Welcome to the 309th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. It's been another great week of critical care publications, including the French NUTRIREA-2 trial, comparing early enteral with early parenteral nutrition in ventilated adults with shock (following on from CALORIES and PePANIC), the Canadian/Australian/New Zealand TRICS3 trial, comparing restrictive with liberal transfusion thresholds in the cardiac surgery patients (following on from TITRe2), as well as RCTs looking at contrast-induced nephropathy (PRESERVE) and late thromboectomy after stroke (DAWN). There are also new guidelines on cardiopulmonary resuscitation and emergency cardiovascular care, and European guidelines on perioperative venous thromboembolism prophylaxis in various settings, as well as narrative reviews on the neurological wake-up test, improving CPR performance and chloride in intensive care units.
For this week's Topic of the Week we now turn to the trials being presented and discussed at #CCR18. First up, we'll look at the MACMAN trial, comparing video with direct laryngoscopy in the ICU, and focus on this question with seven free papers, starting with the trial in tomorrow's Paper of the Day.
It's just 2 months to the Critical Care Reviews Meeting 2018, discussing the best critical care trials of 2017 with their chief investigators. The meeting is filling up fast, with the post meeting meal now full. This is held in "The Bridge" at Titanic, so named as it is the exact height the Bridge was above the water in the original ship. If you'd like to attend please email me and I'll add your name to the waiting list.
Apologies for the late delivery of the newsletter, but I've had a heavy clinical week and am very, very busy preparing for the meeting and writing the book!
- Abstract: Reignier. Enteral versus parenteral early nutrition in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group study (NUTRIREA-2). Lancet 2017;epublished November 8th
- Full Text: Mazer. Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery (TRICS3). N Engl J Med 2017;epublished November 12th
- Full Text: Weisbord. Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine (PRESERVE). N Engl J Med 2017;epublished November 12th
- Full Text: Nogueira. Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct (DAWN Trial). N Engl J Med 2017;epublished November 11th
- Abstract: Penk. Intermittent Versus Continuous and Intermittent Medications for Pain and Sedation After Pediatric Cardiothoracic Surgery; A Randomized Controlled Trial. Crit Care Med 2017;epublished October 12th
- Abstract: Petersen. Untargeted antifungal therapy in adult patients with complicated intra-abdominal infection: a systematic review. Acta Anaesthesiol Scand 2017;epublished November 9th
- Abstract: Liu. The influence of esmolol on septic shock and sepsis: A meta-analysis of randomized controlled studies. Am J Emerg Med 2017;epublished November 7th
- Full Text: Gayet-Ageron. Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients. Lancet 2017;epublished November 7th
- Abstract: Aoyama. Association of Driving Pressure With Mortality Among Ventilated Patients With Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis. Crit Care Med 2017;epublished November 10th
- Abstract: Rhodes. Prolonged Infusion Piperacillin-Tazobactam Decreases Mortality and Improves Outcomes in Severely Ill Patients: Results of a Systematic Review and Meta-Analysis. Crit Care Med 2017;epublished October 28th
- Full Text: Nakanishi. Upper and lower limb muscle atrophy in critically ill patients: an observational ultrasonography study. Intensive Care Med 2017;epublished November 6th
- Abstract: Leisman. Predictors, Prevalence, and Outcomes of Early Crystalloid Responsiveness Among Initially Hypotensive Patients With Sepsis and Septic Shock. Crit Care Med 2017;epublished November 3rd
- Abstract: Frat. Predictors of Intubation in Patients With Acute Hypoxemic Respiratory Failure Treated With a Noninvasive Oxygenation Strategy. Crit Care Med 2017;epublished November 2nd
- Abstract: Schefold. Dysphagia in Mechanically Ventilated ICU Patients (DYnAMICS): A Prospective Observational Trial. Crit Care Med 2017;epublished October 11th
