Welcome to the 408th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
It's a smaller newsletter than usual this week. The highlights of this edition are randomised controlled trials on the effect of a fluid bolus on cardiovascular collapse among critically ill adults undergoing tracheal intubation & a Bayesian re-analysis of the ANDROMEDA-SHOCK trial; a systematic review and meta analysis comparing general anesthesia with procedural sedation in patients with acute ischemic stroke undergoing thrombectomy; and observational studies on vitamin D and acute respiratory infections & computed tomography angiography accuracy in brain death diagnosis. There are also guidelines on community-acquired pneumonia & prognostication in neurocritical care; narrative reviews on the failing right heart, reappraisal of ventilator-free days in critical care research & prone positioning in ARDS; editorials on patient selection in sepsis & the probability of benefit with the use of neuromuscular blockade in patients with ARDS; and commentaries on the importance of timing for the spontaneous breathing trial & lactate guided resuscitation.
This week's Topic of the Week is lung transplatation, which started yesterday with a paper on the indications for lung transplant referral and listing.
If you only have time to read one review article this week, try this one on emergent polymyxin resistance: end of an era?
- Abstract: Janz. Effect of a fluid bolus on cardiovascular collapse among critically ill adults undergoing tracheal intubation (PrePARE): a randomised controlled trial. Lancet 2019;epublished October 1st
- Abstract: Zampieri. Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients with Septic Shock: A Bayesian Reanalysis of the ANDROMEDA-SHOCK Trial. Am J Respir Crit Care Med 2019;epublished October 1st
- Full Text: Bobillo-Perez. Procalcitonin to stop antibiotics after cardiovascular surgery in a pediatric intensive care unit—The PROSACAB study. PLoS One 2019;14(9):e0220686
- Abstract: Stone. Five-Year Outcomes after PCI or CABG for Left Main Coronary Disease. N Engl J Med 2019;epublished September 28th
- Full Text: Davey. Anti-influenza hyperimmune intravenous immunoglobulin for adults with influenza A or B infection (FLU-IVIG): a double-blind, randomised, placebo-controlled trial. Lancet 2019;epublished September 30th
- Abstract: Beigel. Anti-influenza immune plasma for the treatment of patients with severe influenza A: a randomised, double-blind, phase 3 trial. Lancet 2019;epublished September 30th
- Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America. Am J Respir Crit Care Med 2019;200(7):345-e67
- Chinese College of Emergency Physicians (CCEP), Emergency Committee of PLA, Beijing Society for Emergency Medicine, Chinese Emergency Medicine. Expert consensus on nebulization therapy in pre-hospital and in-hospital emergency care. Ann Transl Med 2019;7(18):487
- Gap Analysis Regarding Prognostication in Neurocritical Care: A Joint Statement from the German Neurocritical Care Society and the Neurocritical Care Society. Neurocritical Care 2019;31(2):231–244
- 2019 EACTS/EACTA/EBCP guidelines on cardiopulmonary bypass in adult cardiac surgery. Eur J Cardiothorac Surg 2019;epublished October 2nd
- Yilmaz. The role of endothelial glycocalyx in health and disease. Clin Kid J 2019;12(5):611–619
- Taimeh. Assessment and treatment of the failing right heart: considerations for transplantation referral. J Thorac Dis 2019;11(Suppl 14):S1817-S1820
- Tjong. A comprehensive scoping review on transvenous temporary pacing therapy. Review Article. Neth Heart J 2019;27:462–473
- Giuranno. Radiation-Induced Lung Injury (RILI). Front Oncol 2019;9:877
- Mokra . Corticosteroids in Acute Lung Injury: The Dilemma Continues. Int J Mol Sci 2019;20(19)
- Wang. Advances in severe community-acquired pneumonia. Chin Med J 2019;132(16):1891–1893
- Gattinoni. Prone Positioning in Acute Respiratory Distress Syndrome. Semin Respir Crit Care Med 2019;40(01):094-100
- Huppert. Pathogenesis of Acute Respiratory Distress Syndrome. Semin Respir Crit Care Med 2019;40(01):031-039
- Patel. Extracorporeal membrane oxygenation as rescue therapy for severe hypoxemic respiratory failure. J Thorac Dis 2019;11(Suppl 14):S1688-S1697
- Patel. Bedside troubleshooting during venovenous extracorporeal membrane oxygenation (ECMO). J Thorac Dis 2019;11(Suppl 14):S1698-S1707
- Shweish. Indications for lung transplant referral and listing. J Thorac Dis 2019;11(Suppl 14):S1708-S1720
- Hachem. The role of the immune system in lung transplantation: towards improved long-term results. J Thorac Dis 2019;11(Suppl 14):S1721-S1731
- Parulekar. Detection, classification, and management of rejection after lung transplantation. J Thorac Dis 2019;11(Suppl 14):S1732-S1739
- Saito. Pharmacotherapy and adjunctive treatment for idiopathic pulmonary fibrosis (IPF). J Thorac Dis 2019;11(Suppl 14):S1740-S1754
- Lightle. Breathing lung transplantation with the Organ Care System (OCS) Lung: lessons learned and future implications. J Thorac Dis 2019;11(Suppl 14):S1755-S1760
