Welcome to the 413th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The big news this week is the announcement we are hosting the results of the ANZICS-CTG-endorsed VITAMINS trial, investigating hydrocortisone, thiamine and vitamin C in septic shock, at the Critical Care Reviews Meeting 2020. This will be presented by chief investigator Tomoko Fujii, with the editorial being delivered by Prof Paul Marik, who developed this sepsis cocktail. Prof Marik presented his data for the first time at #CCR17, so it's fitting to have the first randomised data presented back in Titanic. For those who can't make it to Belfast for #CCR20, we will be freely live-streaming the entire 90 minute VITAMINS session, including results presentation, editorial, questions and panel discussion.
Naturally, this week's Topic of the Week is the VITAMINS trial, starting with a paper on hydrocortisone, ascorbic acid and thiamine (HAT therapy) for the treatment of sepsis - focus on ascorbic acid, in tomorrow's Paper of the Day.
- Abstract: François. Prevention of Early Ventilator-Associated Pneumonia after Cardiac Arrest. N Engl J Med 2019;381:1831-1842
- Abstract: Alexander. Oral Lefamulin vs Moxifloxacin for Early Clinical Response Among Adults With Community-Acquired Bacterial Pneumonia. The LEAP 2 Randomized Clinical Trial. JAMA 2019;322(17):1661-1671
- Abstract: Vargas. Epinephrine for out of hospital cardiac arrest: A systematic review and meta-analysis of randomized controlled trials. Resuscitation 2019;epublished November 4th
- Abstract: Li. Resuscitation Fluids in Septic Shock: A Network Meta-Analysis of Randomized Controlled Trials. Shock 2019;epublished November 5th
- Abstract: Heffernan. β-lactam antibiotic versus combined β-lactam antibiotic and single-daily dosing regimens of aminoglycosides for the treatment of serious infections: a meta-analysis. Int J Antimicrob Agents 2019;epublished November 5th
- Abstract: Kamdar. Return to work after critical illness: a systematic review and meta-analysis. Thorax 2019;epublished November 8th
- Abstract: Parry. Six-Minute Walk Distance After Critical Illness: A Systematic Review and Meta-Analysis. J Intensive Care Med 2019;epublished November 5th
- Abstract: Patel. Impact of Extracorporeal Membrane Oxygenation on Mortality in Adults With Cardiac Arrest. Am J Cardiol 2019;epublished September 25th
- Abstract: Rakhra. The ATLANTIC study: Anti-Xa level assessment in trauma intensive care. Injury 2019;epublished October 31st
- Full Text: Van den Bulcke. Ethical climate and intention to leave among critical care clinicians: an observational study in 68 intensive care units across Europe and the United States. Intensive Care Med 2019;epublished November 4th
- Abstract: O’Brien. Association of Postoperative Infection With Risk of Long-term Infection and Mortality. JAMA Surg 2019;epublished November 6th
- Abstract: Luethi. Gender differences in mortality and quality of life after septic shock: A post-hoc analysis of the ARISE study. J Crit Care 2019;epublished November 8th
- Abstract: Bertoni. A novel non-invasive method to detect excessively high respiratory effort and dynamic transpulmonary driving pressure during mechanical ventilation. Critical Care 2019;23:346
- Abstract: Grieco. Physiological Comparison of High-Flow Nasal Cannula and Helmet Noninvasive Ventilation in Acute Hypoxemic Respiratory Failure. Am J Respir Crit Care Med 2019;epublished November 5th
- Abstract: Yelin. Genomic and epidemiological evidence of bacterial transmission from probiotic capsule to blood in ICU patients. Nature Medicine 2019;epublished November 7th
- Full Text: Kalininskiy. E-cigarette, or vaping, product use associated lung injury (EVALI): case series and diagnostic approach. Lancet Respir Med 2019;epublished November 8th
- The role of fibrinogen and fibrinogen concentrate in cardiac surgery: an international consensus statement from the Haemostasis and Transfusion Scientific Subcommittee of the European Association of Cardiothoracic Anaesthesiology. Anaesthesia 2019;74(12):1589-1600
- Pollesello. Short-Term Therapies for Treatment of Acute and Advanced Heart Failure-Why so Few Drugs Available in Clinical Use, Why Even Fewer in the Pipeline? J Clin Med 2019;8(11)
- International Society of Cardiovascular Infectious Diseases Guidelines for the Diagnosis, Treatment and Prevention of Disseminated Mycobacterium chimaera Infection Following Cardiac Surgery with Cardiopulmonary Bypass. J Hosp Infection 2019;epublished November 9th
- Pollesello. Short-Term Therapies for Treatment of Acute and Advanced Heart Failure—Why so Few Drugs Available in Clinical Use, Why Even Fewer in the Pipeline? J Clin Med 2019;8(11):1834;
- Kerstjens. Airway pharmacology: treatment options and algorithms to treat patients with chronic obstructive pulmonary disease. J Thorac Dis 2019;11(Suppl 17):S2200-S2209
- Dias. Diagnosis and management of acute esophageal necrosis. Ann Gastroenterol 2019;32(6):529–540
- Emmanuel. Neurogenic bowel dysfunction. F1000Research 2019, 8(F1000 Faculty Rev):1800