- Full Text: Milton. Early psychological screening of intensive care unit survivors: a prospective cohort study. Critical Care 2017;21:273
- Full Text: Ferreira. Neurally Adjusted Ventilatory Assist (NAVA) or Pressure Support Ventilation (PSV) during spontaneous breathing trials in critically ill patients: a crossover trial. BMC Pulm Med 2017;17(1):139
- Full Text: Corrado. Burden of Adult Community-acquired, Health-care-Associated, Hospital-Acquired, and Ventilator-Associated Pneumonia, New York City, 2010 to 2014. Chest 2017;152(5):930–942
- Full Text: Huang. Hyperbaric Oxygen Therapy Is Associated With Lower Short- and Long-Term Mortality in Patients With Carbon Monoxide Poisoning. Chest 2017;152(5):943–953
- Jakkula. Targeting low- or high-normal Carbon dioxide, Oxygen, and Mean arterial pressure After Cardiac Arrest and REsuscitation: study protocol for a randomized pilot trial (COMACARE study). Trials 2017;18:507
- Meißner. EFFECT of daily antiseptic body wash with octenidine on nosocomial primary bacteraemia and nosocomial multidrug-resistant organisms in intensive care units: design of a multicentre, cluster-randomised, double-blind, cross-over study. BMJ Open 2017;7:e016251
- 2017 American Heart Association Focused Update on Adult Basic Life Support and Cardiopulmonary Resuscitation Quality: An Update to the American Heart Association Guidelines for Cardio pulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2017;epublished November 6th
- 2017 American Heart Association Focused Update on Pediatric Basic Life Support and Cardiopulmonary Resuscitation Quality: An Update to the American Heart Association Guidelines for Cardio pulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2017;epublished November 6th
- 2017 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations Summary. Circulation 2017;epublished November 6th
- Newsome. Guidelines on the management of abnormal liver blood tests. Gut 2017;epublished November 9th
- Maas. Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research. Lancet 2017;epublished November 6th
- ESA VTE Guidelines Task Force. European Guidelines on perioperative venous thromboembolism prophylaxis: Executive summary. Eur J Anaesthesiol 2017;epublished November 6th
- ESA VTE Guidelines Task Force. European guidelines on perioperative venous thromboembolism prophylaxis: Patients with preexisting coagulation disorders and after severe perioperative bleeding. Eur J Anaesthesiol 2017;epublished November 6th
- ESA VTE Guidelines Task Force. European guidelines on perioperative venous thromboembolism prophylaxis: Aspirin. Eur J Anaesthesiol 2017;epublished November 6th
- ESA VTE Guidelines Task Force. European guidelines on perioperative venous thromboembolism prophylaxis: Chronic treatments with antiplatelet agents. Eur J Anaesthesiol 2017;epublished November 6th
- ESA VTE Guidelines Task Force. European guidelines on perioperative venous thromboembolism prophylaxis: Intensive care. Eur J Anaesthesiol 2017;epublished November 6th
- ESA VTE Guidelines Task Force.European guidelines on perioperative venous thromboembolism prophylaxis: Day surgery and fast-track surgery. Eur J Anaesthesiol 2017;epublished November 6th
- ESA VTE Guidelines Task Force. European guidelines on perioperative venous thromboembolism prophylaxis: Neurosurgery. Eur J Anaesthesiol 2017;epublished November 6th
- ESA VTE Guidelines Task Force. European guidelines on perioperative venous thromboembolism prophylaxis: Cardiovascular and thoracic surgery. Eur J Anaesthesiol 2017;epublished November 6th
- Marklund. The Neurological Wake-up Test - A Role in Neurocritical Care Monitoring of Traumatic Brain Injury Patients? Front Neurol 2017;8:540
- Nassar. Improving CPR Performance. Chest 2017; 152(5):1061-1069
- Bowles. Algorithms to guide ambulance clinicians in the management of emergencies in patients with implanted rotary left ventricular assist devices. Emerg Med J 2017;epublished November 10th
- Presti. Mechanisms Underlying HIV-Associated Noninfectious Lung Disease. Chest 2017; 152(5):1053–1060
- Leuschner. Acute Exacerbation in Interstitial Lung Disease. Front Med 2017;4:176
