Welcome to the 396th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the period of July 8th to 14th.
The highlights of this week's edition are randomised controlled trials investigating internal jugular & subclavian ultrasound-guided central venous catheterization, an incentive spirometer patient reminder after CABG & the effect of alirocumab on mortality after acute coronary syndromes; systematic reviews and meta analyses on erythropoiesis-stimulating agents in critically ill patients, extending thrombolysis using perfusion imaging & the west Africa (2013-16) Ebola virus disease epidemic; and observational studies on herpes simplex encephalitis, the effect of the route of nutrition on gut mucosa in ventilated adults with shock & multimorbidity states associated with higher mortality rates in organ dysfunction and sepsis.
There are also narrative reviews on ICU light and noise exposure, post-intensive care syndrome & high-frequency oscillatory ventilation; editorials on infection & enteral feeding intolerance; and commentaries on dealing with internet-based information obtained by families of critically ill patients & ensuring trial conduct is consistent with trial design.
This week's Topic of the Week is cardiac critical care, starting with a paper on arrhythmias and sudden cardiac death in today's Paper of the Day. If you only have time to read one review article this week, try this one on the global ultrasound check for the critically ill.
Hopefully, I'll get the last outstanding newsletter out tomorrow, which means I'll have finally caught up!
- Full Text: Steg. Effect of Alirocumab on Mortality After Acute Coronary Syndromes. An Analysis of the ODYSSEY OUTCOMES Randomized Clinical Trial. Circulation 2019;140:103–112
- Full Text: Quenot. Trisodium citrate 4% versus heparin as a catheter lock for non-tunneled hemodialysis catheters in critically ill patients: a multicenter, randomized clinical trial. Ann Intensive Care 2019;9:75
- Abstract: Eltorai. Effect of an Incentive Spirometer Patient Reminder After Coronary Artery Bypass GraftingA Randomized Clinical Trial. JAMA Surg 2019;154(7):579-588
- Full Text: Doi. The effect of standard and high dose of rikkunshito on achievement of enteral nutrition target in critically ill patients: a pilot randomized controlled trial. Acute Med Surg 2019;epublished July 9th
- Abstract: Shin. Complications in internal jugular vs subclavian ultrasound-guided central venous catheterization: a comparative randomized trial. Intensive Care Med 2019;45(7):968–976
- Full Text: Piva. Early mobilization protocols for critically ill pediatric patients: systematic review. Rev Bras Ter Intensiva 2019;31(2):248-257
- Full Text: Yao. Are Corticosteroids Beneficial for Sepsis and Septic Shock? Based on Pooling Analysis of 16 Studies. Front Pharmacol 2019;10:714
- Full Text: Rojeka. A systematic review and meta-analysis of patient data from the west Africa (2013-16) Ebola virus disease epidemic. Clin Micro Infect 2019;epublished July 5th
- Abstract: Litton. Safety and efficacy of erythropoiesis-stimulating agents in critically ill patients admitted to the intensive care unit: a systematic review and meta-analysis. Intensive Care Med 2019;epublished July 11th
- Abstract: Campbell. Extending thrombolysis to 4·5–9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data. Lancet 2019;394(10193):139-147
- Abstract: Darmon. Changes in critically ill cancer patients’ short-term outcome over the last decades: results of systematic review with meta-analysis on individual data. Intensive Care Med 2019;45(7):977–987
- Abstract: Assoun. Molecular targeted therapy-related life-threatening toxicity in patients with malignancies. A systematic review of published cases. Intensive Care Med 2019;45(7):988–997
- Full Text: Zador. Multimorbidity states associated with higher mortality rates in organ dysfunction and sepsis: a data-driven analysis in critical care. Critical Care 2019;23:247
- Abstract: Anstey. Early osmotherapy in severe traumatic brain injury: an international multicentre study. J Neurotrauma 2019;epublished July 9th
