Just a week until CCR20
Welcome to the 421st Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are randomised controlled trials on the effect of treating parents colonized with Staphylococcus aureus on transmission to neonates in the ICU & endovascular treatment versus standard medical treatment for vertebrobasilar artery occlusion; systematic reviews and meta analyses on acute kidney injury in burn patients & safety of intravenous thrombolysis among patients taking direct oral anticoagulants; and observational studies on potentially preventable intensive care unit admissions in the united states & predicting mortality among critically ill patients with acute kidney injury treated with renal replacement therapy.
There are also narrative reviews on targeted temperature management for ischemic stroke, acute kidney injury & L-lactic acidosis; an editorial on cardiac donation after circulatory death; as well as correspondence on Bayesian analysis in critical care medicine.
This week's Topic of the Week is the CITRIS-ALI trial, starting with a paper from our #CCR20 editorialist Andrew Althouse, on the need to adjust for multiple comparisons in tomorrow's Paper of the Day.
If you only have time to read one review article this week, try this one on post-sepsis syndrome.
- Full Text: Milstone. Effect of treating parents colonized with Staphylococcus aureus on transmission to neonates in the intensive care unit: a randomized clinical trial. JAMA 2019;epublished December 30th
- Abstract: Meyer. Low dose Iloprost effect on platelet aggregation in comatose out-of-hospital cardiac arrest patients: A predefined sub-study of the ENDO-RCA randomized -phase 2- trial. J Crit Care 2019;epublished December 30th
- Abstract: Liu. Endovascular treatment versus standard medical treatment for vertebrobasilar artery occlusion (BEST): an open-label, randomised controlled trial. Lancet Neurol 2019;epublished December 9th
- Full Text: Williams. 0.9% saline versus Plasma-Lyte as initial fluid in children with diabetic ketoacidosis (SPinK trial): a double-blind randomized controlled trial. Crit Care 2020;24(1):1
- Full Text: Giménez-Esparza. The premature closure of ROMPA clinical trial: mortality reduction in septic shock by plasma adsorption. BMJ Open 2019;9(12):e030139
- Full Text: Wang. Prophylactic use of levosimendan in pediatric patients undergoing cardiac surgery: a prospective randomized controlled trial. Critical Care 2019;23:428
- Full Text: Kim. Efficacy of Low-Dose Prophylactic Quetiapine on Delirium Prevention in Critically Ill Patients: A Prospective, Randomized, Double-Blind, Placebo-Controlled Study. J Clin Med 2019;;9(1):E69
- Abstract: Mahran. Effect of 2 Enteral Feeding Schedules on Intra-abdominal Pressure in Patients Receiving Mechanical Ventilation: A Randomized Controlled Trial. Crit Care Nurse 2019;39 (6):29-35
- Abstarct: Shahjouei. Safety of Intravenous Thrombolysis Among Patients Taking Direct Oral Anticoagulants: A Systematic Review and Meta-Analysis. Stroke 2019;epublished December 30th
- Abstract: Pavasini. Complete revascularization reduces cardiovascular death in patients with ST-segment elevation myocardial infarction and multivessel disease: systematic review and meta-analysis of randomized clinical trials. European Heart Journal 2019;ehz896
- Full Text: Folkestad. Acute kidney injury in burn patients admitted to the intensive care unit: a systematic review and meta-analysis. Crit Care 2020;24(1):2
- Full Text: Alharbi. Antibiotic Skin Testing in the Intensive Care Unit: A Systematic Review. Crit Care Nurse 2019;39(6):e1-e9
- Full Text: DeVore. Best practices for emergency surgical airway: A systematic review. Laryngoscope Investig Otolaryngol 2019;4(6):602-608
- Abstract: Weissman. Potentially Preventable Intensive Care Unit Admissions in the United States, 2006 - 2015. Ann Am Thorac Soc 2020;17(1):81-88
- Abstract: LI. Predicting mortality among critically ill patients with acute kidney injury treated with renal replacement therapy: Development and validation of new prediction models. J Crit Care 2019;56:113-119
