CCR-Newsletter-BannerNewsletter 315  |  December 24th 2017

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ADRENAL Trial Result CCR315

Not a bad Christmas present this year....


Welcome to the 315th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. This week we bring you our biggest news yet - Critical Care Reviews Meeting 2018 will host the ANZICS CTG / The George Institute for Global Health ADRENAL trial results in Belfast on January 19th. In addition to discussing the best trials of the year with their chief investigators, and hearing editorials from a select group of internationally renowned trialists, we will also have an entire session dedicated to this landmark trial investigating steroids in septic shock.

After the chief investigator Prof Bala Venkatesh presents the results of ADRENAL, Prof Kathy Rowan will deliver a 15 minute editorial, followed by a 30 minute panel discussion, including three ADRENAL investigators, Prof Karin Amrein, an endocrinologist/intensivist/trialist and Prof Anthony Gordon, who also looked at steroids in sepsis as part of his VANISH trial. Prof Venkatesh will complete the session with a talk dicussing the administration of the ADRENAL trial, including the various issues they faced. If you can't make it, don't worry as the entire ADRENAL session will be live streamed for free, starting at 9am GMT. All the other talks will be recorded and released later for free viewing as usual. The programme is now online also. The meeting still has some availability, so don't wait if you intend on registering. It will sell out quite soon.

In other news, the US FDA has this week surprisingly approved angiotensin II for use in vasodilatory shock. We're lucky enough to have the first author on the recent ATHOS-3 trial, Dr Ashish Khanna, speak at #CCR18 and no doubt discuss this latest announcement.

Contiinuing our build up to #CCR18, this week's Topic of the Week is the ART trial, investigating recruitment manoeuvres and titrated PEEP in ARDS, starting with the ART paper in tomorrow's Paper of the Day.



Review Articles






Annals of Translational Medicine - Series on ICU Ethics



September Announcement 060917 v1


It's now less than a month until the Critical Care Reviews Meeting 2018, where the chief investigators for the best critical care trials of 2017 come to discuss their work and try to answer the question clinicians want to know - should I change my practice based on this trial? From Brisbane, Australia, Prof Bala Venkatesh will explore the ADRENAL trial, examining hydrocortisone in septic shock in the biggest sepsis trial ever undertaken. Working between Dublin and Melbourne, Prof Alistair Nichol will explain the findings of the TRANSFUSE trial, comparing transfusion of the freshest available blood with standard issued red cells. From Nantes, France, Dr Jean-Baptiste Lascarrou will consider the findings of the MACMAN trial, evaluating video laryngoscopy in the ICU. Dr Ashish Khanna, from the Cleveland Clinic, USA, will reflect on ATHOS-3 the first large clinical trial examining angiotensin II in vasodilatory shock. Prof Gavin Perkins, from Warwick in England, will discuss his multi-centre randomized controlled trial BREATHE, evaluating the role of extubation to non-invasive ventilation in patients failing spontaneous breathing trials. Prof John Simpson, from Newcastle, England, will discuss the VAP-RAPID trial, evaluating the use of a biomarker-guided approach to exclude ventilator-associated pneumonia. The final trial added to the programme is the ART trial, investigating alveolar recruitment in ARDS, to be presented by Prof Alexandre Cavalcanti (São Paulo, Brazil). 

We also have Prof Andrew Rhodes, from London, exploring the latest iteration of the Surviving Sepsis Campaign, published earlier this year and Dr Sophie Wallace (Perth, Australia), who will deliver the honorary John Hinds Trauma Lecture, entitled "Disaster on Everest - Trauma at the Top of the World". A new addition to the Critical Care Reviews Meeting format is an incredible editorial team of Prof Kathy Rowan (London), Prof Karin Amrein (Graz), Prof Anders Perner (Copenhagen) and Prof Simon Finfer (Sydney). These noted trialists will provide expert analysis on the major trials being presented.

We sold out #CCR17 and had to turn people away. At present we are way up on registrations compared to the same time-point in 2016. So, if you intend on coming, don't leave it too late to register. There is plenty of space still at present, but I expect the meeting will sell out well before it's date of Friday January 19th. Don't worry if you can't make it, as the talks will be recorded and put online for free viewing as usual. However, there is nothing like being there in person and having the opportunity to chat with these chief investigators. Numbers are strictly limited to ensure this remains a small, intimate meeting. It would be a shame to miss out......especially as we will be hosting the ADRENAL trial results. If you can't make it, don't worry, as in addition to our usual recording and later release of all talks, this year we will be live streaming the ADRENAL session!

CCH Journal

Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive.  If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.

COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.


I hope you find these links useful.

Happy Christmas


Supported by the Health Research Board

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