Merry Christmas
Welcome to the 523rd Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are the RADAR2 randomised controlled trial, investigating the feasibility of conservative fluid administration and deresuscitation in critical illness, as well as an RCT comparing etomidate with ketamine for emergency endotracheal intubation; systematic reviews and meta analyses on utilization and outcomes of extracorporeal CO2 removal & medical futility regarding cardiopulmonary resuscitation in in-hospital cardiac arrests; and observational studies on capillary leak in critically ill patients & albumin and fibrinogen kinetics in sepsis.
There are also guidelines on the use of lung ultrasound in critically ill patients with coronavirus disease 2019 & early management of patients with aneurysmal subarachnoid hemorrhage in a hospital without neurosurgical/neuroendovascular facilities; narrative reviews on nutrition support for critically ill patients & extracorporeal haemoadsorption; editorials on Omicron SARS-CoV-2 variant: what we know and what we don’t & extracorporeal membrane oxygenation for COVID-19; and commentaries on applying syndemic theory to acute illness & the evolving role of ECMO in COVID-19.
If you only have time to read one review article this week, try this one on the current practice and evolving concepts in septic shock resuscitation.
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Research
Randomised Controlled Trials
- Silversides. Feasibility of conservative fluid administration and deresuscitation compared with usual care in critical illness: the Role of Active Deresuscitation After Resuscitation-2 (RADAR-2) randomised clinical trial. Intensive Care Med 2021;epublished December 16th
- Matchett. Etomidate versus ketamine for emergency endotracheal intubation: a randomized clinical trial. Intensive Care Med 2021;epublished December 14th
- Dargaville. Effect of Minimally Invasive Surfactant Therapy vs Sham Treatment on Death or Bronchopulmonary Dysplasia in Preterm Infants With Respiratory Distress Syndrome: The OPTIMIST-A Randomized Clinical Trial.JAMA 2021;epublished December 13th
- Merchante. Early Use of Sarilumab in Patients Hospitalised with COVID-19 Pneumonia and Features of Systemic Inflammation. Antimicrob Agents Chemother 2021;epublished December 13th
- Maskin. High- Versus Low-Dose Dexamethasone for the Treatment of COVID-19-Related Acute Respiratory Distress Syndrome: A Multicenter, Randomized Open-Label Clinical Trial. J Intensive Care Med 2021;epublished December 13th
- Ortigoza. Efficacy and Safety of COVID-19 Convalescent Plasma in Hospitalized PatientsA Randomized Clinical Trial. JAMA Intern Med 2021;epublished December 13th
- Lascarrou. Impact of rewarming rate on interleukin-6 levels in patients with shockable cardiac arrest receiving targeted temperature management at 33 °C: the ISOCRATE pilot randomized controlled trial. Crit Care 2021;25:434
- Clark. Intravenous albumin for the prevention of hemodynamic instability during sustained low-efficiency dialysis: a randomized controlled feasibility trial (The SAFER-SLED Study). Ann Intensive Care 2021;11:174
- Fisher. Namilumab or infliximab compared with standard of care in hospitalised patients with COVID-19 (CATALYST): a randomised, multicentre, multi-arm, multistage, open-label, adaptive, phase 2, proof-of-concept trial. Lancet Respir Med 2021;epublished December 16th
- Kassem. Role of AScorbic acid Infusion in critically ill patients with Transfusion Related Acute Lung Injury (ASTRALI). Br J Clin Pharmacol 2021;epublished December 5th
Systematic Review & Meta Analyses
- Yu. Utilization and outcomes of extracorporeal CO2 removal (ECCO2 R): Systematic review and meta-analysis of arterio-venous and veno-venous ECCO2 R approaches. Artif Organs 2021;epublished December 12th
- Moullaali. Early lowering of blood pressure after acute intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data. J Neurol Neurosurg Psych 2022;93:6-13
- Beck. Medical futility regarding cardiopulmonary resuscitation in in-hospital cardiac arrests of adult patients: A systematic review and Meta-analysis. Resuscitation 2021;epublished December 8th
- Smith. Conservative management of occult pneumothorax in mechanically ventilated patients: A systematic review and meta-analysis. J Trauma Acute Care Surg 2021;91(6):1025-1040
- Plotnikoff. Patient discharge from intensive care: an updated scoping review to identify tools and practices to inform high-quality care. Crit Care 2021;25:438
