Welcome to the 301st Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. The highlights of this week's edition are randomised controlled trials on checklists for endotracheal intubation of critically ill adults, nebulized vs intravenous amikacin for hospital and ventilator-acquired pneumonia and transfusions in burns; a new European / Latin American guideline on the management of hospital-acquired pneumonia and ventilator-associated pneumonia; plus reviews on heart-lung interactions, ARDS and critical illness-associated diaphragm weakness.
- Full Text: Janz. A multicenter, randomized trial of a checklist for endotracheal intubation of critically ill adults (Check-UP Trial). Chest 2017;epublished September 13th
- Abstract: Hassan. Nebulized Versus IV Amikacin as Adjunctive Antibiotic for Hospital and Ventilator-Acquired Pneumonia Postcardiac Surgeries: A Randomized Controlled Trial. Crit Care Med 2017;epublished August 28th
- Abstract: Palmieri. Transfusion Requirement in Burn Care Evaluation (TRIBE): A Multicenter Randomized Prospective Trial of Blood Transfusion in Major Burn Injury. Annals of Surgery 2017;266(4):595-602
- Abstract: Logallo. Tenecteplase versus alteplase for management of acute ischaemic stroke (NOR-TEST): a phase 3, randomised, open-label, blinded endpoint trial. Lancet Neurology 2017;16(10):781–788
- Abstract: Delorme. Effects of High-Flow Nasal Cannula on the Work of Breathing in Patients Recovering From Acute Respiratory Failure. Crit Care Med 2017;epublished August 28th
- Abstract: Glumac. Effects of dexamethasone on early cognitive decline after cardiac surgery: A randomised controlled trial. Eur J Anaesth 2017;epublished May 18th
- Full Text: Liu. The influence of analgesic-based sedation protocols on delirium and outcomes in critically ill patients: A randomized controlled trial. PLoS One 2017;12(9):e0184310
- Abstract: Ng. Effect of nicotine replacement therapy on mortality, delirium, and duration of therapy in critically ill smokers: a systematic review and meta-analysis. Anaesth Intensive Care 2017;45(5):556-561
- Abstract: Liu. Effect of simvastatin in patients with aneurysmal subarachnoid hemorrhage: A systematic review and meta-analysis. Am J Emerg Med 2017;epublished September 5th
- Abstract: Pavasini. Extracorporeal Circulatory Support in Acute Coronary Syndromes: A Systematic Review and Meta-Analysis. Crit Care Med 2017;epublished August 24th
- Abstract: Dupont. Antifungal Prevention of Systemic Candidiasis in Immunocompetent ICU Adults: Systematic Review and Meta-Analysis of Clinical Trials. Crit Care Med 2017;epublished August 28th
- Abstract: Trauer. Quantifying the Effects of Prior Acetyl-Salicylic Acid on Sepsis-Related Deaths: An Individual Patient Data Meta-Analysis Using Propensity Matching. Crit Care Med 2017;epublished August 9th
- Abstract: Goldfarb. Outcomes of Patient- and Family-Centered Care Interventions in the ICU: A Systematic Review and Meta-Analysis. Crit Care Med 2017;epublished July 26th
- Abstract: Meade. Severity of Hypoxemia and Effect of High-Frequency Oscillatory Ventilation in Acute Respiratory Distress Syndrome. Am J Resp Crit Care Med 2017;196(6):727-733
- Abstract: Yao. Enteral versus parenteral nutrition in critically ill patients with severe pancreatitis: a meta-analysis. Eur J Clin Nutr 2017;epublished September 13th
- Abstract: Simon. Outcomes of restrictive versus liberal transfusion strategies in older adults from nine randomised controlled trials: a systematic review and meta-analysis. Lancet Haematology 2017;epublished September 11th
- Full Text: Rhee. Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014. JAMA 2017;epublished September 13th
- Abstract: Debaty. Long-Term Prognostic Value of Gasping During Out-of-Hospital Cardiac Arrest. Journal of the American College of Cardiology 2017;70(12):
- Full Text: Caironi. Circulating Biologically Active Adrenomedullin (bio-ADM) Predicts Hemodynamic Support Requirement and Mortality During Sepsis. Chest 2017;152(2):312-320
- Abstract: Salih. Intracranial pressure and cerebral perfusion pressure in patients developing brain death. J Crit Care 2016;34:1-6
- Full Text: Chan. Association of Trial Registration With Reporting of Primary Outcomes in Protocols and Publications. JAMA 2017;epublished September 11th
- Abstract: Chan. Are physical measures related to patient-centred outcomes in ARDS survivors? Thorax 2017;72:884-892
