Welcome to the 555th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature for the week of July 25th to 31st. Finally, we've caught up!
The highlights of this week's edition are randomised controlled trials on dosing strategies of tranexamic acid for red blood cell transfusion in patients undergoing cardiac surgery & preoperative antithrombin supplementation in patients at risk for antithrombin deficiency after cardiac surgery.; systematic reviews and meta analyses on high versus low dose corticosteroids in COVID-19 patients & Intensive Care Unit diaries; and observational studies on endotypes of traumatic brain injury & long-term cognitive function in ICU-treated COVID-19 patients. There is also a consensus statement on advanced bleeding control in combat casualty care; narrative reviews on inhaled sedation in the intensive care unit & the myths and misconceptions of airway pressure release ventilation; editorials on sensitivity analysis in clinical trials & SARS-CoV-2 vaccination efficacy on hospitalisation and variants; as well as commentaries on the evolution of sedation management in the ICU & lung and diaphragm protective ventilation guided by esophageal pressure.
If you only have time to read one review article this week, try this one on the physiological and pathophysiological consequences of mechanical ventilation.
The videos from CCR22 continue to be released, with the FIRST-ABC trial result presentation the latest to be posted. Our latest visual abstract from Jakub Fronczek is on the CLASSIC trial.