CCR-Newsletter-BannerNewsletter 412  |  November 4th 2019

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VITAMINS Ed 291019


Welcome to the 412th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.

The highlights of this week's edition are a systematic review and meta analysis on do-not-intubate orders in patients with acute respiratory failure; and observational studies on long-term outcomes following severe traumatic brain injury in older adults & epidemiology of intra-abdominal infection and sepsis in critically ill patients. There are also guidelines on intracranial pressure monitoring & REBOA; narrative reviews on bedside ultrasound to assess fluid status & perioperative blood and coagulation management during cardiac surgery; an editorial on T cell exhaustion in sepsis; and commentaries on auto-immune encephalitis & less is more, but are we doing enough?; as well as correspondence on early use of norepinephrine for sepsis & hyperoxemia

This week's Topic of the Week is another of our CCR20 trials, the BIRDS trial, investigating APRV in ARDS. We start with a paper on APRV for ARDS: the complexities of a mode and how it affects even the best trials, in today's Paper of the Day.

If you only have time to read one review article this week, try this one on preparing intensive care for the next pandemic influenza.

We have started to announce the editorialists for the trials to be presented at the Critical Care Reviews Meeting 2020. Prof Paul Marik will give the editorial on the VITAMINS trial, investigating the Marik Protocol of vitamin C, hydrocortisone and thiamine in septic shock. Asst Prof Andrew Althouse will deliver the editorial on the CITRIS-ALI trial, examining vitamin C in sepsis-induced ARDS. If you haven't booked yet, please don't delay too long. Our free creche has only a few spaces left too, so please don't miss out if you require childcare.



Review Articles








CCR20 Meeting

CCR20 201019

Now in it's 8th year, the Critical Care Reviews Meeting brings the chief investigators for the best critical care trials of the previous year to Titanic, Belfast, to discuss their studies. We aim to decide whether these trials are sufficiently robust to support their findings and if we should consider changing practice on the basis of them. To help in this endeavour we invite world leading experts to provide independent editorial overviews and have panel discussions to delve deep into the specifics of each trial. In addition, we also have detailed discussions on research methodology, to encourage critical thinking about the scientific findings which form the basis of our clinical practice. It's not just about specific trials though; for 2020, we have a distinguished panel of trialists, methodologists, statisticians and clinicians provide insight into the mysteries of clinical trial interpretation. We also have the annual honorary John Hinds Lecture, to be delivered by Prof Kathryn Maitland, entitled "A Higher Calling: Two Decades of Emergency Research in Africa", and finish the meeting with the incredibly popular "Informal Chat", where the faculty and delegates congregate in the bar and an enormous, meandering discussion about all things critical care takes place.

Based on our feedback from last year, we've reverted to keeping everyone on the same floor during breaks. In addition, we will also provide a sleeping area for those post-call to rest for a few hours as needed. As before, we are offering free childcare and a baby feeding area, where the meeting will live streamed. All dietary requirements are catered for also. Please get in touch if you have any specific needs. We sold out last year, so please don't delay if you want to attend. As usual, CPD points will be applied for in due course.

CCH Journal

Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive.  If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.

COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.

I hope you find these links useful.

Until next week


Supported by the Health Research Board

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