Welcome to the 538th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are the long term outcomes of the CS2 trial, comparing dexamethasone 12 mg with 6 mg in patients with COVID-19 and severe hypoxaemia; a systematic review and meta analysis on brain tissue oxygen guided management on patient outcomes following severe traumatic brain injury; and a substudy of the BaSICS trial, investigating the association between the type of fluid received prior to enrollment, type of admission, and effect of balanced crystalloid in critically ill adults.
There are also guidelines on the management of heart failure & micronutrient administration; and narrative reviews on the early management of severe traumatic brain injury & airway pressure release ventilation. If you only have time to read one review article this week, try this one on acute coronary syndromes.
This week we announced the addition of the results presentation of the PREPARE II trial to the CCR22 meeting programme. This multi-centre RCT evaluates the prevention of cardiovascular collapse with the administration of fluid resuscitation during induction and intubation in the critically ill. Already, we will be hosting the results of the CLASSIC trial, investigating a restrictive fluid approach in septic shock; the LOVIT trial, examining vitamin C in sepsis; the FIRST ABC trial (step up), comparing high flow nasal oxygen with continuous positive airway pressure in critically ill children with acute respiratory failure; and LONG-HOT, the one year outcomes of the HOT-ICU trial, testing restrictive and liberal oxygenation targets in patients with acute hypoxaemic respiratory failure. If you haven't yet registered, don't miss out.
On Thursday April 7th, at 19:30 UTC+1, Dr Padmanabhan Ramnarayan from Imperial College London will present the results of the FIRST ABC (step down) trial, comparing high flow nasal oxygen with continuous positive airway pressure in recently extubated critically ill children. Join us as we hear the results of the first component of this two trial project. The second will be presented in person at CCR22.