Hot Articles

Randomised Controlled Trials

• Panigada. A Randomized Controlled Trial of Antithrombin Supplementation During Extracorporeal Membrane Oxygenation. Crit Care Med 2020;epublished September 17th
• Eisen. Effect of aspirin on deaths associated with sepsis in healthy older people (ANTISEPSIS): a randomised, double-blind, placebo-controlled primary prevention trial. Lancet Respir Med 2020;epublished September 17th
• The Writing Committee for the REMAP-CAP Investigators. Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial. JAMA 2020;epublished September 2nd
• Tomazini. Effect of Dexamethasone on Days Alive and Ventilator-Free in Patients With Moderate or Severe Acute Respiratory Distress Syndrome and COVID-19. The CoDEX Randomized Clinical Trial. JAMA 2020;epublished September 2nd
• Dequin. Effect of Hydrocortisone on 21-Day Mortality or Respiratory Support Among Critically Ill Patients With COVID-19. A Randomized Clinical Trial. JAMA 2020;epublished September 2nd
• Karalapillai. Effect of Intraoperative Low Tidal Volume vs Conventional Tidal Volume on Postoperative Pulmonary Complications in Patients Undergoing Major SurgeryA Randomized Clinical Trial. JAMA 2020;324(9):848-858

Systematic Reviews & Meta Analysis

• The WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group. Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19. A Meta-analysis. JAMA 2020;epublished September 2nd

Observational Studies

• Grunau. Association of Intra-arrest Transport vs Continued On-Scene Resuscitation With Survival to Hospital Discharge Among Patients With Out-of-Hospital Cardiac Arrest. JAMA 2020;324(11):1058-1067

Guidelines & Position Statements

• WHO. Corticosteroids for COVID-19. Living Guidance. Epublished September 2nd

Randomised Controlled Trials

• Moskowitz. Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock. The ACTS Randomized Clinical Trial. JAMA 2020;324(7):642-650
• Hwang. Combination therapy of vitamin C and thiamine for septic shock: a multi-centre, double-blinded randomized, controlled study. Intensive Care Med 2020;epublished August 11th
• Franz. Effects of Liberal vs Restrictive Transfusion Thresholds on Survival and Neurocognitive Outcomes in Extremely Low-Birth-Weight InfantsThe ETTNO Randomized Clinical Trial. JAMA 2020;324(6):560-570
• Determination of Brain Death/Death by Neurologic Criteria. The World Brain Death Project. JAMA 2020;epublished August 3rd

Pilot Randomised Controlled Trials

• Tiacharoen. Protocolized Sedative Weaning vs Usual Care in Pediatric Critically Ill Patients: A Pilot Randomized Controlled Trial. Indian J Crit Care Med 2020;24(6):451–458

Guidelines & Position Statements

• Determination of Brain Death/Death by Neurologic Criteria. The World Brain Death Project. JAMA 2020;epublished August 3rd

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Randomised Controlled Trials

• Turan. Effect of Intravenous Acetaminophen on Postoperative Hypoxemia After Abdominal SurgeryThe FACTOR Randomized Clinical Trial. JAMA 2020;324(4):350-358
• Rossetti. Continuous vs Routine Electroencephalogram in Critically Ill Adults With Altered Consciousness and No Recent Seizure. A Multicenter Randomized Clinical Trial. JAMA Neurol 2020;epublished July 27th
• The RECOVERY Collaborative Group. Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report. N Engl J Med 2020;epublished July 17th
• The STARRT-AKI Investigators. Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury. N Engl J Med 2020;383:240-251
• Schepers. Urgent endoscopic retrograde cholangiopancreatography with sphincterotomy versus conservative treatment in predicted severe acute gallstone pancreatitis (APEC): a multicentre randomised controlled trial. Lancet 2020;396(10245):167-176
• Turan. Dexmedetomidine for reduction of atrial fibrillation and delirium after cardiac surgery (DECADE): a randomised placebo-controlled trial. Lancet 2020;396(10245):177-185
• Iglesias. Outcomes of Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in the Early Treatment of Sepsis. The ORANGES Trial. Chest 2020;158(1):164–173
• Chang. Combined Treatment With Hydrocortisone, Vitamin C, and Thiamine for Sepsis and Septic Shock. A Randomized Controlled Trial. Chest 2020;158(1):174–182

Press Release

1. Update on the phase III COVACTA trial of Actemra/RoActemra in hospitalised patients with severe COVID-19 associated pneumonia. Roche 2020;epublished July 29th

Systematic Reviews & Meta Analyses

1. Turner. Association of checklist use in endotracheal intubation with clinically important outcomes: a systematic review and meta-analysis. JAMA Netw Open 2020;3(7):e209278
2. Parhar. Standardized Management for Hypoxemic Respiratory Failure and ARDS: Systematic Review & Meta-analysis. Chest 2020;epublished July 3rd

Observational Studies

1. Folegatti. Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial. Lancet 2020;epublished July 20th
2. Zhu. Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet 2020;epublished July 20th
3. Jackson. An mRNA Vaccine against SARS-CoV-2 — Preliminary Report. N Engl J Med 2020;epublished July 14th
4. Carfì. Persistent Symptoms in Patients After Acute COVID-19. JAMA 2020;epublished July 9th
5. Paterson. The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings. Brain 2020;epublished July 8th
6. Pollán. Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study. Lancet 2020;epublished July 6th
7. Foster. The Association Between Discharge Delay from Intensive Care and Patient Outcomes. Am J Respir Crit Care Med 2020;epublished July 10th
8. Dufort. Multisystem Inflammatory Syndrome in Children in New York State. N Engl J Med 2020;epublished June 29th
9. Feldstein. Multisystem Inflammatory Syndrome in U.S. Children and Adolescents. N Engl J Med 2020;epublished June 29th

Guidelines & Position Statements

1. Rochwerg. Remdesivir for severe covid-19: a clinical practice guideline. BMJ 2020;370:m2924
2. Recommendations of the Working Groups from the Spanish Society of Intensive and Critical Care Medicine and Coronary Units (SEMICYUC) for the management of adult critically ill patients in the coronavirus disease (COVID-19). Medicina Intensiva 2020;epublished July 7th
3. Guimarães. Position Statement: Cardiopulmonary Resuscitation of Patients with Confirmed or Suspected COVID-19 - 2020. Arq Bras Cardiol 2020 ;114(6):1078-1087
4. Triage of Scarce Critical Care Resources in COVID-19 An Implementation Guide for Regional Allocation. An Expert Panel Report of the Task Force for Mass Critical Care and the American College of Chest Physicians. Chest 2020;158(1):212–225
5. Prevention, Diagnosis, and Treatment of VTE in Patients With COVID-19. CHEST Guideline and Expert Panel Report. Chest 2020;epublished June 2nd

Randomised Controlled Trials

1. The HALT-IT Trial Collaborators. Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial. Lancet 2020;395(10241):1927-1936
2. Pfortmueller. Hypertonic saline for fluid resuscitation in ICU patients post-cardiac surgery (HERACLES): a double-blind randomized controlled clinical trial. Intensive Care Med 2020;epublished June 9th
3. Li. Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19A Randomized Clinical Trial. JAMA 2020;epublished June 3rd
4. Boulware. A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19. N Engl J Med 2020;epublished June 3rd
5. Borges. Duration of antibiotic therapy in critically ill patients: a randomized controlled trial of a clinical and C-reactive protein-based protocol versus an evidence-based best practice strategy without biomarkers. Crit Care 2020;24:281

Press Releases

1. No clinical benefit from use of lopinavir-ritonavir in hospitalised COVID-19 patients studied in RECOVERY. Statement from the Chief Investigators of the Randomised Evaluation of COVid-19 thERapY (RECOVERY) Trial on lopinavir-ritonavir, 29 June 2020
2. RECOVERY Trial Investigators. Low-cost dexamethasone reduces death by up to one third in hospitalised patients with severe respiratory complications of COVID-19. Press Release June 16th
3. Statement from the Chief Investigators of the Randomised Evaluation of COVid-19 thERapY (RECOVERY) Trial on hydroxychloroquine

Retractions

• Mehra. Retraction: Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19. N Engl J Med. DOI: 10.1056/NEJMoa2007621. N Engl J Med 2020;epublished June 4th
• Mehra. Retraction: "Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis". Lancet 2020;epublished June 4th

Pilot Randomised Controlled Trials

1. Zampieri. Bundle of Coated Devices to Reduce Nosocomial Infections in the Intensive Care Unit: CRITIC Pilot Randomized Controlled Trial. Annals ATS 2020;epublished June 11thAnnals ATS 2020;epublished June 11th

Systematic Review & meta Analysis

1. Ferreyro. Association of Noninvasive Oxygenation Strategies With All-Cause Mortality in Adults With Acute Hypoxemic Respiratory FailureA Systematic Review and Meta-analysis. JAMA 2020;epublished June 4th
2. Chu. Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis. Lancet 2020;epublished June 1st

Observational Studies

• Whittaker. Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2. JAMA 2020;epublished June 8th
• Rowan. Early Use of Adjunctive Therapies for Pediatric Acute Respiratory Distress Syndrome: A PARDIE Study. Am J Respir Crit Care 2020;201(11):1389–1397

Guidelines & Position Statements

1. European Resuscitation Council COVID-19 Guidelines Executive Summary. Resuscitation 2020;epublished June 8th
2. Aziz. Managing ICU surge during the COVID‑19 crisis: rapid guidelines. Intensive Care Med 2020;epublished June 8th
3. Shang. Management of critically ill patients with COVID-19 in ICU: statement from front-line intensive care experts in Wuhan, China. Annals Intensive Care 2020;10:73
4. Critical Care for COVID-19 Affected Patients: Position Statement of the Indian Society of Critical Care Medicine. Indian J Crit Care Med 2020;24(4):222–241
5. Prevention, diagnosis and treatment of venous thromboembolism in patients with COVID-19: CHEST Guideline and Expert Panel Report. Chest 2020;epublished June 2nd
6. The Use of Bronchoscopy During the COVID-19 Pandemic. CHEST/AABIP Guideline and Expert Panel Report. Chest 2020;epublished April 30th
7. Use of Tracheostomy During the COVID-19 Pandemic: CHEST/AABIP/AIPPD: Expert Panel Report. Chest 2020;epublished June 5th

Randomised Controlled Trials

1. Beigel. Remdesivir for the Treatment of Covid-19 — Preliminary Report. N Engl J Med 2020;epublished May 22nd
2. Goldman. Remdesivir for 5 or 10 Days in Patients with Severe Covid-19. N Engl J Med 2020;epublished May 27th
3. Cao. Ruxolitinib in treatment of severe coronavirus disease 2019 (COVID-19): A multicenter, single-blind, randomized controlled trial, J Allergy Clin Immunol 2020;epublished May 26th
4. Cao. A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19. N Engl J Med 2020;382:1787-1799
5. Hung. Triple combination of interferon beta-1b, lopinavir-ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial. Lancet 2020;epublished May 8th
6. Francois. Nangibotide in patients with septic shock: a Phase 2a randomized controlled clinical trial. Intensive Care Med 2020;epublished May 28th
7. Hung. Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial. Lancet 2020;395(10238):1695-1704
8. Tang. Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial. BMJ 2020;369:m1849
9. Yang. Endovascular Thrombectomy with or without Intravenous Alteplase in Acute Stroke. N Engl J Med 2020;epublished May 6th
10. Sadan. Low-chloride- versus high-chloride-containing hypertonic solution for the treatment of subarachnoid hemorrhage–related complications: The ACETatE (A low ChloriE hyperTonic solution for brain Edema) randomized trial. J Intensive Care 2020;8:32

Pilot Randomised Controlled Trials

1. Deng. A pilot randomised controlled trial of the management of systolic blood pressure during endovascular thrombectomy for acute ischaemic stroke. Anaesthesia 2020;75(6):739-746
2. Van Dyck. Towards a fasting-mimicking diet for critically ill patients: the pilot randomized crossover ICU-FM-1 study. Crit Care 2020;24:249
3. Hadfield. Neurally adjusted ventilatory assist versus pressure support ventilation: a randomized controlled feasibility trial performed in patients at risk of prolonged mechanical ventilation. Critical Care 2020;24:220

