Welcome to the 535th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlight of this week's edition is the publication of the RePHILL trial, investigating prehospital blood product transfusion in patients with traumatic haemorrhage. We hosted the results of this trial as a livestream last Monday - the recording can be viewed here.
The other highlights of this newsletter are a randomised controlled trial on the effects of physiologic point-of-care cardiopulmonary resuscitation training on survival in cardiac arrest in pediatric ICUs; systematic reviews and meta analyses on vitamin C in critically ill patients & tranexamic acid in gastrointestinal bleeding; observational studies on whole genome sequencing in patients with critical Covid-19 & the association of ICU admission and outcomes in sepsis and acute respiratory failure.
There is also a set of guidelines on prehospital airway management; narrative reviews on chest tube management & indirect calorimetry in patients with sepsis; a commentary on REBOA in post-partum haemorrhage; as well as correspondence on limitations of the ARDS criteria during high-flow oxygen or non-invasive ventilation & stimulating neural pathways to reduce mechanical ventilation–associated neurocognitive dysfunction.
If you only have time to read one review article this week, try this one on a biological definition of ARDS.
Registration for CCR22, on June 15th to 17th at Titanic Belfast, is open. We have details of two superb panel discussions to announce this week.
Our next livestream is due for the start of April. More details will be provided very soon.