CCR-Newsletter-BannerNewsletter 311  |  November 26th 2017

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CCR18 ATHOS3 261117

 ATHOS-3 Trial


Welcome to the 311th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. The highlights of this week's newsletter are two randomised controlled trials on high-volume hemofiltration in adult burn patients with septic shock and AKI & the effect of earplugs and eye mask on sleep in critically ill patients; a meta analysis on renal replacement therapy intensity for AKI; an observational study reporting outcomes after VV ECMO referral for respiratory failure; narrative reviews on the TAME cardiac arrest trial, perioperative cardiac arrest and cardiac output monitoring validation studies; as well as editorials on 48-hour targeted temperature management & iatrogenic hemodilution; plus a commentariy on complications of regional citrate anticoagulation.

There are also two series of reviews articles, from the BJA on "Landmarks in UK Anaesthesia", and from Nephron on "Acute Kidney Injury". If you only have time to read one article this week, check out this excellent overview of Free Open Access Medical Education (FOAMed) by Chris Nickson, one of the main people responsible for this outstanding movement.

Continuing our theme of focusing on the main papers to be presented and discussed at #CCR18, this week's Topic of the Week is the ATHOS-3 trial, investigating angiotension II in vasodilatory shock, and starting with the trial itself in tomorrow's Paper of the Day.

The latest news on the Critical Care Reviews Meeting 2018 is the addition of Prof Simon Finfer (Sydney) to the editorial team, which includes Prof Kathy Rowan (London), Prof Karin Amrein (Graz), and Prof Anders Perner (Copenhagen). The best crtical care trials of 2017 will be subjected to some of the most incisive thinkers in the speciality. If you want to understand the methodological strengths and weaknesses of the evidence which underpins our practice, this is the meeting for you. Hopefully, we might have one little more surprise to announce in the next few weeks also.....



Review Articles











It's now less than 2 months until the Critical Care Reviews Meeting 2018, where the chief investigators for the best critical care trials of 2017 come to discuss their work and try to answer the question clinicians want to know - should I change my practice based on this trial? From Brisbane, Australia, Prof Bala Ventakesh will explore the ADRENAL trial, examining hydrocortisone in septic shock in the biggest sepsis trial ever undertaken. Working between Dublin and Melbourne, Prof Alistair Nichol will explain the findings of the TRANSFUSE trial, comparing transfusion of the freshest available blood with standard issued red cells. From Nantes, France, Dr Jean-Baptiste Lascarrou will consider the findings of the MACMAN trial, evaluating video laryngoscopy in the ICU. Dr Ashish Khanna, from the Cleveland Clinic, USA, will reflect on ATHOS-3 the first large clinical trial examining angiotensin II in vasodilatory shock. Prof Gavin Perkins, from Warwick in England, will discuss his multi-centre randomized controlled trial BREATHE, evaluating the role of extubation to non-invasive ventilation in patients failing spontaneous breathing trials. Prof John Simpson, from Newcastle, England, will discuss the VAP-RAPID trial, evaluating the use of a biomarker-guided approach to exclude ventilator-associated pneumonia. The final trial added to the programme is the ART trial, investigating alveolar recruitment in ARDS, to be presented by Prof Alexandre Cavalcanti (São Paulo, Brazil). 

We also have Prof Andrew Rhodes, from London, exploring the latest iteration of the Surviving Sepsis Campaign, published earlier this year and Dr Sophie Wallace (Perth, Australia), who will deliver the honorary John Hinds Trauma Lecture, entitled "Disaster on Everest - Trauma at the Top of the World". A new addition to the Critical Care Reviews Meeting format is an incredible editorial team of Prof Kathy Rowan (London), Prof Karin Amrein (Graz), Prof Anders Perner (Copenhagen) and Prof Simon Finfer (Sydney). These noted trialists will provide expert analysis on the major trials being presented.

We sold out #CCR17 and had to turn people away. At present we are way up on registrations compared to the same time-point in 2016. So, if you intend on coming, don't leave it too late to register. There is plenty of space still at present, but I expect the meeting will sell out well before it's date of Friday January 19th. Don't worry if you can't make it, as the talks will be recorded and put online for free viewing as usual. However, there is nothing like being there in person and having the opportunity to chat with these chief investigators. Numbers are strictly limited to ensure this remains a small, intimate meeting. It would be a shame to miss out......



State-of-the-Art is back, for the 3rd year of its new format and an all-new venue in Liverpool for 2017. The futurism and innovation theme continues with novel topics including robotics, optical imaging of bacterial infection, new technology in patient recovery, and new device interventions in acute cardiology.  

However, the focus on day-to-day care is not lost, and there are clinical updates in acute medicine, ARDS, mechanical ventilation, trauma, nutrition, rehabilitation, endocrine management in ICU,  cancer patients in ICU, the difficult and altered airway, and much more.  Pragmatic "how I treat..." sessions proved popular last year and will continue, along with meaningful debates on UK critical care, including the trend toward centralisation.  

In addition, the trademark vibe of SOA will still be there with pop-up talks, panel debates, 'meet the expert' booths, new generation video e-posters, parent and infant facilities, two drinks evenings, and a new final night after-party.  Registration and abstract submission is now open at

Marina Bay Singapore SeanLoh WO


Fancy attending a leading intensive care medicine conference with worldwide experts in one of Asia Pacific’s most vibrant countries? At SG ANZICS 2018 in Singapore, you can meet renowned experts from all parts of the world at their plenary sessions, breakfast and lunch symposia and interactive conference sessions. Choose from our 10 preconference critical care workshops on offer and also showcase your poster to make an impression on international attendees.

SG ANZICS is an annual intensive care meeting jointly organized by the Society of Intensive Care Medicine (SICM), Singapore and the Australia-New Zealand Intensive Care Society (ANZICS). In 2017, we had 1200 attendees from more than 35 different countries. We are also proud to announce that we have awarded 30 Education Grants to low and lower-middle income countries and affirm our commitment to improve critical care in developing Asia-Pacific countries.

Our 5th meeting is scheduled for 17-21 May 2018 in Suntec Convention Centre. It promises to be better than ever! Timothy Buchman, Hayley Gershengorn, Anthony Gordon, Michael Pinsky, David Pilcher and Francesca Rubulotta are among a list of illustrious speakers confirmed for the conference.  Do keep your dates free and block your calendars.  Visit to find out more!

CCH Journal

Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive.  If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.

COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.


I hope you find these links useful.

Until next week



Supported by the Health Research Board

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