Observational Studies

1. COVIDSurg Collaborative. Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study. Lancet 2020;epublished May 29th
2. Elharrar. Use of Prone Positioning in Nonintubated Patients With COVID-19 and Hypoxemic Acute Respiratory Failure. JAMA 2020;epublished May 15th
3. Geleris. Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19. N Engl J Med 2020;epublished May 7th
4. Mahévas. Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data. BMJ 2020;369:m1844 
5. Rosenberg. Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State. JAMA 2020;epublished May 11th
6. Sartini. Respiratory Parameters in Patients With COVID-19 After Using Noninvasive Ventilation in the Prone Position Outside the Intensive Care Unit. JAMA 2020;epublished May 15th
7. Elharrar. Use of Prone Positioning in Nonintubated Patients With COVID-19 and Hypoxemic Acute Respiratory Failure. JAMA 2020;epublished May 15th
8. Geleris. Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19. N Engl J Med 2020;epublished May 7th
9. Mahévas. Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data. BMJ 2020;369:m1844 

Guidelines & Position Statements

1. Consensus guidelines for managing the airway in patients with COVID ‐19. Anaesthesia 2020;75(6):785-799
2. Cook. Guidelines for the Acute Treatment of Cerebral Edema in Neurocritical Care Patients. Neurocrit Care 2020;32:647–666
3. Coccolini. Liver trauma: WSES 2020 guidelines. World J Emerg Surg 2020;15:24
4. Takhar. Recommendation of a practical guideline for safe tracheostomy during the COVID-19 pandemic. Eur Arch Otorhinolaryngol 2020;epublished April 21st
5. Making Medical Treatment Decisions for Unrepresented Patients in the ICU. An Official American Thoracic Society/American Geriatrics Society Policy Statement. Am J Respir Crit Care Med 2020;201(10):1182–1192
6. Harhay. Contemporary strategies to improve clinical trial design for critical care research: insights from the First Critical Care Clinical Trialists Workshop. Intensive Care Med 2020;46:930–942
7. Advanced Pulmonary and Cardiac Support of COVID-19 Patients. Emerging Recommendations From ASAIO—a Living Working Document. Heart Failure. 2020;13:e007175
8. Clinical Consensus Recommendations Regarding Non-Invasive Respiratory Support in the Adult Patient with Acute Respiratory Failure Secondary to SARS-CoV-2 infection. Revista Española de Anestesiología y Reanimación 2020;epublished May 7th
9. Abdul-Aziz. Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper. Intensive Care Med 2020;epublished May 7th
10. Recommendations from the Sociedade Portuguesa de Cuidados Intensivos and Infection & Sepsis Group for intensive care approach to COVID-19. Rev Bras Ter Intensiva. 2020;32(1):2-10
11. Legrand. Management of severe thermal burns in the acute phase in adults and children. Anaesth Crit Care Pain Med 2020;39(2):253-267
12. Bouzat. Early management of severe abdominal trauma. Anaesth Crit Care Pain Med 2020;39(2):269-277
13. French recommendations for the management of patients with spinal cord injury or at risk of spinal cord injury. Anaesth Crit Care Pain Med 2020;39(2):279-289
14. Gruel. Diagnosis and management of heparin-induced thrombocytopenia. Anaesth Crit Care Pain Med 2020;39(2):291-310

Randomised Controlled Trials

1. Wang. Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial. Lancet 2020;epublished April 29th
2. Lau. Timing of Endoscopy for Acute Upper Gastrointestinal Bleeding. N Engl J Med 2020;382:1299-1308
3. Deane. Outcomes Six Months after Delivering 100% or 70% of Enteral Calorie Requirements during Critical Illness (TARGET). A Randomized Controlled Trial. Am J Respir Crit Care Med 2020;814–822
4. Lertwattanachai. Clinical outcomes of empirical high-dose meropenem in critically ill patients with sepsis and septic shock: a randomized controlled trial. J Intensive Care 2020;8:26
5. McNelly. Effect of intermittent or continuous feed on muscle wasting in critical illness: A phase II clinical trial. Chest 2020;epublished April 2nd

Pilot Randomised Controlled Trials

1. Kakihana. Efficacy and safety of landiolol, an ultra-short-acting β1-selective antagonist, for treatment of sepsis-related tachyarrhythmia (J-Land 3S): a multicentre, open-label, randomised controlled trial. Lancet Respir Med 2020;epublished March 31st
2. Schomer. Effect of Flumazenil on Hypoactive Delirium in the ICU: A Double-Blind, Placebo-Controlled Pilot Study. Crit Care Expl 2020;2:e0085

Systematic Review & meta Anaysis

1. Gaudry. Delayed versus early initiation of renal replacement therapy for severe acute kidney injury: a systematic review and individual patient data meta-analysis of randomised clinical trials. Lancet 2020;epublished April 23rd
2. Fernando. Diagnosis of ventilator-associated pneumonia in critically ill adult patients—a systematic review and meta-analysis. Intensive Care Med 2020;epublished April 18th

Observational Studies

1. Jernigan. Multidrug-Resistant Bacterial Infections in U.S. Hospitalized Patients, 2012–2017. N Engl J Med 2020;382:1309-1319
2. Du. Clinical Features of 85 Fatal Cases of COVID-19 from Wuhan: A Retrospective Observational Study. Am J Respir Crit Care 2020;epublished April 3rd
3. Zhou. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020;395(10229):1054-1062
4. Bhatraju. Covid-19 in Critically Ill Patients in the Seattle Region — Case Series. N Engl J Med 2020;epublished March 30th
5. Wang. The experience of high-flow nasal cannula in hospitalized patients with 2019 novel coronavirus-infected pneumonia in two hospitals of Chongqing, China. Annals of Intensive Care 2020;10:37
6. Grasselli. Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy. JAMA 2020;epublished April 6th

Guidelines & Position Statements

1. Yang. Expert recommendations on blood purification treatment protocol for patients with severe COVID-19: Recommendation and consensus. Chronic Dis Transl Med 2020;epublished April 28th
2. Yang. Imaging of coronavirus disease 2019: A Chinese expert consensus statement. Eur J Radiol 2020;127:109008
3. Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19. Clinical Infectious Diseases 2020;epublished April 27th
4. Sudden Cardiac Arrest Survivorship: A Scientific Statement From the American Heart Association. Circulation 2020;141:e654–e685
5. Bartlett. Initial ELSO Guidance Document: ECMO for COVID-19 Patients with Severe Cardiopulmonary Failure. ASAIO 2020;epublished March 30th
6. Martin. Perioperative Quality Initiative (POQI) consensus statement on fundamental concepts in perioperative fluid management: fluid responsiveness and venous capacitance. Perioper Med 2020;9:12.
7. Cinesi Gómez. Clinical Consensus Recommendations Regarding Non-Invasive Respiratory Support in the Adult Patient with Acute Respiratory Failure Secondary to SARS-CoV-2 infection. Arch Bronconeumol 2020;epublished March 30th
8. Rascado Sedes. Contingency plan for the intensive care services for the COVID-19 pandemic. Med Intensiva 2020;epublished April 23rd
9. Guidelines for the management of glucocorticoids during the peri‐operative period for patients with adrenal insufficiency. Guidelines from the Association of Anaesthetists, the Royal College of Physicians and the Society for Endocrinology UK. Anaesthesia 2020;75(5):654-663
10. ISTH interim guidance on recognition and management of coagulopathy in COVID-19. J Thromb Haemost 2020;epublished March 25th
11. Management of SARS-CoV-2 infection: recommendations of the Polish Association of Epidemiologists and Infectiologists. Pol Arch Intern Med 2020;130:352-357
12. Foust. International Expert Consensus Statement on Chest Imaging in Pediatric COVID-19 Patient Management: Imaging Findings, Imaging Study Reporting and Imaging Study Recommendations. Radiology: Cardiothoracic Imaging 2020;epublished April 23rd
13. Kim. Interim Guidelines on Antiviral Therapy for COVID-19. Infect Chemother 2020;epublished April 23rd
14. Triage of scarce critical care resources in COVID-19: an implementation guide for regional allocation An expert panel report of the Task Force for Mass Critical Care and the American College of Chest Physicians. Chest 2020;epublished April 11th
15. Leisman. Development and Reporting of Prediction Models: Guidance for Authors From Editors of Respiratory, Sleep, and Critical Care Journals. Crit Care Med 2020;48(5):623-633
16. Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19 Infection. IDSA 2020;epublished April 11th
17. Interim Guidance for Basic and Advanced Life Support in Adults, Children, and Neonates With Suspected or Confirmed COVID-19: From the Emergency Cardiovascular Care Committee and Get With the Guidelines®-Resuscitation Adult and Pediatric Task Forces of the American Heart Association in Collaboration with lots of other groups. Circulation 2020;epublished April 9th
18. Shanthanna. Caring for patients with pain during the COVID‐19 pandemic: Consensus recommendations from an international expert panel. Anaesthesia 2020;epublished April 7th
19. Harhay. Methodologic Guidance and Expectations for the Development and Reporting of Prediction Models and Causal Inference Studies. Ann Thor Med 2020;epublished April 10th
20. The Role of Chest Imaging in Patient Management during the COVID-19 Pandemic: A Multinational Consensus Statement from the Fleischner Society. Radiology 2020;epublished April 7th
21. Song. Recommendations on cardiopulmonary resuscitation strategy and procedure for novel coronavirus pneumonia. Resuscitation 2020;epublished April 7th
22. Ball. Management of the neurologically deceased organ donor: A Canadian clinical practice guideline. CMAJ 2020;192:E361­9

Randomised Controlled Trials

• Cao. A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe COVID-19. N Engl J Med 2020;epublished March 18th
• Wu. High-flow nasal-oxygenation-assisted fibreoptic tracheal intubation in critically ill patients with COVID-19 pneumonia: a prospective randomised controlled trial. Br J Anaesth 2020;epublished March 19th

Pilot Randomised Controlled Trials

• The ECMO-PT Study Investigators. Early mobilisation during extracorporeal membrane oxygenation was safe and feasible: a pilot randomised controlled trial. Intensive Care Med 2020;epublished March 16th

Observational Studies

• Zhang. Treatment with convalescent plasma for critically ill patients with SARS-CoV-2 infection. Chest 2020;epublished March 31st
• Shen. Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma. JAMA 2020;epublished March 27th
• Zeng. Antibodies in Infants Born to Mothers With COVID-19 Pneumonia. JAMA 2020;epublished March 26th
• Dong. Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn. JAMA 2020;epublished March 26th
• Li. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia. N Engl J Med 2020;382:1199-1207
• Vincent. Prevalence and Outcomes of Infection Among Patients in Intensive Care Units in 2017. JAMA 2020;epublished March 24th
• Pompeii. Training and Fit Testing of Health Care Personnel for Reusable Elastomeric Half-Mask Respirators Compared With Disposable N95 Respirators. JAMA 2020;epublished March 25th
• Auriemma. Acute respiratory distress syndrome-attributable mortality in critically ill patients with sepsis. Intensive Care Med 2020;epublished March 23rd
• Chang. Time Kinetics of Viral Clearance and Resolution of Symptoms in Novel Coronavirus Infection. Am J Respir Crit Care 2020;epublished March 23rd
• Arentz. Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State. JAMA 2020;epublished March 19th
• Pung. Investigation of three clusters of COVID-19 in Singapore: implications for surveillance and response measures. Lancet 2020;epublished March 16th

Guidelines & Position Statements

• Cook. Consensus Guidelines for Managing the Airway in Patients With COVID-19. Anaesthesia 2020;epublished March 27th
• Radiological Society of North America Expert Consensus Statement on Reporting Chest CT Findings Related to COVID-19. Endorsed by the Society of Thoracic Radiology, the American College of Radiology, and RSNA.
• ASA. Joint Statement on Multiple Patients Per Ventilator. Epublished March 26th, 2020.
• Noninvasive respiratory support in the hypoxaemic peri-operative/periprocedural patient: a joint ESA/ESICM guideline. Intensive Care Med 2020;epublished March 10th

