Welcome to the 415th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The big news this week is the announcement that the Critical Care Reviews Meeting 2020 will be hosting the ICNARC sponsored 65 trial results, investigating permissive hypotension in adults aged older than 65 years with distributive hypotension and receiving vasopressors. This landmark trial in 2,600 patients will be presented at 9am on Thursday, January 16th, in Titanic, Belfast. This session will be freely live-streamed for those unable to make it.
Continuing our focus on the trials being presented at the Critical Care Reviews Meeting 2020, this week's Topic of the Week can only be the 65 trial, starting with the SEPSISPAM trial in today's Paper of the Day.
If you only have time to read one review article this week, try this one on eye signs for the neurologist in the ICU.
- Abstract: Koziarz. Bedside Optic Nerve Ultrasonography for Diagnosing Increased Intracranial Pressure: A Systematic Review and Meta-analysis. Annals Internal Med 2019;epublished November 19th
- Abstract: Li. Prognosis of β-adrenergic blockade therapy on septic shock and sepsis: A systematic review and meta-analysis of randomized controlled studies. Cytokine 2019;126:154916
- Full Text: Zwager. Why physiology will continue to guide the choice between balanced crystalloids and normal saline: a systematic review and meta-analysis. Crit Care 2019;23(1):366
- Abstract: Rali. Non-Invasive Cardiac Output Monitoring in Cardiogenic Shock – The NICOMTM Study. J Cardiac Failure 2019;epublished November 18th
- Full Text: Yoshida. Prognostic impact of sustained new‑onset atrial fibrillation in critically ill patients. Intensive Care Med 2019;epublished November 4th
- Abstract: Young. Conservative oxygen therapy for mechanically ventilated adults with sepsis: a post hoc analysis of data from the intensive care unit randomized trial comparing two approaches to oxygen therapy (ICU-ROX). Intensive Care Med 2019;epublished November 20th
- Abstract: Fernando. Frailty and invasive mechanical ventilation: association with outcomes, extubation failure, and tracheostomy. Intensive Care Med 2019;45(12):1742-1752
- Full Text: Abe. Implementation of earlier antibiotic administration in patients with severe sepsis and septic shock in Japan: a descriptive analysis of a prospective observational study. Critical Care 2019;23:360
- Full Text: Sahetya. Association between hospital mortality and inspiratory airway pressures in mechanically ventilated patients without acute respiratory distress syndrome: a prospective cohort study. Critical Care 2019;23:367
- Full Text: Amin. The Evolving Landscape of Impella® Use in the United States Among Patients Undergoing Percutaneous Coronary Intervention with Mechanical Circulatory Support. Circulation 2019;epublished November 17th
- Wan. Neurosurgical Care of Nonpowder Firearm Injuries: A Narrative Review of the Literature. Emergency Medicine International 2019;4680184
- Meenakshisundaram. Eye signs for the neurologist in the Intensive Care Unit. Neurol Neurochir Pol 2019;epublished November 20th
- Mathew. Chest radiographs of cardiac devices (Part 1): Lines, tubes, non-cardiac medical devices and materials. SA J Radiol 2019;23(1):1729
- Mathew. Chest radiographs of cardiac devices (Part 1): Cardiovascular implantable electronic devices, cardiac valve prostheses and Amplatzer occluder devices. SA J Radiol 2019;23(1):1730
- Mathew. Chest radiographs of cardiac devices (Part 2): Ventricular assist devices. SA J Radiol 2019;23(1):1732
- Fuentes. VpALI—Vaping-related Acute Lung Injury: A New Killer Around the Block. Mayo Clin Proc 2019;epublished November 22nd
- van Zanten. Nutrition therapy and critical illness: practical guidance for the ICU, post-ICU, and long-term convalescence phases. Critical Care 2019;23:368
- Girling. Acute kidney injury and adverse outcomes of critical illness: correlation or causation? Clinical Kidney Journal sfz158,
- Burstein. Anticoagulation with direct thrombin inhibitors during extracorporeal membrane oxygenation. World J Crit Care Med 2019;8(6):87-98
- Lai. Meropenem-Vaborbactam in the Treatment of Acute Bacterial Infections. J Clin Med 2019;8(10):1650
- Fadel. Traumatic blunt cardiac injuries: An updated narrative review. Int J Crit Illn Inj Sci 2019;9:113-9
- Procianoy. The challenges of neonatal sepsis management. Jornal de Pediatria 2019;epublished November 17th
