Critical Care Reviews Newsletter
Newsletter 500 | July 11th 2021
Welcome to the 500th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The first newsletter was sent on December 14th, 2011, and now nine and a half years later, we reach number 500. The entire archive of newsletters is safely stored and will be added to this latest version of the website as soon as I can do so. Newsletter 1 contained links to just 11 articles. The newsletter has grown to become the best resource for staying up-to-date with the critical care literature and is received by thousands globally every week. Like everything else at Critical Care Reviews, this is provided free of charge. We strive to promote open access to scientific advancement for the benefit of all, and do so across our range of activities - newsletter, website, meeting, livestreams, podcast and book. If you haven't yet helped support our work, please consider doing so. Our work is free to access, but neither free to create nor share.
The highlights of this week's edition are the WHO REACT Group's prospective systematic review and meta analysis on IL-6 antagonists in patients hospitalized for COVID-19; a small randomised controlled trial investigating induced hypernatremia in patients with moderate-to-severe ARDS; and an observational study on the effects of standard vs energy-dense formulae on gastric retention, energy delivery, and glycemia in critically ill patients. There are also guidelines on myocarditis in children & emergency laparotomy enhanced recovery after surgery; narrative reviews on non-invasive ventilatory support and high-flow nasal oxygen as first-line treatment of acute hypoxemic respiratory failure & energetic dysfunction in sepsis; editorials on the worrying aspects of COVID-19 experimental interventions & the need for a comprehensive international clinical epidemiology of ARDS; and commentaries on when an airway plateau pressure above 30 cmH2O could be acceptable in ARDS patients & potential COVID-19 endgame scenarios; as well as correspondence on Choosing Wisely for COVID-19.
If you only have time to read one review article this week, try this one on acute respiratory distress syndrome.
CCR Podcast
Earlier in the week, Prof Manu Shankar-Hari joined me on the podcast to discuss the WHO REACT Group's prospective systematic review and meta analysis on IL-6 antagonists in COVID-19. Next week, I hope to have the latest edition to our podcast series on the REMAP-CAP adaptive platform trial, as well as Niklas Nielsen's answers to the questions posted by viewers on the TTM2 trial results livestream.
CCR Livestreams
We have now confirmed two further major trial result livestreams, which will take place in early August. More details next week.
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Research
Randomised Controlled Trials
- Chapple. Use of a High-Protein Enteral Nutrition Formula to Increase Protein Delivery to Critically Ill Patients: A Randomized, Blinded, Parallel-Group, Feasibility Trial. JPEN J Parenter Enteral Nutr 2021;45(4):699-709
- Bihari. Induced hypernatremia in patients with moderate-to-severe ARDS: a randomized controlled study. ICMx 2021;9:33
- Pang. Lung Ultrasound–Guided Emergency Department Management of Acute Heart Failure (BLUSHED-AHF): A Randomized Controlled Pilot Trial. J Am Coll Cardiol HF 2021;epublished July 7th
Systematic Reviews & Meta Analyses
- The WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group. Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19A Meta-analysis. JAMA 2021;epublished July 6th
- Pavlov. Awake prone positioning in non-intubated patients with acute hypoxemic respiratory failure due to COVID-19: A systematic review of proportional outcomes comparing observational studies with and without awake prone positioning in the setting of COVID-19. Respir Care 2021;epublished July 7th
- Shenoy. SARS-CoV-2 (COVID-19), viral load and clinical outcomes; lessons learned one year into the pandemic: A systematic review. World J Crit Care Med 2021;10(4):132-150
Observational Studies
- Schmidt. Tracheostomy management in patients with severe acute respiratory distress syndrome receiving extracorporeal membrane oxygenation: an International Multicenter Retrospective Study. Crit Care 2021;25:238
- Chapple. Effects of Standard vs Energy-Dense Formulae on Gastric Retention, Energy Delivery, and Glycemia in Critically Ill Patients. JPEN J Parenter Enteral Nutr 2021;45(4):710-719
Protocols and Statistical Analysis Plans
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Guidelines
- 2021 Korean Society of Myocardial Infarction Expert Consensus Document on Revascularization for Acute Myocardial Infarction. Korean Circ J 2021;51(4):289-307
- Malin. Key summary of German national treatment guidance for hospitalized COVID-19 patients Key pharmacologic recommendations from a national German living guideline using an Evidence to Decision Framework (last updated 17.05.2021). Infection 2021;epublished July 6th
- Understanding the Host in the Management of Pneumonia. An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc 2021;18(7):1087–1097
- Diagnosis and Management of Myocarditis in Children: A Scientific Statement From the American Heart Association. Circulation 2021;epublished July 7th
- Arslan. 2020 ESC Guidelines on acute coronary syndrome without ST-segment elevation. Recommendations and critical appraisal from the Dutch ACS and Interventional Cardiology working groups. Netherlands Heart Journal 2021;epublished July 7th
- Guidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS) Society Recommendations: Part 1-Preoperative: Diagnosis, Rapid Assessment and Optimization. World J Surg 2021;45(5):1272-1290