Randomised Controlled Trials

Pilot Randomised Controlled Trials

Observational Studies

Guidelines & Position Statements

Randomised Controlled Trials

Pilot Randomised Controlled Trials

Observational Studies

Guidelines & Position Statements

Randomised Controlled Trials

Pilot Randomised Controlled Trials

Observational Studies

Guidelines & Position Statements

Randomised Controlled Trials

Pilot Randomised Controlled Trials

Observational Studies

Guidelines & Position Statements

Randomised Controlled Trials

Pilot Randomised Controlled Trials

Observational Studies

Guidelines & Position Statements

Randomised Controlled Trials

Pilot Randomised Controlled Trials

Observational Studies

Guidelines & Position Statements

Randomised Controlled Trials

Pilot Randomised Controlled Trials

Observational Studies

Guidelines & Position Statements

Randomised Controlled Trials

• Maitland. Transfusion Volume for Children with Severe Anemia in Africa. N Engl J Med 2019; 381:420-431
• Maitland. Immediate Transfusion in African Children with Uncomplicated Severe Anemia. N Engl J Med 2019; 381:407-419
• Hodgson. Maximal Recruitment Open Lung Ventilation in Acute Respiratory Distress Syndrome (PHARLAP): A Phase II, Multicenter, Randomized, Controlled Trial. Am J Respir Crit Care Med 2019;epublished July 29th
• Johnston. Intensive vs Standard Treatment of Hyperglycemia and Functional Outcome in Patients With Acute Ischemic Stroke. The SHINE Randomized Clinical Trial. JAMA 2019;322(4):326-335
• Rosa. Effect of Flexible Family Visitation on Delirium Among Patients in the Intensive Care Unit. The ICU Visits Randomized Clinical Trial. JAMA 2019;322(3):216-228
• Garrouste-Orgeas. Effect of an ICU Diary on Posttraumatic Stress Disorder Symptoms Among Patients Receiving Mechanical Ventilation. A Randomized Clinical Trial. JAMA 2019;322(3):229-239
• Min. Randomized Trial Comparing Early and Late Administration of Rocuronium Before and After Checking Mask Ventilation in Patients With Normal Airways. Anesthesia & Analgesia 2019;129(2):380-386
• Lv. Early TIPS with covered stents versus standard treatment for acute variceal bleeding in patients with advanced cirrhosis: a randomised controlled trial. Lancet Gastroenterol Hepatol 2019;4(8):587-598
• Lambrichts. Hartmann's procedure versus sigmoidectomy with primary anastomosis for perforated diverticulitis with purulent or faecal peritonitis (LADIES): a multicentre, parallel-group, randomised, open-label, superiority trial. Lancet Gastroenterol Hepatol 2019;4(8):599-610
• Houston. Gastroenteritis aggressive versus slow treatment for rehydration (GASTRO): a phase II rehydration trial for severe dehydration: WHO plan C versus slow rehydration. BMC Medicine 2019;17:122
• Mertz. Continual hemodynamic monitoring with a single-use transesophageal echocardiography probe in critically ill patients with shock: a randomized controlled clinical trial. Intensive Care Med 2019;epublished July 4th

Pilot Randomised Controlled Trials

• Karvellas. Intraoperative continuous renal replacement therapy during liver transplantation: a pilot randomized-controlled trial (INCEPTION). Can J Anesth 2019;epublished July 26th
• Winterhalter. Effect of iloprost inhalation on postoperative outcome in high-risk cardiac surgical patients: a prospective randomized-controlled multicentre trial (ILOCARD). Can J Anesth 2019;66(8):907–920
• McCaughey. Abdominal functional electrical stimulation to assist ventilator weaning in critical illness: a double-blinded, randomised, sham-controlled pilot study. Critical Care 2019;23:261
• Karvellas. Intraoperative continuous renal replacement therapy during liver transplantation: a pilot randomized-controlled trial (INCEPTION). Can J Anesth 2019;epublished July 26th

Observational Studies

• Kalenga. The Ongoing Ebola Epidemic in the Democratic Republic of Congo, 2018–2019. N Engl J Med 2019;381:373-383
• Kahn. Association Between State-Mandated Protocolized Sepsis Care and In-hospital Mortality Among Adults With Sepsis. JAMA 2019;322(3):240-250

Guidelines & Position Statements

• Evidence-based review of trauma center care and routine palliative care processes for geriatric trauma patients; A collaboration from the American Association for the Surgery of Trauma Patient Assessment Committee, the American Association for the Surgery of Trauma Geriatric Trauma Committee, and the Eastern Association for the Surgery of Trauma Guidelines Committee. J Trauma 2019;86(4):737-743
• 2019 ACC/AHA/ASE advanced training statement on echocardiography (revision of the 2003 ACC/AHA clinical competence statement on echocardiography): a report of the ACC Competency Management Committee. Cardiovascular Imaging 2019;12:e000026
• Scheutz. Procalcitonin (PCT)-guided antibiotic stewardship: an international experts consensus on optimized clinical use. Clin Chem Lab Med 2019;57(9):1308-1318
• Brilakis. Guiding Principles for Chronic Total Occlusion Percutaneous Coronary Intervention. A Global Expert Consensus. Circulation 2019;140:420–433
• Management of acute liver failure. Clinical guideline from the Catalan Society of Digestology. Gastroenterol Hepatol 2019;42(1):51-64
• Lutwicka. Managing and preventing vascular catheter infections: A position paper of the international society for infectious diseases. Int J Infect Dis 2019;84:22–29
• Infection Study Group of Chinese Thoracic Society, Chinese Medical Association. Chinese guidelines for the diagnosis and treatment of hospital-acquired pneumonia and ventilator-associated pneumonia in adults (2018 Edition). J Thorac Dis 2019;11(6):2581-2616
• 2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society in Collaboration With the Society of Thoracic Surgeons. Circulation 2019;140:e125–e151

Randomised Controlled Trials

• Writing Committee for the PROBESE Collaborative Group of the PROtective VEntilation Network (PROVEnet) for the Clinical Trial Network of the European Society of Anaesthesiology. Effect of Intraoperative High Positive End-Expiratory Pressure (PEEP) With Recruitment Maneuvers vs Low PEEP on Postoperative Pulmonary Complications in Obese Patients. A Randomized Clinical Trial. JAMA 2019;epublished June 3rd
• Song. XueBiJing Injection Versus Placebo for Critically Ill Patients With Severe Community-Acquired Pneumonia. A Randomized Controlled Trial. Crit Care Med 2019;epublished June 3rd
• Östberg. Positive End-expiratory Pressure and Postoperative Atelectasis: A Randomized Controlled Trial. Anesthesiology 2019;epublished May 14th
• Kumar. Thromboelastography-Guided Blood Component Use in Patients With Cirrhosis With Nonvariceal Bleeding: A Randomized Controlled Trial. Hepatology 2019;epublished May 31st

Pilot Randomised Controlled Trials

• de Azevedo. Optimized calorie and high protein intake versus recommended caloric-protein intake in critically ill patients: a prospective, randomized, controlled phase II clinical trial. Rev Bras Ter Intensiva 2019;epublished May 23rd

Observational Studies

• Kalenga. The Ongoing Ebola Epidemic in the Democratic Republic of Congo, 2018–2019. N Engl J Med 2019;epublished May 29th
• Riva. Survival in out-of-hospital cardiac arrest after standard cardiopulmonary resuscitation or chest compressions only before arrival of emergency medical services: nationwide study during three guideline periods. Circulation 2019;139:2600–2609

Guidelines & Position Statements

• Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update. Hepatol Int 2019;epublished June 6th
• Esophageal emergencies: WSES guidelines. World Journal of Emergency Surgery 2019;14:26

Randomised Controlled Trials

• Brown. Effect of Targeting Mean Arterial Pressure During Cardiopulmonary Bypass by Monitoring Cerebral Autoregulation on Postsurgical Delirium Among Older Patients. A Nested Randomized Clinical Trial. JAMA Surg 2019;epublished May 22nd
• Manley. Nasal High-Flow Therapy for Newborn Infants in Special Care Nurseries (HUNTER trial). N Engl J Med 2019;380(21):2031-2040
• Shi. Effect of perioperative administration of dexmedetomidine on delirium after cardiac surgery in elderly patients: a double-blinded, multi-center, randomized study. Clin Interv Aging 2019;14:571-575
• Neugebauer. Outcomes of Hypothermia in Addition to Decompressive Hemicraniectomy in Treatment of Malignant Middle Cerebral Artery Stroke. A Randomized Clinical Trial. JAMA Neurol 2019;76(5):571-579
• Nordberg. Effect of Trans-Nasal Evaporative Intra-arrest Cooling on Functional Neurologic Outcome in Out-of-Hospital Cardiac Arrest. The PRINCESS Randomized Clinical Trial. JAMA 2019;321(17):1677-1685
• Henry. Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke. N Engl J Med 2019; 380:1795-1803
• Heyland. A multicenter, randomized, double-blind study of ulimorelin and metoclopramide in the treatment of critically ill patients with enteral feeding intolerance: PROMOTE trial. Intensive Care Med 2019;45(5):647-656
• Landsperger. The effect of adhesive tape versus endotracheal tube fastener in critically ill adults: the endotracheal tube securement (ETTS) randomized controlled trial. Critical Care 2019;23:161

American Thoracic Society Meeting

• The National Heart, Lung, and Blood Institute PETAL Clinical Trials Network. Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome (ROSE trial). N Engl J Med 2019;epublished May 19th
• Shehabi. Early Sedation with Dexmedetomidine in Critically Ill Patients (SPICE III trial). N Engl J Med 2019;epublished May 19th
• Vincent. Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy. The SCARLET Randomized Clinical Trial. JAMA 2019;epublished May 19th

Pilot RCTs

• Aubron. Low-Dose Versus Therapeutic Anticoagulation in Patients on Extracorporeal Membrane Oxygenation: A Pilot Randomized Trial. Crit Care Med 2019;epublished April 25th

Observational Studies

• Shankar-Hari. Risk Factors at Index Hospitalization Associated With Longer-term Mortality in Adult Sepsis Survivors. JAMA Netw Open 2019;2(5):e194900
• Schmidt. Mechanical Ventilation Management during ECMO for ARDS: An International Multicenter Prospective Cohort (LIFEGARDS Study). Am J Respir Crit Care Med 2019;epublished May 30th
• Rafi. Doppler sonography of cerebral blood flow for early prognostication after out-of-hospital cardiac arrest: DOTAC study. Resuscitation 2019;epublished May 27th

American Thoracic Society Meeting

• Seymour. Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis. JAMA 2019;epublished May 19th

Guidelines & Position Statements

• Hutchinson. Consensus statement from the International Consensus Meeting on the Role of Decompressive Craniectomy in the Management of Traumatic Brain Injury. Acta Neurochirurgica 2019;epublished May 28th
• ICS/FICM. Guidance on: Transfer of the Critically Ill Adult. Epublished May 28th 2019
• Nanclares. WACEM consensus paper on deep venous thrombosis after traumatic spinal cord injury. J Emerg Trauma Shock 2019;12:150-4
• 2019 WACEM - Academic college of emergency experts consensus recommendations on admission criteria to pediatric intensive care unit from the emergency departments in India. J Emerg Trauma Shock 2019;12:155-62
• Griffiths. Guidelines on the management of acute respiratory distress syndrome. BMJ Open Respiratory Research 2019;6:e000420
• SCAI clinical expert consensus statement on the classification of cardiogenic shock. Catheter Cardiovasc Interv 2019;epublished May 19th
• Current endovascular strategies for posterior circulation large vessel occlusion stroke: report of the Society of NeuroInterventional Surgery Standards and Guidelines Committee. Journal of NeuroInterventional Surgery 2019;epublished May 18th
• EASL Clinical Practice Guidelines: Drug-induced liver injury. J Hepatology 2019;70(6):1222-1261
• 2019 EACTS Expert Consensus on long-term mechanical circulatory support. Eur J Cardiothorac Surg 2019;epublished May 17th
• Management of antiplatelet therapy for non elective invasive procedures of bleeding complications: proposals from the French working group on perioperative haemostasis (GIHP), in collaboration with the French Society of Anaesthesia and Intensive Care Medicine (SFAR). Anaesth Crit Care Pain Med 2019;38:289–30
• Párniczky. Antibiotic therapy in acute pancreatitis: From global overuse to evidence based recommendations. Pancreatology 2019;epublished April 19th
• AAST Critical Care Committee clinical consensus: ECMO, nutrition. Extracorporeal membrane oxygenation (ECMO) Nutrition. Trauma Surgery & Acute Care Open 2019;4:e000304
• American Association for the Surgery of Trauma emergency general surgery guideline summaries 2018: acute appendicitis, acute cholecystitis, acute diverticulitis, acute pancreatitis, and small bowel obstructionAcute cholecystitis management guidelines summaryAcute colonic diverticulitis management guidelines summaryIntestinal obstruction due to adhesions guideline summary, Acute pancreatitis management guidelines summary. Trauma Surgery & Acute Care Open 2019;4:e000281
• Engelman. Guidelines for Perioperative Care in Cardiac Surgery. Enhanced Recovery After Surgery Society Recommendations. JAMA Surg 2019;epublished May 4th

Randomised Controlled Trials

• Kho. Multicentre pilot randomised clinical trial of early in-bed cycle ergometry with ventilated patients. BMJ Open Respir Res 2019;6(1):e000383
• Chen. Nasal High-Frequency Oscillatory Ventilation in Preterm Infants With Respiratory Distress Syndrome and ARDS After Extubation. A Randomized Controlled Trial. Chest 2019;155(4):740–748
• Peden. Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery (EPOCH): a stepped-wedge cluster-randomised trial. Lancet 2019;epublished April 25th