- Abstract: Cortazar. Clinical Features and Outcomes of Immune Checkpoint Inhibitor-Associated AKI: A Multicenter Study. J Am Soc Nephrol 2020;epublished January 2nd
- Full Text: Martin. Nationwide survey on training and device utilization during tracheal intubation in French intensive care units. Annals Intensive Care 2020;10:2
- Full Text: Saccheri. ICU-acquired weakness, diaphragm dysfunction and long-term outcomes of critically ill patients. Annals Intensive Care 2020;10:1
- Full Text: Wiersema. Burden of acute kidney injury and 90-day mortality in critically ill patients. BMC Nephrol 2019;21(1):1
- Full Text: Nakashima. Dexmedetomidine improved renal function in patients with severe sepsis: an exploratory analysis of a randomized controlled trial. J Intensive Care 2020;8:1
- Full Text: Schlapbach. Defining benefit threshold for extracorporeal membrane oxygenation in children with sepsis—a binational multicenter cohort study. Critical Care 2019;23:429
- Sahuquillo. Decompressive craniectomy for the treatment of high intracranial pressure in closed traumatic brain injury. Cochrane Database of Systematic Reviews 2019, Issue 12. Art. No.: CD003983
- Chen. Hypertonic saline versus other intracranial pressure–lowering agents for people with acute traumatic brain injury. Cochrane Database of Systematic Reviews 2019, Issue 12. Art. No.: CD010904
- Dieter. Traumatic Brain Injury and Posttraumatic Stress Disorder: Comorbid Consequences of War. Neuroscience Insights 2019;14:1–17
- Rossett. Nonconvulsive seizures and nonconvulsive status epilepticus in the neuro ICU should or should not be treated aggressively: A debate. Clin Neurophysiol Pract 2019;4:170-177
- Chang. Bispectral Index Monitoring andIntraoperative Awareness. Anaesthesia Tutorial of the Week 2019;epublished December 31st
- Lee. Cefepime-induced neurotoxicity. J Neurocrit Care 2019;12(2):74-84
- Belrose. Anesthesiology and cognitive impairment: a narrative review of current clinical literature. BMC Anesthesiology 2019;19:241
- Hong. Targeted temperature management for ischemic stroke. J Neurocrit Care 2019;12(2):67-73
- Vagionas. Daily sedation interruption and mechanical ventilation weaning: a literature review. Anaesthesiol Intensive Ther 2019;51(5):380-389
- Jain. Chest radiography in adult critical care unit: A pictorial review. Indian J Radiol Imaging 2019;29:418-25
- Levy. How We Approach Central Venous Catheter Safety: A Multidisciplinary Perspective. J Pediatric Infect Dis Soc 2019;epublished December 30th
- Gulati. Acute Myocardial Infarction in Young Individuals. Mayo Clin Proc 2020;95(1):136–156
- Shiroff. Surgical stabilization of rib fractures. J Cardiothorac Trauma 2019;4:41-7
- Coary. New horizons in rib fracture management in the older adult. Age and Ageing 2019;00:1–7
- Han. Strategies to Enhance Mesenchymal Stem Cell-Based Therapies for Acute Respiratory Distress Syndrome. Stem Cells Int 2019;2019:5432134
- Al Otair. Ventilator- and interface-related factors influencing patient-ventilator asynchrony during noninvasive ventilation. Ann Thorac Med 2020;15:1-8
- Weiss. Acute Kidney Injury. Dtsch Arztebl Int 2019;116(49):833-842
- Han. Mechanisms and therapeutic targets of ischemic acute kidney injury. Kidney Res Clin Pract 2019;38(4):427–440
- Kamel. L-lactic acidosis: pathophysiology, classification, and causes; emphasis on biochemical and metabolic basis. Kidney International 2019;97(1):75-88
- Haldar. Artificial Blood: A Futuristic Dimension of Modern Day Transfusion. Cardiovasc Hematol Agents Med Chem 2019;17(1):11–16
- Mostel. Post-sepsis syndrome – an evolving entity that afflicts survivors of sepsis. Molecular Medicine 2020;26:6
- Maegele. The Diagnosis and Treatment of Acute Traumatic Bleeding and Coagulopathy. Dtsch Arztebl Int 2019;116:799-806
- Rutkiewicz. Yew poisoning – pathophysiology, clinical picture, management and perspective of fat emulsion utilization. Anaesthesiol Intensive Ther 2019;51(5):404–408