- Yoshiji. Evidence-based clinical practice guidelines for Liver Cirrhosis 2020. J Gastroenterol 2021;epublished July 7th
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Reviews
Clinical
COVID-19
- Swenson. The Pathophysiology and Dangers of Silent Hypoxemia in COVID-19 Lung Injury. Ann Am Thorac Soc 2021;18(7):1098–1105
- Wang. Respiratory care for the critical patients with 2019 novel coronavirus. Respir Med 2021;186:106516
- Nitesh. What we learned in the past year in managing our COVID-19 patients in intensive care units? World J Crit Care Med 2021;10(4):81-101
- Chiurlo. Invasive fungal infections in patients with COVID-19: a review on pathogenesis, epidemiology, clinical features, treatment, and outcomes. New Microbiol 2021;44(2):71-83
- Shang. Contemporary narrative review of treatment options for COVID-19. Respirology 2021;epublished July 8th
- Sridhar. Pathophysiology of infection with SARS-CoV-2—What is known and what remains a mystery. Respirology 2021;epublished May 26th
- Battaglini. Noninvasive respiratory support and patient self-inflicted lung injury in COVID-19: a narrative review. Br J Anaesth 2021;epublished June 3rd
- Legrand. Pathophysiology of COVID-19-associated acute kidney injury. Nat Rev Nephrol 2021;epublished July 5th
- Mahalaxmi. Mucormycosis: An opportunistic pathogen during COVID-19. Environ Res 2021;epublished July 6th
- Farshidfar. Cardiovascular complications of COVID-19. JCI Insight 2021;6(13):e148980
Neurological
- Barbosa-Silva. Infectious disease-associated encephalopathies. Crit Care 2021;25:236
- Dang. Predictive modeling in neurocritical care using causal artificial intelligence. World J Crit Care Med 2021;10(4):112-119
- Edlow. Therapies to Restore Consciousness in Patients with Severe Brain Injuries: A Gap Analysis and Future Directions. Neurocrit Care 2021;35(Suppl 1):68-85
- Claassen. Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness. Neurocrit Care 2021;35(Suppl 1):4–23
- Luppi. Mechanisms Underlying Disorders of Consciousness: Bridging Gaps to Move Toward an Integrated Translational Science. Neurocrit Care 2021;35:37–54
- Cavka. Diaphragm Pacing and a Model for Respiratory Rehabilitation After Spinal Cord Injury. J Neurol Phys Ther 2021;45(3):235-242
Circulatory
Respiratory
- Meyer. Acute respiratory distress syndrome. Lancet 2021;epublished July 1st
- Grieco. Non-invasive ventilatory support and high-flow nasal oxygen as first-line treatment of acute hypoxemic respiratory failure and ARDS. Intensive Care Med 2021;epublished July 7th
Renal
Endocrine
Haematological
Sepsis
- Preau. Energetic dysfunction in sepsis: a narrative review. Ann Intensive Care 2021;11(1):104
- Pravda. Sepsis: Evidence-based pathogenesis and treatment. World J Crit Care Med 2021;10(4):66-80
- Raine. Management of Acinetobacter baumannii infection in intensive care units. Afr J Thorac Crit Care Med 2021;27(1):
Trauma
Paediatrics
Obstetrics
Pre-Clinical
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Editorials
- Singer. Do not just sit there, do something … but do no harm: the worrying aspects of COVID-19 experimental interventions. Intensive Care Med 2021;epublished July 5th
- Tognoni. Why and how do we need comprehensive international clinical epidemiology of ARDS?. Intensive Care Med 2021;epublished July 3rd
- Hauw-Berlemont. Gender imbalance in intensive care: High time for action and evaluation!. Crit Care 2021;25:239
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Commentaries
- Diehl. When could airway plateau pressure above 30 cmH2O be acceptable in ARDS patients?. Intensive Care Med 2021;epublished July 8th
- Reintam Blaser. The gut in COVID-19. Intensive Care Med 2021;epublished July 8th
- Kofman. Potential COVID-19 Endgame Scenarios. Eradication, Elimination, Cohabitation, or Conflagration? JAMA 2021;epublished July 8th
- Hays Shapshak, A. Religious Perspectives on Death by Neurological Criteria: The Role of the Hospital Chaplain. Neurocrit Care 2021;epublished June 30th
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Correspondence
- Pramesh. Choosing Wisely for COVID-19: ten evidence-based recommendations for patients and physicians. Nat Med 2021;epublished July 5th
- Calisher. Science, not speculation, is essential to determine how SARS-CoV-2 reached humans. Lancet 2021;epublished July 5th
- Rochwerg. WHO COVID-19 therapeutic guidelines. Lancet 2021;398(10295):117
- Patriquin. Therapeutic Plasma Exchange in Vaccine-Induced Immune Thrombotic Thrombocytopenia. N Engl J Med 2021;epublished July 7th
- Kurtz. SAPS-3 performance for hospital mortality prediction in 30,571 patients with COVID-19 admitted to ICUs in Brazil. Intensive Care Med 2021;epublished July 10th
- Levy. Not All Breaths That Follow a Ventilator Cycle Are Reverse Triggering. Ann Am Thorac Soc 2021;18(7):1263-1264
- Rybalko. Cytokine adsorption and ECMO in patients with COVID-19. Lancet Respir Med 2021;epublished July 6th
- Nardelli. Lancet Respir Med 2021;epublished July 6th
- Wang. Find the real responders and improve the outcome of awake prone positioning. Crit Care 2021;25:242
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Case Reports
- Hayon. Skin-to-skin care with sedated and ventilated mother. Intensive Care Med 2021;epublished July 5th
- Oulego-Erroz. Diagnosis of spontaneous intestinal perforation using point of care ultrasound. Intensive Care Med 2021;epublished July 9th
- Viskin. Long QT Syndrome and Torsade de Pointes Ultimately Treated With Quinidine: Introducing the Concept of Pseudo–Torsade de Pointes. Circulation 2021;144(1):85–89
I hope you've found the first 500 newsletters useful.
Until next week
Rob
Supported by the Health Research Board
