospital-acquired infections & real-time therapeutic drug monitoring; and commentaries on timing of early mobilization to optimize outcomes in mechanically ventilated ICU patients & restrictive fluid therapy and high-dose vitamin C in sepsis.
If you only have time to read one review article this week, try this one on POCUS shock management.
The videos from CCR22 are now being released. This week we posted the recording of the PREPARE II trial, evaluating the efficacy of a fluid bolus for the prevention of cardiovascular collapse in patients receiving emergency intubation. LOVIT, FIRST-ABC and CLASSIC have already been released. Jakub Fronczek has also produced a superb visual abstract on the PREPAREII trial.
The Blog has been quiet for the past year. We've restarted it by reposting a great article from Dr Ed Palmer on the Fragility Index. Just how useful a concept is it?
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