Pilot RCTs

• Poli. Cytokine clearance with CytoSorb® during cardiac surgery: a pilot randomized controlled trial. Critical Care 2019;23:108
• Hay. The hospital-based evaluation of laxative prophylaxis in ICU (HELP-ICU): A pilot cluster-crossover randomized clinical trial. J Crit Care 2019;52:82-91
• Jeon. Procalcitonin-Guided Treatment on Duration of Antibiotic Therapy and Cost in Septic Patients (PRODA): a Multi-Center Randomized Controlled Trial. J Korean Med Sci 2019;34(14):e110
• Pinder. Effect of physostigmine on recovery from septic shock following intra-abdominal infection - Results from a randomized, double-blind, placebo-controlled, monocentric pilot trial (Anticholium® per Se). J Crit Care 2019;epublished April 9th
• Geri. Hemodynamic efficiency of hemodialysis treatment with high cut-off membrane during the early period of post-resuscitation shock: The HYPERDIA trial. Resuscitation 2019;epublished April 8th
• Corl. The Restrictive IV Fluid Trial in Severe Sepsis and Septic Shock (RIFTS). A Randomized Pilot Study. Crit Care Med 2019;epublished April 12th
• Ferrando. High-flow nasal cannula oxygenation reduces postoperative hypoxemia in morbidly obese patients: a randomized controlled trial. Minerva Anestesiol 2019;epublished April 16th
• Benadin. High versus low mean arterial pressures in hepatorenal syndrome: A randomized controlled pilot trial. J Crit Care 2019;epublished April 15th

Guidelines & Position Statements

• Vlaar. A consensus redefinition of transfusion‐related acute lung injury. Transfusion 2019;epublished April 16th
• Statement paper on diversity for the European Society of Intensive Care Medicine (ESICM). Intensive Care Med 2019;epublished April 4th
• Cardiorenal Syndrome: Classification, Pathophysiology, Diagnosis, and Treatment Strategies: A Scientific Statement From the American Heart Association. Circulation 2019;139:e840–e878
• Koo. Korean clinical practice guideline for perioperative red blood cell transfusion from Korean Society of Anesthesiologists. Korean J Anesthesiol 2019;72(2):91–118
• Perioperative Quality Initiative consensus statement on the physiology of arterial blood pressure control in perioperative medicine. Br J Anaesth 2019;122(5):542–551
• Perioperative Quality Initiative consensus statement on preoperative blood pressure, risk and outcomes for elective surgery. Br J Anaesth 2019;122(5):552–562
• Perioperative Quality Initiative consensus statement on intraoperative blood pressure, risk and outcomes for elective surgery. Br J Anaesth 2019;122(5):563–574
• Perioperative Quality Initiative consensus statement on postoperative blood pressure, risk and outcomes for elective surgery. Br J Anaesth 2019;122(5):575–586

Randomised Controlled Trials

• Kirpalani. Effect of Sustained Inflations vs Intermittent Positive Pressure Ventilation on Bronchopulmonary Dysplasia or Death Among Extremely Preterm Infants. The SAIL Randomized Clinical Trial (SAIL). JAMA 2019;321(12):1165-1175
• Yau. Intramyocardial Injection of Mesenchymal Precursor Cells and Successful Temporary Weaning From Left Ventricular Assist Device Support in Patients With Advanced Heart Failure. A Randomized Clinical Trial. JAMA 2019;321(12):1176-1186
• Nasi. Early Manipulation of Arterial Blood Pressure in Acute Ischemic Stroke (MAPAS): Results of a Randomized Controlled Trial. Neurocritical Care 2019;30(2):372-379
• Ameloot. Early goal-directed haemodynamic optimization of cerebral oxygenation in comatose survivors after cardiac arrest: the Neuroprotect post-cardiac arrest trial. Eur Heart J 2019;epublished March 20th
• Frat. Non-invasive ventilation versus high-flow nasal cannula oxygen therapy with apnoeic oxygenation for preoxygenation before intubation of patients with acute hypoxaemic respiratory failure: a randomised, multicentre, open-label trial. Lancet Respir Med 2019;epublished March 18th

American College of Cardiology Meeting

• Lemkes. Coronary Angiography after Cardiac Arrest without ST-Segment Elevation (COACT). N Engl J Med 2019;epublished March 18th
• Landoni. Volatile Anesthetics versus Total Intravenous Anesthesia for Cardiac Surgery (MYRIAD). N Engl J Med 2019;epublished March 19th
• Mehra. A Fully Magnetically Levitated Left Ventricular Assist Device — Final Report (MOMENTUM 3). N Engl J Med 2019;epublished March 17th
• Lopes. Antithrombotic Therapy after Acute Coronary Syndrome or PCI in Atrial Fibrillation (AUGUSTUS). N Engl J Med 2019;epublished March 17th

Pilot RCTs

• Macdonald. Bolus therapy with 3% hypertonic saline or 0.9% saline in emergency department patients with suspected sepsis: A pilot randomised controlled trial. J Crit Care 2019;epublished March 28th
• Møller. Low vs. high hemoglobin trigger for Transfusion in Vascular surgery (TV): a randomized clinical feasibility trial. Blood 2019:blood-2018-10-877530
• Gobatto. Transfusion requirements after head trauma: a randomized feasibility controlled trial. Crit Care 2019;23(1):89
• Peters. Permissive versus restrictive temperature thresholds in critically ill children with fever and infection: a multicentre randomized clinical pilot trial (FEVER). Critical Care 2019;23:69

Guidelines & Position Statements

• The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition. Critical Care 2019;23:98
• Optimization of the treatment with beta-lactam antibiotics in critically ill patients—guidelines from the French Society of Pharmacology and Therapeutics (Société Française de Pharmacologie et Thérapeutique—SFPT) and the French Society of Anaesthesia and Intensive Care Medicine (Société Française d’Anesthésie et Réanimation—SFAR). Critical Care 2019;23:104
• Mueller. Patient Blood Management. Recommendations From the 2018 Frankfurt Consensus Conference. JAMA 2019;321(10):983-997
• Management of Stroke in Neonates and Children: A Scientific Statement From the American Heart Association/American Stroke Association. Stroke 2019;50:e51–e96
• Khilnani. Guidelines for Antibiotic Prescription in Intensive Care Unit. Indian Journal of Critical Care Medicine 2019;23(Suppl 1):S1-S63
• Rodrigues. Indian Antimicrobial Prescription Guidelines in Critically Ill Immunocompromised Patients. Indian Journal of Critical Care Medicine 2019;23(Suppl 1):S64-96
• Therapy for Pulmonary Arterial Hypertension in Adults. Update of the CHEST Guideline and Expert Panel Report. Chest 2019;155(3):565–586
• Sociedade Portuguesa de Cuidados Intensivos guidelines for stress ulcer prophylaxis in the intensive care unit. Rev Bras Ter Intensiva 2019;epublished February 28th
• Guidelines for the Management of Pediatric Severe Traumatic Brain Injury, Third Edition: Update of the Brain Trauma Foundation Guidelines, Executive Summary. Ped Crit Care Med 2019;20(3S):S1-S82

Randomised Controlled Trials

• Subramaniam. Effect of Intravenous Acetaminophen vs Placebo Combined With Propofol or Dexmedetomidine on Postoperative Delirium Among Older Patients Following Cardiac SurgeryThe DEXACET Randomized Clinical Trial. JAMA 2019;321(7):686-696
• Guitton. Nasal high-flow preoxygenation for endotracheal intubation in the critically ill patient: a randomized clinical trial. Intensive Care Med 2019;epublished January 21st
• Goharani. Real-time compression feedback for patients with in-hospital cardiac arrest: a multi-center randomized controlled clinical trial. Journal of Intensive Care 2019;7:5
• Permpikul. Early Use of Norepinephrine in Septic Shock Resuscitation (CENSER) : A Randomized Trial. AM J espir Crit Care Med 2019;epublished February 1st
• Onland. Effect of Hydrocortisone Therapy Initiated 7 to 14 Days After Birth on Mortality or Bronchopulmonary Dysplasia Among Very Preterm Infants Receiving Mechanical Ventilation. A Randomized Clinical Trial (STOP-BPD Study). JAMA 2019;321(4):354-363
• The RIGHT-2 Investigators. Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomised, sham-controlled, blinded, phase 3 trial. Lancet 2019;epublished February 6th
• Anderson. Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial. Lancet 2019;epublished February 7th
• Hanley. Efficacy and safety of minimally invasive surgery with thrombolysis in intracerebral haemorrhage evacuation (MISTIE III): a randomised, controlled, open-label, blinded endpoint phase 3 trial. Lancet 2019;epublished February 7th
• Evald. Prolonged targeted temperature management reduces memory retrieval deficits six months post-cardiac arrest: A randomised controlled trial. Resuscitation 2019;134:1–9

Society of Critical Care Medicine Congress 2019

• Hernández. Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock. The ANDROMEDA-SHOCK Randomized Clinical Trial. JAMA 2019;epublished February 17th
• Wade. Effect of a Nurse-Led Preventive Psychological Intervention on Symptoms of Posttraumatic Stress Disorder Among Critically Ill Patients. A Randomized Clinical Trial. JAMA 2019;epublished February 18th
• Beitler. Effect of Titrating Positive End-Expiratory Pressure (PEEP) With an Esophageal Pressure–Guided Strategy vs an Empirical High PEEP-Fio2 Strategy on Death and Days Free From Mechanical Ventilation Among Patients With Acute Respiratory Distress Syndrome. A Randomized Clinical Trial. JAMA 2019;epublished February 18th
• Casey. Bag-Mask Ventilation during Tracheal Intubation of Critically Ill Adults. N Engl J Med 2019;epublished February 18th
• Arabi. Adjunctive Intermittent Pneumatic Compression for Venous Thromboprophylaxis. N Engl J Med 2019;epublished February 18th

Observational Studies

• Combes. Feasibility and safety of extracorporeal CO2 removal to enhance protective ventilation in acute respiratory distress syndrome: the SUPERNOVA study. Intensive Care Med 2019;epublished February 21st
• Rhee. Prevalence, Underlying Causes, and Preventability of Sepsis-Associated Mortality in US Acute Care Hospitals. JAMA Netw Open 2019;2(2):e187571

Guidelines & Position Statements

• Diagnosis and management of acute lower gastrointestinal bleeding: guidelines from the British Society of Gastroenterology. Gut 2019;epublished February 12th
• Wiegele. Diagnostic and therapeutic approach in adult patients with traumatic brain injury receiving oral anticoagulant therapy: an Austrian interdisciplinary consensus statement. Crit Care 2019;23(1):62
• Management of sepsis in neutropenic cancer patients: 2018 guidelines from the Infectious Diseases Working Party (AGIHO) and Intensive Care Working Party (iCHOP) of the German Society of Hematology and Medical Oncology (DGHO). Ann Hematol 2019;epublished February 22nd
• Chinese expert consensus on the treatment of modern combat-related spinal injuries. Military Medical Research 2019;6:6
• Crewdson. Best practice advice on pre-hospital emergency anaesthesia & advanced airway management. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2019;27:6
• KSHF Guidelines for the Management of Acute Heart Failure: Part I. Definition, Epidemiology and Diagnosis of Acute Heart Failure. Korean Circ J 2019;49(1):1-21
• KSHF Guidelines for the Management of Acute Heart Failure: Part II. Treatment of Acute Heart Failure. Korean Circ J 2019;49(1):22–45
• KSHF Guidelines for the Management of Acute Heart Failure: Part III. Specific Management of Acute Heart Failure According to the Etiology and Co-morbidity. Korean Circ J 2019;49(1):46-68
• Experts’ guidelines of intubation and extubation of the ICU patient of French Society of Anaesthesia and Intensive Care Medicine (SFAR) and French-speaking Intensive Care Society (SRLF). Annals of Intensive Care 2019;9:13
• Russell. Brain death, the determination of brain death, and member guidance for brain death accommodation requests: AAN position statement. Neurology 2019;92:228–232
• Fichtner. Mechanical Ventilation and Extracorporeal Membrane Oxygenation in Acute Respiratory Insufficiency. Dtsch Arztebl Int 2018;115(50):840-7
• Guidelines for the safe provision of anaesthesia in magnetic resonance units 2019: Guidelines from the Association of Anaesthetists and the Neuro Anaesthesia and Critical Care Society of Great Britain and Ireland. Anaesthesia 2019;epublished February 3rd
• International Consensus Guidelines for the Optimal Use of the Polymyxins: Endorsed by the American College of Clinical Pharmacy (ACCP), European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDSA), International Society for Anti-infective Pharmacology (ISAP), Society of Critical Care Medicine (SCCM), and Society of Infectious Diseases Pharmacists (SIDP). Pharmacotherapy 2019;39(1):10-39
• Fluid administration for acute circulatory dysfunction using basic monitoring: narrative review and expert panel recommendations from an ESICM task force. Intensive Care Med 2019;epublished November 19th
• The ELSO Maastricht Treaty for ECLS Nomenclature: abbreviations for cannulation configuration in extracorporeal life support - a position paper of the Extracorporeal Life Support Organization. Critical Care 2019;23:36
• The Evolving Role of the Cardiac Catheterization Laboratory in the Management of Patients With Out-of-Hospital Cardiac Arrest: A Scientific Statement From the American Heart Association. Circulation 2019;epublished February 14th
• 2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation. Circulation 2019;epublished January 28th
• European Resuscitation Council Guidelines for Resuscitation: 2018 Update – Antiarrhythmic drugs for cardiac arrest. Resuscitation 2019;134:99–103