- Shimoda-Sakano. Epidemiology of pediatric cardiopulmonary resuscitationEpidemiology of pediatric cardiopulmonary resuscitation. Jornal de Pediatria 2019;epublished September 30th
- Nascimento-Carvalho. Community-acquired pneumonia among children: the latest evidence for an updated management. Jornal de Pediatria 2019;epublished September 10th
- da Costa. Viral encephalitis: a practical review on diagnostic approach and treatmen. Jornal de Pediatria 2019;epublished September 9th
- Shankar-Hari. Should we consider blocking the inhibitory immune checkpoint molecules for treating T cell exhaustion in sepsis? Intensive Care Med 2019;October 28th
- Félix. Translational medicine between human and veterinary emergency and critical care medicine: a story meant to have a happy ending. Critical Care 2019;23:361
- Martin. Might children rust? What are the risks of supplemental oxygen in acute illness. Archives of Disease in Childhood 2019;104:106-107
- Lüsebrink. Ten things ICU specialists need to know about new valvular procedures in interventional cardiology. Intensive Care Med 2019;epublished November 4th
- Farina. Reconsidering Dexmedetomidine for Sedation in the Critically Ill: Implications of the SPICE III Trial. Annals of Pharmacology 2019;epublished November 19th
- Ñamendys‑Silva. Less is more, but are we doing enough? Intensive Care Med 2019;epublished October 24th
- Wei. Coronary Microvascular Dysfunction Causing Cardiac Ischemia in Women. JAMA 2019;epublished November 18th
- Bauchner. The Challenges of Sharing Data in an Era of Politicized Science. JAMA 2019;epublished November 21st
- Parikh. Addressing Bias in Artificial Intelligence in Health Care. JAMA 2019;epublished November 22nd
- Peterson. Machine Learning, Predictive Analytics, and Clinical PracticeCan the Past Inform the Present? JAMA 2019;epublished November 22nd
- Hwang. Lifecycle Regulation of Artificial Intelligence– and Machine Learning–Based Software Devices in Medicine. JAMA 2019;epublished November 22nd
- Claassen. Coma science: intensive care as the new frontier. Intensive Care Med 2019;epublished November 20th
Now in it's 8th year, the Critical Care Reviews Meeting brings the chief investigators for the best critical care trials of the previous year to Titanic, Belfast, to discuss their studies. We aim to decide whether these trials are sufficiently robust to support their findings and if we should consider changing practice on the basis of them. To help in this endeavour we invite world leading experts to provide independent editorial overviews and have panel discussions to delve deep into the specifics of each trial. In addition, we also have detailed discussions on research methodology, to encourage critical thinking about the scientific findings which form the basis of our clinical practice. It's not just about specific trials though; for 2020, we have a distinguished panel of trialists, methodologists, statisticians and clinicians provide insight into the mysteries of clinical trial interpretation, as well as a panel discission on the proposed MEGA-ROX trial, potentially a game changer for critical care trials. We are delighted to have the opportunity to conduct a one-on-one interview with the editor-in-chief of JAMA, Prof Howard Bauchner, in discussion with Prof Marion Campbell. As usual, we eound off the formal programme with the annual honorary John Hinds Lecture, to be delivered by Prof Kathryn Maitland, entitled "A Higher Calling: Two Decades of Emergency Research in Africa", and finish the meeting with the incredibly popular "Informal Chat", where the faculty and delegates congregate in the bar and an enormous, meandering discussion about all things critical care takes place.
For CCR20, we are hosting 3 major trial results presentations, PEPTIC, 65 & VITAMINS, as well as discussing 9 of the best trials from 2019 - COACT, TRACT, ICU-ROX, SPICE III, BiRDS, ROSE, CITRIS-ALI, SEPSIS-ACT & HYPERION.
Based on our feedback from last year, we've reverted to keeping everyone on the same floor during breaks. In addition, we will also provide a sleeping area for those post-call to rest for a few hours as needed. As before, we are offering free childcare and a baby feeding area, where the meeting will live streamed. All dietary requirements are catered for also. Please get in touch if you have any specific needs. We sold out last year, so please don't delay if you want to attend. As usual, CPD points will be applied for in due course.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board