Welcome to the 418th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are randomised controlled trials on high-dose vitamin D3 for critically ill, vitamin D–deficient patients & fresh vs standard-issue red blood cell transfusions in critically ill pediatric patients; systematic reviews and meta analyses on return to work after critical illness & early versus delayed mobilization; and observational studies on frailty, cognition, activity of daily life and comorbidities on outcome in acutely admitted patients over 80 years in European ICUs, & assessment of variability in end-of-life care delivery in American ICUs.
There are also guidelines on lung–kidney interactions in critically ill patients & bleeding in patients hospitalized in the intensive cardiac care unit; narrative reviews on reversal of vasodilatory shock & drug-induced acute kidney injury; and commentaries on whether enteral nutrition can be given to patients on vasopressors & whether critical care patients hibernate? There are also editorials on tranexamic acid and the CRASH III trial & the persistent potential of extracorporeal therapies in liver failure; as well as correspondence on how high PEEP may have reduced injurious transpulmonary pressure swings in the ROSE trial.
This week's Topic of the Week is the ROSE trial, continuing with a paper on the current evidence from three randomized controlled trials on neuromuscular blockade in ARDS in today's Paper of the Day.
If you only have time to read one review article this week, try this one on the critical care management of toxicities associated with targeted agents and immunotherapies for cancer.
Critical Care Reviews Meeting 2020
The programme for the meeting is available as a pdf. If you plan on attending, please don't leave it too long before registering as you might be disappointed, We sold out the last couple of years and are on course to do so again this year.
- Abstract: The National Heart, Lung, and Blood Institute PETAL Clinical Trials Network. Early High-Dose Vitamin D3 for Critically Ill, Vitamin D–Deficient Patients (VIOLET). N Engl J Med 2019;epublished December 11th
- Abstract: Spinella. Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients. A Randomized Clinical Trial (ABC-PICU). JAMA 2019;322(22):2179-2190
- Full Text: Moja. Effectiveness of a Hospital-Based Computerized Decision Support System on Clinician Recommendations and Patient OutcomesA Randomized Clinical Trial. JAMA Netw Open 2019;2(12):e1917094
- Abstract: Nong. Noninvasive ventilation support during fiberoptic bronchoscopy-guided nasotracheal intubation effectively prevents severe hypoxemia. J Crit Care 2020;56:12-17
- Full Text: Möckel. Improve Management of acute heart failure with ProcAlCiTonin in EUrope: results of the randomized clinical trial IMPACT EU Biomarkers in Cardiology (BIC). Eur J Heart Fail 2019;epublished December 12th
- Full Text: Guérin. Low-pressure support vs automatic tube compensation during spontaneous breathing trial for weaning. Annals of Intensive Care 2019;9:137
- Full Text: Margadant. The Nursing Activities Score Per Nurse Ratio Is Associated With In-Hospital Mortality, Whereas the Patients Per Nurse Ratio Is Not. Crit Care Med 2020 48:3–9
- Abstract: Ferrando. Effects of oxygen on post-surgical infections during an individualised perioperative open-lung ventilatory strategy: a randomised controlled trial. Br J Anaesth 2019;epublished November 22nd
- Abstract: Goh. A meta-analysis of the outcomes following enteral vs parenteral nutrition in the open abdomen in trauma patients. J Crit Care 2020;56:42-48
- Full Text: Flanders. The effect of dexmedetomidine and clonidine on the inflammatory response in critical illness: a systematic review of animal and human studies. Critical Care 2019;23:402
- Abstract: Kamdar. Return to work after critical illness: a systematic review and meta-analysis. Thorax 2020;75:17-27
- Full Text: Cabrini. Tracheal intubation in patients at risk for cervical spinal cord injury: a systematic review. Acta Anaesthesiol Scand 2019;epublished December 14th
- Full Text: Herrera-Perez. Meta-Research: A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals. eLife 2019;8:e45183
- Full Text: Okada. Early versus delayed mobilization for in-hospital mortality and health-related quality of life among critically ill patients: a systematic review and meta-analysis. J Intensive Care 2019;7:57
- Full Text: Chen. A meta-analysis of the effects of therapeutic hypothermia in adult patients with traumatic brain injury. Critical Care 2019;23:396
- Full Text: Koozi. C-reactive protein as a prognostic factor in intensive care admissions for sepsis: A Swedish multicenter study. J Crit Care 2019;epublished December 11th