Randomised Controlled Trials

• Mistraletti. Enteral versus intravenous approach for the sedation of critically ill patients: a randomized and controlled trial (SedaEN trial). Critical Care 2019;23:3

Pilot RCTs

• Semler. Conservative Fluid Management After Sepsis Resuscitation: A Pilot Randomized Trial. J Intensive Care Med 2019;epublished January 10th
• Scully. Calibrated cardiac output monitoring versus standard care for fluid management in the shocked ICU patient: a pilot randomised controlled trial. J Intensive Care 2019;7:1

Randomised Controlled Trials

• Lalgudi Ganesan. Airway Pressure Release Ventilation in Pediatric Acute Respiratory Distress Syndrome. A Randomized Controlled Trial. Am J Respir Crit Care Med 2018;198(9):1199-1207
• Kofoed. Early Versus Standard Care Invasive Examination and Treatment of Patients With Non-ST-Segment Elevation Acute Coronary Syndrome VERDICT Randomized Controlled Trial. Circulation 2018;138:2741–2750
• Jernberg. Long-Term Effects of Oxygen Therapy on Death or Hospitalization for Heart Failure in Patients With Suspected Acute Myocardial Infarction. Circulation 2018;138:2754–2762
• Balakrishnan. Hydrocortisone, Vitamin C and thiamine for the treatment of sepsis and septic shock following cardiac surgery. Indian J Anaesth 2018;62:934-9
• Jones. Effect of Levocarnitine vs Placebo as an Adjunctive Treatment for Septic Shock. The Rapid Administration of Carnitine in Sepsis (RACE) Randomized Clinical Trial. JAMA Netw Open 2018;1(8):e186076

Pilot RCTs

• Hawchar. Extracorporeal cytokine adsorption in septic shock: A proof of concept randomized, controlled pilot study. J Crit Care 2018;49:172-178

Observational Studies

Guidelines & Position Statements

• Chinese society of cardiology expert consensus statement on the diagnosis and treatment of adult fulminant myocarditis. Sci China Life Sci 2018;epublished December 3rd
• Association of Anaesthetists: anaesthesia and peri‐operative care for Jehovah's Witnesses and patients who refuse blood. Anaesthesia 2019;74:74-82
• Swiss Academy of Medical Sciences. Medical-ethical guidelines: Management of dying and death. Swiss Med Wkly. 2018;148:w14664
• Terra. Recommendations of the Brazilian society of hepatology for the management of acute kidney injury in patients with cirrhosis. Arq Gastroenterol 2018;55(3):314-320
• Tracheotomy in the intensive care unit: Guidelines from a French expert panel: The French Intensive Care Society and the French Society of Anaesthesia and Intensive Care Medicine. Anaesthesia Critical Care & Pain Medicine 2018;37(3):281-294
• Targeted temperature management in the ICU: Guidelines from a French expert panel. Anaesthesia Critical Care & Pain Medicine 2018;37(5):481-491
• Terra. Recommendations of the Brazilian society of hepatology for the management of acute kidney injury in patients with cirrhosis. Arq Gastroenterol 2018;55(3):314-320
• Tracheotomy in the intensive care unit: Guidelines from a French expert panel: The French Intensive Care Society and the French Society of Anaesthesia and Intensive Care Medicine. Anaesthesia Critical Care & Pain Medicine 2018;37(3):281-294
• Targeted temperature management in the ICU: Guidelines from a French expert panel. Anaesthesia Critical Care & Pain Medicine 2018;37(5):481-491
• Clinical Practice Guidelines by the Infectious Diseases Society of America: 2018 Update on Diagnosis, Treatment, Chemoprophylaxis, and Institutional Outbreak Management of Seasonal Influenza. Clinical Infectious Diseases 2018;ciy866
• Society of Cardiovascular Anesthesiologists/European Association of Cardiothoracic Anaesthetists Practice Advisory for the Management of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery. Anesth Analg 2019;128(1):33–42
• 2018 WSES/SIS-E consensus conference: recommendations for the management of skin and soft-tissue infections. World Journal of Emergency Surgery 2018;13:58

Chinese Combat Injury Guidelines

• Chinese expert consensus on echelons treatment of thoracic injury in modern warfare. Military Medical Research 2018;5:34
• Chinese expert consensus on echelons treatment of pelvic fractures in modern war. Military Medical Research 2018;5:21
• Expert consensus on the evaluation and diagnosis of combat injuries of the Chinese People’s Liberation Army. Military Medical Research 2018;5:6

American Society of Haematology Venous Thromboembolism Guideline

• American Society of Hematology 2018 guidelines for management of venous thromboembolism: prophylaxis for hospitalized and nonhospitalized medical patients. Blood Adv 2018; 2:3198-3225
• American Society of Hematology 2018 guidelines for management of venous thromboembolism: diagnosis of venous thromboembolism. Blood Adv 2018;2:3226-3256
• American Society of Hematology 2018 guidelines for management of venous thromboembolism: optimal management of anticoagulation therapy. Blood Adv 2018;2:3257-3291
• American Society of Hematology 2018 Guidelines for management of venous thromboembolism: treatment of pediatric venous thromboembolism. Blood Adv 2018;2:3292-3316
• American Society of Hematology 2018 guidelines for management of venous thromboembolism: venous thromboembolism in the context of pregnancy. Blood Adv 2018;2:3317-3359
• American Society of Hematology 2018 guidelines for management of venous thromboembolism: heparin-induced thrombocytopenia. Blood Adv 2018;2:3360-3392

Randomised Controlled Trials

• Curley. Randomized Trial of Platelet-Transfusion Thresholds in Neonates (PlaNeT2 MATISSE Trial). N Engl J Med 2018;epublished November 2nd
• Macdonald. Restricted fluid resuscitation in suspected sepsis associated hypotension (REFRESH): a pilot randomised controlled trial. Intensive Care Med 2018;epublished October 31st

Observational Studies

• Moseby-Knappe. Serum Neurofilament Light Chain for Prognosis of Outcome After Cardiac Arrest. JAMA Neurol 2018;epublished October 29th

Guidelines & Position Statements

• Cook. DELTA2 guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial. BMJ 2018;363:k3750
• Leone. Brief summary of French guidelines for the prevention, diagnosis and treatment of hospital-acquired pneumonia in ICU. Annals of Intensive Care 2018;8:104
• Gomes. Consensus Protocol for the Treatment of Super-Refractory Status Epilepticus. Acta Med Port 2018;31(10):598-605

Randomised Controlled Trials

ESICM Trials

• Krag. Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU (SUP-ICU). N Engl J Med 2018;epublished October 24th
• Cooper. Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients With Severe Traumatic Brain Injury: The POLAR Randomized Clinical Trial. JAMA 2018;epublished October 24th
• Writing Group for the PReVENT Investigators. Effect of a Low vs Intermediate Tidal Volume Strategy on Ventilator-Free Days in Intensive Care Unit Patients Without ARDSA Randomized Clinical Trial. JAMA 2018;epublished October 24th
• Azoulay. Effect of High-Flow Nasal Oxygen vs Standard Oxygen on 28-Day Mortality in Immunocompromised Patients With Acute Respiratory Failure: The HIGH Randomized Clinical Trial. JAMA 2018;epublished October 24th
• Pickkers. Effect of Human Recombinant Alkaline Phosphatase on 7-Day Creatinine Clearance in Patients With Sepsis-Associated Acute Kidney Injury (STOP-ICU): A Randomized Clinical Trial. JAMA 2018;epublished October 24th
• El Khamali. Effects of a Multimodal Program Including Simulation on Job Strain Among Nurses Working in Intensive Care Units (SISTRESSREA): A Randomized Clinical Trial. JAMA 2018;epublished October 24th
• The TARGET Investigator. Energy-Dense versus Routine Enteral Nutrition in the Critically Ill. N Engl J Med 2018;epublished October 22nd
• Girard. Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness. N Engl J Med 2018;epublished October 22nd
• Goligher. Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome and Posterior Probability of Mortality Benefit in a Post Hoc Bayesian Analysis of a Randomized Clinical Trial. JAMA 2018;epublished October 22nd
• Wittekamp. Decontamination Strategies and Bloodstream Infections With Antibiotic-Resistant Microorganisms in Ventilated Patients. A Randomized Clinical Trial (RGNOSIS). JAMA 2018;epublished October 22nd
• Perkins. Effect of Protocolized Weaning With Early Extubation to Noninvasive Ventilation vs Invasive Weaning on Time to Liberation From Mechanical Ventilation Among Patients With Respiratory Failure. The Breathe Randomized Clinical Trial. JAMA 2018;epublished October 22nd
• Dellinger. Effect of Targeted Polymyxin B Hemoperfusion on 28-Day Mortality in Patients With Septic Shock and Elevated Endotoxin Level. The EUPHRATES Randomized Clinical Trial. JAMA. 2018;320(14):1455-1463
• Mårtensson. Small volume resuscitation with 20% albumin in intensive care: physiological effects. Intensive Care Med 2018;epublished October 21st
• Milési. A multicenter randomized controlled trial of a 3-L/kg/min versus 2-L/kg/min high-flow nasal cannula flow rate in young infants with severe viral bronchiolitis (TRAMONTANE 2). Intensive Care Med 2018;epublished October 21st
• Lopez-de-Sa. A multicentre randomized pilot trial on the effectiveness of different levels of cooling in comatose survivors of out-of-hospital cardiac arrest: the FROST-I trial. Intensive Care Med 2018;epublished October 21st

Non-ESICM Trials

• Komorowski. The Artificial Intelligence Clinician learns optimal treatment strategies for sepsis in intensive care. Nature Medicine 2018;epublished October 22nd
• Barbar. Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis (IDEAL-ICU Trial). N Engl J Med 2018;379:1431-1442
• Birenbaum. Cricoid Pressure Compared With a Sham Procedure in Rapid Sequence Induction of Anesthesia. JAMA Surg 2018;epublished October 17th

Guidelines & Position Statements

• Singer. ESPEN guideline on clinical nutrition in the intensive care unit. Clinical Nutrition 2018;epublished September 29th
• The updated German "Polytrauma - Guideline": an extensive literature evaluation and treatment recommendation for the care of the critically injured patient. Eur J Trauma Emerg Surg 2018;44(Suppl 1):1

Randomised Controlled Trials

• Holland. Effect of Algorithm-Based Therapy vs Usual Care on Clinical Success and Serious Adverse Events in Patients with Staphylococcal Bacteremia. A Randomized Clinical Trial. JAMA 2018;320(12):1249-1258
• Harris. Effect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance. A Randomized Clinical Trial (MERINO). JAMA 2018;320(10):984-994
• Wang. Effect of a Strategy of Initial Laryngeal Tube Insertion vs Endotracheal Intubation on 72-Hour Survival in Adults With Out-of-Hospital Cardiac ArrestA Randomized Clinical Trial. JAMA 2018;320(8):769-778
• Benger. Effect of a Strategy of a Supraglottic Airway Device vs Tracheal Intubation During Out-of-Hospital Cardiac Arrest on Functional OutcomeThe AIRWAYS-2 Randomized Clinical Trial. JAMA 2018;320(8):779-791

Guidelines & Position Statements

• Andrews. Targeted temperature management in patients with intracerebral haemorrhage, subarachnoid haemorrhage, or acute ischaemic stroke: consensus recommendations. Br J Anaesth. 2018;121(4):768-775
• 2018 ESC/EACTS Guidelines on myocardial revascularization. European Journal of Cardio-Thoracic Surgery 2018;ezy289
• 2018 ESC/ESH Guidelines for the management of arterial hypertension. European Heart Journal 2018;epublished August 25th