- Parikh. Pharmacotherapy for pulmonary arterial hypertension. J Thorac Dis 2019;11(Suppl 14):S1767-S1781
- Kao. Postoperative management of lung transplant recipients. J Thorac Dis 2019;11(Suppl 14):S1782-S1788
- Sahay. Evaluation and classification of pulmonary arterial hypertension. J Thorac Dis 2019;11(Suppl 14):S1789-S1799
- Nguyen. Review of donor and recipient surgical procedures in lung transplantation. J Thorac Dis 2019;11(Suppl 14):S1810-S1816
- Yun. Lung transplant with bronchial arterial revascularization: review of surgical technique and clinical outcomes. J Thorac Dis 2019;11(Suppl 14):S1821-S1828
- Carney. The role of imaging in gastrointestinal bleed. Cardiovasc Diagn Ther 2019;9(Suppl 1):S88-S96
- Claassen. Brain Oxygen Monitoring and the Potential for Precision Medicine for Acutely Brain-Injured Patients. Neurocritical Care 2019;31(2):247–248
- Oda. Local anesthetic systemic toxicity: proposed mechanisms for lipid resuscitation and methods of prevention. J Anesthesia 2019;33(5):569–571
- Hasegawa. Patient selection in sepsis: precision medicine using phenotypes and its implications for future clinical trial design. J Thorac Dis 2019;11(9):3672-3675
- de Souza. Probability of benefit with the use of neuromuscular blockade in patients with acute respiratory distress syndrome. J Thorac Dis 2019;11(9):3676-3680
- Rolli. Treatment of anaemia in the “ERAS” era: how far can we go? J Thorac Dis 2019;11(9):3692-3695
- Lorusso. What you do not know, you do not recognize…and you do not improve future patient care…particularly in extracorporeal life support (ECLS) patients. J Thorac Dis 2019;11(Suppl 15):S1930-S1934
- Kramer. Neurocritical Care: A Growing International Collaborative. Neurocritical Care 2019;epublished September 30th
- Quenot. Treatment of sepsis-induced acute kidney injury in the ICU: the therapeutic targets do not seem to be established yet. Ann Transl Med 2019;7(Suppl 6):S181
- Tufoni. Prolonged albumin administration in patients with decompensated cirrhosis: the amount makes the difference. Ann Transl Med 2019;7(Suppl 6):S201
- Perren. The importance of timing for the spontaneous breathing trial. Ann Transl Med 2019;7(Suppl 6):S210
- Midega. Avoiding desaturation during endotracheal intubation: is high-flow nasal cannula the answer? Ann Transl Med 2019;7(Suppl 6):S211
- Girotra. Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): are neurologists feeling more comfortable to RESTART antiplatelet? Ann Transl Med 2019;7(Suppl 6):S214
- Berger. Nutrition determines outcome after severe burns. Ann Transl Med 2019;7(Suppl 6):S216
- Eun. Safety and efficacy of restarting antiplatelet therapy after intracerebral hemorrhage. Ann Transl Med 2019;7(Suppl 6):S218
- Ganau. Efficacy and safety profiles of mechanical and pharmacological thromboprophylaxis. Ann Transl Med 2019;7(Suppl 6):S224
- Suarez-Sipmann. PEEP titration guided by transpulmonary pressure: lessons from a negative trial. J Thorac Dis 2019;11(Suppl 15):S1957-S1962
- Marik. Lactate guided resuscitation—nothing is more dangerous than conscientious foolishness. J Thorac Dis 2019;11(Suppl 15):S1969-S1972
- Iwata. Importance of intraoperative fluid management. J Thorac Dis 2019;11(Suppl 15):S2002-S2004
Now in it's 8th year, the Critical Care Reviews Meeting brings the chief investigators for the best critical care trials of the previous year to Titanic, Belfast, to discuss their studies. We aim to decide whether these trials are sufficiently robust to support their findings and if we should consider changing practice on the basis of them. To help in this endeavour we invite world leading experts to provide independent editorial overviews and have panel discussions to delve deep into the specifics of each trial. In addition, we also have detailed discussions on research methodology, to encourage critical thinking about the scientific findings which form the basis of our clinical practice. It's not just about specific trials though; for 2020, we have a distinguished panel of trialists, methodologists, statisticians and clinicians provide insight into the mysteries of clinical trial interpretation. We also have the annual honorary John Hinds Lecture, to be delivered by Prof Kathryn Maitland, entitled "A Higher Calling: Two Decades of Emergency Research in Africa", and finish the meeting with the incredibly popular "Informal Chat", where the faculty and delegates congregate in the bar and an enormous, meandering discussion about all things critical care takes place.
Based on our feedback from last year, we've reverted to keeping everyone on the same floor during breaks. In addition, we will also provide a sleeping area for those post-call to rest for a few hours as needed. As before, we are offering free childcare and a baby feeding area, where the meeting will live streamed. All dietary requirements are catered for also. Please get in touch if you have any specific needs. We sold out last year, so please don't delay if you want to attend. As usual, CPD points will be applied for in due course.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board