- Full Text: Baggerman. Muscle wasting associated co-morbidities, rather than sarcopenia are risk factors for hospital mortality in critical illness. J Crit Care 2020;56:31-36
- Full Text: Javaudin. Improving identification of pulmonary embolism-related out-of-hospital cardiac arrest to optimize thrombolytic therapy during resuscitation. Critical Care 2019;23:409
- Abstract: Lemasle. Bioactive Adrenomedullin, Organ Support Therapies, and Survival in the Critically Ill: Results from the French and European Outcome Registry in ICU Study. Crit Care Med 2020;48(1):49-55
- Abstract: Rosa. Early and Late Mortality Following Discharge From the ICU: A Multicenter Prospective Cohort Study. Critical Care Med 2020;48(1):64-72
- Abstract: Guidet. The contribution of frailty, cognition, activity of daily life and comorbidities on outcome in acutely admitted patients over 80 years in European ICUs: the VIP2 study. Intensive Care Med 2019;epublished November 29th
- Full Text: Kruser. Assessment of Variability in End-of-Life Care Delivery in Intensive Care Units in the United States. JAMA Netw Open 2019;2(12):e1917344
- Management of bleeding in patients hospitalized in the intensive cardiac care unit. Expert Opinion of the Association of Intensive Cardiac Care and Section of Cardiovascular Pharmacotherapy of the Polish Cardiac Society in cooperation with specialists in other fields of medicine. Kardiol Pol 2019;epublished December 9th
- Imaging in patients with suspected acute heart failure: timeline approach position statementon behalf of the Heart Failure Association ofthe European Society of Cardiology. European Journal of Heart Failure 2019
- Kidney and uro-trauma: WSES-AAST guidelines. World J Emerg Surg 2019;14:54
- Joannidis. Lung–kidney interactions in critically ill patients: consensus report of the Acute Disease Quality Initiative (ADQI) 21 Workgroup. Intensive Care Med 2019;epublished December 9th
- Thorup. Effects of Vasopressors on Cerebral Circulation and Oxygenation. A Narrative Review of Pharmacodynamics in Health and Traumatic Brain Injury. J Neurosurgical Anesthesiology 2020;32(1):18–28
- Cottrell. Anesthesia and Cognitive Outcome in Elderly Patients. A Narrative Viewpoint. J Neurosurgical Anesthesiology 2020;32(1):9–17
- Cottrell. Anesthesia and Cognitive Outcome in Elderly Patients. A Narrative Viewpoint. J Neurosurgical Anesthesiol 2020;32(1):9–17
- Baldo. The anaesthetist, opioid analgesic drugs, and serotonin toxicity: a mechanistic and clinical review. Br J Anaesth 2020;124(1):44–62
- Chow. Reversal of Vasodilatory Shock: Current Perspectives on Conventional, Rescue, and Emerging Vasoactive Agents for the Treatment of Shock. Anesth Analg 2019;130(1):15-30
- Karamchandani. Atrial Fibrillation: Current Evidence and Management Strategies During the Perioperative Period. Anesth Analg 2019;130(1):2-13
- Molero-Díez. Fourth universal definition of myocardial infarction: perioperative anesthetic considerations. Colombian Journal of Anesthesiology 2019;47(3):175-177
- Lim. Awake supraglottic airway guided flexible bronchoscopic intubation in patients with anticipated difficult airways: a case series and narrative review. Korean Journal of Anesthesiology 2019;72(6):548-557
- Kim. High-flow nasal oxygenation for anesthetic management. Korean Journal of Anesthesiology 2019;72(6):527-547
- Perazella. Drug-induced acute kidney injury: diverse mechanisms of tubular injury. Curr Opin Crit Care 2019;25(6):550–557
- Wittekamp. Selective decontamination of the digestive tract (SDD) in critically ill patients: a narrative review. Intensive Care Med 2019;epublished December 9th
- Wattal. Neonatal Sepsis: Mortality and Morbidity in Neonatal Sepsis due to Multidrug-Resistant (MDR) Organisms: Part 1. Indian J Pediatr 2019;epublished December 11th
- Gutierrez. Critical Care Management of Toxicities Associated With Targeted Agents and Immunotherapies for Cancer. Crit Care Med 2020;48(1):10-21
- Durand. You Are Only as Frail as Your Arteries: Prehabilitation of Elderly Surgical Patients. Current Anesthesiology Reports 2019;9(4):380–386
- Uppal. Transversus Abdominis Plane (TAP) and Rectus Sheath Blocks: a Technical Description and Evidence Review. Current Anesthesiology Reports 2019;9:479–487
- Komorowski. Clinical management of sepsis can be improved by artificial intelligence: yes. Intensive Care Med 2019;epublished December 13th
- Benichou. The artificial kidney induces acute kidney injury: yes. Intensive Care Med 2019;epublished December 12th
- Shah. Trial sequential analysis: adding a new dimension to meta‐analysis. Anaesthesia 2020;75:15–20