- Abstract: Uhl. Laboratory predictors of bleeding and the effect of platelet and RBC transfusions on bleeding outcomes in the PLADO trial. Blood 2017;130:1247
- Abstract: Dupuis. Effect of Transfusion on Mortality and Other Adverse Events Among Critically Ill Septic Patients: An Observational Study Using a Marginal Structural Cox Model. Crit Care Med 2017;epublished September 12th
- Abstract: Faguer. Heparin-Free Prolonged Intermittent Hemodialysis Using Calcium-Free Citrate Dialysate in Critically Ill Patients. Crit Care Med 2017;epublished August 28th
- Abstract: Kentish-Barnes. "It Was the Only Thing I Could Hold Onto, But....": Receiving a Letter of Condolence After Loss of a Loved One in the ICU: A Qualitative Study of Bereaved Relatives' Experience. Crit Care Med 2017;epublished August 28th
- Abstract: Duan. Management of ARDS and Refractory Hypoxemia: A Multicenter Observational Study. Ann Am Thorac Soc 2017;epublished September 14th
- Abstract: Soltész. The effect of neuromuscular blockade on the efficiency of facemask ventilation in patients difficult to facemask ventilate: a prospective trial. Anaesthesia 2017;epublished September 14th
- Abstract: Sjövall. Maximally effective dosing regimens of meropenem in patients with septic shock. Journal of Antimicrobial Chemotherapy 2017;epublished September 12th
- Abstract: Kamdar. Return to work and lost earnings after acute respiratory distress syndrome: a 5-year prospective, longitudinal study of long-term survivors. Thorax 2017;epublished September 16th
- Reddy. Postoperative delirium in elderly citizens and current practice. J Anaesthesiol Clin Pharmacol 2017;33:291-9
- Grübler. Basic concepts of heart-lung interactions during mechanical ventilation. Swiss Med Wkly 2017;147:w14491
- Slikkerveer. Therapeutic application of contrast ultrasound in ST elevation myocardial infarction: Role in coronary thrombosis and microvascular obstruction. European Heart Journal: Acute Cardiovascular Care 2017;epublished September 4th
Series from Circulation Research on Cardiomyopathies
- Braunwald. Cardiomyopathies: An Overview. Circ Res 2017;121:711-721
- McKenna. Classification, Epidemiology, and Global Burden of Cardiomyopathies. Circ Res 2017;121:722-730
- McNally. Dilated Cardiomyopathy: Genetic Determinants and Mechanisms. Circ Res 2017;121:731-748
- Marian. Hypertrophic Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy. Circ Res 2017;121:749-770
- Nishimura. Hypertrophic Obstructive Cardiomyopathy: Surgical Myectomy and Septal Ablation. Circ Res 2017;121:771-783
- Corrado. Arrhythmogenic Cardiomyopathy. Circ Res 2017;121:784-802
- Trachtenberg. Inflammatory Cardiomyopathic Syndromes. Circ Res 2017;121:803-818
- Muchtar. Restrictive Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy. Circ Res 2017;121:819-837
- Towbin. Cardiomyopathies Due to Left Ventricular Noncompaction, Mitochondrial and Storage Diseases, and Inborn Errors of Metabolism. Circ Res 2017;121:838-854
- Lee. Pediatric Cardiomyopathies. Circ Res 2017;121:855-873
- Jan. Modern Imaging Techniques in Cardiomyopathies. Circ Res 2017;121:874-891
- Rashid. Percutaneous tracheostomy: a comprehensive review. J Thorac Dis 2017;9(Suppl 10):S1128-S1138
- Chiumello. Respiratory support in patients with acute respiratory distress syndrome: an expert opinion. Critical Care 2017;21:240
- Dres. Critical illness-associated diaphragm weakness. Intensive Care Med 2017;epublished September 15th
- Grünig. Diagnosis of Swimming Induced Pulmonary Edema—A Review. Front Physiol 2017;8:652
- Kaatz. Reversing factor Xa inhibitors – clinical utility of andexanet alfa. Journal of Blood Medicine 2017;8:141-149
- Kapoor. Action and resistance mechanisms of antibiotics: A guide for clinicians. J Anaesthesiol Clin Pharmacol 2017;33:300-5
- Nunez Lopez. Predicting and managing sepsis in burn patients: current perspectives. Therapeutics and Clinical Risk Management 2017;13:1107-1117
- Ptohis. Contemporary Role of Embolization of Solid Organ and Pelvic Injuries in Polytrauma Patients. Front Surg 2017;4:43
- Abou. Vascular Shunts in Civilian Trauma. Front Surg 2017;4:39
- Giannakopoulos. Management of Peripheral and Truncal Venous Injuries. Front Surg 2017;4:46
- Burki. Pediatric ventricular assist devices: current challenges and future prospects. Vasc Health Risk Manag 2017;13:177-185
