Welcome to the 501st Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are randomised controlled trials on lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19 & the impact of nursing delirium preventive interventions in the ICU; systematic reviews and meta analyses on platelet-to-red blood cell ratio and mortality in bleeding trauma patients & higher versus lower positive end-expiratory pressure in patients without ARDS; and observational studies on extracorporeal membrane oxygenation for COVID-19–associated severe ARDS in Chile & 3-month, 6-month, 9-month, and 12-month respiratory outcomes in patients following COVID-19-related hospitalisation.
There is also a military guideline on whole blood transfusion; narrative reviews on emerging SARS-CoV-2 variants of concern and potential intervention approaches & precision medicine and heterogeneity of treatment effect in therapies for ARDS; editorials on acute myocardial infarction with cardiogenic shock & writing a narrative review article; and a commentary on recovery after prolonged ICU treatment in patients with COVID-19.
If you only have time to read one review article this week, try this one on acute kidney injury.