- Yu. Utilization and outcomes of extracorporeal CO2 removal (ECCO2 R): Systematic review and meta-analysis of arterio-venous and veno-venous ECCO2 R approaches. Artif Organs 2021;epublished December 12th
Observational Studies
- Puybasset. Prognostic value of global deep white matter DTI metrics for 1-year outcome prediction in ICU traumatic brain injury patients: an MRI-COMA and CENTER-TBI combined study. Intensive Care Med 2021;epublished December 14th
- Chiumello. Positive end-expiratory pressure in COVID-19 acute respiratory distress syndrome: the heterogeneous effects. Crit Care 2021;25(1):431
- Omiya. Albumin and fibrinogen kinetics in sepsis: a prospective observational study. Crit Care 2021;25:436
- Vanhorebeek. Persisting neuroendocrine abnormalities and their association with physical impairment 5 years after critical illness. Crit Care 2021;25:430
- Giosa. Orthodeoxia and its implications on awake-proning in COVID-19 pneumonia. Crit Care 2021;25:429
- Nunez. Bleeding and thrombotic events in adults supported with venovenous extracorporeal membrane oxygenation: an ELSO registry analysis. Intensive Care Med 2021;epublished December 18th
- Wollborn. Diagnosing capillary leak in critically ill patients: development of an innovative scoring instrument for non-invasive detection. Ann. Intensive Care 2021;11:175
- Rass. The effect of the volemic and cardiac status on brain oxygenation in patients with subarachnoid hemorrhage: a bi-center cohort study. Ann. Intensive Care 2021;11:176
- Peters-Sengers. Source-specific host response and outcomes in critically ill patients with sepsis: a prospective cohort study. Intensive Care Med 2021;epublished December 13th
- Nedergaard. Failure of non-sedation strategy in critically ill, mechanically ventilated patients - a retrospective, post-hoc analysis of the NONSEDA trial. J Crit Care 2021;68:66-71
- Sarma. Clinical Significance of Early Echocardiographic Changes after Resuscitated Out-of-Hospital Cardiac Arrest. resuscitation 2021;epublished December 16th
- Pisani. Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies. Lancet Glob Health 2021;epublished December 13th
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Guidelines
- Nasa. Expert Consensus Statements on the Use of Corticosteroids in Non-severe COVID-19. Indian J Crit Care Med 2021;25(11):1280-1285
- Italian Society of Anesthesia, Analgesia, Resuscitation, and Intensive Care expert consensus statement on the use of lung ultrasound in critically ill patients with coronavirus disease 2019 (ITACO). J Anesth Analg Crit Care 2021;1:16
- Early management of patients with aneurysmal subarachnoid hemorrhage in a hospital without neurosurgical/neuroendovascular facilities: a consensus and clinical recommendations of the Italian Society of Anesthesia and Intensive Care (SIAARTI). J Anesth Analg Crit Care 2021;1:10
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Reviews
Clinical
COVID-19
- Mazzeo. Cerebral venous sinus thrombosis (CVST) associated with SARS-CoV-2 vaccines: clues for an immunopathogenesis common to CVST observed in COVID-19. J Anesth Analg Crit Care 2021;1:15
- De Cassai. Research on SARS-COV-2 pandemic: a narrative review focused on the Italian contribution. J Anesth Analg Crit Care 2021;1:14
Respiratory
- Villar. Unsuccessful and Successful Clinical Trials in Acute Respiratory Distress Syndrome: Addressing Physiology-Based Gaps. Front Physiol 2021;12:774025
- Longhini. Should high-flow through nasal cannula be used during bronchoscopy in critically ill patients with hypoxemic acute respiratory failure?. J Anesth Analg Crit Care 2021;1:4
Nutrition
- Al-Dorzi. Nutrition support for critically ill patients. JPEN J Parenter Enteral Nutr 2021;45:S47–S59
- Flower. Should nutrition therapy be modified to account for mitochondrial dysfunction in critical illness? JPEN J Parenter Enteral Nutr 2021;45:S60-S65
- McClave. Can feeding strategies alter immune signaling and gut sepsis in critical illness? JPEN J Parenter Enteral Nutr 2021;45:S66-S73
- Patel. Enteral nutrition in septic shock: A pathophysiologic conundrum. JPEN J Parenter Enteral Nutr 2021;45:S74-S78
- Preiser. A guide to enteral nutrition in intensive care units: 10 expert tips for the daily practice. Crit Care 2021;25:424
- Di Giacinto. Emergencies in obese patients: a narrative review. J Anesth Analg Crit Care 2021;1:13
Hepatobiliary
Sepsis