- Nicolescu. Perioperative Surgical Home. Meeting tomorrow’s challenges. Rom J Anaesth Intensive Care. 2016;23(2):141–147
- Bindu. Temperature management under general anesthesia: Compulsion or option. J Anaesthesiol Clin Pharmacol 2017;33:306-16
- Schieren. Anaesthetic management of patients with myopathies. European Journal of Anaesthesiology 2017;34(10):641-649
Series from the Indian Journal of Anaesthesia on Circulatory Conditions
- Misra. Systemic hypertension and non-cardiac surgery. Indian J Anaesth 2017;61:697-704
- Choudhury. Post-cardiac transplant recipient: Implications for anaesthesia. Indian J Anaesth 2017;61:768-74
- Sarkar. Basics of cardiopulmonary bypass. Indian J Anaesth 2017;61:760-7
- Kumar. Severe pulmonary hypertension and right ventricular failure. Indian J Anaesth 2017;61:753-9
- Junghare. Congenital heart diseases and anaesthesia. Indian J Anaesth 2017;61:744-52
- Chakravarthy. Anaesthetic consideration in patients with cardiac implantable electronic devices scheduled for surgery. Indian J Anaesth 2017;61:736-43
- Juneja. Cardiomyopathies and anaesthesia. Indian J Anaesth 2017;61:728-35
- Paul. Valvular heart disease and anaesthesia. Indian J Anaesth 2017;61:721-7
- Parida. Cardiac tachyarrhythmias and anaesthesia: General principles and focus on atrial fibrillation. Indian J Anaesth 2017;61:712-20
- Hedge. The patient with ischaemic heart disease undergoing non cardiac surgery. Indian J Anaesth 2017;61:705-11
- International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia. Eur Respir J 2017;50(3):1700582
- Kozek-Langenecker. European guidelines on perioperative venous thromboembolism prophylaxis: Surgery in the elderly. Eur J Anaesthesiol 2017;epublished September 9th
- Hinkelbein. European Society of Anaesthesiology and European Board of Anaesthesiology guidelines for procedural sedation and analgesia in adults. Eur J Anaesthesiol 2017;epublished September 5th
- Sümpelmann. Perioperative intravenous fluid therapy in children: guidelines from the Association of the Scientific Medical Societies in Germany. Paediatr Anaesth 2017;27:10–18
- Bassetti. Principles of antimicrobial stewardship for bacterial and fungal infections in ICU. Intensive Care Med 2017;epublished September 12th
- Zhao. The renoprotective properties of xenon and argon in kidney transplantation. European Journal of Anaesthesiology 2017;34(10):637–640
- Goyal. Stay calm and register your trial… its time. J Anaesthesiol Clin Pharmacol 2017;33:287-8
- Parsons. Geo-economic Variations and ARDS. If a Tree Falls in a Forest… Chest 2017;152(3):461-462
- Shen. Concurrence of Inappropriate Antidiuretic Hormone Secretion and Cerebral Salt Wasting Syndromes after Traumatic Brain Injury. Front Neurosci 2017;11:499
- Bhatt. Dermal tattooing following intravenous methylene blue for refractory hypotension after coronary artery bypass grafting. Int J Crit Illn Inj Sci 2017;7:181-2
It's now just 4 months until the Critical Care Reviews Meeting 2018, where the chief investigators for the best critical care trials of 2017 come to discuss their work and try to answer the question clinicians want to know - should I change my practice based on this trial? From Brisbane, Australia, Prof Bala Ventakesh will explore the ADRENAL trial, examining hydrocortisone in septic shock in the biggest sepsis trial ever undertaken. Working between Dublin and Melbourne, Prof Alistair Nichol will explain the findings of the TRANSFUSE trial, comparing transfusion of the freshest available blood with standard issued red cells. From Nantes, France, Dr Jean-Baptiste Lascarrou will consider the findings of the MACMAN trial, evaluating video laryngoscopy in the ICU. Dr Ashish Khanna, from the Cleveland Clinic, USA, will reflect on ATHOS-3 the first large clinical trial examining angiotensin II in septic shock. Prof Gavin Perkins, from Warwick in England, will discuss his multi-centre randomized controlled trial Breathe, evaluating the role of extubation to non-invasive ventilation in patients failing spontaneous breathing trials. Prof John Simpson, from Newcastle, England, will discuss the VAP-RAPID trial, evaluating the use of a biomarker-guided approach to exclude ventilator-associated pneumonia. The final trial added to the programme is the ART Trial. Prof Alexandre Biasi Cavalcanti (São Paulo) will explain this Brazilian investigation testing alveolar recruitment in ARDS.
