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Foundational Trials Collection

Introducing our latest resource – Foundational Trials in Critical Care. Replacing our old Top 100 Trials, this new collection presents the trials that underpin modern intensive care practice.

All trials are fully appraised in the same systematic manner, allowing clinicians to easily follow every trial. If you are new to critical care, need a resource to guide those new to the field, or just want to refresh your knowledge, then enjoy reading our Foundational Trials Collection.

We’ll release one every few days, starting with arguably the most impactful trial of them all – ARMA. Our second trial is the landmark Kress trial on daily sedation interuptions from 2000.

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Latest Randomised Trials

Last updated July 8th

Latest Meta Analyses

Last updated July 8th

Latest Observational Studies

Last updated July 6th

Latest Guidelines

Last updated July 8th

Latest Narrative Reviews

Last updated July 11th

Latest Editorials

Last updated July 10th

Latest Commentaries

Last updated July 10th

CCR Down Under 2025

Registration has opened for CCR Down Under in Melbourne, on December 9th and 10th, again at the Edge in Federation Square.

We aim to bring another set of fantastic international critical care trials to Australia. If you are interested in the science underlying clinical practice, this is the meeting for you.

We're delighted to be partnering once again with the Alfred Intensive Care Academic Centre, and this year, with Monash University.

If you missed the presentations last December, the presentations of the so far published trials are available here.

Register

CCR Content

Bag of TPN

Paper of the Day

Friday, July 11th

Harrington. Acute Decompensated Heart Failure in the Setting of Acute Coronary Syndrome. JACC Heart Fail 2022;10(6):404-414

Join us to read one paper per day and cover the spectrum of critical care across 2025. Previous papers of the day are available here.

Have it emailed to you!

image: Shutterstock / Pitchyfoto
Bedside vial of dexmedetomidine

Foundational Trials

The Acute Respiratory Distress Syndrome Network. Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome. N Engl J Med 2000; 342:1301-1308

We start a new section looking at the foundation trials in critical care and start with probably the most important trial yet in the field.

added July 2nd

image: Shutterstock / Sora
CCR Newsletter icon

Newsletter 708

Critical Care Reviews Newsletter 708, bringing you the best critical care research and open access articles for the week June 30th to July 6th.

Subscriptions are available to individuals and departments.

added July 6th

CCR Meeting Talks

After 14 meetings, we have a huge collection of superb presentations. We'll showcase them here, one at a time.

CCR25

John Hinds Lecture

Prof John Myburgh delivers a remarkable John Hinds Lecture at the Critical Care Reviews Meeting 2025, titled Ukuthola Ubuhle