CCR-Newsletter-BannerNewsletter 418  |  December 19th 2019

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Welcome to the 418th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.

The highlights of this week's edition are randomised controlled trials on high-dose vitamin D3 for critically ill, vitamin D–deficient patients & fresh vs standard-issue red blood cell transfusions in critically ill pediatric patients; systematic reviews and meta analyses on return to work after critical illness & early versus delayed mobilization; and observational studies on frailty, cognition, activity of daily life and comorbidities on outcome in acutely admitted patients over 80 years in European ICUs, & assessment of variability in end-of-life care delivery in American ICUs.

There are also guidelines on lung–kidney interactions in critically ill patients & bleeding in patients hospitalized in the intensive cardiac care unit; narrative reviews on reversal of vasodilatory shock & drug-induced acute kidney injury; and commentaries on whether enteral nutrition can be given to patients on vasopressors  & whether critical care patients hibernate? There are also editorials on tranexamic acid and the CRASH III trial & the persistent potential of extracorporeal therapies in liver failure; as well as correspondence on how high PEEP may have reduced injurious transpulmonary pressure swings in the ROSE trial

This week's Topic of the Week is the ROSE trial, continuing with a paper on the current evidence from three randomized controlled trials on neuromuscular blockade in ARDS in today's Paper of the Day.

If you only have time to read one review article this week, try this one on the critical care management of toxicities associated with targeted agents and immunotherapies for cancer.

Critical Care Reviews Meeting 2020

The programme for the meeting is available as a pdf. If you plan on attending, please don't leave it too long before registering as you might be disappointed, We sold out the last couple of years and are on course to do so again this year.

 

Research

Review Articles

Neurological

Circulatory

Respiratory

Hepatobiliary

Sepsis

Toxicology

Perioperative

CCR20 Meeting

Now in it's 8th year, the Critical Care Reviews Meeting brings the chief investigators for the best critical care trials of the previous year to Titanic, Belfast, to discuss their studies. We aim to decide whether these trials are sufficiently robust to support their findings and if we should consider changing practice on the basis of them. To help in this endeavour we invite world leading experts to provide independent editorial overviews and have panel discussions to delve deep into the specifics of each trial. In addition, we also have detailed discussions on research methodology, to encourage critical thinking about the scientific findings which form the basis of our clinical practice. It's not just about specific trials though; for 2020, we have a distinguished panel of trialists, methodologists, statisticians and clinicians provide insight into the mysteries of clinical trial interpretation, as well as a panel discission on the proposed MEGA-ROX trial, potentially a game changer for critical care trials. We are delighted to have the opportunity to conduct a one-on-one interview with the editor-in-chief of JAMA, Prof Howard Bauchner, in discussion with Prof Marion Campbell. As usual, we eound off the formal programme with the annual honorary John Hinds Lecture, to be delivered by Prof Kathryn Maitland, entitled "A Higher Calling: Two Decades of Emergency Research in Africa", and finish the meeting with the incredibly popular "Informal Chat", where the faculty and delegates congregate in the bar and an enormous, meandering discussion about all things critical care takes place.

For CCR20, we are hosting 3 major trial results presentations, PEPTIC, 65 & VITAMINS, as well as discussing 9 of the best trials from 2019 - COACT, TRACT, ICU-ROX, SPICE III, BiRDS, ROSE, CITRIS-ALI, SEPSIS-ACT & HYPERION

Based on our feedback from last year, we've reverted to keeping everyone on the same floor during breaks. In addition, we will also provide a sleeping area for those post-call to rest for a few hours as needed. As before, we are offering free childcare and a baby feeding area, where the meeting will live streamed. All dietary requirements are catered for also. Please get in touch if you have any specific needs. We sold out last year, so please don't delay if you want to attend. As usual, CPD points will be applied for in due course.

CCH Journal

Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive.  If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.

COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.

I hope you find these links useful.


Until next week

Rob

Supported by the Health Research Board

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