- Full Text: Tatham. The National Institute for Health Research Critical Care Research Priority Setting Survey 2018. JICS 2019;epublished July 8th
- Abstract: Suntrup-Krueger. Extubation Readiness in Critically Ill Stroke Patients. A Prospective Observational Trial on When and How to Assess. Stroke 2019;epublished July 8th
- Abstract: Jaquet. Functional outcomes in adult patients with herpes simplex encephalitis admitted to the ICU: a multicenter cohort study. Intensive Care Med 2019;epublished July 10th
- Abstract: Kishimori. Intra-aortic balloon pump and survival with favorable neurological outcome after out-of-hospital cardiac arrest: a multicenter, prospective propensity score-matched study. Resuscitation 2019;epublished July 11th
- Abstract: Piton. Impact of the route of nutrition on gut mucosa in ventilated adults with shock: an ancillary of the NUTRIREA-2 trial. Intensive Care Med 2019;45(7):948–956
- Hwang. Combination therapy of vitamin C and thiamine for septic shock in a multicentre, double-blind, randomized, controlled study (ATESS): study protocol for a randomized controlled trial. Trials 2019;20:420
- da Costa. Glibenclamide in aneurysmatic subarachnoid hemorrhage (GASH): study protocol for a randomized controlled trial. Trials 2019;20:413
- Prigerson. Enhancing & Mobilizing the POtential for Wellness & Emotional Resilience (EMPOWER) among Surrogate Decision-Makers of ICU Patients: study protocol for a randomized controlled trial. Trials 2019;20:408
- Simons. Impact of intensive care unit light and noise exposure on critically ill patients. Neth J Crit Care 2019;27(4):145-9
- Furtado. Inferior vena cava evaluation in fluid therapy decision making in intensive care: practical implications. Rev Bras Ter Intensiva 2019;31(2):240-247
- Meyers. High-frequency oscillatory ventilation: A narrative review. Can J Respir Ther 2019;55:40-46
- Keddissi. Fluid management in Acute Respiratory Distress Syndrome: A narrative review. Can J Respir Ther 2019;55:1–8
- Angeli. News in Pathophysiology, Definition and Classification of Hepatorenal Syndrome: a step beyond the International Club of Ascites (ICA) Consensus document. J Hepatology 2019;epublished July 11th
- Vora. Hypotension in Cirrhosis. Clin Liver Dis 2019;13(6):149–153
- Sharma. Liver‐Kidney: Indications, Patient Selection, and Allocation Policy. Clin Liver Dis 2019;13(6):165–169
- Zhao. Combined Heart and Liver Transplant: Indication, Patient Selection, and Allocation Policy. Clin Liver Dis 2019;13(6):170–175
- VanHuis. Myth: Liver Transplant Provides a Cure for Liver Disease. Clin Liver Dis 2019;13(6):154–157
- Levitsky. Does the Liver Provide Immunosuppressive Advantage? Clin Liver Dis 2019;13(6):180–183
- Feder. Reset osmostat: Facts and controversies. Indian J Nephrol 2019;29:232-4
- Nussbaum. Diagnosing acute interstitial nephritis: considerations for clinicians. Clin Kid J 2019;epublished July 11th
- Urits. A Comprehensive Update of Current Anesthesia Perspectives on Therapeutic Hypothermia. Advances in Therapy 2019;epublished July 12th
- Constantinescu. Clinical Approach to the Patient in Critical State Following Immunotherapy and/or Stem Cell Transplantation: Guideline for the On-Call Physician. J Clin Med 2019;8(6):884
- Iba. Diagnosis of sepsis‐induced disseminated intravascular coagulation and coagulopathy. Acute Med Surg 2019;6:223–232
- Erdem. Assessing the Microcirculation With Handheld Vital Microscopy in Critically Ill Neonates and Children: Evolution of the Technique and Its Potential for Critical Care. Front Pediatr 2019;7:273
- Tavares. Global Ultrasound Check for the Critically lll (GUCCI)—a new systematized protocol unifying point-of-care ultrasound in critically ill patients based on clinical presentation. Open Access Emergency Medicine 2019(11):133—145
- Inoue. Post-intensive care syndrome: its pathophysiology, prevention, and future directions. Acute Med Surg 2019;6(3):233-246
- Ranganathan. Study designs: Part 1 – An overview and classification. Perspect Clin Res 2018;9:184-6
- Aggarwal. Study designs: Part 2 – Descriptive studies. Perspect Clin Res 2019;10:34-6
