Welcome to the 492nd Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are randomised controlled trials on convalescent plasma in patients admitted to hospital with COVID-19 & cytokine adsorption in patients with severe COVID-19 pneumonia requiring extracorporeal membrane oxygenation; systematic reviews and meta analyses on early vasopressin use in patients with septic shock & factor Xa inhibitor reversal in acute major bleeding; and observational studies on nurse-to-patient ratios & changes in UK in-hospital mortality in the first wave of COVID-19.
There are also guidelines on pediatric severe traumatic brain injury & postoperative acute kidney injury in adult non-cardiac surgery; narrative reviews on the furosemide stress test & perioperative care in cardiac surgery; editorials on the unprecedented challenges facing ICUs during the COVID-19 pandemic & management of severe covid-19; and commentaries on a tricompartmental model of lung oxygenation disruption to explain pulmonary and systemic pathology in severe COVID-19 & reconceptualizing how to support surrogates making medical decisions for critically ill patients.
If you only have time to read one review article this week, try this one on acute myopathy and muscle wasting after sepsis.