Randomised Controlled Trials

• Wang. Effect of a Strategy of Initial Laryngeal Tube Insertion vs Endotracheal Intubation on 72-Hour Survival in Adults With Out-of-Hospital Cardiac ArrestA Randomized Clinical Trial. JAMA 2018;320(8):769-778
• Benger. Effect of a Strategy of a Supraglottic Airway Device vs Tracheal Intubation During Out-of-Hospital Cardiac Arrest on Functional OutcomeThe AIRWAYS-2 Randomized Clinical Trial. JAMA 2018;320(8):779-791
• Maze. Six-Month Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery (TRICS). N Engl J Med 2018;epublished August 26th
• Thiele. One-Year Outcomes after PCI Strategies in Cardiogenic Shock (CULPRIT-SHOCK). N Engl J Med 2018;epublished August 25th
• Inwald. Restricted fluid bolus volume in early septic shock: results of the Fluids in Shock pilot trial. Arch Dis Child 2018;epublished August 7th
• Mahmoodpoor. Effect of a Probiotic Preparation on Ventilator-Associated Pneumonia in Critically Ill Patients Admitted to the Intensive Care Unit: A Prospective Double-Blind Randomized Controlled Trial. Nutr Clin Pract 2018;epublished August 8th
• Atan. A Double-Blind Randomized Controlled Trial of High Cutoff Versus Standard Hemofiltration in Critically Ill Patients With Acute Kidney Injury. Crit Care Med 2018;epublished August 1st

Guidelines & Position Statements

• Fourth Universal Definition of Myocardial Infarction. JACC 2018;epublished August 24th
• Devlin. Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU. Crit Care Med 2018;46(9):e825-e873
• Lamontagne. Corticosteroid therapy for sepsis: a clinical practice guideline. BMJ 2018;362:k3284
• The use of viscoelastic haemostatic assays in the management of major bleeding: A British Society for Haematology Guideline. Br J Haematol 2018;epublished August 2nd

Randomised Controlled Trials

• Sperry. Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock (PAMPer Study). N Engl J Med 2018;379(4):315-326
• Fossat. Effect of In-Bed Leg Cycling and Electrical Stimulation of the Quadriceps on Global Muscle Strength in Critically Ill Adults. A Randomized Clinical Trial. JAMA 2018;320(4):368-378
• Moore. Plasma-first resuscitation to treat haemorrhagic shock during emergency ground transportation in an urban area: a randomised trial. Lancet 2018;epublished July 19th
• Perkins. A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest (PARAMEDIC2). N Engl J Med 2018;epublished July 18th
• Liu. Terlipressin versus norepinephrine as infusion in patients with septic shock: a multicentre, randomised, double-blinded trial. Intensive Care Med 2018;epublished July 3rd

Observational Studies

• Salter. Changes in Temperature Management of Cardiac Arrest Patients Following Publication of the Target Temperature Management Trial. Crit Care Med 2018;epublished July 30th
• Evans. Association Between the New York Sepsis Care Mandate and In-Hospital Mortality for Pediatric Sepsis. JAMA 2018;320(4):358-367

Guidelines & Position Statements

• Doherty. Multidisciplinary guidelines for the management of paediatric tracheostomy emergencies. Anaesthesia 2018;epublished July 31st
• European Association for the Study of the Liver Clinical Practice Guidelines for the management of patients with decompensated cirrhosis. J Hepatology 2018;69(2):404-460
• Canadian Stroke Best Practice Recommendations for Acute Stroke Management: Prehospital, Emergency Department, and Acute Inpatient Stroke Care, 6th Edition, Update 2018, Int J Stroke 2018;epublished January 1st
• Management of Acute Respiratory Distress Syndrome. Faculty of Intensive Care Medicine 2018;epublished July 6th
• Surviving sepsis campaign: research priorities for sepsis and septic shock. Intensive Care Med 2018;epublished July 3rd

Randomised Controlled Trials

• Jaber. Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial. Lancet 2018;epublished June 14th
• Kuppermann. Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis. N Engl J Med 2018; 378:2275-2287
• Atkinson. Does Point-of-Care Ultrasonography Improve Clinical Outcomes in Emergency Department Patients With Undifferentiated Hypotension? An International Randomized Controlled Trial From the SHoC-ED Investigators. Annals Emerg Med 2018;epublished June 2nd

Pilot Randomised Controlled Trials

• Peters. Conservative versus liberal oxygenation targets in critically ill children: the randomised multiple-centre pilot Oxy-PICU trial. Intensive Care Med 2018;epublished June 4th
• de Jong. The safety and efficacy of nicotine replacement therapy in the intensive care unit: a randomised controlled pilot study. Annals of Intensive Care 2018;8:70

Guidelines & Position Statements

• Kiehl. Consensus statement for cancer patients requiring intensive care support. Ann Hematol 2018;97(7):1271–1282

Randomised Controlled Trials

• Combes. Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome (EOLIA Trial). N Engl J Med 2018;378:1965-75
• White. A Randomized Trial of a Family-Support Intervention in Intensive Care Units (Partner Trial). N Engl J Med 2018;epublished May 23rd
• Huang. Procalcitonin-Guided Use of Antibiotics for Lower Respiratory Tract Infection (ProACT). N Eng J Med 2018;epublished May 20th
• Sprigg. Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial. Lancet 2018;epublished May 16th
• Driver. Effect of Use of a Bougie vs Endotracheal Tube and Stylet on First-Attempt Intubation Success Among Patients With Difficult Airways Undergoing Emergency Intubation. A Randomized Clinical Trial. JAMA 2018;epublished May 16th
• Myles. Restrictive versus Liberal Fluid Therapy for Major Abdominal Surgery. N Eng J Med 2018;epublished May 10th

Guidelines & Position Statements

• Brenner. Joint statement from the American College of Surgeons Committee on Trauma (ACS COT) and the American College of Emergency Physicians (ACEP) regarding the clinical use of Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA). Trauma Surgery & Acute Care Open 2018;3:e000154

Randomised Controlled Trials

• Ganesan. Airway Pressure Release Ventilation in Pediatric Acute Respiratory Distress Syndrome: a Randomized Controlled Trial. Am J Respir Crit Care Med 2018;epublished April 11th

Meta Analyses

• Chu. Mortality and morbidity in acutely ill adults treated with liberal versus conservative oxygen therapy (IOTA): a systematic review and meta-analysis. Lancet 2018;epublished April 28th

Guidelines & Position Statements

• Perner. Expert statement for the management of hypovolemia in sepsis. Intensive Care Med 2018;epublished April 25th
• British Thoracic Society Quality Standards for acute non-invasive ventilation in adults. BMJ Open Respir Res 2018;5(1):e000283
• Evaluation and Management of Right-Sided Heart Failure: A Scientific Statement From the American Heart Association. Circulation 2018;epublished April 12th

Randomised Controlled Trials

• Gehlbach. The Effects of Timed Light Exposure in Critically Ill Patients: A Randomized Controlled Pilot Study. Am J Respir Crit Care Med 2018;epublished March 12th
• Skrobik. Low-Dose Nocturnal Dexmedetomidine Prevents ICU Delirium. A Randomized, Placebo-controlled Trial. Am J Respir Crit Care Med 2018;197(9):1147–1156

Pilot Randomised Controlled Trials

• Gathier. Induced Hypertension for Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage: A Randomized Clinical Trial. Stroke 2018;49(1):76-83

Guidelines & Position Statements

• Trouillet. Tracheotomy in the intensive care unit: guidelines from a French expert panel. Ann Intensive Care 2018;8(1):37
• Treatment of infections caused by multidrug-resistant Gram-negative bacteria: report of the British Society for Antimicrobial Chemotherapy/Healthcare Infection Society/British Infection Association Joint Working Party. Journal of Antimicrobial Chemotherapy 2018;73(suppl 3):iii2–iii78
• Oddo. Fluid therapy in neurointensive care patients: ESICM consensus and clinical practice recommendations. Intensive Care Med 2018;epublished March 2nd

Observational Studies

• de Grooth. Unexplained mortality differences between septic shock trials: a systematic analysis of population characteristics and control-group mortality rates. Intensive Care Med 2018;epublished March 15th

Randomised Controlled Trials

• Annane. Hydrocortisone plus Fludrocortisone for Adults with Septic Shock (APROCCHSS). N Engl J Med 2018;378:809-818
• Semler. Balanced Crystalloids versus Saline in Critically Ill Adults (SMART). N Engl J Med 2018;epublished February 27th
• Self. Balanced Crystalloids versus Saline in Noncritically Ill Adults (SALT-ED). N Engl J Med 2018;epublished February 27th
• Jabre. Effect of Bag-Mask Ventilation vs Endotracheal Intubation During Cardiopulmonary Resuscitation on Neurological Outcome After Out-of-Hospital Cardiorespiratory Arrest (CAAM). A Randomized Clinical Trial. JAMA 2018;epublished February 27th
• van Meenen. Effect of On-Demand vs Routine Nebulization of Acetylcysteine With Salbutamol on Ventilator-Free Days in Intensive Care Unit Patients Receiving Invasive Ventilation (NEBULAE). A Randomized Clinical Trial. JAMA 2018;epublished February 27th
• Parshuram. Effect of a Pediatric Early Warning System on All-Cause Mortality in Hospitalized Pediatric Patients. The EPOCH Randomized Clinical Trial. JAMA 2018;epublished February 27th
• Kaye. Effect of Meropenem-Vaborbactam vs Piperacillin-Tazobactam on Clinical Cure or Improvement and Microbial Eradication in Complicated Urinary Tract Infection. The TANGO I Randomized Clinical Trial. JAMA 2018;319(8):788-799
• van den Boogaard. Effect of Haloperidol on Survival Among Critically Ill Adults With a High Risk of Delirium. The REDUCE Randomized Clinical Trial. JAMA 2018;319(7):680-690
• Wright. Intensive versus standard physical rehabilitation therapy in the critically ill (EPICC): a multicentre, parallel-group, randomised controlled trial. Thorax 2018;73:213-221
• Paul. Colistin alone versus colistin plus meropenem for treatment of severe infections caused by carbapenem-resistant Gram-negative bacteria: an open-label, randomised controlled trial. Lancet Respir Med 2018;epublished February 15

Guidelines & Position Statements

• Scandinavian SSAI clinical practice guideline on choice of inotropic agent for patients with acute circulatory failure. Acta Anaesthesiologica Scandinavica 2018;epublished February 25th
• Misango. Haemodynamic assessment and support in sepsis and septic shock in resource-limited settings. Trans R Soc Trop Med Hyg 2018;00:1–7
• The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016). Journal of Intensive Care 2018;6:7

Randomised Controlled Trials

• van Duijn. The effects of antibiotic cycling and mixing on antibiotic resistance in intensive care units: a cluster-randomised crossover trial (SATURN). Lancet Infect Dis 2018;epublished January 24th
• Ferrando. Individualised perioperative open-lung approach versus standard protective ventilation in abdominal surgery (iPROVE): a randomised controlled trial. Lancet Respir Med 2018;epublished January 19th
• Albers. Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging (DEFUSE 3). N Engl J Med 2018;epublished January 24th
• Venkatesh. Adjunctive Glucocorticoid Therapy in Patients with Septic Shock (ADRENAL). N Engl J Med 2018;epublished January 19th
• Itenov. Induced hypothermia in patients with septic shock and respiratory failure (CASS): a randomised, controlled, open-label trial. Cooling and Surviving Septic Shock (CASS) Trial Collaboration. Lancet Respir Med 2018;epublished January 8th
• Ribaric. Prophylactic versus clinically-driven antibiotics in comatose survivors of out-of-hospital cardiac arrest-A randomized pilot study. Resuscitation 2017;111:103-109

Guidelines & Position Statements

• 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke 2018;epublished January 24th

Randomised Controlled Trials

• van der Kooi. Prevention of hospital infections by intervention and training (PROHIBIT): results of a pan-European cluster-randomized multicentre study to reduce central venous catheter-related bloodstream infections. Intensive Care Med 2017;epublished December 16th
• Torres. Ceftazidime-avibactam versus meropenem in nosocomial pneumonia, including ventilator-associated pneumonia (REPROVE): a randomised, double-blind, phase 3 non-inferiority trial. Lancet Infectious Dis 2017;epublished December 15th
• Thwaites. Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet 2017;epublished December 14th
• Arola. Inhaled Xenon Attenuates Myocardial Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest: The Xe-Hypotheca Trial. J Am Coll Cardiol 2017;70(21):2652-2660
• Alam. Prehospital antibiotics in the ambulance for sepsis: a multicentre, open label, randomised trial (PHANTASi Trial). Lancet Respir Med 2017;epublished November 28th
• Kalfon. A tailored multicomponent program to reduce discomfort in critically ill patients: a cluster-randomized controlled trial (IPREA Study). Intensive Care Med 2017;epublished November 27th

