CCR26

Registration is now open

ImmunoSep Trial

Prof Evangelos Giamarellos-Bourboulis (Athens) presents the results of the ImmunoSep trial at CCR Down Under 2025 in Melbourne. ImmunoSep investigates a precision medicine approach for immune modulation in sepsis. An independent editorial is delivered by Prof Sarah Sasson (Sydney). Prof Andrew Udy (Melbourne) chairs a panel discussion between Sandra Peake (Adelaide), Chris Seymour (Pittsburgh) and Jessica Kasza (Melbourne). The ImmunoSep trial was simultaneously published in JAMA on December 9th, 2025.

added December 31st

Trialists' Summary

Prof Evangelos Giamarellos-Bourboulis (Athens) summarises the ImmunoSep trial

Papers

Journal Watch Latest

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Sample Issue

Guideline

Brain Trauma Foundation Guidelines for the Management of Penetrating Traumatic Brain Injury, Second Edition

added October 27th

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Narrative Review

Mottale. The metabolic response to stress in critical illness: updated review on the pathophysiological mechanisms, consequences, and therapeutic implications. Ann Intensive Care 2025;15:174

added October 27th

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Randomised Controlled Trial

Pettilä. Targeted Tissue Perfusion Versus Macrocirculatory-Guided Standard Care in Patients With Septic Shock: A Randomized Clinical Trial-The TARTARE-2S Trial. Crit Care Med 2025;epublished October 17th

added October 17th

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Randomised Controlled Trial

Khan. Slow-tempo music and delirium/coma-free days among older adults undergoing mechanical ventilation: a randomized clinical trial. JAMA Intern Med 2025;epublished Oct 13th

added October 17th

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Systematic Review & Meta Analysis

Su. Is volatile sedation truly associated with increased mortality in mechanically ventilated critically ill adults compared to intravenous sedation? Moving beyond pairwise meta-analysis to individual agent assessment via Bayesian network meta-analysis. Crit Care 2025;29:435

added October 17th

image: Shutterstock / Zay Nyi Nyi

Peripheral intra venous callula being flushed

Systematic Review & Meta Analysis

Petros. Peripheral line for vasopressor administration: prospective multicenter observational cohort study for survival and safety. PLoS One 2025;20(10):e0333275

added October 17th

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Narrative Reviews

Zhang. Thrombolytic therapy efficacy in cardiopulmonary resuscitation: investigating the effect of recombinant tissue plasminogen activator. Mol Med Rep 2025;32:335

added October 17th

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Narrative Review

Jain. Post-operative infection treatment in cardiac surgery: current practices and future directions. Perioper Med 2025;14:110

added October 17th

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CCR Meeting Talks

After 14 meetings, we have a huge collection of superb presentations. We'll showcase them here, one at a time.

CCR24

BLING III Trial Results

Jeff Lipman, Dorrilyn Rajbhandari, Joel Dulhunty & Mohd (Hafiz) Abdul-Aziz present the results of the BLING III trial and associated systematic review and meta analysis at the Critical Care Reviews Meeting 2024, in Titanic Belfast. BLING III compared continuous with intermittent beta lactam antibiotic administration in critically ill patients with sepsis.

added December 30th

CCR Content

Paper of the Day

Povoa. How to approach a patient hospitalized for pneumonia who is not responding to treatment?. Intensive Care Med 2025;51:893–903

Wednesday, January 7th

Highlighted Narrative Reviews

Hydroxyethyl starch fluid hanging from a drip stand

Foundational Trials

We're putting together a collection of the trials which have formed the foundation of contemporary critical care over the past quarter of a century. The trials are critiqued and further reading provided, giving an excellent opportunity to learn about landmark trials or refresh your knowledge.

CCR26

Registration is now open

ImmunoSep Trial

Trialists' Summary

Papers

Journal Watch Latest

Would you like to receive the latest critical care literature every weekend? Get the Critical Care Reviews Newsletter - there's nothing else like it!

Guideline

Narrative Review

Randomised Controlled Trial

Randomised Controlled Trial

Systematic Review & Meta Analysis

Systematic Review & Meta Analysis

Narrative Reviews

Narrative Review

CCR Meeting Talks

After 14 meetings, we have a huge collection of superb presentations. We'll showcase them here, one at a time.

CCR24

BLING III Trial Results

CCR Content

Paper of the Day

Latest Newsletter

Highlighted Narrative Reviews

Foundational Trials

Highlighted Guidelines

Would you like to receive the latest critical care literature every weekend?
Get the Critical Care Reviews Newsletter - there's nothing else like it!