Welcome to the 411th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. The highlights of this week's edition are randomised controlled trials comparing fibrinogen concentrate with cryoprecipitate after cardiac surgery & depths of anaesthesia in major surgery; systematic reviews and meta analyses on timing of initiation of renal replacement therapy for acute kidney injury & procalcitonin-guided antibiotic therapy; and observational studies on laryngeal injury after prolonged mechanical ventilation & IMPELLA mechanical support in patients with acute myocardial infarction complicated by cardiogenic shock. There are also narrative reviews on the perioperative stress response & technology-enabled clinical trials; and editorials on optimising power to avoid VILI & the role of sugammadex; as well as correspondence which has caused some controvery on social media, on sepsis hysteria .
Continuing the build up to the Critical Care Reviews Meeting 2020, this week's Topic of the Week is the SPICE III trial, investigating dexmedetomidine sedation in ICU, starting with a paper on dexmedetomidine: present and future directions in tomorrow's Paper of the Day.
If you only have time to read one review article this week, try this one on complications of temporary percutaneous mechanical circulatory support for cardiogenic shock.
- Full Text: Callum. Effect of Fibrinogen Concentrate vs Cryoprecipitate on Blood Component Transfusion After Cardiac Surgery. The FIBRES Randomized Clinical Trial. JAMA 2019;epublished October 21st
- Abstract: Wang. Effect of the Tailored, Family-Involved Hospital Elder Life Program on Postoperative Delirium and Function in Older Adults. A Randomized Clinical Trial. JAMA Intern Med 2019;epublished October 21st
- Full Text: Nejla. Comparison Between Continuous and Intermittent Administration of Hydrocortisone During Septic Shock. A Randomized Controlled Clinical Trial. Shock 2019;52(5):481–486
- Abstract: Tajamul. Neurally-Adjusted Ventilatory Assist Versus Noninvasive Pressure Support Ventilation in COPD Exacerbation: The NAVA-NICE Trial. Respir Care 2019;epublished October 22nd
- Full Text: Short. Anaesthetic depth and complications after major surgery: an international, randomised controlled trial. Lancet 2019;epublished October 20th
- Commentary: Galley. Deep anaesthesia and poor outcomes: the jury is still out. Lancet 2019;epublished October 20th
- Full Text: Lertjitbanjong. Acute Kidney Injury after Lung Transplantation: A Systematic Review and Meta-Analysis. J Clin Med 2019;8(10)
- Full Text: Bañares. Meta-analysis of individual patient data of albumin dialysis in acute-on-chronic liver failure: focus on treatment intensity. Therap Adv Gastroenterol 2019 Sep 27;12:1756284819879565
- Full Text: Maitra. Noninvasive Ventilation and Oxygen Therapy after Extubation in Patients with Acute Respiratory Failure: A Meta-analysis of Randomized Controlled Trials. Indian J Crit Care Med 2019;23(9):414-422
- Full Text: Xiao. Early versus late initiation of renal replacement therapy for acute kidney injury in critically ill patients: A systematic review and meta-analysis. PLoS One 2019;14(10):e0223493
- Full Text: Peng. Ineffectiveness of procalcitonin-guided antibiotic therapy in severely critically ill patients: A meta-analysis. Int J Infect Dis 2019;85:158-166
- Abstract: Shinn. Incidence and Outcomes of Acute Laryngeal Injury After Prolonged Mechanical Ventilation. Crit Care Med 2019;epublished October 17th
- Full Text: Keita. Subsequent mortality in survivors of Ebola virus disease in Guinea: a nationwide retrospective cohort study. Lancet Infect Dis 2019;19(11):1202-1208
- Abstract: Zeymer. Use of the IMPELLA mechanical support device in patients with acute myocardial infarction complicated by cardiogenic shock - Results of the CULPRIT-SHOCK trial. Eur Heart J 2019;40(Suppl 1):ehz746.0677
- Abstract: Zeymer. Current spectrum and 1-year mortality of cardiogenic shock in Europe. Results of the CULPRIT-SHOCK randomized clinical trial and registry. Eur Heart J 2019;40(Suppl 1):ehz748.0480
- Abstract: Miyamoto. Association between intravenous contrast media exposure and non-recovery from dialysis-requiring septic acute kidney injury: a nationwide observational study. Intensive Care Med 2019;45(11):1570–1579
- Abstract: Sivanathan. Mental illness after admission to an intensive care unit. Intensive Care Med 2019;45(11):1550–1558
- Abstract: Barco. Trends in mortality related to pulmonary embolism in the European Region, 2000–15: analysis of vital registration data from the WHO Mortality Database. Lancet Respir Med 2019;epublished October 12th
- Rothstein. SSEP retains its value as predictor of poor outcome following cardiac arrest in the era of therapeutic hypothermia. Critical Care 2019;23:327
- Mittal. OSCE: Status epilepticus. J Pediatr Crit Care 2019;6(5):75-82
- Teleanu. Antioxidant Therapies for Neuroprotection—A Review. J Clin Med 2019;8(10):1659
