Welcome to the 412th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are a systematic review and meta analysis on do-not-intubate orders in patients with acute respiratory failure; and observational studies on long-term outcomes following severe traumatic brain injury in older adults & epidemiology of intra-abdominal infection and sepsis in critically ill patients. There are also guidelines on intracranial pressure monitoring & REBOA; narrative reviews on bedside ultrasound to assess fluid status & perioperative blood and coagulation management during cardiac surgery; an editorial on T cell exhaustion in sepsis; and commentaries on auto-immune encephalitis & less is more, but are we doing enough?; as well as correspondence on early use of norepinephrine for sepsis & hyperoxemia.
This week's Topic of the Week is another of our CCR20 trials, the BIRDS trial, investigating APRV in ARDS. We start with a paper on APRV for ARDS: the complexities of a mode and how it affects even the best trials, in today's Paper of the Day.
If you only have time to read one review article this week, try this one on preparing intensive care for the next pandemic influenza.
We have started to announce the editorialists for the trials to be presented at the Critical Care Reviews Meeting 2020. Prof Paul Marik will give the editorial on the VITAMINS trial, investigating the Marik Protocol of vitamin C, hydrocortisone and thiamine in septic shock. Asst Prof Andrew Althouse will deliver the editorial on the CITRIS-ALI trial, examining vitamin C in sepsis-induced ARDS. If you haven't booked yet, please don't delay too long. Our free creche has only a few spaces left too, so please don't miss out if you require childcare.
- Full Text: Becher. Adaptive mechanical ventilation with automated minimization of mechanical power—a pilot randomized cross-over study. Critical Care 2019;23:338
- Abstract: Files. A randomized pilot study of nitrate supplementation with beetroot juice in acute respiratory failure. Nitric Oxide 2019;epublished October 25th
- Full Text: Yang. Low versus high pulse oxygen saturation directed oxygen therapy in critically ill patients: a randomized controlled pilot study. J Thorac Dis 2019;11(10):4234-4240
- Full Text: Wright. Examining Risk: A Systematic Review of Perioperative Cardiac Risk Prediction Indices. Mayo Clin Proc 2019;94(11):2277–2290
- Full Text: Chen. Efficacy and safety of haloperidol for delirium prevention in adult patients: An updated meta-analysis with trial sequential analysis of randomized controlled trials. J Clin Anesth 2019;epublished October 28th
- Abstract: Wilson. Do-not-intubate orders in patients with acute respiratory failure: a systematic review and meta-analysis. Intensive Care Med 2019;epublished October 28th
- Abstract: Angriman. The harm of high-frequency oscillatory ventilation (HFOV) in ARDS is not related to a high baseline risk of acute cor pulmonale or short-term changes in hemodynamics. Intensive Care Med 2019;epublished October 29th
- Full Text: Aretha. Extracorporeal Life Support: The Next Step in Moderate to Severe ARDS-A Review and Meta-Analysis of the Literature. Biomed Res Int 2019;2019:1035730
- Full Text: Barbateskovic. Haloperidol for the treatment of delirium in critically ill patients: a systematic review with meta-analysis and Trial Sequential Analysis. Acta Anaesthesiol Scand 2019;epublished October 29th
- Abstract: Maiden. Long-Term Outcomes Following Severe Traumatic Brain Injury in Older Adults: A Registry-Based Cohort Study. Am J Respir Crit Care Med 2019;epublished October 28th
- Full Text: Blot. Epidemiology of intra-abdominal infection and sepsis in critically ill patients: “AbSeS”, a multinational observational cohort study and ESICM Trials Group Project. Intensive Care Med 2019;epublished October 29th
- Full Text: van Mourik. Cumulative fluid balance predicts mortality and increases time on mechanical ventilation in ARDS patients: An observational cohort study. PLoS One 2019;30;14(10):e0224563
- Full Text: Skulec. Correlation between end-tidal carbon dioxide and the degree of compression of heart cavities measured by transthoracic echocardiography during cardiopulmonary resuscitation for out-of-hospital cardiac arrest. Critical Care 2019;23:334
