Welcome to the 520th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are randomised controlled trials on prostacyclin in mechanically ventilated patients with COVID-19 & midodrine as adjunctive vasopressor for low-dose vasopressor-dependent hypotension; systematic reviews and meta analyses on noninvasive respiratory support following extubation in critically ill adults & esophageal pressure monitoring during mechanical ventilation; and observational studies on mechanisms of oxygenation responses to proning and recruitment in COVID-19 pneumonia & fungal infections in mechanically ventilated patients with COVID-19.
There is also a guidelines on prehospital blood product transfusion; narrative reviews on acute pulmonary embolism & temporary mechanical circulatory support in cardiogenic shock; an editorial on randomized controlled trials versus systematic reviews and meta-analyses; and a commentary on decarbonizing the U.S. health sector.
If you only have time to read one review article this week, try this one on coagulopathies in intensive care medicine.
The results of the COCA trial, investigating calcium for out-of-hospital cardiac arrest, will be presented at a Critical Care Reviews Trial Results Livestream, on Tuesday November 30th at 19:30 UTC+0. Further details are available on the livestream webpage. As always, viewing is free; in addition, we have applied for CPD points for those wishing to claim them - these will be available shortly for a small charge.
After the virtual eCCR21 meeting this year, in 2022 we return to the iconic Titanic Belfast for our 10th anniversary meeting next June, 15th to 17th, 2022. Including major trial results presentations, reviews of the best trials of the preceding year and talks on various aspects of trials, CCR22 has become the niche meeting for the latest in critical care trials. Registration will open shortly, initially for registered CCR subscribers, before opening to the wider critical care community. The meeting sells out every year, so don't wait and miss out.