CCR-Newsletter-BannerNewsletter 410  |  October 20th 2019

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The last trial to be added to the CCR20 programme is HYPERION


Welcome to the 410th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.

The highlights of this week's edition are two randomised controlled trials presented at the World Congress of Intensive Care in Melbourne this week; CRASH-3, investigating tranexamic acid in traumatic brain injury, and ICU-ROX, one of the trials being discussed at #CCR20, comparing conservative with standard oxygenation in mechanically ventilated ICU patients. There are also systematic reviews and meta analyses on imaging for neuroprognostication after cardiac arrest & decompressive craniectomy for severe traumatic brain injury; observational studies comparing short-term dialysis catheter with central venous catheter infections in ICU patients & natural light exposure on delirium burden; and the protocol for the VITAMINS trial, another of our #CCR20 trials. There are also guidelines on inotropes for the management of acute and advanced heart failure & antimotility agents for acute noninfectious diarrhea; two ultrasound-based narrative reviews on whole body ultrasound in the operating room and ICU & ultrasound-guided peripheral venous cannulation; editorials on ventilation and ARDS, intracranial pressure monitoring & pneumonia research; and commentariess on extracorporeal devices in critical care & vasopressors, antiarrhythmics, oxygen, and intubation in out-of-hospital cardiac arrest.

In CCR20 news, the final trial added to the scientific programme is HYPERION, comparing 33ºC with 37ºC post non-shockable cardiac arrest, to be presented by Dr Jean-Baptiste Lascarrou from Nantes. Continuing our theme of looking at the trials to be presented and discussed at CCR20, this week's focus trial is HYPERION and the Topic of the Week is targeted temperature management post cardiac arrest, starting with a paper on targeted temperature management for non-shockable cardiac arrests: the debate must go on in tomorrow's Paper of the Day.

If you only have time to read one review article this week, try this one on understanding and enhancing sepsis survivorship.

Finally, Critical Care Reviews is 10 years old this week!



Review Articles











CCR20 Meeting

CCR20 010819 Widget

Now in it's 8th year, the Critical Care Reviews Meeting brings the chief investigators for the best critical care trials of the previous year to Titanic, Belfast, to discuss their studies. We aim to decide whether these trials are sufficiently robust to support their findings and if we should consider changing practice on the basis of them. To help in this endeavour we invite world leading experts to provide independent editorial overviews and have panel discussions to delve deep into the specifics of each trial. In addition, we also have detailed discussions on research methodology, to encourage critical thinking about the scientific findings which form the basis of our clinical practice. It's not just about specific trials though; for 2020, we have a distinguished panel of trialists, methodologists, statisticians and clinicians provide insight into the mysteries of clinical trial interpretation. We also have the annual honorary John Hinds Lecture, to be delivered by Prof Kathryn Maitland, entitled "A Higher Calling: Two Decades of Emergency Research in Africa", and finish the meeting with the incredibly popular "Informal Chat", where the faculty and delegates congregate in the bar and an enormous, meandering discussion about all things critical care takes place.

Based on our feedback from last year, we've reverted to keeping everyone on the same floor during breaks. In addition, we will also provide a sleeping area for those post-call to rest for a few hours as needed. As before, we are offering free childcare and a baby feeding area, where the meeting will live streamed. All dietary requirements are catered for also. Please get in touch if you have any specific needs. We sold out last year, so please don't delay if you want to attend. As usual, CPD points will be applied for in due course.

CCH Journal

Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive.  If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.

COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.

I hope you find these links useful.

Until next week


Supported by the Health Research Board

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