- Abstract: Hu. Discrimination, Abuse, Harassment, and Burnout in Surgical Residency Training. N Engl J Med 2019;381:1741-1752
- Abstract: DeFilipp. Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant. N Engl J Med 2019;epublished October 30th
- Abstract: Bougouin. Extracorporeal cardiopulmonary resuscitation in out-of-hospital cardiac arrest: a registry study. European Heart Journal 2019;ehz753
- Abstract: Venkatesh. Hydrocortisone Compared with Placebo in Patients with Septic Shock Satisfying the Sepsis-3 Diagnostic Criteria and APROCCHSS Study Inclusion Criteria: A Post Hoc Analysis of the ADRENAL Trial. Anesthesiology 2019;epublished October 16th
- A management algorithm for patients with intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC). Intensive Care Med 2019;epublished October 28th
- Clinical use of resuscitative endovascular balloon occlusion of the aorta (REBOA) in civilian trauma systems in the USA, 2019: a joint statement from the American College of Surgeons Committee on Trauma, the American College of Emergency Physicians, the National Association of Emergency Medical Services Physicians and the National Association of Emergency Medical Technicians. Trauma Surg Acute Care Open 2019;4(1):e000376
- Volovici. Evolution of Evidence and Guideline Recommendations for the Medical Management of Severe Traumatic Brain Injury. J Neurotrauma 2019;36(22):3183-3189
- Khalid. Autonomic dysfunction following traumatic brain injury: translational insights. Neurosurg Focus 2019;47(5):E8
- Li. The finer scale of consciousness: quantum theory. Ann Transl Med 2019;7(20):585
- Jacob. Prevention of Cardiac Surgery-Associated Acute Kidney Injury. A Review of Current Strategies. Anesthesiology Clinics 2019;37(4):729–749
- Smit-Fun. Heart Failure in Adult Patients with Congenital Heart Disease. Anesthesiology Clinics 2019;37(4):751–768
- Piotrkowski. Use of bedside ultrasound to assess fluid status: a literature review. Polish Archives Of Internal Medicine 2019;129(10):692-699
- Moscatelli. An Emerging Cardiovascular Disease: Takotsubo Syndrome. BioMed Research International 2019;6571045
- Nayar. Management of community-acquired bacterial pneumonia in adults: Limitations of current antibiotics and future therapies. Lung India 2019;36:525-33
- Braithwaite. New Techniques for Optimization of Donor Lungs/Hearts. Anesthesiology Clinics 2019;37(4):639–660
- Xue. The Management of Glucocorticoid Therapy in Liver Failure. Front Immunol 10:2490
- Xu. Portal pressure monitoring—state-of-the-art and future perspective. Ann Transl Med 2019;7(20):583
- Meesters. Optimizing Perioperative Blood and Coagulation Management During Cardiac Surgery. Anesthesiology Clinics 2019;37(4):713–728
- Arora. Physiology of Oxygen Transport and its Determinants in Intensive Care Unit. Indian J Crit Care Med 2019;23(Suppl 3):S172–S177
- Hegde. Approach to an Anemic Critically Ill Patient. Indian J Crit Care Med 2019;23(Suppl 3):S178–S180
- Chacko. Red Blood Cell Transfusion Thresholds in Critically Ill Patients. Indian J Crit Care Med 2019;23(Suppl 3):S181–S184
- Aluru. Thrombocytopenia in Intensive Care Unit. Indian J Crit Care Med 2019;23(Suppl 3):S185–S188
- Karanth. Transfusion Triggers for Platelets and Other Blood Products. Indian J Crit Care Med 2019;23(Suppl 3):S189–S190
- Salunke. Hemophagocytic Syndrome—An Approach to the Management. Indian J Crit Care Med 2019;23(Suppl 3):S191–S196
- Sinha. Clotting Catastrophies in the Intensive Care Unit. Indian J Crit Care Med 2019;23(Suppl 3):S197–S201
- Govil. Point-of-care Testing of Coagulation in Intensive Care Unit: Role of Thromboelastography. Indian J Crit Care Med 2019;23(Suppl 3):S202–S206
- Khasne. Landmark Papers on Blood and Component Transfusion Therapy in the Critically Ill: A Critical Analysis. Indian J Crit Care Med 2019;23(Suppl 3):S207–S211
- Jagathkar. How to Audit Transfusion Practices in the Intensive Care Unit? Indian J Crit Care Med 2019;23(Suppl 3):S212–S214
- Singh. Approach to the Coagulopathic Patient in the Intensive Care Unit. Indian J Crit Care Med 2019;23(Suppl 3):S215–S220
- Chacko. Reversal of Anticoagulants in Critical Care. Indian J Crit Care Med 2019;23(Suppl 3):S221–S225
- Das. Hemostatic Agents in Critically Ill Patients. Indian J Crit Care Med 2019;23(Suppl 3):S226–S229