- Ranganathan. Study designs: Part 3 - Analytical observational studies. Perspect Clin Res 2019;10:91-4
- Aggarwal. Study designs: Part 4 – Interventional studies. Perspect Clin Res 2019;10:137-9
- Oldman. Data integrity issues: catalyst for a more robust approach to research on perioperative oxygen therapy? Perioper Med (Lond) 2019;4;8:7
- Benedek. New ICCUs – a Modern Perspective on Acute Cardiac Care. Journal of Cardiovascular Emergencies 2019;5(2):47-49
- Anonymous. Physician burnout: a global crisis. Lancet 2019;394(10193):93
- Anonymous. Research integrity: recognising the responsibilities of authors. Lancet 2019;394(10193):94
- Arabi. When and how to manage enteral feeding intolerance? Intensive Care Med 2019;45(7):1029–1031
- Walsh. Learning from aftercare to improve acute care. Intensive Care Med 2019;45(7):1022-1024
- Martin‑Loeches. Focus on infection. Intensive Care Med 2019;epublished June 18th
- Miller. Redefining the Physician’s Role in Cost-Conscious CareThe Potential Role of the Electronic Health Record. JAMA 2019;epublished July 12th
- Miller. Perioperative fluid management: moving toward more answers than questions—a commentary on the RELIEF study. Perioperative Medicine 2019;8:2
- Cao. What do non-critical care residents actually learn during an intensive care unit rotation: time to find out! Can J Anesth 2019;66(8):874–876
- Kelly. Ensuring trial conduct is consistent with trial design: assumption is the enemy of quality. Trials 2019;20:416
- Nguyen. Dealing with internet-based information obtained by families of critically ill patients. Intensive Care Med 2019;epublished May 9th
- Costerus. Infection-triggered haemophagocytic lymphohistiocytosis. Neth J Crit Care 2019;27(4):156-8
- Leuverink. A case of shock due to compression of the right atrium by the liver after postoperative bleeding. Neth J Crit Care 2019;27(4):159-61
- Peelen. The dangers of argon, an inert industrial gas: beware of asphyxiation. Neth J Crit Care 2019;27(4):165-8
- Markusse. Colonic pseudo-obstruction caused by MELAS syndrome. Neth J Crit Care 2019;27(4):169-70
- van de Venne. Blue-leg syndrome. Neth J Crit Care 2019;27(4):171-2
- Diop. Cardiopulmonary resuscitation-related left gastric artery laceration. Intensive Care Med 2019;epublished March 21st
Now in it's 8th year, the Critical Care Reviews Meeting brings the chief investigators for the best critical care trials of the previous year to Titanic, Belfast, to discuss their studies. We aim to decide whether these trials are sufficiently robust to support their findings and if we should consider changing practice on the basis of them. To help in this endeavour we invite world leading experts to provide independent editorial overviews and have panel discussions to delve deep into the specifics of each trial. In addition, we also have detailed discussions on research methodology, to encourage critical thinking about the scientific findings which form the basis of our clinical practice. It's not just about specific trials though; for 2020, we have a distinguished panel of trialists, methodologists, statisticians and clinicians provide insight into the mysteries of clinical trial interpretation. We also have the annual honorary John Hinds Trauma Lecture, and finish the meeting with the incredibly popular "Informal Chat", where the faculty and delegates congregate in the bar and an enormous, meandering discussion about all things critical care takes place.
Based on our feedback from last year, we've reverted to keeping everyone on the same floor during breaks. In addition, we will also provide a sleeping area for those post-call to rest for a few hours as needed. As before, we are offering free childcare and a baby feeding area, where the meeting will live streamed. All dietary requirements are catered for also. Please get in touch if you have any specific needs. We sold out last year, so please don't delay if you want to attend. As usual, CPD points will be applied for in due course.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board