
Paper of the Day
Sunday, February 16th
Motohashi. Toxicology in the emergency department: what's new? Br J Hosp Med 2022;83(9):1-16
Join us to read one paper per day and cover the spectrum of critical care across 2024. Previous papers of the day are available here.

Guideline

Commentary
added February 11th

Narrative Review
added February 10th

Guideline
added February 10th

Narrative Review
added February 10th
Check out this short video from the Critical Care Reviews Meeting 2024. If you're interested in critical care trials, this is the meeting for you.
The Critical Care Reviews Meeting is a focused trials meeting. We host the results of the most impactful and important critical care trials in the world. In 2024, between our Belfast and Melbourne meetings, we hosted 19 major trial results, plus many accompanying systematic reviews and meta analyses.
Many of these presentations were in conjunction with simultaneous publications in the New England Journal of Medicine, JAMA and NEJM Evidence.
If you haven't been yet, check out our video - there's no other meeting like it.
Trial Announcements

RESCUE 3
Trial Registration | Trial Protocol | RESCUE 2

INDex-CTP
Trial Registration | Trial Protocol

ENCOMPASS

TTM2 Biomarker

PROMIZING

FLUID

UK-ROX

GASTROSAM

TARGET Protein
updated February 4th

Paper of the Day
Tuesday, February 11th
Join us to read one paper per day and cover the spectrum of critical care across 2024. Previous papers of the day are available here.

Narrative Review
added January 29th

Narrative Review
added January 29th

Narrative Review
added January 28th

Narrative Review
added January 25th

Narrative Review
added January 25th
Glucose Control IPDMA presentation at CCR24
Simon Finfer (Sydney) and Derick Adigbli (Melbourne) present the results of an IPDMA of intensive glucose control in the critically ill at the Critical Care Reviews Meeting 2024. Lennie Derde (Utrecht) delivers an independent editorial. Danny McAuley (Belfast) chairs the session.
This IPDMA was simultaneously published in NEJM Evidence.
added January 24th
TGC-FAST presentation at CCR24
Jan Gunst (Leuven) presents the TGC-FAST trial at the Critical Care Reviews Meeting 2024. Lennie Derde delivers an independent editorial. The session is chaired by Danny McAuley (Belfast).
TGC-FAST was published in the New England Journal of Medicine.
added January 24th
CYCLE presentation at CCR24
Michelle Kho and Heather O'Grady present the results of the CYCLE trial at the Critical Care Reviews Meeting 2024. CYCLE investigates the use of in-bed ergometry in the critically ill mechanically ventilated patient.
The session is chaired by Marion Campbell. Panellists include Andrew Althouse, Carol Hodgson, Kevin Gibbs and Paul Mouncey.
CYCLE was simultaneously published in NEJM Evidence.
added January 23rd

Narrative Review
added January 25th

Editorial
added January 20th

Editorial
Young. Using AI to detect and treat delirium. Intensive Care Med 2025;epublished January 20th
added January 20th
John Hinds Lecture 2024

Professor Kathy Rowan delivers the 2024 John Hinds Lecture, entitled "ICNARC at 30 - Back to the Future".
added January 21st
NICO presentation at CCR24
Yonathan Freund (Paris) presents the NICO trial at the Critical Care Reviews Meeting 2024 in Titanic Belfast. Sheila Myatra (Mumbai) delivers an independent editorial. The session is chaired by Danny McAuley (Belfast).
The NICO trial investigated non-invasive airway management of patients comatose from acute poisoning.
NICO was previously published in JAMA.
added January 17th

Editorial

Newsletter 684
Critical Care Reviews Newsletter 684, bringing you the best critical care research and open access articles for the week January 13th to 19th.
Subscriptions are available to individuals and departments.
added January 19th

