Top Circulatory Trials
ALPS
In 3026 adults with out-of-hospital shock-refractory ventricular fibrillation or pulseless ventricular tachycardia after at least one shock, neither amiodarone (n=974) nor lidocaine (n=993) resulted in a significantly higher rate of survival or favorable neurologic outcome than the rate with placebo (n=1059).
N Engl J Med 2016; 374:1711-1722
IABP-SHOCK II
In 600 patients with acute myocardial infarction induced cardiogenic shock, the addition of an intra-aortic balloon pump, in addition early revascularisation and best medical management, did not improve 30-day mortality; IABP group, 39.7% vs. control group, 41.3%; relative risk 0.96; 95% CI, 0.79 to 1.17; P=0.69.
IABP-SHOCK II
In 600 patients with acute myocardial infarction induced cardiogenic shock, the addition of an intra-aortic balloon pump, in addition early revascularisation and best medical management, did not improve 30-day mortality; IABP group, 39.7% vs. control group, 41.3%; relative risk 0.96; 95% CI, 0.79 to 1.17; P=0.69.
Targeted Temperature Management
General
- Lascarrou. Targeted Temperature Management for Cardiac Arrest with Nonshockable Rhythm. N Engl J Med N Engl J Med 2019;381:2327-2337
- Nordberg. Effect of trans-nasal evaporative intra-arrest cooling on functional neurologic outcome in out-of-hospital cardiac arrest: the PRINCESS randomized clinical trial. JAMA 2019;321(17):1677–85
- Kirkegaardl. Targeted temperature management for 48 vs 24 hours and neurologic outcome after out-of-hospital cardiac arrest: a randomized clinical trial. JAMA 2017;318:341-350
- Bernard. Induction of Therapeutic Hypothermia During Out-of-Hospital Cardiac Arrest Using a Rapid Infusion of Cold Saline: The RINSE Trial (Rapid Infusion of Cold Normal Saline). Circulation 2016;134(11):797-805
- Moler. Therapeutic Hypothermia after Out-of-Hospital Cardiac Arrest in Children (THAPCA Trial). N Engl J Med 2015;epublished April 25th
- Nielsen. Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest (TTM study). N Engl J Med 2013;369:2197-2206
- Kim. Effect of Prehospital Induction of Mild Hypothermia on Survival and Neurological Status Among Adults With Cardiac Arrest: A Randomized Clinical Trial. JAMA 2014;311(1):45-52
- Bernard. Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia. N Engl J Med 2002; 346:557-563
- The Hypothermia after Cardiac Arrest Study Group. Mild Therapeutic Hypothermia to Improve the Neurologic Outcome after Cardiac Arrest. N Engl J Med 2002; 346:549-556
Method of Temperature Control
Drug Therapy
Combination Therapy
- Mentzelopoulos. Vasopressin, Steroids, and Epinephrine and Neurologically Favorable Survival After In-Hospital Cardiac Arrest: A Randomized Clinical Trial. JAMA 2013;310(3):270
- Olasveengen. Intravenous Drug Administration During Out-of-Hospital Cardiac Arrest: A Randomized Trial. JAMA 2009;302(20):2222-2229
Adrenaline
- Perkins. A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest (PARAMEDIC2). N Engl J Med 2018;epublished July 18th
- Jacobs. Effect of adrenaline on survival in out-of-hospital cardiac arrest: A randomised double-blind placebo-controlled trial (PACA Trial). Resuscitation 2011;82(9):1138-43
Antiarrthymics
Airway Management
Cricoid Pressure
SGA vs ETT
- Wang. Effect of a Strategy of Initial Laryngeal Tube Insertion vs Endotracheal Intubation on 72-Hour Survival in Adults With Out-of-Hospital Cardiac Arrest. A Randomized Clinical Trial. JAMA 2018;320(8):769-778
- Benger. Effect of a Strategy of a Supraglottic Airway Device vs Tracheal Intubation During Out-of-Hospital Cardiac Arrest on Functional OutcomeThe AIRWAYS-2 Randomized Clinical Trial. JAMA 2018;320(8):779-791
Bougie Use
Bag Mask Ventilation
