CCR-Newsletter-BannerNewsletter 407  |  September 29th 2019

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The latest trial added to the CCR20 programme is CITRIS-ALI


Welcome to the 407th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.

The highlights of this week's edition are two randomised controlled trials on antibiotics for pneumonia; lefamulin vs moxifloxacin in community-acquired pneumonia & ceftolozane–tazobactam vs meropenem for nosocomial pneumonia; systematic reviews and meta analyses on intensity of renal replacement treatment for acute kidney injury & meta-analyses in critical care; and observational studies on plasma-to–red blood cell transfusion ratio in adults with severe traumatic bleeding & lung ultrasound for early diagnosis of postoperative need for ventilatory support.

There are also guidelines on withholding and withdrawing life-support in adults in emergency care & fluid resuscitation in the peri-acute kidney injury period; narrative reviews on psychopathology after admission to ICU & present and future of carbapenem-resistant enterobacteriaceae infections; editorials on recruiting the microcirculation in septic shock & clinical trial data sharing (read the correspondence section below too...); and commentaries on post-traumatic stress in the intensive care unit & advances in fluid assessment and kidney injury prediction.

This week's Topic of the Week is influenza, starting with a paper on a year of terror and a century of reflection: perspectives on the great influenza pandemic of 1918–1919 in tomorrow's Paper of the Day. If you only have time to read one review article this week, try this one on fluid management in the perioperative setting.

This week's CCR19 presentation releases were PAMPer & its editorial, plus POLAR and its editorial. The other talks from CCR19, and previous CCR meetings, are available here.


Review Articles









CCR20 Meeting

CCR20 290819 Widget

Now in it's 8th year, the Critical Care Reviews Meeting brings the chief investigators for the best critical care trials of the previous year to Titanic, Belfast, to discuss their studies. We aim to decide whether these trials are sufficiently robust to support their findings and if we should consider changing practice on the basis of them. To help in this endeavour we invite world leading experts to provide independent editorial overviews and have panel discussions to delve deep into the specifics of each trial. In addition, we also have detailed discussions on research methodology, to encourage critical thinking about the scientific findings which form the basis of our clinical practice. It's not just about specific trials though; for 2020, we have a distinguished panel of trialists, methodologists, statisticians and clinicians provide insight into the mysteries of clinical trial interpretation. We also have the annual honorary John Hinds Lecture, to be delivered by Prof Kathryn Maitland, entitled "A Higher Calling: Two Decades of Emergency Research in Africa", and finish the meeting with the incredibly popular "Informal Chat", where the faculty and delegates congregate in the bar and an enormous, meandering discussion about all things critical care takes place.

Based on our feedback from last year, we've reverted to keeping everyone on the same floor during breaks. In addition, we will also provide a sleeping area for those post-call to rest for a few hours as needed. As before, we are offering free childcare and a baby feeding area, where the meeting will live streamed. All dietary requirements are catered for also. Please get in touch if you have any specific needs. We sold out last year, so please don't delay if you want to attend. As usual, CPD points will be applied for in due course.

CCH Journal

Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive.  If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.

COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.

I hope you find these links useful.

Until next week


Supported by the Health Research Board

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