Welcome to the 419th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are randomised controlled trials on comparing rocuronium with succinylcholine on endotracheal intubation in out-of-hospital rapid sequence intubation & inhaled amikacin adjunctive to intravenous standard-of-care antibiotics in mechanically ventilated patients with Gram-negative pneumonia; systematic reviews and meta analyses on adverse events during intrahospital transport of critically ill children & whether norepinephrine or vasopressin should be discontinued first in septic shock; and observational studies on vitamin E acetate in bronchoalveolar-lavage fluid associated with EVALI & the association of prehospital plasma transfusion with survival in trauma patients with hemorrhagic shock.
There are also narrative reviews on fluid administration strategies in traumatic brain injury & comparison between thromboelastography and thromboelastometry; editorials on controversies surrounding prevention of ventilator-associated pneumonia & anaesthetic management of the airway after blunt and penetrating neck injury; and commentaries on clinically meaningful benefit in clinical research & organising international research in critical care medicine.
If you only have time to read one review article this week, try this one on acute kidney injury from sepsis.
- Abstract: Guihard. Effect of Rocuronium vs Succinylcholine on Endotracheal Intubation Success Rate Among Patients Undergoing Out-of-Hospital Rapid Sequence Intubation. A Randomized Clinical Trial. JAMA 2019;322(23):2303-2312
- Abstract: Kozhuharov. Effect of a Strategy of Comprehensive Vasodilation vs Usual Care on Mortality and Heart Failure Rehospitalization Among Patients With Acute Heart Failure. The GALACTIC Randomized Clinical Trial. JAMA 2019;322(23):2292-2302
- Abstract: Niederman. Inhaled amikacin adjunctive to intravenous standard-of-care antibiotics in mechanically ventilated patients with Gram-negative pneumonia (INHALE): a double-blind, randomised, placebo-controlled, phase 3, superiority trial. Lancet Infect Dis 2019;epublished December 19th
- Abstract: Haydar. Adverse Events During Intrahospital Transport of Critically Ill Children: A Systematic Review. Anesth Analg 2019;epublished December 16th
- Abstract: dos Santos. Systematic Review and Meta-Analysis of Effects of Transfusion on Hemodynamic and Oxygenation Variables. Critical Care Med 2019;epublished November 27th
- Abstract: Zongsheng. Norepinephrine vs Vasopressin. Which Vasopressor Should Be Discontinued First in Septic Shock? A Meta-Analysis. Shock 2020;53(1):50–57
- Full Text: Blount. Vitamin E Acetate in Bronchoalveolar-Lavage Fluid Associated with EVALI. N Engl J Med 2019;epublished December 20th
- Abstract: Pusateri. Association of Prehospital Plasma Transfusion With Survival in Trauma Patients With Hemorrhagic Shock When Transport Times Are Longer Than 20 MinutesA Post Hoc Analysis of the PAMPer and COMBAT. JAMA Surg 2019;epublished December 18th
- Abstract: Shalish. Assessment of Extubation Readiness Using Spontaneous Breathing Trials in Extremely Preterm Neonates. JAMA Pediatr 2019;epublished December 20th
- Abstract: Bonafide. Association Between Mobile Telephone Interruptions and Medication Administration Errors in a Pediatric Intensive Care Unit. JAMA Pediatr 2019;epublished December 20th
- Abstract: Rassi. Fresh frozen plasma transfusion in patients with cirrhosis and coagulopathy: Effect on conventional coagulation tests and thrombomodulin-modified thrombin generation. J Hepatology 2020;72(1):85–94
- Abstract: Nakashima. Public-access defibrillation and neurological outcomes in patients with out-of-hospital cardiac arrest in Japan: a population-based cohort study. Lancet 2019;394(10216):2255-2262
- Abstract: McGreevy. Feasibility and Clinical Outcome of Reboa in Patients with Impending Traumatic Cardiac Arrest. Shock 2019;epublished December 16th
- Safi. Beta-blockers for suspected or diagnosed acute myocardial infarction. Cochrane Database of Systematic Reviews 2019, Issue 12. Art. No.: CD012484
- Wrzosek. Perioperative restrictive versus goal-directed fluid therapy for adults undergoing major non-cardiac surgery. Cochrane Database of Systematic Reviews 2019, Issue 12. Art. No.: CD012767
- Brand. Prophylactic antibiotics for penetrating abdominal trauma. Cochrane Database of Systematic Reviews 2019, Issue 12. Art. No.: CD007370
- Herrod. Prophylactic antibiotics for penetrating abdominal trauma: duration of use and antibiotic choice. Cochrane Database of Systematic Reviews 2019, Issue 12. Art. No.: CD010808
- Moskowitz. Ascorbic Acid, Corticosteroids and Thiamine in Sepsis (ACTS) protocol and statistical analysis plan: a prospective, multicentre, double-blind, randomised, placebo-controlled clinical trial. BMJ Open 2019;9(12):e034406
- Roggeveen. Right Dose Right Now: bedside data-driven personalized antibiotic dosing in severe sepsis and septic shock - rationale and design of a multicenter randomized controlled superiority trial. Trials 2019;20(1):745
- Franklin. Multicentre, randomised trial to investigate early nasal high-flow therapy in paediatric acute hypoxaemic respiratory failure: a protocol for a randomised controlled trial-a Paediatric Acute respiratory Intervention Study (PARIS 2). BMJ Open 2019;9(12):e030516
- Al Harbi. Neuromuscular-blocking agent use in critically ill patients. Saudi Crit Care J 2019;3:33-7