- Rajewska. The Jehovah’s Witness obstetric patient – a literature review. Anaesthesiol Intensive Ther 2019;51,5:390–403
- Kany. Cytokines in Inflammatory Disease. Int J Mol Sci 2019;20(23):6008
- Perazella. Immune checkpoint inhibitor nephrotoxicity: what do we know and what should we do? Kidney International 2019;97(1):62-74
- Turgeon. Cardiac donation after circulatory death: the heart of the matter. Can J Anaesth 2020;epublished January 2nd
- Orihuela. Can animal models really teach us anything about pneumonia? Pro. Eur Respir J 2020;55(1):1901539
- Metersky. Can animal models really teach us anything about pneumonia? Con. Eur Respir J 2020;55(1):1901525
- Bourgault. Take Control of Your Work Environment and Personal Well-being. Crit Care Nurse 2019;39(6):10-13
- Yarnell. Bayesian Analysis in Critical Care Medicine. Am J Respir Crit Care Med 2020;epublished January 3rd
- Tang. Doripenem for treating nosocomial pneumonia and ventilator-associated pneumonia. Lancet Infect Dis 2020;20(1):P20
- Dusseau. To fix or not to fix: Delayed repair of anterior flail in the frail and multiply injured. J Cardiothorac Trauma 2019;4:49-51
- Lobo. 82-Year-Old Woman With Acute-Onset Left-Sided Weakness. Mayo Clin Proc 2020;95(1):164–168
- Kashou. 85-Year-Old Man With Chest Pain. Mayo Clin Proc 2020;95(1):e1–e6
- Araj. Pulseless Paradoxus: A Unique Sign of Cardiac Tamponade in the Era of Continuous Flow Left Ventricular Assist Devices. Mayo Clin Proc 2020;95(1):199–200
- Aftab. Vaping-associated Lung Injury. Cureus 2019;11(11):e6216
- Lee. Oxygen supplementation via high-flow nasal cannula is an effective treatment for pneumocephalus. J Neurocrit Care 2019;12(2):98-101
Now in it's 8th year, the Critical Care Reviews Meeting brings the chief investigators for the best critical care trials of the previous year to Titanic, Belfast, to discuss their studies. We aim to decide whether these trials are sufficiently robust to support their findings and if we should consider changing practice on the basis of them. To help in this endeavour we invite world leading experts to provide independent editorial overviews and have panel discussions to delve deep into the specifics of each trial. In addition, we also have detailed discussions on research methodology, to encourage critical thinking about the scientific findings which form the basis of our clinical practice. It's not just about specific trials though; for 2020, we have a distinguished panel of trialists, methodologists, statisticians and clinicians provide insight into the mysteries of clinical trial interpretation, as well as a panel discission on the proposed MEGA-ROX trial, potentially a game changer for critical care trials. We are delighted to have the opportunity to conduct a one-on-one interview with the editor-in-chief of JAMA, Prof Howard Bauchner, in discussion with Prof Marion Campbell. As usual, we eound off the formal programme with the annual honorary John Hinds Lecture, to be delivered by Prof Kathryn Maitland, entitled "A Higher Calling: Two Decades of Emergency Research in Africa", and finish the meeting with the incredibly popular "Informal Chat", where the faculty and delegates congregate in the bar and an enormous, meandering discussion about all things critical care takes place.
For CCR20, we are hosting 3 major trial results presentations, PEPTIC, 65 & VITAMINS, as well as discussing 9 of the best trials from 2019 - COACT, TRACT, ICU-ROX, SPICE III, BiRDS, ROSE, CITRIS-ALI, SEPSIS-ACT & HYPERION.
Based on our feedback from last year, we've reverted to keeping everyone on the same floor during breaks. In addition, we will also provide a sleeping area for those post-call to rest for a few hours as needed. As before, we are offering free childcare and a baby feeding area, where the meeting will live streamed. All dietary requirements are catered for also. Please get in touch if you have any specific needs. We sold out last year, so please don't delay if you want to attend. As usual, CPD points will be applied for in due course.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board