Prof Bala Venkatesh presents the ADRENAL Trial Results at #CCR18
Welcome to the 319th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. My apologies this is a few days late, but it's been an exciting and busy last week.
The Critical Care Reviews Meeting 2018 was a huge success, headed by the fascinating presentation of the ADRENAL trial results by Prof Bala Venkatesh. Huge congratulations are due to Prof Venkatesh and his co-investigators for the successful completion of this landmark study. Due to the importance of this trial, we have put the results presentation, editorial by Prof Kathy Rowan, questions section, panel discussion, and talk on the issues faced by the ADRENAL investigators, immediately online in a partly edited format. These will be updated in due course. The other presentations were also excellent, culminating in an outstanding John Hinds Trauma Lecture by Dr Sophie Wallace. All talks will be sequentially made freely available on the website over the coming weeks. I'm also hugely grateful to the tireless work of my co-organisers Dr LJ Mottram, Dr Chris Nutt, Dr Catriona Kelly and Mr Chris Waring. Due to the success of the meeting, next year we move to a 2-day event, on Thursday & Friday, January 17th & 18th 2019, again at Titanic, Belfast. We already have several exceptional speakers and trials lined up!
Not only did we have the meeting, we also launched the Critical Care Reviews Book 2018, summarising, critiquing and putting in context the best critical care trials of 2017. Four colleagues (Dr Chris Gowers, Dr Dominic Trainor, Dr Peter McGuigan and Dr Chris Nutt) and I have spent the past year writing this and we are delighted to make it freely available as a pdf download. Print copies are also available at little over cost price.
There can only be one Topic of the Week - the ADRENAL trial. For a change, we turn to the reaction on social media and see what the online commentary on this trial has been. Normal service will resume this later this week.
- Full Text: Venkatesh. Adjunctive Glucocorticoid Therapy in Patients with Septic Shock. N Engl J Med 2018;epublished January 19th
- Abstract: Ferrando. Individualised perioperative open-lung approach versus standard protective ventilation in abdominal surgery (iPROVE): a randomised controlled trial. Lancet Respir Med 2018;epublished January 19th
- Abstract: Abuzaid. Oxygen Therapy in Patients with Acute Myocardial Infarction: a Systemic Review and Meta-Analysis. Am J Med 2018;epublished January 17th
- Full Text: Cabrini. Tracheal intubation in critically ill patients: a comprehensive systematic review of randomized trials. Critical Care 2018;22:6
- Full Text: Hermanides. Glycaemic control targets after traumatic brain injury: a systematic review and meta-analysis. Critical Care 2018;22:11
- Full Text: Pu. Effect of Sivelestat Sodium in Patients With Acute Lung Injury or Acute Respiratory Distress Syndrome. A Meta-analysis of Randomized Controlled Trials. BMC Pulm Med 2017;17(148)
- Abstract: Maiolo. Reclassifying Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med 2018;epublished January 18th
- Abstract: Gaudry. Timing of Renal Support and Outcome of Septic Shock and Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med 2018;epublished January 19th
- Abstract: Esnault. Evaluation of Almitrine Infusion During Veno-Venous Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome in Adults. Anesth Analg. 2018;epublished January 15th
- Full Text: Gayat. Determinants of long-term outcome in ICU survivors: results from the FROG-ICU study. Critical Care 2018;22:8
- Full Text: Page. Emergency department hyperoxia is associated with increased mortality in mechanically ventilated patients: a cohort study. Critical Care 2018;22:9
- Full Text: van Puffelen. Cost-effectiveness study of early versus late parenteral nutrition in critically ill children (PEPaNIC): preplanned secondary analysis of a multicentre randomised controlled trial. Critical Care 2018;22:4
- Yu. Cerebral near-infrared spectroscopy (NIRS) for perioperative monitoring of brain oxygenation in children and adults. Cochrane Database of Systematic Reviews 2018, Issue 1. Art. No.: CD010947
- Vietto. Prostanoids for critical limb ischaemia. Cochrane Database of Systematic Reviews 2018, Issue 1. Art. No.: CD006544
- McTague. Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children. Cochrane Database of Systematic Reviews 2018, Issue 1. Art. No.: CD001905
- Lewis. Propofol for the promotion of sleep in adults in the intensive care unit. Cochrane Database of Systematic Reviews 2018, Issue 1. Art. No.: CD012454
- Akinseye. Simultaneous acute cardio-cerebral infarction: is there a consensus for management? Ann Transl Med 2018;6(1):7
- Coquerel. The apelinergic system as an alternative to catecholamines in low-output septic shock. Critical Care 2018;22:10
- Roumelioti. Fluid balance concepts in medicine: Principles and practice. World J Nephrol 2018;7(1):1–28
- Latham. Access site complications in transcutaneous aortic valve replacement: frequency, outcomes, prevention, and treatment. Ann Transl Med 2018;6(1):14
- Vedantham. How I use catheter-directed interventional therapy to treat patients with venous thromboembolism. Blood 2018;epublished January 2nd
- Shah. Update: non-invasive ventilation in chronic obstructive pulmonary disease. J Thorac Dis 2018;10(Suppl 1):S71-S79
- Pengo. Cardiorespiratory interaction with continuous positive airway pressure. J Thorac Dis 2018;10(Suppl 1):S57-S70
- Van Gastel. Camera-based pulse-oximetry - validated risks and opportunities from theoretical analysis. Biomed Opt Express 2018;9(1):102–119
- Kingma. The Physiopathology of Cardiorenal Syndrome: A Review of the Potential Contributions of Inflammation. J Cardiovasc Dev Dis 2017;4(4):21
- Peeters. Adrenocortical Stress Response during the Course of Critical Illness. Comprehensive Physiology 2017;8:283–298
- de Mattos. Acute-on-chronic liver failure—old concepts made clearer. Transl Gastroenterol Hepatol 2017;2:111
- Björnsson. Mortality associated with drug-induced liver injury (DILI). Transl Gastroenterol Hepatol 2017;2:114
- Cardim. Handheld Echography devices: ready for prime time? European Heart Journal 2018;39(4):262–263
- Kesecioğlu. Intensive Care Medicine: Organization, Education and Politics. Turk J Anaesthesiol Reanim. 2017; 45(6): 325-326
- Ball. Intensive Care Medicine: Different Recipes for Shared Goals. Turk J Anaesthesiol Reanim 2017;45:327-8
- Gregoretti. Noninvasive Ventilation in Hypoxemic Patients: an Ongoing Soccer Game or a Lost One? Turk J Anaesthesiol Reanim 2017;45(6):329-331
- Hill. Noninvasive Ventilation for Acute Hypoxemic Respiratory Failure/ARDS – is There a Role? Turk J Anaesthesiol Reanim. 2017; 45(6): 332-334
- Nayyar. When more is not better—appropriately excluding patients from mechanical circulatory support therapy. Ann Transl Med 2018;6(1):9
- McMahon. Evolution of Continuing Medical Education. Promoting Innovation Through Regulatory Alignment. JAMA 2018;epublished January 22nd
- Various. Bivalirudin versus Heparin Monotherapy in Myocardial Infarction. N Engl J Med 2018; 378:298-301
- Various. Noninferiority Trials. N Engl J Med 2018; 378:303-305
- Kellum. The definition of acute kidney injury. Lancet 2018;391(10117):202–203
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Until next week
Supported by the Health Research Board