- Junior. Cerebral hemodynamic and metabolic changes in fulminant hepatic failure. Arq Neuropsiquiatr 2017;75(7):470-476
- Bandak. Chloride in intensive care units: a key electrolyte. F1000Res 2017;6:1930
- Pavlakou. Oxidative Stress and Acute Kidney Injury in Critical Illness: Pathophysiologic Mechanisms—Biomarkers—Interventions, and Future Perspectives. Oxid Med Cell Longev 2017;2017:6193694
- Pilmis. Piperacillin–tazobactam as alternative to carbapenems for ICU patients. Annals of Intensive Care 2017;7:113
- Meng. Comprehensive Guidance for Antibiotic Dosing in Obese Adults. Pharmacotherapy 2017;37:1415–1431
- Liu. Geriatric Anesthesia-related Morbidity and Mortality in China: Current Status and Trend. Chin Med J 2017;130:2738-49
- Goulopoulou. Maternal Vascular Physiology in Preeclampsia. Hypertension 2017;70:1066-1073
- Fumeaux. Does interprofessionality work in Swiss ICUs and should it be encouraged? Swiss Med Wkly 2017;147:w14549
- Alexander. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview. British Journal of Pharmacology 2017;174:S1–S16
- Alexander. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein‐coupled receptors. British Journal of Pharmacology 2017;174:S17–S129
- Alexander. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Ligand‐gated ion channels. British Journal of Pharmacology 2017;174:S130–S159
- Alexander. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Voltage‐gated ion channels. British Journal of Pharmacology 2017;174:160–S194
- Alexander. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Other ion channels. British Journal of Pharmacology 2017;174:S195–S207
- Alexander. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Nuclear hormone receptors. British Journal of Pharmacology 2017;174:S208–S224
- Alexander. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Catalytic receptors. British Journal of Pharmacology 2017;174:S225–S271
- Alexander. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Enzymes. British Journal of Pharmacology 2017;174:S272–S359
- Alexander. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Transporters. British Journal of Pharmacology 2017;174:S360–S446
- Lowenstern. In-hospital cardiac arrest: Complex clinical challenges in need of unique solutions. American Heart Journal 2017;193:104–107
- Paiva. Biomarker-guided antifungal therapy in patients with suspected invasive candidiasis: Ready for prime time? Intensive Care Med 2017;epublished November 8th
- Mahankali. Interventional radiology: A disruptive innovation which is transforming management of post-partum haemorrhage. J Obstet Anaesth Crit Care 2017;7:65-8
- Various. Levosimendan in Cardiac Surgery. N Engl J Med 2017;377:1899-1901
- Various. Acute Respiratory Distress Syndrome. N Engl J Med 2017;377:1903-1905
- Various. Five-Year Outcomes after On-Pump and Off-Pump Coronary-Artery Bypass. N Engl J Med 2017;377:1896-1899
- Xue. Comparing Ramped Position vs Sniffing Position for Intubation. Study Design Is Crucial. Chest 2017;152(5):1091–1092
- Semler. Response. Chest 2017;152(5):1092–1093
- Egan. Compartment Syndrome. N Engl J Med 2017;377:1877
- Abbasi. Usefulness of Ultrasound to Help Solve Severe Sepsis. Chest 2017;152(5):e105-e108
- Melamed. Diagnostic Value of Quantitative Chest CT Scan in a Case of Spontaneous Pneumothorax. Chest 2017;152(5):e109–e114
- Cherian. A 53-Year-Old Man With a Bronchial Mass and Multiple Bone Lesions. Chest 2017;152(5):e115–e119Chest 2017;152(5):e115–e119
- Haw. A 47-Year-Old Man With Recurrent Unilateral Pleural Effusion. Chest 2017;152(5):e121–e124Chest 2017;152(5):e121–e124
- Goto. Perimortem cesarean delivery and subsequent emergency hysterectomy: new strategy for maternal cardiac arrest. Acute Med Surg 2017;4:467–471