Randomised Controlled Trial
HEMOTION presentation at CCR24
Alexis Turgeon and Francois Lauzier (both Quebec City) present the results of the HEMOTION trial at the Critical Care Reviews Meeting 2024 in Titanic Belfast. HEMOTION compared liberal with restrictive transfusion thresholds in critically ill patients with traumatic brain injury.
The session is chaired by Catriona Kelly (Dublin). John Myburgh (Sydney) delivers an independent editorial. Anthony Gordon (London), Marion Campbell (Aberdeen), Alistair Nichol (Dublin) and Carol Hodgson (Melbourne) contribute to a panel discussion.
HEMOTION was simultaneously published in the New England Journal of Medicine.
added January 14th

Randomised Controlled Trial
added January 15th

Randomised Controlled Trial

Narrative Review
added January 13th
PREOXI presentation at CCR24
Jonathan Casey and Kevin Gibbs present the results of the PREOXI trial at the Critical Care Reviews Meeting 2024, in Titanic Belfast. PREOXI investigated non-invasive ventilation for preoxygenation in emergency intubation in the critically ill.
Yonathan Freund delivers an independent editorial. Catriona Kelly chairs a panel discussion with Anthony Gordon, Sheila Myatra, Victoria Cornelius and Jan Gunst.
PREOXI was simultaneously published in the New England Journal of Medicine.
added January 9th

Narrative Review
added January 13th

Narrative Review
added January 13th

Narrative Review
added January 8th
DEFENDER presentation at CCR24
Profs Caio Tavares and Fernando Zampieri present the results of the DEFENDER trial at the Critical Care Reviews Meeting 2024, in Titanic Belfast.
DEFENDER investigated the efficacy of dapagliflozin in the critically ill.
Danny McAuley delivers an independent editorial and Christopher Seymour chairs a panel discussion between Simon Finfer, Lennie Derde, Marion Campbell and Catherine McKenzie.
DEFENDER was simultaneously published in JAMA.
added January 7th

Narrative Review
added January 8th

Guideline
added January 8th

Editorial
added January 7th
REVISE presentation at CCR24
Deborah Cook and Adam Deane present the results of the REVISE trial, plus an accompanying systematic review and meta analysis, at the Critical Care Reviews Meeting 2024, in Titanic Belfast.
REVISE investigates the efficacy of stress ulcer prophylaxis with pantoprazole in critically ill mechanically ventilated patients.
Kathy Rowan delivers an editorial and Darren Taichman chairs a panel discussion between David Harrison, Martina Baiardo Redaelli, Madiha Hasmi and Danny McAuley.
REVISE was simultaneously published in the New England Journal of Medicine. The SRMA was simultaneously published in NEJM Evidence.
added January 6th

Editorial
added January 7th

Observational Study
Added January 7th

Meta Analysis
NAVIGATE presentation at CCR24
Profs Giacomo Monti and Giovanni Landoni present the results of the NAVIGATE trial at the Critical Care Reviews Meeting 2024 in Titanic Belfast.
added January 2nd

RCT

Meta Analysis
Added January 2nd

RCT
Added January 1st

Observational Study
Added January 1st

Narrative Review
Reignier. Nutritional Support in the ICU. BMJ 2025;388:e077979
Added January 3rd
CCR Down Under 2025
Week of December 8th
Due to the success of CCR Down Under, we're heading back to Melbourne in December 2025 for another 2 day event.
Join us in the Edge, Federation Square, to hear the results of the best critical care trials in the world.
Registration will open in May.
CCR Down Under is run in partnership with The Alfred Intensive Care Academic Centre.


Narrative Review
Added December 30th

Narrative Review
Added December 30th

Narrative Review
Added December 30th

Narrative Review
Added December 30th

Narrative Review
Lee. Intracerebral hemorrhage. Cerebrovasc Dis Extra 2025;15(1):1-8
Added December 30th

Editorial
Added December 30th

Editorial
Added December 30th

Commentary
Myriam. Red blood cell transfusion in brain injury: Is it solely a matter of hemoglobin threshold?. Crit Care 2024;28:430
Added December 30th

Commentary
Added December 30th

Commentary
Added December 30th