Guidelines & Position Statements

• Harvey. Management of perceived devastating brain injury after hospital admission: a consensus statement from stakeholder professional organizations. Br J Anaesth 2018;120(1):138–145
• Antimicrobial resistance and antibiotic stewardship programs in the ICU: insistence and persistence in the fight against resistance. A position statement from ESICM/ESCMID/WAAAR round table on multi-drug resistance. Intensive Care Med 2017;epublished December 29th
• Unanticipated difficult airway management in children - the consensus statement of the Paediatric Anaesthesiology and Intensive Care Section and the Airway Management Section of the Polish Society of Anaesthesiology and Intensive Therapy and the Polish Society of Neonatology. Anaesthesiol Intensive Ther 2017;49(5):336-349
• Gamble. Guidelines for the Content of Statistical Analysis Plans in Clinical Trials. JAMA 2017;318(23):2337-234
• Intensive care in severe malaria: Report from the task force on tropical diseases by the World Federation of Societies of Intensive and Critical Care Medicine. J Crit Care 2018;43:356–360
• Ebola virus disease: Report from the task force on tropical diseases by the World Federation of Societies of Intensive and Critical Care Medicine. J Crit Care 2018;43:352–355
• Dengue fever: Report from the task force on tropical diseases by the World Federation of Societies of Intensive and Critical Care Medicine. J Crit Care 2018;43:346–351
• Chinese Collaboration Group for Emergency Airway Management. Clinical consensus of emergency airway management. J Thorac Dis 2017;9(11):4599-4606
• 2017 ACC Expert Consensus Decision Pathway on Management of Bleeding in Patients on Oral Anticoagulants. JACC 2017;epublished December 1st

Chung. High-volume hemofiltration in adult burn patients with septic shock and acute kidney injury: a multicenter randomized controlled trial (RESCUE). Critical Care 2017;21:289

Godier. Use of factor concentrates for the management of perioperative bleeding: guidance from the SSC of the ISTH. J Thromb Haemost 2017;epublished November 2nd

Select International Federation for Emergency Medicine Consensus Statement: Sonography in hypotension and cardiac arrest (SHoC): An international consensus on the use of point of care ultrasound for undifferentiated hypotension and during cardiac arrest. CJEM 2017;19(6):459-470

ESA VTE Guidelines Task Force. European guidelines on perioperative venous thromboembolism prophylaxis: Intensive care. Eur J Anaesthesiol 2017;epublished November 6th

Nogueira. Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct (DAWN Trial). N Engl J Med 2017;epublished November 11th

Weisbord. Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine (PRESERVE). N Engl J Med 2017;epublished November 12th

Mazer. Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery (TRICS3). N Engl J Med 2017;epublished November 12th

Reignier. Enteral versus parenteral early nutrition in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group study (NUTRIREA-2). Lancet 2017;epublished November 8th

Laptook. Effect of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death or Disability Among Newborns With Hypoxic-Ischemic Encephalopathy. A Randomized Clinical Trial. JAMA 2017;318(16):1550-1560

Stöckl. Continuous versus intermittent neuromuscular blockade in patients during targeted temperature management after resuscitation from cardiac arrest—A randomized, double blinded, double dummy clinical trial. Resuscitation 2017;120:14-19

Koster. Safety of mechanical chest compression devices AutoPulse and LUCAS in cardiac arrest: a randomized clinical trial for non-inferiority. European Heart Journal 2017;38(40):3006–3013

The Implementation of Targeted Temperature Management: An Evidence-Based Guideline from the Neurocritical Care Society. Neurocrit Care 2017;epublished October 16th

Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail 2017;epublished October 16th

Koch. A Randomized Clinical Trial of Red Blood Cell Transfusion Triggers in Cardiac Surgery. Ann Thorac Surg 2017;104(4):1243-1250

Jaillette. Impact of tapered-cuff tracheal tube on microaspiration of gastric contents in intubated critically ill patients: a multicenter cluster-randomized cross-over controlled trial. Intensive Care Med 2017;43(11):1562–1571

Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (Part II): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017. Intnsive Care Med 2017;epublished October 31st

Treatment and Outcome of Hemorrhagic Transformation After Intravenous Alteplase in Acute Ischemic Stroke: A Scientific Statement for Healthcare Professionals From the American Heart Association / American Stroke Association. Stroke 2017;epublished November 2nd

Thiele. PCI Strategies in Patients with Acute Myocardial Infarction and Cardiogenic Shock (CULPRIT-SHOCK). N Engl J Med 2017;epublished October 30th

van Brunschot. Endoscopic or surgical step-up approach for infected necrotising pancreatitis: a multicentre randomised trial. Lancet 2017;epublished November 3rd

European Stroke Organization guideline for the diagnosis and treatment of cerebral venous thrombosis – endorsed by the European Academy of Neurology. Eur J Neurol 2017;24:1203–1213

30th Annual ESICM Congress (LIVES2017, Vienna) 

New Engl J Med - Age of Transfused Red Cells

• Cooper. Age of Red Cells for Transfusion and Outcomes in Critically Ill Adults (TRANSFUSE). N Engl J Med 2017;epublished September 27th

JAMA - Alveolar Recruitment in ARDS

• ART Trial Investigators Writing Group. Effect of Lung Recruitment and Titrated Positive End-Expiratory Pressure (PEEP) vs Low PEEP on Mortality in Patients With Acute Respiratory Distress Syndrome. A Randomized Clinical Trial (ART). JAMA 2017;epublished September 27th

JAMA - Intra-Operative Blood Pressure Management

• Futier. Effect of Individualized vs Standard Blood Pressure Management Strategies on Postoperative Organ Dysfunction Among High-Risk Patients Undergoing Major Surgery. A Randomized Clinical Trial (INPRESS). JAMA 2017;epublished September 27th

JAMA - Systematic ICU Admission for Elderly Sick Patients

• Guidet. Effect of Systematic Intensive Care Unit Triage on Long-term Mortality Among Critically Ill Elderly Patients in France. A Randomized Clinical Trial (ICU-CUB 2). JAMA 2017;epublished September 27th

JAMA - Early Goal-Directed Sepsis Care in Zambia

• Andrews. Effect of an Early Resuscitation Protocol on In-hospital Mortality Among Adults With Sepsis and Hypotension. A Randomized Clinical Trial. JAMA 2017;epublished September 27th

Intensive Care Medicine - Early Goal-Directed Nutrition

• Allingstrup. Early goal-directed nutrition versus standard of care in adult intensive care patients: the single-centre, randomised, outcome assessor-blinded EAT-ICU trial. Intensive Care Med 2017;epublished September 22nd

Intensive Care Medicine - Airway Pressure Release Ventilation

• Zhou. Early application of airway pressure release ventilation may reduce the duration of mechanical ventilation in acute respiratory distress syndrome. Intensive Care Med 2017;epublished September 22nd

Intensive Care Medicine - Spontaneous Breathing Trials

• Fernandez. Reconnection to mechanical ventilation for 1 h after a successful spontaneous breathing trial reduces reintubation in critically ill patients: a multicenter randomized controlled trial. Intensive Care Med 2017;epublished September 22nd

Intensive Care Medicine - Biomarker-Guided Strategy for Discontinuing Antifungal Therapy

• Rouzé. Biomarker-based strategy for early discontinuation of empirical antifungal treatment in critically ill patients: a randomized controlled trial. Intensive Care Med 2017;epublished September 22nd

Kneyber. Recommendations for mechanical ventilation of critically ill children from the Paediatric Mechanical Ventilation Consensus Conference (PEMVECC). Intensive Care Med 2017;epublished September 22nd

Intensive Care Medicine - Positioning for VAP

• Bassi. Randomized, multicenter trial of lateral Trendelenburg versus semirecumbent body position for the prevention of ventilator-associated pneumonia. Intensive Care Med 2017;epublished June 20th

Intensive Care Medicine - Adrenal Insufficiency Guideline

• Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (Part I): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017. Intensive Care Med 2017;epublished September 21st

Circulation - Cardiogenic Shock Guideline

• Contemporary Management of Cardiogenic Shock: A Scientific Statement From the American Heart Association. Circulation 2017;epublished September 18th

Lancet Respiratory Medicine - Sedation Interruption

• Chanques. Immediate interruption of sedation compared with usual sedation care in critically ill postoperative patients (SOS-Ventilation): a randomised, parallel-group clinical trial. Lancet Respir Med 2017;epublished September 18th

Chest - Checklists for ICU Intubation

• Janz. A multicenter, randomized trial of a checklist for endotracheal intubation of critically ill adults (Check-UP Trial). Chest 2017;epublished September 13th

Critical Care Medicine - Nebulized Versus IV Amikacin in VAP

• Hassan. Nebulized Versus IV Amikacin as Adjunctive Antibiotic for Hospital and Ventilator-Acquired Pneumonia Postcardiac Surgeries: A Randomized Controlled Trial. Crit Care Med 2017;epublished August 28th

European Respiratory Journal - HAP / VAP Guideline

• International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia. Eur Respir J 2017;50(3):1700582

Annals of Surgery - Transfusion Thresholds in Burns

• Palmieri. Transfusion Requirement in Burn Care Evaluation (TRIBE): A Multicenter Randomized Prospective Trial of Blood Transfusion in Major Burn Injury. Annals of Surgery 2017;266(4):595-602

Critical Care - Loxapine for Agitation

• Gaudry. Loxapine to control agitation during weaning from mechanical ventilation. Critical Care 2017;21:235

Critical Care - Recombinant ACE 2 in ARDS

• Kahn. A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome. Critical Care 2017 21:234

J Crit Care - Enteral Nutrition as Stress Prophylaxis

• El-Kersh. Enteral nutrition as stress ulcer prophylaxis in critically ill patients: A randomized controlled exploratory study. J Crit Care 2017;43:108-113

Am J Respir Crit Care Med - Coping Skills in ICU Survivors

• Cox. Effects of a Telephone- and Web-based Coping Skills Training Program Compared to an Education Program for Survivors of Critical Illness and Their Family Members: A Randomized Clinical Trial. Am J Respir Crit Care Med 2017;epublished September 5th 

European Respiratory Journal - NIV Guideline

• Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure. European Respiratory Journal 2017;50(2):1602426

NEJM - Oxygen in Acute Myocardial Infarction

• Hofmann. Oxygen Therapy in Suspected Acute Myocardial Infarction (DETO2X–SWEDEHEART). N Engl J Med 2017;epublished August 28th

Crit Care Resusc - Earplugs for Sleep Quality

• Litton. Quality sleep using earplugs in the intensive care unit: the QUIET pilot randomised controlled trial. Crit Care Resus 2017;19(2):128-133

Resuscitation - Intermittent vs Continuous Neuromuscular Blockade during Temperature Management post Cardiac Arrest

• Stöckl. Continuous versus intermittent neuromuscular blockade in patients during targeted temperature management after resuscitation from cardiac arrest - A randomized, double blinded, double dummy, clinical trial. Resuscitation 2017;epublished August 28th

JAMA - Ganciclovir in CMV-Positive Critically Ill Patients

• Limaye. Effect of Ganciclovir on IL-6 Levels Among Cytomegalovirus-Seropositive Adults With Critical IllnessA Randomized Clinical Trial. JAMA 2017;318(8):731-740

Critical Care - Serlipressin in Septic Shock

• Russell. Selepressin, a novel selective vasopressin V1A agonist, is an effective substitute for norepinephrine in a phase IIa randomized, placebo-controlled trial in septic shock patients. Critical Care 2017;21:213

Critical Care Medicine - Simulation for ECMO Emergencies

• Zakhary. The Utility of High-Fidelity Simulation for Training Critical Care Fellows in the Management of Extracorporeal Membrane Oxygenation Emergencies: A Randomized Controlled Trial. Crit Care Med 2017;45(8):1367-1373

Critical Care Medicine - Exposure Keratopathy

• Bendavid. Prevention of Exposure Keratopathy in Critically Ill Patients: A Single-Center, Randomized, Pilot Trial Comparing Ocular Lubrication With Bandage Contact Lenses and Punctal Plugs. Crit Care Med 2017;epublished August 17th

Critical Care - Software-Guided Glycaemic Control

• Mesotten. Software-guided versus nurse-directed blood glucose control in critically ill patients: the LOGIC-2 multicenter randomized controlled clinical trial. Critical Care 2017;21:212

Thorax - Rehabilitation in the ICU

• Wright. Intensive versus standard physical rehabilitation therapy in the critically ill (EPICC): a multicentre, parallel-group, randomised controlled trial. Thorax 2017;epublished August 5th

JAMA - 24 vs 48 Hours of Hypothermia post Cardiac Arrest

• Kirkegaard. Targeted Temperature Management for 48 vs 24 Hours and Neurologic Outcome After Out-of-Hospital Cardiac Arrest. A Randomized Clinical Trial. JAMA 2017;318(4):341-350