- Sonneville. Understanding auto-immune encephalitis in the ICU. Intensive Care Med 2019;epublished September 25th
- Pasipoularides. Emulating Leonardo da Vinci (1452–1519): convergence of science and art in biomedical research and practice. Cardiovascular Research 2019;cvz275
- Ñamendys-Silva. Less is more, but are we doing enough? Intensive Care Med 2019;epublished October 24th
- El Bèze. Early Use of Norepinephrine for Sepsis: Promising Results That Require Confirmation. Am J Respir Crit Care Med 2019;200(9):1191
- Tung. Norepinephrine for Early Shock Control in Sepsis. Am J Respir Crit Care Med 2019;200(9):1192
- Tasker. Hyperoxemia and Death of Critically Ill: Is There a Problem of Confounding by Indication or Outcome? Am J Respir Crit Care Med 2019;epublished October 31st
- Lellouche. Hyperoxemia: The Poison is in the Dose. Am J Respir Crit Care Med 2019;epublished October 31st.
- Roux. Conventional amphotericin B should remain in the armamentarium as a cheap and efficient waiting solution. Intensive Care Med 2019;epublished October 16th
- Barbar. Initiation of renal replacement therapy in patients with septic acute kidney injury: right timing or right patient? Ann Transl Med 2019;7(20):598
- Chen. Indications for contrast enhanced computed tomography in patients with sepsis induced acute kidney injury. Ann Transl Med 2019;7(20):597
- Laurent. The effect visiting relatives in the adult ICU has on children. Intensive Care Med 2019;45:1490–1492
- Honore. How levosimendan can improve renal function? Critical Care 2019;23:331
- Jouffroy. Positive cultures and clinical outcomes in septic patients: be aware of the influence from patient selection and the in-hospital confounders. Critical Care 2019 23:332
- Honore. What should be the best dialysis catheter lock in critically ill patients? Critical Care 2019, 23:339
- Post. Comment upon “Time to epinephrine treatment is associated with the risk of mortality in children who achieve sustained ROSC after traumatic out-of-hospital cardiac arrest”. Critical Care 2019;23:336
- Sakai. Absence of Adverse Neurological Outcomes in a Non-Neurologically Injured Polytrauma Patient Despite Extreme and Prolonged Treatment-Resistant Hypotension: A Case Report. A&A Practice 2019;13(9):358-361
- Yu. Detection of an inferior vena cava thrombus in transit by ultrasound. Intensive Care Med 2019;epublished September 18th
Now in it's 8th year, the Critical Care Reviews Meeting brings the chief investigators for the best critical care trials of the previous year to Titanic, Belfast, to discuss their studies. We aim to decide whether these trials are sufficiently robust to support their findings and if we should consider changing practice on the basis of them. To help in this endeavour we invite world leading experts to provide independent editorial overviews and have panel discussions to delve deep into the specifics of each trial. In addition, we also have detailed discussions on research methodology, to encourage critical thinking about the scientific findings which form the basis of our clinical practice. It's not just about specific trials though; for 2020, we have a distinguished panel of trialists, methodologists, statisticians and clinicians provide insight into the mysteries of clinical trial interpretation. We also have the annual honorary John Hinds Lecture, to be delivered by Prof Kathryn Maitland, entitled "A Higher Calling: Two Decades of Emergency Research in Africa", and finish the meeting with the incredibly popular "Informal Chat", where the faculty and delegates congregate in the bar and an enormous, meandering discussion about all things critical care takes place.
Based on our feedback from last year, we've reverted to keeping everyone on the same floor during breaks. In addition, we will also provide a sleeping area for those post-call to rest for a few hours as needed. As before, we are offering free childcare and a baby feeding area, where the meeting will live streamed. All dietary requirements are catered for also. Please get in touch if you have any specific needs. We sold out last year, so please don't delay if you want to attend. As usual, CPD points will be applied for in due course.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board