- Bakker. Current practice and evolving concepts in septic shock resuscitation. Intensive Care Med 2021;epublished December 15th
- Supady. Extracorporeal haemoadsorption: does the evidence support its routine use in critical care? Lancet Respir Med 2021;epublished December 15th
- Sullivan. Endothelial glycocalyx degradation during sepsis: Causes and consequences. Matrix Biol Plus 2021;12:100094
Pre-Clinical
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Editorials
- Wollborn. Cardiac Anesthesiologists’ and Intensivists’ Impact in the Treatment of Patients at Advanced Heart Failure Centers. J Cardiothor Vasc Anesth 2021;epublished December 16th
- Ferré. Omicron SARS-CoV-2 variant: What we know and what we don’t. Anaesth Crit Care Pain Med 2021;epublished December 10th
- Leone. Selective digestive decontamination and COVID-19: Uncertainty in a moving area. Anaesth Crit Care Pain Med 2021;epublished December 14th
- Laverdure. Extracorporeal membrane oxygenation for COVID-19: Some answers and a remaining question. Anaesth Crit Care Pain Med 2022;41(1):100986
- La Caze. Determining the obligations of the pharmaceutical industry during the pandemic. Anaesth Crit Care Pain Med 2022;41(1):100988
- Kelly. The potential for artificial intelligence to predict clinical outcomes in patients who have acquired acute kidney injury during the perioperative period. Perioper Med 2021;10:49
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Commentaries
- MacLaren. Treating the Most Critically Ill Patients With COVID-19. The Evolving Role of Extracorporeal Membrane Oxygenation. JAMA 2021;epublished December 17th
- Rudd. Applying Syndemic Theory to Acute Illness. JAMA 2021;epublished December 17th
- Blaine. Pro–Con Debate: Viscoelastic Hemostatic Assays Should Replace Fixed Ratio Massive Transfusion Protocols in Trauma. Anesth Analg 2022;134(1):21-31
- Supady. Extracorporeal haemoadsorption: does the evidence support its routine use in critical care? Lancet Respir Med 2021;epublished December 15th
- Morens. Universal Coronavirus Vaccines — An Urgent Need. N Engl J Med 2021;epublished December 15th
- Adler-Milstein. Next-Generation Artificial Intelligence for DiagnosisFrom Predicting Diagnostic Labels to “Wayfinding”. JAMA 2021;epublished December 9th
- Langouche. Hyperglycemia and insulin resistance in COVID-19 versus non-COVID critical illness: Are they really different?. Crit Care 2021;25:437
- Adamo. The ‘Ten Commandments’ of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure, Eur Heart J 2021;ehab853
- Pisani. Do we need a 6D’s Framework of Nutritional Stewardship in critical care?. J Anesth Analg Crit Care 2021;1:5
- May. Eight unanswered questions about the COVID-19 pandemic. Nat Med 2021;27:2058–2061
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Correspondence
- Andersen. Calcium Administration and Post-Cardiac Arrest Ionized Calcium Values According to Intraosseous or Intravenous Administration – a Post Hoc Analysis of a Randomized Trial. Resuscitation 2021;epublished December 16th
- Li. Can serum markers of brain injury predict good neurological outcome after out‑of‑hospital cardiac arrest?. Intensive Care Med 2021;epublished December 16th
- Honore. Anisodamine microcirulatory effects in septic shock: be aware of cardiac side effects. Crit Care 2021;25:433
- von Groote. The AKI care bundle: all bundle components are created equal—are they?. Intensive Care Med 2021;epublished December 18th
- de Grooth. Pick your prior: scepticism about sceptical prior beliefs. Intensive Care Med 2021;epublished December 17th
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Case Reports
- Piastra. Life-threatening complications of streptococcal sepsis: a PICU contemporary series. J Anesth Analg Crit Care 2021;1:24
- Lersy. Meningeal inflammation and cerebral vasculitis during acute COVID-19 with spontaneous regression. Intensive Care Med 2021;epublished December 16th
- Mundi. Case presentation and panel discussion: Critical illness. JPEN J Parenter Enteral Nutr 2021;45:S79-S84
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News
- Burki. Omicron variant and booster COVID-19 vaccines. Lancet Respir Med 2021;epublished December 17th
- Rubin. COVID-19 Vaccine Makers Plan for Annual Boosters, but It’s Not Clear They’ll Be Needed. JAMA 2021;326(22):2247-2249
- Abbasi. Immunocompromised Patients With COVID-19 Receive Interferon Gamma. JAMA 2021;326(22):2250
I hope you find this newsletter useful.
Merry Christmas
Rob
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