- Grottke. Four-factor Prothrombin Complex Concentrate for the Management of Patients Receiving Direct Oral Activated Factor X Inhibitors. Anesthesiology 2019;131:1153-1165
- Cleland. Iron homeostasis and perioperative management of iron deficiency. BJA Education 2019;19(12):390–397
- Formanek. Advances in the Diagnosis and Management of Invasive Fungal Disease. Chest 2019;156(5):834–842
- Horak. Back to Basics: Recognition of Sepsis with New Definition. J Clin Med 2019;8:1838
- Wang. Antifungal agents for invasive candidiasis in non-neutropenic critically-illadults: what do the guidelines recommend? Int J Infect Dis 2019;89:137-145Int J Infect Dis 2019;89:137-145
- Khodamoradi. The Role of Microbiota in Preventing Multidrug-Resistant Bacterial Infections. Dtsch Arztebl Int 2019;116:670-6
- Murao. A Systematic Summary of Systematic Reviews on Anticoagulant Therapy in Sepsis. J Clin Med 2019;8(11):1869
- Dewachter. Perioperative anaphylaxis: pathophysiology, clinical presentation and management. BJA Education 2019;19(10):313–320
- Taniguchi. Leptospirosis: one of the forgotten diseases. Intensive Care Med 2019;epublished November 4th
- Ioannidis. The Ninth International Congress on Peer Review and Scientific PublicationA Call for Research. JAMA 2019;322(17):1658-1660
- Sessler. Intensivist Burnout. Running on Empty? Chest 2019;156(5):817–819
- Corradi. What’s new in ultrasound-based assessment of organ perfusion in the critically ill: expanding the bedside clinical monitoring window for hypoperfusion in shock. Intensive Care Med 2019;epublished October 25th
- El‐Ghazali. Pre‐incision hypotension and the association with postoperative acute kidney injury – an opportunity to improve peri‐operative outcomes? Br J Anaesth 2019;74(12):1611-16141611-1614
- Lucas. Vitamin D and Health Outcomes. Then Came the Randomized Clinical Trials. JAMA 2019;epublished November 8th
- Sharma. Should We Use DSI or not—What does the PADIS 2018 Guidelines Recommend? Indian J Crit Care Med 2019;23(10):491
- Wang. Caution should be taken when using electronic health record database. Critical Care 2019 23:345
- Luo. High-flow nasal cannula oxygen therapy versus conventional oxygen therapy in patients after planned extubation. Critical Care 2019;23:344
- Redant. Hemoadsorption efficacy for uncomplicated high-risk cardiac surgery. Critical Care 2019;23:343
- Mileo. The haemostasis traffic light: a pragmatic tool for bleeding management. Br J Anaesth 2019;74(12):1623-1624
- Sotiriou. Reversal of severe hypoxemia by administration of nitric oxide‑echocardiographic findings. Intensive Care Med 2019;epublished October 25th
- Mohammed. Pulmonary Hyperinfection with Strongyloides stercoralis in an Immunocompetent Patient. Indian J Crit Care Med 2019;23(10):481–483
- Chawla. A Rare Case of Neurogenic Pulmonary Edema Following High-voltage Electrical Injury. Indian J Crit Care Med 2019;23(10):486–488
- Wiskar. A 48-Year-Old Man With Refractory Hypoxic Respiratory Failure. Chest 2019;156(5):e91–e94
- de la Motte. An 82-Year-Old Man With Sleep-Onset Insomnia, Breathing Arrest, and Heart Failure. Chest 2019;156(5):e95–e98
- Ziatabar. A 44-Year-Old Man With Dyspnea and a Pulmonary Artery Filling Defect. Chest 2019;156(5):e103–e106
- Miles. A 43-Year-Old Woman With Hoarseness of Voice and Chest Pressure. Chest 2019;156(5):e107–e110
Now in it's 8th year, the Critical Care Reviews Meeting brings the chief investigators for the best critical care trials of the previous year to Titanic, Belfast, to discuss their studies. We aim to decide whether these trials are sufficiently robust to support their findings and if we should consider changing practice on the basis of them. To help in this endeavour we invite world leading experts to provide independent editorial overviews and have panel discussions to delve deep into the specifics of each trial. In addition, we also have detailed discussions on research methodology, to encourage critical thinking about the scientific findings which form the basis of our clinical practice. It's not just about specific trials though; for 2020, we have a distinguished panel of trialists, methodologists, statisticians and clinicians provide insight into the mysteries of clinical trial interpretation. We also have the annual honorary John Hinds Lecture, to be delivered by Prof Kathryn Maitland, entitled "A Higher Calling: Two Decades of Emergency Research in Africa", and finish the meeting with the incredibly popular "Informal Chat", where the faculty and delegates congregate in the bar and an enormous, meandering discussion about all things critical care takes place.
Based on our feedback from last year, we've reverted to keeping everyone on the same floor during breaks. In addition, we will also provide a sleeping area for those post-call to rest for a few hours as needed. As before, we are offering free childcare and a baby feeding area, where the meeting will live streamed. All dietary requirements are catered for also. Please get in touch if you have any specific needs. We sold out last year, so please don't delay if you want to attend. As usual, CPD points will be applied for in due course.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board