- Alharthy. Fluid administration strategies in traumatic brain injury. Saudi Crit Care J 2019;3:15-8
- Khan. Central line-associated bloodstream infections in the Kingdom of Saudi Arabia. Saudi Crit Care J 2019;3:43-8
- Moore. Thrombocytopenia in Cirrhosis: A Review of Pathophysiology and Management Options. Clin Liver Dis 2019;epublished December 20th
- Perricone. Acute‐on‐Chronic Liver Failure: A Distinct Clinical Syndrome That Has Reclassified Cirrhosis. Clin Liver Dis 2019;epublished December 20th
- Peerapornratana. Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment. Kidney Int 2019;96(5):1083–1099
- Krawczeski. Cardiopulmonary Bypass and AKI: AKI Is Bad, So Let's Get Beyond the Diagnosis. Front Pediatr 2019;7:492
- Sakai. Comparison between thromboelastography and thromboelastometry. Minerva Anestesiologica 2019;85(12):1346-56
- Moron. The Importance of the Microbiome in Critically Ill Patients: Role of Nutrition. Nutrients 2019;11(12):3002
- Lehman. Countering Gram-Negative Antibiotic Resistance: Recent Progress in Disrupting the Outer Membrane with Novel Therapeutics. Antibiotics 2019;8(4):163
- Júnior. Expanding indications and results for the use of resuscitative endovascular balloon occlusion of the aorta - REBOA. Rev Col Bras Cir 2019;46(5):e20192334
- Capdevila. Catheter use in regional anesthesia: pros and cons. Minerva Anestesiologica 2019;85(12):1357-64
- Al Dhoayan. Machine learning applications in critical care. Saudi Crit Care J 2019;3:29-32
- Al-Dorzi. Prevention of pressure injury in the intensive care unit. Saudi Crit Care J 2019;3:24-8
- Biancatelli. The antiviral properties of vitamin C. Expert Rev Anti Infect Ther 2019;epublished December 18th
- Colombo. The zero-VAP sophistry and controversies surrounding prevention of ventilator-associated pneumonia. Intensive Care Med 2019;epublished December 16th
- Owston. The anaesthetic management of the airway after blunt and penetrating neck injury. Trauma 2020;22(1):3–6
- Dobson. Special announcement: Guidelines to the Practice of Anesthesia—Revised Edition 2020. Can J Anesth 2020;67:1–8
- Reade. Delirium: one size does not fit all. Intern Med J 2019;49(12):1469-1471
- Bruijns. Looking back over a decade with the African Journal of Emergency Medicine. Af J Emerg Med 2019;9(4):163-164
- De Waele. Organising international research in critical care medicine: current challenges and potential solutions. Lancet Respir Med 2019;epublished December 17th
- Weinfurt. Clarifying the Meaning of Clinically Meaningful Benefit in Clinical Research. Noticeable Change vs Valuable Change. JAMA 2019;322(24):2381-2382
- Prasad. Statistical Significance versus Clinical Importance. Neurol India 2019;67:1513-4
- Matheny. Artificial Intelligence in Health Care. A Report From the National Academy of Medicine. JAMA 2019;epublished December 17th
- Morgan. Who is in control of artificial intelligence and can we trust them? Lancet Neurology 2019;epublished November 20th
Now in it's 8th year, the Critical Care Reviews Meeting brings the chief investigators for the best critical care trials of the previous year to Titanic, Belfast, to discuss their studies. We aim to decide whether these trials are sufficiently robust to support their findings and if we should consider changing practice on the basis of them. To help in this endeavour we invite world leading experts to provide independent editorial overviews and have panel discussions to delve deep into the specifics of each trial. In addition, we also have detailed discussions on research methodology, to encourage critical thinking about the scientific findings which form the basis of our clinical practice. It's not just about specific trials though; for 2020, we have a distinguished panel of trialists, methodologists, statisticians and clinicians provide insight into the mysteries of clinical trial interpretation, as well as a panel discission on the proposed MEGA-ROX trial, potentially a game changer for critical care trials. We are delighted to have the opportunity to conduct a one-on-one interview with the editor-in-chief of JAMA, Prof Howard Bauchner, in discussion with Prof Marion Campbell. As usual, we eound off the formal programme with the annual honorary John Hinds Lecture, to be delivered by Prof Kathryn Maitland, entitled "A Higher Calling: Two Decades of Emergency Research in Africa", and finish the meeting with the incredibly popular "Informal Chat", where the faculty and delegates congregate in the bar and an enormous, meandering discussion about all things critical care takes place.
For CCR20, we are hosting 3 major trial results presentations, PEPTIC, 65 & VITAMINS, plus the IHME SEPSIS study results, as well as discussing 9 of the best trials from 2019 - COACT, TRACT, ICU-ROX, SPICE III, BiRDS, ROSE, CITRIS-ALI, SEPSIS-ACT & HYPERION.
Based on our feedback from last year, we've reverted to keeping everyone on the same floor during breaks. In addition, we will also provide a sleeping area for those post-call to rest for a few hours as needed. As before, we are offering free childcare and a baby feeding area, where the meeting will live streamed. All dietary requirements are catered for also. Please get in touch if you have any specific needs. We sold out last year, so please don't delay if you want to attend. As usual, CPD points will be applied for in due course.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board