It's now just 2 months until the Critical Care Reviews Meeting 2018, where the chief investigators for the best critical care trials of 2017 come to discuss their work and try to answer the question clinicians want to know - should I change my practice based on this trial? From Brisbane, Australia, Prof Bala Ventakesh will explore the ADRENAL trial, examining hydrocortisone in septic shock in the biggest sepsis trial ever undertaken. Working between Dublin and Melbourne, Prof Alistair Nichol will explain the findings of the TRANSFUSE trial, comparing transfusion of the freshest available blood with standard issued red cells. From Nantes, France, Dr Jean-Baptiste Lascarrou will consider the findings of the MACMAN trial, evaluating video laryngoscopy in the ICU. Dr Ashish Khanna, from the Cleveland Clinic, USA, will reflect on ATHOS-3 the first large clinical trial examining angiotensin II in septic shock. Prof Gavin Perkins, from Warwick in England, will discuss his multi-centre randomized controlled trial Breathe, evaluating the role of extubation to non-invasive ventilation in patients failing spontaneous breathing trials. Prof John Simpson, from Newcastle, England, will discuss the VAP-RAPID trial, evaluating the use of a biomarker-guided approach to exclude ventilator-associated pneumonia. The final trial added to the programme is the ART Trial. Prof Alexandre Biasi Cavalcanti (São Paulo) will explain this Brazilian investigation testing alveolar recruitment in ARDS.
We also have Prof Andrew Rhodes, from London, exploring the latest iteration of the Surviving Sepsis Campaign, published earlier this year and Dr Sophie Wallace (Perth, Australia), who will deliver the honorary John Hinds Trauma Lecture, entitled "Disaster on Everest - Trauma at the Top of the World"
We sold out #CCR17 and had to turn people away. At present we are way up on registrations compared to the same time-point in 2016. So, if you intend on coming, don't leave it too late to register. There is plenty of space still at present, but I expect the meeting will sell out well before it's date of Friday January 19th. Don't worry if you can't make it, as the talks will be recorded and put online for free viewing as usual. However, there is nothing like being there in person and having the opportunity to chat with these chief investigators. Numbers are strictly limited to ensure this remains a small, intimate meeting. It would be a shame to miss out......
State-of-the-Art is back, for the 3rd year of its new format and an all-new venue in Liverpool for 2017. The futurism and innovation theme continues with novel topics including robotics, optical imaging of bacterial infection, new technology in patient recovery, and new device interventions in acute cardiology.
However, the focus on day-to-day care is not lost, and there are clinical updates in acute medicine, ARDS, mechanical ventilation, trauma, nutrition, rehabilitation, endocrine management in ICU, cancer patients in ICU, the difficult and altered airway, and much more. Pragmatic "how I treat..." sessions proved popular last year and will continue, along with meaningful debates on UK critical care, including the trend toward centralisation.
In addition, the trademark vibe of SOA will still be there with pop-up talks, panel debates, 'meet the expert' booths, new generation video e-posters, parent and infant facilities, two drinks evenings, and a new final night after-party. Registration and abstract submission is now open at http://soa.ics.ac.uk.
We are very pleased to announce the 6th International Fluid Academy Days (iFAD), which will take place on November 23-25th 2017 at the Hilton Hotel in Antwerp, Belgium. The iFAD is an innovative Critical Care Educational meeting in true SMACC spirit. This conference provides the highest quality of Critical Care education and is guaranteed to innovate and inspire. Recent advances in fluid management, and hemodynamic and organ function monitoring in the critical care setting will be reviewed in a comprehensive manner for intensivists, anaesthesiologists and emergency physicians as well as interested internists and surgeons.
The iFAD Faculty is the most provocative, engaging, motivating and inspiring group of international educational speakers and as organizing committee we want to ensure we have the participants, sponsors and endorsers to match. Together, we make iFAD stand apart from other Critical Care conferences.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board
Tags: Newsletter 309