The latest trial added to the CCR20 programme is VITAMINS
Welcome to the 403rd Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are randomised controlled trials on the effects of vasopressin on transfusion requirements in trauma & complete vs culprit only PCI revascularization for myocardial infarction; a systematic review and meta analysis on IV immunoglobulin in sepsis; and an observational study looking at the association between acute kidney injury and neurological outcome or death at 6 months in out-of-hospital cardiac arrest. There is also a guideline on laboratory testing in the diagnosis of fungal infections; plus narrative reviews on hyperventilation in neurological patients & early brain injury after poor-grade subarachnoid hemorrhage; commentaries on death by organ donation & artificial intelligence in perioperative medicine; and correspondence on managing ICP-CPP & tidal volume.
This week's Topic of the Week is the second of a two part series looking at alcoholic liver disease, this week focusing on the complications of cirrhosis. We start with a paper on hepatorenal syndrome in tomorrow's Paper of the Day.
If you only have time to read one article this week, try this editorial from Prof Howard Bauchner, the Editor-in-Chief of JAMA, about the reporting and interpretation of randomized clinical trials. This topic, and others, will be advanced in more depth at the Critical Care Reviews Meeting 2020, where Prof Marion Campbell will interview Prof Bauchner over an hour in "The Editor's View".
Two sets of presentations from CCR19, POPPI & MIND-USA, were released this week. These are available in both video and podcast format. The full set to date, and our previous year's talks, are available here.
- Full Text: Sims. Effect of Low-Dose Supplementation of Arginine Vasopressin on Need for Blood Product Transfusions in Patients With Trauma and Hemorrhagic Shock. A Randomized Clinical Trial. JAMA Surg 2019;epublished August 28th
- Podcast: Author Interview Podcast
- Abstract: Luiking. A randomized-controlled trial of arginine infusion in severe sepsis on microcirculation and metabolism. Clinical Nutrition 2019;epublished August 27th
- Abstract: O'Riordan. Once-daily oral omadacycline versus twice-daily oral linezolid for acute bacterial skin and skin structure infections (OASIS-2): a phase 3, double-blind, multicentre, randomised, controlled, non-inferiority trial. Lancet Respir Med 2019;epublished August 29th
- Abstract: Mahta. Complete Revascularization with Multivessel PCI for Myocardial Infarction (COMPLETE Trial). N Engl J Med 2019;epublished September 1st
- Abstract: Schüpke. Ticagrelor or Prasugrel in Patients with Acute Coronary Syndromes (ISAR-REACT 5 Trial). N Engl J Med 2019;epublished September 1st
- Abstract: Yang. Evaluation of the Effect of Intravenous Immunoglobulin Dosing on Mortality in Patients with Sepsis: A Network Meta-analysis. Clinical Therapeutics 2019;epublished August 27th
- Full Text: Tian. Efficacy of pentoxifylline treatment for neonatal sepsis: a meta-analysis of randomized controlled studies. Italian Journal of Pediatrics 2019;45:108
- Abstract: Brown. Balanced Crystalloids Versus Saline in Sepsis: A Secondary Analysis of the SMART Trial. Am J Respir Crit Care Med 2019;epublished August 27th
- Abstract: Hope. The Association between Pre-Hospital Vulnerability, ARDS Development and Mortality among At-Risk Adults: Results from the LIPS-A Clinical Trial. Annals ATS 2019;epublished August 27th
- Abstract: Lee. Association between acute kidney injury and neurological outcome or death at 6 months in out-of-hospital cardiac arrest: A prospective, multicenter, observational cohort study. J Crit Care 2019;epublished August 28th
- Full Text: Vallabhajosyula. Acute respiratory failure and mechanical ventilation in cardiogenic shock complicating acute myocardial infarction in the USA, 2000–2014. Annals of Intensive Care 2019;9:96
- Abstract: Gattinoni. Understanding Lactatemia in Human Sepsis. Potential Impact for Early Management. Am J Respir Crit Care Med 2019;200(5):582–589
- Abstract: Poh. A Safe and Effective Low Dose Regional Citrate Anticoagulation Protocol for Continuous Renal Replacement Therapy. Nephrology 2019;epublished August 30th
- Zhang. Hyperventilation in neurological patients: from physiology to outcome evidence. Curr Opin Anesthesiol 2019;32(5):568-573
- Rass. Early Brain Injury After Poor-Grade Subarachnoid Hemorrhage. Current Neurology and Neuroscience Reports 2019;19:78
- Al-Sulaiman. Clinical aspects, diagnosis and management of cerebral vein and dural sinus thrombosis: A literature review. Saudi J Med Med Sci 2019;7:137-45
- Sjaus. The Use of Subcostal Echocardiographic Views to Guide the Insertion of a Right Ventricular Temporary Transvenous Pacemaker—Description of the Technique. J Cardiothorac Vasc Anesth 2019;33(10):2797-2803
- Buchmann. Takotsubo Cardiomyopathy—Acute Cardiac Dysfunction Associated With Neurological and Psychiatric Disorders. Front Neurol 2019;10:917
- Verjans. Artificial intelligence for the general cardiologist. Neth Heart J 2019;27:389–391
