Critical Care Reviews Newsletter

Welcome to the 488th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature from April 12th to 18th, 2021.

The highlights of this week's edition are randomised controlled trials on the effect of infusion set replacement intervals on catheter-related bloodstream infections & Mycobacterium w in severe presumed Gram-negative sepsis; systematic reviews and meta analyses on the relationship between depth of sedation and intensive care outcome & the time to initiation of renal replacement therapy among critically ill patients with AKI; and observational studies on time-limited trials among critically ill patients with advanced medical illnesses and reduction of nonbeneficial ICU treatments & evolving changes in mortality of 13,301 critically ill adult patients with COVID-19 over 8 months.

There is also a guideline on infarction-related cardiogenic shock, as well as the PRISMA 2020 statement for reporting systematic reviews; narrative reviews on acute decompensation and acute-on-chronic liver failure & management for the drowning patient; an editorial on rehabilitation after critical illness; and commentaries on non-invasive respiratory support strategies in COVID-19 & industry-sponsored speaker programs; as well as two further case reports on thrombosis and thrombocytopaenia after receipt of the ChAdOx1 nCoV-19 vaccine.

If you only have time to read one review article this week, try this one on interleukin-6: obstacles to targeting a complex cytokine in critical illness.