Critical Care Reviews Newsletter
Newsletter 474 | January 10th 2021
Welcome to the 474th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. It's a small newsletter as it's the week before the annual meeting, and I have limited time to put this together.
The highlights of this week's edition are four randomised controlled trials: firstly, the preprint of the REMAP-CAP IL-6 receptor anatgonists domain; secondly, another tocilizumab trial, this time in a more general population of patients hospitalized with Covid-19 pneumonia; thirdly, early high-titer plasma therapy to prevent severe Covid-19 in older adults; and finally, pulsed intravenous methylprednisolone in patients hospitalised with severe COVID-19.
There will be lots of activity around the meeting this week, starting with the release of the programme tonight. Registration, the release of the livestream url and other information is also due imminently.
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Randomised Controlled Articles
- PrePrint: The REMAP-CAP Investigators. Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19 – Preliminary report. medRxiv 2021;epublished January 7th
- Full Text: Salama. Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia. N Engl J Med 2021;384:20-30
- Full Text: Edalatifard. Intravenous methylprednisolone pulse as a treatment for hospitalised severe COVID-19 patients: results from a randomised controlled clinical trial. Eur Respir J 2020;56:2002808
- Full Text: Libster. Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults. N Engl J Med 2021;epublished January 6th
- Full Text: Macedo. A randomized trial of albumin infusion to prevent intradialytic hypotension in hospitalized hypoalbuminemic patients. Crit Care 2021;25:18
Systematic Reviews & Meta Analyses
- Full Text: Menges. Systematic early versus late mobilization or standard early mobilization in mechanically ventilated adult ICU patients: systematic review and meta-analysis. Crit Care 2021;25:16
- Full Text: Li. Timing of renal replacement therapy initiation for acute kidney injury in critically ill patients: a systematic review of randomized clinical trials with meta-analysis and trial sequential analysis. Crit Care 2021;25:15
- Abstract: Sud. Comparative Effectiveness of Protective Ventilation Strategies for Moderate and Severe ARDS: Network Meta-Analysis. Am J Respir Crit Care Med 2021;epublished January 6th
- Abstract: Patell. Pharmacologic Thromboprophylaxis and Thrombosis in Hospitalized Patients with COVID-19: A Pooled Analysis. Thromb Haemost 2020;epublished December 30th
Observational Studies
- Full Text: Yasuda. Occurrence and incidence rate of peripheral intravascular catheter-related phlebitis and complications in critically ill patients: a prospective cohort study (AMOR-VENUS study). J Intensive Care 2021;9:3
- Abstract: Couturaud. Prevalence of Pulmonary Embolism Among Patients With COPD Hospitalized With Acutely Worsening Respiratory Symptoms. JAMA 2021;325(1):59-68
- Full Text: Huang. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet 2021;epublished January 8th
- Full Text: Pun. Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study. Lancet Respir Med 2021;epublished January 8th
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Clinical
COVID-19
- Scholkmann. The Role of Methemoglobin and Carboxyhemoglobin in COVID-19: A Review. J Clin Med 2021;10(1):50
- Robba. Coagulative Disorders in Critically Ill COVID-19 Patients with Acute Distress Respiratory Syndrome: A Critical Review. J Clin Med 2021;10(1):140
- Higham. COVID-19 and COPD: a narrative review of the basic science and clinical outcomes. Eur Respir Rev 2020;29:200199
- Kapoor. COVID-19 and the perioperative neuroscience - A narrative review. Saudi J Anaesth 2021;15:19-26
- Goudra. Anesthesia for GI endoscopy in the era of COVID-19. Saudi J Anaesth 2021;15:27-32
- Mishra. Pain management in COVID-19 pediatric patients—An evidence- based review. Saudi J Anaesth 2021;15:33-9
Neurological
- Tenovuo. Assessing the Severity of Traumatic Brain Injury—Time for a Change? J Clin Med 2021;10(1):148
- Spencer. Update: Microdialysis for Monitoring Cerebral Metabolic Dysfunction after Subarachnoid Hemorrhage. J Clin Med 2021;10(1):100
Circulatory
Respiratory
- Rodrigues. Current developments and future directions in respiratory physiotherapy. Eur Respir Rev 2020;29:200264
- Rosell. Therapeutic bronchoscopy for central airway diseases. Eur Respir Rev 2020;29:190178
Metabolic
Sepsis
Paediatrics
Non-Clinical
- Lund. Evidence-Based Research Series-Paper 2 : Using an Evidence-Based Research approach before a new study is conducted to ensure value. J Clin Epi 2021;129:158-166
- Lund. Evidence-Based Research Series-Paper 3: Using an Evidence-Based Research approach to place your results into context after the study is performed to ensure usefulness of the conclusion. J Clin Epi 2021;129:167-171
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- Godoy. Ketamine in acute phase of severe traumatic brain injury “an old drug for new uses?”. Crit Care 2021;25:19
- Lauring. Genetic Variants of SARS-CoV-2—What Do They Mean? JAMA 2021;epublished January 6th
- Kirby. New variant of SARS-CoV-2 in UK causes surge of COVID-19. Lancet Respir Med 2021;epublished January 5th
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- Joffre. Microcirculation-targeted resuscitation in septic shock: can complex problems have simple answers?. Ann. Intensive Care 2021;11:1
- Lee. Microvascular Injury in the Brains of Patients with Covid-19. N Engl J Med 2021;epublished December 30th
- Various. Tocilizumab in Covid-19. N Engl J Med 2021;384:86-87
- Zhang. ECMO support for COVID-19: a balancing act. Lancet 2021;397(10269):94-95
- Camporota. Consensus on the referral and admission of patients with severe respiratory failure to the NHS ECMO service. Lancet Respir Med 2020;epublished January 8th
Until next week
Rob