- Siegersma. Artificial intelligence in cardiovascular imaging: state of theart and implications for the imaging cardiologist. Neth Heart J 2019;27:403–413
- Benjamins. A primer in artificial intelligence in cardiovascular medicine. Neth Heart J 2019;27:392–402
- Voelker. Blood transfusion associated lung injury. J Thorac Dis 2019;11(8):3609-3615
- Godement. Hemodynamic monitoring of ARDS by critical care echocardiography. J Emerg Crit Care Med 2019;3:36
- Beaubien-Souligny. The Role of Point-of-Care Ultrasound Monitoring in Cardiac Surgical Patients With Acute Kidney Injury. J Cardiothorac Vasc Anesth 2019;33(10):2781-2796
- Feng. Transfusion in adults and children undergoing neurosurgery: the outcome evidence. Curr Opin Anesthesiol 2019;32(5):574-57
- Vinholt. The role of platelets in bleeding in patients with thrombocytopenia and hematological disease. Clin Chem Lab Med 2019;epublished August 29th
- Galliera. Clinical application of presepsin as diagnostic biomarker of infection: overview and updates. Clin Chem Lab Med 2019;epublished August 17th
- Kahlmeter. Point-Counterpoint: Differences between the European Committee on Antimicrobial Susceptibility Testing and Clinical and Laboratory Standards Institute Recommendations for Reporting Antimicrobial Susceptibility Results. J Clin Microbiol 57:e01129-19
- Miller. Clinical utility of advanced microbiologytesting tools. J Clin Microbiol 57:e00495-19
- Permall. Current insights in non-invasive ventilation for the treatment of neonatal respiratory disease. Italian Journal of Pediatrics 2019;45:105
- Garrido. Breathless and dying on Mount Everest. Lancet Respr Med 2019;epublished August 16th
- Maheshwari. Perioperative intelligence: applications of artificial intelligence in perioperative medicine. J Clin Monit Comput 2019;epublished August 29th
- Chartash. Physicians in the Era of Automation: The Case for Clinical Expertise. MDM Policy Pract 2019;4(2):2381468319868968
- Ely. Death by organ donation: euthanizing patients for their organs gains frightening traction. Intensive Care Med 2019;epublished August 23rd
- Glazier. Success of Opt-In Organ Donation Policy in the United States. JAMA 2019;322(8):719-720
- Wice. A Difficult Conversation. JAMA 2019;322(8):727-728
- Freeman. How I manage ICP-CPP: a visual, yet individualized approach. Critical Care 2019;23:287
- Honore. Icatibant, another piece of the therapeutic puzzle regarding hemodynamic side effects of angiotensin-converting enzyme inhibitors. Critical Care 2019;23:289
- Simonis. The tidal volume fix and more…. J Thorac Dis 2019;11(8):E117-E122
- Chousterman. Delaying Renal Replacement Therapy Could Be Harmful in Patients with Acute Brain Injury. Am J Respir Crit Care Med 2019;200(5):645–646
- Schwarz. Pathological Sleep and Wakefulness in the ICU and Weaning Failure: A Causal Relationship? Am J Respir Crit Care Med 2019;200(5):647-648
- Shaffu. Funny waves in repolarisation and tachycardia in a patient suspected for Brugada syndrome. Neth Heart J 2019;27:451–452
- Hermanides. A rare but devastating cause of cardiac tamponade. Neth Heart J 2019;27:453
- Cowley. Macrophage activation syndrome in a patient with systemic lupus erythematosus. Pol Arch Intern Med 2019;129(7-8):535-538
Now in it's 8th year, the Critical Care Reviews Meeting brings the chief investigators for the best critical care trials of the previous year to Titanic, Belfast, to discuss their studies. We aim to decide whether these trials are sufficiently robust to support their findings and if we should consider changing practice on the basis of them. To help in this endeavour we invite world leading experts to provide independent editorial overviews and have panel discussions to delve deep into the specifics of each trial. In addition, we also have detailed discussions on research methodology, to encourage critical thinking about the scientific findings which form the basis of our clinical practice. It's not just about specific trials though; for 2020, we have a distinguished panel of trialists, methodologists, statisticians and clinicians provide insight into the mysteries of clinical trial interpretation. We also have the annual honorary John Hinds Lecture, to be delivered by Prof Kathryn Maitland, entitled "A Higher Calling: Two Decades of Emergency Research in Africa", and finish the meeting with the incredibly popular "Informal Chat", where the faculty and delegates congregate in the bar and an enormous, meandering discussion about all things critical care takes place.
Based on our feedback from last year, we've reverted to keeping everyone on the same floor during breaks. In addition, we will also provide a sleeping area for those post-call to rest for a few hours as needed. As before, we are offering free childcare and a baby feeding area, where the meeting will live streamed. All dietary requirements are catered for also. Please get in touch if you have any specific needs. We sold out last year, so please don't delay if you want to attend. As usual, CPD points will be applied for in due course.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board