Welcome to the 483rd Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition include the pre-print of the multi-platform therapeutic anticoagulation in critically ill patients with Covid-19 randomised controlled trial, the full results session of which we'll be live-streaming over the next number of weeks. There are additional preprints, from the RECOVERY Collaborative Group investigating convalescent plasma in patients admitted to hospital with COVID-19, & a report on awake prone position in adult non-intubated patients with acute hypoxaemic respiratory failure secondary to COVID-19. There are systematic reviews and meta analyses on between-trial heterogeneity in ARDS research & the incidence of VTE and bleeding among hospitalized patients with Coronavirus disease 2019; and an observational study on heterogeneity of treatment effect with dexmedetomidine in mechanically ventilated critically ill patients.
There are also guidelines on the invasive management of acute myocardial infarction complicated by cardiogenic shock & opioid-associated out-of-hospital cardiac arrest; narrative reviews on the use of extracorporeal CO2 removal in acute respiratory failure & acute decompensation and acute-on-chronic liver failure; an editorial on COVID-19 and acute kidney injury; and a commentary on Candida colonization in the respiratory tract. If you only have time to read one review article this week, try this one on severe covid-19 pneumonia.
Despite the roll-out of COVID-19 vaccines globally, there remains uncertainty as to how next Winter will unfold. As such, we have taken the decision to move CCR22 from our usual January slot to June, to avoid the peak of the Winter viral season. A Summer meeting in Belfast will have a different feel, with long days of sunlight and (possibly...) evening heat, in contrast to our usual mid-Winter cold and occasional snow. We're delighted to be returning to our home venue of Titanic Belfast for our 10th anniversary meeting - world class science is guaranteed, along with great music, food and craic. Those who registered for CCR21 and had their registrations rolled over to CCR22 will be emailed separately, and will retain their registration. For everyone else, we'll let you know in advance when registration is likely to open.