CCR-Newsletter-BannerNewsletter 417  |  December 9th 2019

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IHME SEPSIS Study Results to be presented at CCR20


Welcome to the 417th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.

The highlights of this week's edition are the VAPrapid2 randomised controlled trial investigating biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia; a systematic review and meta analysis investigating the effects of continuous epinephrine infusion on survival; and an observational studies assessing the association between supraphysiologic arterial oxygen levels and mortality. There is also a guideline on the transfer of the brain‐injured patient; narrative reviews on processed EEG monitoring for anesthesia and intensive care, ventricular assist device implantation in patients with a failing systemic right ventricle & monitoring of regional lung ventilation using electrical impedance tomography; and a commentary on producing and using trustworthy evidence.

The big news this week is the announcement the results of the landmark IHME Sepsis Study will be presented at the Critical Care Reviews Meeting 2020 next month. Dr Kristina Rudd from Pittsburgh, USA, will present the results, establishing the true global burden of sepsis for the very first time. The editorial will be delivered by Prof Kathryn Maitland, to be followed by a panel discussion from clinicians and scientists from North America, Africa, Europe, Asia and Australasia. For those who can't make it, we will be providing a free, worldwide live stream of these important data, starting at 16:35 local time in Belfast, Northern Ireland.

Continuing our focus on CCR20 presentations, this week's Topic of the Week is, based on the IHME Sepsis Study, sepsis epidemiology, starting with a paper on the global burden of sepsis: barriers and potential solutions in today's Paper of the Day.

If you only have time to read one review article this week, try this one on the management of severe acute pancreatitis.



Review Articles










CCR20 Meeting

Now in it's 8th year, the Critical Care Reviews Meeting brings the chief investigators for the best critical care trials of the previous year to Titanic, Belfast, to discuss their studies. We aim to decide whether these trials are sufficiently robust to support their findings and if we should consider changing practice on the basis of them. To help in this endeavour we invite world leading experts to provide independent editorial overviews and have panel discussions to delve deep into the specifics of each trial. In addition, we also have detailed discussions on research methodology, to encourage critical thinking about the scientific findings which form the basis of our clinical practice. It's not just about specific trials though; for 2020, we have a distinguished panel of trialists, methodologists, statisticians and clinicians provide insight into the mysteries of clinical trial interpretation, as well as a panel discission on the proposed MEGA-ROX trial, potentially a game changer for critical care trials. We are delighted to have the opportunity to conduct a one-on-one interview with the editor-in-chief of JAMA, Prof Howard Bauchner, in discussion with Prof Marion Campbell. As usual, we eound off the formal programme with the annual honorary John Hinds Lecture, to be delivered by Prof Kathryn Maitland, entitled "A Higher Calling: Two Decades of Emergency Research in Africa", and finish the meeting with the incredibly popular "Informal Chat", where the faculty and delegates congregate in the bar and an enormous, meandering discussion about all things critical care takes place.

For CCR20, we are hosting 3 major trial results presentations, PEPTIC, 65 & VITAMINS, one major sepsis epidemiological study - IHME Sepsis - as well as discussing 9 of the best trials from 2019 - COACT, TRACT, ICU-ROX, SPICE III, BiRDS, ROSE, CITRIS-ALI, SEPSIS-ACT & HYPERION

Based on our feedback from last year, we've reverted to keeping everyone on the same floor during breaks. In addition, we will also provide a sleeping area for those post-call to rest for a few hours as needed. As before, we are offering free childcare and a baby feeding area, where the meeting will live streamed. All dietary requirements are catered for also. Please get in touch if you have any specific needs. We sold out last year, so please don't delay if you want to attend. As usual, CPD points will be applied for in due course.

CCH Journal

Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive.  If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.

COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.

I hope you find these links useful.

Until next week


Supported by the Health Research Board

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