- Fuhrmann. The persistent potential of extracorporeal therapies in liver failure. Intensive Care Med 2019;epublished December 9th
- Taccone. Is tranexamic acid going to CRASH the management of traumatic brain injury? Intensive Care Med 2019;epublished December 9th
- Forni. The Janus faces of bicarbonate therapy in the ICU: not sure! Intensive Care Med 2019;epublished December 9th
- Abbasi. Patient With Tetraplegia Tests Brain-Controlled Exoskeleton. JAMA 2019;322(22):2161
- Arabi. Enteral Nutrition Should Not Be Given to Patients on Vasopressor Agents. Crit Care Med 2019;48(1):119-121
- Wischmeyer. Enteral Nutrition Can Be Given to Patients on Vasopressors. Crit Care Med 2019;48(1):122-125
- Stanzani. Do critical care patients hibernate? Theoretical support for less is more. Intensive Care Med 2019;epublished December 9th
- Honore. Dysbiosis of the microbiota in neurocritically ill patients associated with coma and death: ammonia as a potential missing link. Critical Care 2019;23:403
- Honore. Optimizing ceftolozane-tazobactam dosage during continuous renal replacement therapy: additional insights. Critical Care 2019;23:406
- Borges. High PEEP may have reduced injurious transpulmonary pressure swings in the ROSE trial. Critical Care 2019;23:404
- Ischaki. “Blow with the high flow” an updated algorithm. J Emerg Crit Care Med 2019;3:61
- Damas. Right-to-left shunt secondary to duplicated superior vena cava as etiology of ischemic stroke. J Emerg Crit Care Med 2019;3:57
- Au. A special cause of acute coronary syndrome in patients supported with VA ECMO. J Emerg Crit Care Med 2019;3:58
- De Backer. Critical Ultrasounds: a foreword. J Emerg Crit Care Med 2019;3:62
- Yeh. Association and dissociation of microcirculation and macrocirculation in critically ill patients with shock. J Emerg Crit Care Med 2019;3:60
- Shaqiri. Images from a fulminant mesenteric artery thrombosis. J Emerg Crit Care Med 2019;3:56
- Finneran. Ultrasound-guided percutaneous intercostal nerve cryoneurolysis for analgesia following traumatic rib fracture: a case series. Korean Journal of Anesthesiology 2019;epublished November 5th
- Choi. Anaphylaxis induced by sugammadex and sugammadex- rocuronium complex: A case report. 2019;epublished October 17th
Now in it's 8th year, the Critical Care Reviews Meeting brings the chief investigators for the best critical care trials of the previous year to Titanic, Belfast, to discuss their studies. We aim to decide whether these trials are sufficiently robust to support their findings and if we should consider changing practice on the basis of them. To help in this endeavour we invite world leading experts to provide independent editorial overviews and have panel discussions to delve deep into the specifics of each trial. In addition, we also have detailed discussions on research methodology, to encourage critical thinking about the scientific findings which form the basis of our clinical practice. It's not just about specific trials though; for 2020, we have a distinguished panel of trialists, methodologists, statisticians and clinicians provide insight into the mysteries of clinical trial interpretation, as well as a panel discission on the proposed MEGA-ROX trial, potentially a game changer for critical care trials. We are delighted to have the opportunity to conduct a one-on-one interview with the editor-in-chief of JAMA, Prof Howard Bauchner, in discussion with Prof Marion Campbell. As usual, we eound off the formal programme with the annual honorary John Hinds Lecture, to be delivered by Prof Kathryn Maitland, entitled "A Higher Calling: Two Decades of Emergency Research in Africa", and finish the meeting with the incredibly popular "Informal Chat", where the faculty and delegates congregate in the bar and an enormous, meandering discussion about all things critical care takes place.
For CCR20, we are hosting 3 major trial results presentations, PEPTIC, 65 & VITAMINS, as well as discussing 9 of the best trials from 2019 - COACT, TRACT, ICU-ROX, SPICE III, BiRDS, ROSE, CITRIS-ALI, SEPSIS-ACT & HYPERION.
Based on our feedback from last year, we've reverted to keeping everyone on the same floor during breaks. In addition, we will also provide a sleeping area for those post-call to rest for a few hours as needed. As before, we are offering free childcare and a baby feeding area, where the meeting will live streamed. All dietary requirements are catered for also. Please get in touch if you have any specific needs. We sold out last year, so please don't delay if you want to attend. As usual, CPD points will be applied for in due course.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board