- Subramaniam. Complications of Temporary Percutaneous Mechanical Circulatory Support for Cardiogenic Shock: An Appraisal of Contemporary Literature. Cardiol Ther 2019;epublished October 23rd
- Gupta. A Review of Antithrombotic Treatment in Critical Limb Ischemia After Endovascular Intervention. CardiCardiol Ther 2019;epublished October 19th
- Moore. Imaging of acute pulmonary embolism: an update. Cardiovasc Diagn Ther 2018;8(3):225-243
- Reis. Acute pulmonary embolism: endovascular therapy. Cardiovasc Diagn Ther 2018;8(3):244-252
- Chamarthy. Pulmonary vascular pathophysiology. Cardiovasc Diagn Ther 2018;8(3):208-213
- Collins. Antifibrotic therapy for fibrotic lung disease beyond idiopathic pulmonary fibrosis. Eur Respir Rev 2019;28:190022
- Somogyi. The therapy of idiopathic pulmonary fibrosis: what is next? Eur Respir Rev 2019;28:190021
- Szabo. Pathogenesis of Acute-on-Chronic Liver Failure in Patients With Infection. Clin Liver Dis 2019;14(3):103-106
- Piano. Current Concepts on Bacterial and Fungal Infections in Cirrhosis. Clin Liver Dis 2019;14(3):87–91
- Wong. Clinical Consequences of Infection in Cirrhosis: Organ Failures and Acute‐on‐Chronic Liver Failure. Clin Liver Dis 2019;14(3):92–97
- Bajaj. Altered Microbiota in Cirrhosis and Its Relationship to the Development of Infection. Clin Liver Dis 2019;14(3):107–111
- Van Jacobs. Frailty Assessment in Patients with Liver Cirrhosis. Clin Liver Dis 2019;14(3):121–125
- Mittal. Clinical Update: Acute liver failure. J Pediatr Crit Care 2019;6(5):67-74
- Misra. Roadblocks and Opportunities to the Implementation of Novel Therapies for Acute Kidney Injury: A Narrative Review. Can J Kidney Health Dis 2019;6:2054358119880519
- Mulley. Tissue typing for kidney transplantation for the general nephrologist. Nephrology 2019;24(10):997-1000
- Burstein. Anticoagulation with direct thrombin inhibitors during extracorporeal membrane oxygenation. World J Crit Care Med 2019;8(6):87-98
- Fouzia. Coagulopathies in critically ill patients. J Pediatr Crit Care 2019;6(5):35-48
- Manou-Stathopoulou. Redefining the perioperative stress response: a narrative review. Br J Anaesth 2019;123(5):570–583
- Fiore. Preventing opioid prescription after major surgery: a scoping review of opioid-free analgesia. Br J Anaesth 2019;123(5):627–636
- Marini. How I optimize power to avoid VILI. Crit Care 2019;23(1):326
- Quintão. Reporting guidelines:tools to increase the completeness and transparency of your anesthesiology research paper. Rev Bras Anestesiol 2019;epublished October 23rd
- Kaye. The role of sugammadex, a novel cyclodextrin compound in modern anesthesia practice: conventional neuromuscular physiology and clinical pharmacology. Expert Rev Clin Pharmacol 2019;12(10):917-919
- Singer. Sepsis hysteria: excess hype and unrealistic expectations. Lancet 2019;394(10208):1513-1514
- Redant. Urgent need for a randomized controlled trial with only septic patients! Annals of Intensive Care 2019;9:121
- Miscellaneous. Transfusion Timing and Volume in African Children with Severe Anemia. N Engl J Med 2019;381:1686-1688
Now in it's 8th year, the Critical Care Reviews Meeting brings the chief investigators for the best critical care trials of the previous year to Titanic, Belfast, to discuss their studies. We aim to decide whether these trials are sufficiently robust to support their findings and if we should consider changing practice on the basis of them. To help in this endeavour we invite world leading experts to provide independent editorial overviews and have panel discussions to delve deep into the specifics of each trial. In addition, we also have detailed discussions on research methodology, to encourage critical thinking about the scientific findings which form the basis of our clinical practice. It's not just about specific trials though; for 2020, we have a distinguished panel of trialists, methodologists, statisticians and clinicians provide insight into the mysteries of clinical trial interpretation. We also have the annual honorary John Hinds Lecture, to be delivered by Prof Kathryn Maitland, entitled "A Higher Calling: Two Decades of Emergency Research in Africa", and finish the meeting with the incredibly popular "Informal Chat", where the faculty and delegates congregate in the bar and an enormous, meandering discussion about all things critical care takes place.
Based on our feedback from last year, we've reverted to keeping everyone on the same floor during breaks. In addition, we will also provide a sleeping area for those post-call to rest for a few hours as needed. As before, we are offering free childcare and a baby feeding area, where the meeting will live streamed. All dietary requirements are catered for also. Please get in touch if you have any specific needs. We sold out last year, so please don't delay if you want to attend. As usual, CPD points will be applied for in due course.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board