We also have Prof Andrew Rhodes, from London, exploring the latest iteration of the Surviving Sepsis Campaign, published earlier this year and Dr Sophie Wallace (Perth, Australia), who will deliver the honorary John Hinds Trauma Lecture, entitled "Disaster on Everest - Trauma at the Top of the World"
We sold out #CCR17 and had to turn people away. At present we are way up on registrations compared to the same time-point in 2016. So, if you intend on coming, don't leave it too late to register. There is plenty of space still at present, but I expect the meeting will sell out well before it's date of Friday January 19th. Don't worry if you can't make it, as the talks will be recorded and put online for free viewing as usual. However, there is nothing like being there in person and having the opportunity to chat with these chief investigators. Numbers are strictly limited to ensure this remains a small, intimate meeting. It would be a shame to miss out......
The ANZICS/ACCCN Annual Scientific Meeting, which incorporates the annual Paediatric and Neonatal Intensive Care Conference, will be held at the Gold Coast Convention and Exhibition Centre, 11-13 October 2017. The Annual Scientific Meeting will be the preeminent critical care conference in Australasia for the calendar year and will be an important platform that will allow doctors, nurses and allied health practitioners to meaningfully connect and discuss new developments and research in the field of intensive and critical care.
The theme of the Meeting is “Thinking Outside the Flags” and will focus upon innovative and challenging advances that lie outside the safe zone of current practice, as well as the potential dangers that they may bring. A number of highly regarded international speakers will join our distinguished national and local speakers, experts in the field of intensive care medicine, nursing and allied health, promising delegates an exciting and challenging program.
Registration and the call for abstracts will open on 20 March 2017. For further information or to express your interest in attending, please visit http://intensivecareasm2017.com.au/.
#BMBTL17 is a conference on resuscitation that focuses on the skills and knowledge needed to bring your critically ill patients…back to life !
With cutting edge topics and a world class faculty, the conferences will be packed with clinical pearls and only the stuff that matters !
Ventilation, airway, EKGs, pediatric pearls, ultrasound and so much more…don’t miss this amazing conference ! It will be held on October 16th 2017 in downtown Montreal.
FemInEM.org is excited to bring you our first ever, in person conference, FIX2017! The FemInEM Idea Exchange is all about education, inspiration and motivation. Our world renowned faculty will speak from their hearts and minds, providing the substance and spark for you to change the world. We will meet, greet and motivate each other, pushing the limits of our previous selves. You won't want to miss it - October 4th to 6th, NYC.
State-of-the-Art is back, for the 3rd year of its new format and an all-new venue in Liverpool for 2017. The futurism and innovation theme continues with novel topics including robotics, optical imaging of bacterial infection, new technology in patient recovery, and new device interventions in acute cardiology.
However, the focus on day-to-day care is not lost, and there are clinical updates in acute medicine, ARDS, mechanical ventilation, trauma, nutrition, rehabilitation, endocrine management in ICU, cancer patients in ICU, the difficult and altered airway, and much more. Pragmatic "how I treat..." sessions proved popular last year and will continue, along with meaningful debates on UK critical care, including the trend toward centralisation.
In addition, the trademark vibe of SOA will still be there with pop-up talks, panel debates, 'meet the expert' booths, new generation video e-posters, parent and infant facilities, two drinks evenings, and a new final night after-party. Registration and abstract submission is now open at http://soa.ics.ac.uk.
We are very pleased to announce the 6th International Fluid Academy Days (iFAD), which will take place on November 23-25th 2017 at the Hilton Hotel in Antwerp, Belgium. The iFAD is an innovative Critical Care Educational meeting in true SMACC spirit. This conference provides the highest quality of Critical Care education and is guaranteed to innovate and inspire. Recent advances in fluid management, and hemodynamic and organ function monitoring in the critical care setting will be reviewed in a comprehensive manner for intensivists, anaesthesiologists and emergency physicians as well as interested internists and surgeons.
The iFAD Faculty is the most provocative, engaging, motivating and inspiring group of international educational speakers and as organizing committee we want to ensure we have the participants, sponsors and endorsers to match. Together, we make iFAD stand apart from other Critical Care conferences.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board