JPEN - Paediatric Nutritional Support Guideline

• Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Pediatric Critically Ill Patient: Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition. JPEN J Parenter Enteral Nut 2017;41(5):706–742

Journal of Intensive Care - Japanese ARDS Guideline

• Hashimoto. The clinical practice guideline for the management of ARDS in Japan. Journal of Intensive Care 2017;5:50

Chinese Medical Journal - EEG Monitoring Guideline

• Neurocritical Care Committee of the Chinese Society of Neurology (NCC/CSN). Recommendations for Electroencephalography Monitoring in Neurocritical Care Units. Chin Med J 2017;130:1851-5

Lancet respiratory Medicine - Simvastatin for Prevention & Treatment of ICU Delirium

• Page. Evaluation of early administration of simvastatin in the prevention and treatment of delirium in critically ill patients undergoing mechanical ventilation (MoDUS): a randomised, double-blind, placebo-controlled trial. Lancet Respir Med 2017;epublished July 19th

Journal of Critical Care - Furosemide in Early Acute Kidney Injury

• Bagshaw. The effect of low-dose furosemide in critically ill patients with early acute kidney injury: A pilot randomized blinded controlled trial (the SPARK study). J Crit Care 2017;epublished July 12th

Lancet - Procalcitonin-Guided Antibiotics in Early Sepsis

• Stocker. Procalcitonin-guided decision making for duration of antibiotic therapy in neonates with suspected early-onset sepsis: a multicentre, randomised controlled trial (NeoPIns). Lancet 2017;epublished July 12th

Minerva Pneumologica - NIV vs IMV in Hypoxaemic Respiratory Failure

• Belenguer-Muncharaz. Non-invasive ventilation versus invasive mechanical ventilation in patients with hypoxemic acute respiratory failure in an Intensive Care Unit. A randomized controlled study. Minerva Pneumologica 2017;56(1):1-10

JAMA Cardiology - Spironolactone in Acute Heart Failure

• Butler. Efficacy and Safety of Spironolactone in Acute Heart Failure: The ATHENA-HF Randomized Clinical Trial. JAMA Cardiol 2017;epublished July 12th

Anaesth Crit Care Pain - French TTM Guideline

• Cariou. Targeted temperature management in the ICU: guidelines from a French expert panel. Anaesth Crit Care Pain Med 2017;epublished July 5th

World Jounal of Emergency Surgery - Intra-Abdominal Infections Guideline

• The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines for management of intra-abdominal infections. World J Emerg Surg 2017;12:29

Critical Care Medicine - Blood flow & CRRT Circuit Lifespan

• Fealy. Faster Blood Flow Rate Does Not Improve Circuit Life in Continuous Renal Replacement Therapy: A Randomized Controlled Trial. Crit Care Med 2017;epublished June 24th

European Heart Journal - Safety of Mechanical Chest Compression Devices

• Koster. Safety of mechanical chest compression devices AutoPulse and LUCAS in cardiac arrest: a randomized clinical trial for non-inferiority. Eur Heart J 2017;epublished July 1st

Journal of Korean medical Science - Mild Hypothermia for Poor Grade Subarachnoid Haemorrhage

• Choi. Feasibility and Safety of Mild Therapeutic Hypothermia in Poor-Grade Subarachnoid Hemorrhage: Prospective Pilot Study. J Korean Med Sci 2017;32(8):1337-1344

Critical Care Medicine - Shenfu Injection post Cardiac Arrest

• Zhang. Efficacy and Safety of Combination Therapy of Shenfu Injection and Postresuscitation Bundle in Patients With Return of Spontaneous Circulation After In-Hospital Cardiac Arrest: A Randomized, Assessor-Blinded, Controlled Trial. Crit Care Med 2017;epublished June 28th

JAMA - Cooling post Neonatal Hypoxic-Ischaemic Encephalopathy

• Shankaran. Effect of Depth and Duration of Cooling on Death or Disability at Age 18 Months Among Neonates With Hypoxic-Ischemic Encephalopathy. A Randomized Clinical Trial. JAMA 2017;318(1):57-67

Circulation - N-Acetylcysteine & Nitrate Therapy in STEMI

• Pasupathy. Early use of N-Acetylcysteine (NAC) with Nitrate Therapy in Patients Undergoing Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction Reduces Myocardial Infarct Size (The NACIAM Trial). Circulation 2017;epublished June 20th

Thorax - Post ICU Rehabilitation

McDowell. Effectiveness of an exercise programme on physical function in patients discharged from hospital following critical illness: a randomised controlled trial (the REVIVE trial) Thorax 2017;72:594-595

JAMA - FAST Scan in Paediatric Trauma

• Holmes. Effect of Abdominal Ultrasound on Clinical Care, Outcomes, and Resource Use Among Children With Blunt Torso Trauma. A Randomized Clinical Trial. JAMA 2017;317(22):2290-2296

J Allergy Clin Immunol Pract - Icatibant for ACE Inhibitor-Induced Angioedema

• Sinert. Randomized Trial of Icatibant for Angiotensin-Converting Enzyme Inhibitor-Induced Upper Airway Angioedema. J Allergy Clin Immunol Pract 2017;epublished May 25th

Ann Emerg Med - High Flow Nasal Oxygen in Cardiogenic Pulmonary Oedema

• Makdee. High-Flow Nasal Cannula Versus Conventional Oxygen Therapy in Emergency Department Patients With Cardiogenic Pulmonary Edema: A Randomized Controlled Trial. Ann Emerg Med 2017;epublished June 7th

Critical Care - Supplementary Parenteral Nutrition

• Wischmeyer. A randomized trial of supplemental parenteral nutrition in underweight and overweight critically ill patients: the TOP-UP pilot trial. Critical Care 2017;21:142

JAMA Surgery - Intraoperative Dexmedetomidine & Post-Op Cognitive Dysfunction

• Deiner. Intraoperative Infusion of Dexmedetomidine for Prevention of Postoperative Delirium and Cognitive Dysfunction in Elderly Patients Undergoing Major Elective Noncardiac Surgery: A Randomized Clinical Trial. JAMA Surg 2017;7:e171505

Intensive Care Med - AKI Guideline

• Joannidis. Prevention of acute kidney injury and protection of renal function in the intensive care unit: update 2017. Expert opinion of the Working Group on Prevention, AKI section, European Society of Intensive Care Medicine. Intensive Care Med 2017;epublished June 2nd

American Thoracic Society Conference

NEJM - Angiotensin II for Septic Shock

• Khanna. Angiotensin II for the Treatment of Vasodilatory Shock (ATHOS-3 Trial). N Engl J Med 2017;epublished May 21st

NEJM - Time to Treatment in Sepsis

• Seymour. Time to Treatment and Mortality during Mandated Emergency Care for Sepsis. N Engl J Med 2017;epublished May 21st

JAMA - Outcome Prediction ICU

• Detsky. Discriminative Accuracy of Physician and Nurse Predictions for Survival and Functional Outcomes 6 Months After an ICU Admission. JAMA 2017;epublished May 21st

Thorax - BTS Oxygen Use Guideline

• O'Driscoll. BTS guideline for oxygen use in adults in healthcare and emergency settings. Thorax 2017; 72:ii1-ii90

Crit Care Medicine - Paediatric & Neonatal Septic Shock Guideline

• American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock. Crit Care Med 2017;45(6):1061-1093

Neurology - Brain Injury after CPR Guideline

• Geocadin. Practice guideline summary: Reducing brain injury following cardiopulmonary resuscitation. Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology 2017;epublished May 10th

Chest - Positioning for Endotracheal Intubation

• Semler. A Multicenter, Randomized Trial of Ramped Position versus Sniffing Position during Endotracheal Intubation of Critically Ill Adults. Chest 2017;epublished May 12th

Resuscitation - Video versus Direct Laryngoscopy for Paramedic Endotracheal Intubation

• Abstract:  Ducharme. A pilot, prospective, randomized trial of video versus direct laryngoscopy for paramedic endotracheal intubation. Resuscitation 2017;114:121–126

European Journal of Anaesthesiology - Severe Perioperative Bleeding Guideline

• Kozek-Langenecker. Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology: First update 2016. European Journal of Anaesthesiology 2017;34(6):332–395

Annals of Intensive Care - Post Extubation High Flow Nasal Oxygen

• Fernandez. High-flow nasal cannula to prevent postextubation respiratory failure in high-risk non-hypercapnic patients: a randomized multicenter trial. Annals of Intensive Care 2017;7:47

Crit Care Medicine - Stress Ulcer Prophylaxis

• Alhazzani. Withholding Pantoprazole for Stress Ulcer Prophylaxis in Critically Ill Patients: A Pilot Randomized Clinical Trial and Meta-Analysis. Crit Care Med 2017;epublished April 27th

American Heart Journal - Nitric Oxide in Acute PE

• Kline. Randomized trial of inhaled nitric oxide to treat acute pulmonary embolism: The iNOPE trial. Am Heart J 2017;186:100-110

N Eng J Med - Bystander Efforts in Out-of-Hospital Cardiac Arrest

• Kragholm. Bystander Efforts and 1-Year Outcomes in Out-of-Hospital Cardiac Arrest. N Engl J Med 2017;376:1737-1747

Lancet - Tranexamic Acid for Post Partum Haemorrhage

• WOMAN Trial Collaborators. Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial. Lancet 2017;epublished April 26th

Lancet Haematology - FFP vs Coagulation Factor Concentrates for Traumatic Coagulopathy

• Innerhofer. Reversal of trauma-induced coagulopathy using first-line coagulation factor concentrates or fresh frozen plasma (RETIC): a single-centre, parallel-group, open-label, randomised trial. Lancet Haematology 2017;epublished April 27th

JAMA Internal Medicine - Antiviral Therapy for CMV Reactivation

• Cowley. Safety and Efficacy of Antiviral Therapy for Prevention of Cytomegalovirus Reactivation in Immunocompetent Critically Ill Patients: A Randomized Clinical Trial. JAMA Intern Med 2017;epublished April 24th

Annals of Thoracic Surgery - Corticosteroids in Neonatal Cardiac Operations

• Suominen. Stress-Dose Corticosteroid Versus Placebo in Neonatal Cardiac Operations: A Randomized Controlled Trial. Ann Thorac Surg 2017;epublished April 20th

JAMA - Postoperative Troponin Elevation in Noncardiac Surgery

• VISION Study Investigators. Association of Postoperative High-Sensitivity Troponin Levels With Myocardial Injury and 30-Day Mortality Among Patients Undergoing Noncardiac Surgery. JAMA 2017;317(16):1642-1651

Intensive Care Medicine - Immunoglobulin for Necrotising Soft Tissue Infection

• Madsen. Immunoglobulin G for patients with necrotising soft tissue infection (INSTINCT): a randomised, blinded, placebo-controlled trial. Intensive Care Med 2017;epublished April 18th

New England Journal of Medicine - Ularitide in Acute Heart Failure

• Packer. Effect of Ularitide on Cardiovascular Mortality in Acute Heart Failure (TRUE-AHF). N Engl J Med 2017;epublished April 12th

Intensive Care Medicine - NIV Post Extubation in Chronic Respiratory Disorders

• Vargas. Intermittent noninvasive ventilation after extubation in patients with chronic respiratory disorders: a multicenter randomized controlled trial (VHYPER). Intensive Care Med 2017;epublished April 9th

Intensive Care Medicine - IV Chloride Restriction in Cardiac Surgery

• McIlroy. Effects of restricting perioperative use of intravenous chloride on kidney injury in patients undergoing cardiac surgery: the LICRA pragmatic controlled clinical trial. Intensive Care Med 2017;epublished March 25th

International Symposium on Intensive Care & Emergency Medicine

N Engl J Med - Levosimendan post Cardiac Surgery

• Landoni. Levosimendan for Hemodynamic Support after Cardiac Surgery (CHEETAH Study). N Engl J Med 2017;epublished March 21st

JAMA - Intraoperative Alveolar Recruitment

• Leme. Effect of Intensive vs Moderate Alveolar Recruitment Strategies Added to Lung-Protective Ventilation on Postoperative Pulmonary Complications. A Randomized Clinical Trial. JAMA 2017;epublished March 21st

JAMA - Dexmedetomidine Sedation in Sepsis

• Yu Kawazoe. Effect of Dexmedetomidine on Mortality and Ventilator-Free Days in Patients Requiring Mechanical Ventilation With Sepsis. A Randomized Clinical Trial (DESIRE Trial). JAMA 2017;epublished March 21st

N Engl J Med - Early Goal-Directed Therapy in Sepsis