VITAMIN C - A Love Story Vitamin C in Critical Illness Critical Care Reviews Blog 5    |    October 17th, 2025  |  Rob Mac Sweeney twitter vimeo instagram social This email address is being protected from spambots. You need JavaScript enabled to view it. Image: Shutterstock | Medical-R Vitamin C – A Love Story Every generation of clinicians inherits a remedy that seems to promise more than mere biology should allow. For our forebears at sea it was citrus, the difference between life and death on a latish...

The Etomidate Conundrum Etomidate for Rapid Sequence Intubation in the Critically Ill. Critical Care Reviews Blog 4    |    September 4th, 2025 Rob Mac Sweeney twitter vimeo instagram social This email address is being protected from spambots. You need JavaScript enabled to view it. social                                                           Image: Shutterstock | JFontan The Etomidate Conundrum Induction for rapid sequence intubation (RSI) in the critically ill often feels like the swing of a...

Archive CCR Blog Image: Shutterstock / PeopleImages 2025 Vitamin C - A Love Story Vitamin C in critical illness has always hinted at more than scurvy’s salvation. From Lind’s lemons to Linus Pauling’s promise to an ICU cocktail that briefly looked like a cure, the arc swings between elegant biology and stubborn clinical reality. We track the enzymes and endothelium, the catecholamines and carnitine, and the redox alchemy that can both shield and scorch. Then we meet the trials—VITAMINS neutral, LOVIT unnerving—and ask why sepsis would not yield while burns, post-arrest...

Critical Care Reviews Blog Exploring the why of critical care trials Critical care trials are fascinating to ponder. Some report findings of benefit with the investigational intervention, many report an inconclusive answer or apparent lack of efficacy. Some report harm. This blog will explore the why of critical care trials - why was this intervention successful, why was this intervention ineffective, why was the trial drug harmful. Join us for a weekly in-depth exploration of the latest major critical care trials. Blog 1 will be released Monday, October 4th The REST Trial ECCO2R...

The REST Trial Ultra-Low Tidal Volume Ventilation & Extracorporeal CO2 Removal McNamee JJ, Gillies MA, Barrett NA, Perkins GD, Tunnicliffe W, et al. Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure. The REST Randomized Clinical Trial. JAMA 2021;326(11):1013-1023 Critical Care Reviews Blog 1    |    October 4th, 2021  |  Rob Mac Sweeney social social social ...

Fragility Index The minimum number of subjects whose status would have to change from a non-event to an event to convert a statistically significant result of the trial into a non-significant result This guest post by Dr Ed Palmer was originally posted on June 29th, 2022, on his blog. It has been reposted here with his permission. Critical Care Reviews Blog 2    |    August 1st, 2022  |  Ed Palmer - Guest Post social social social social social social social Brian A....

The RE-ENERGIZE Trial Enteral Glutamine for Treatment of Burn Injuries Heyland DK, Wibbenmeyer L, Pollack JA, Friedman B, Turgeon AF, Eshraghi N, et al. A Randomized Trial of Enteral Glutamine for Treatment of Burn Injuries. N Engl J Med 2022;387:1001-1010 Critical Care Reviews Blog 3    |    December 20th, 2023  |  Pål CJ Morberg & Rob Mac Sweeney twitter instagram This email address is being protected from spambots. You need JavaScript enabled to view it. Image: Shutterstock | Medical-R The Trial In critically ill patients with deep second- or...