6 Month Warning! Tickets are Selling Fast!
Welcome to the 291st Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
It's now just 6 months until the Critical Care Reviews Meeting 2018, where the chief investigators for the best critical care trials of 2017 come to discuss their work and try to answer the question clinicians want to know - should I change my practice based on this trial? From Brisbane, Australia, Prof Bala Ventakesh will explore the ADRENAL trial, examining hydrocortisone in septic shock in the biggest sepsis trial ever undertaken. Splitting his time between Dublin and Melbourne, Prof Alistair Nichol will explain the findings of the TRANSFUSE trial, comparing transfusion of the freshest available blood with standard issue red cells. From Nantes, France, Dr Jean-Baptiste Lascarrou will consider the findings of the MACMAN trial, evaluating video laryngoscopy in the ICU. Dr Ashish Khanna, from the Cleveland Clinic, USA, will reflect on ATHOS-3, the first large clinical trial examining angiotensin II in septic shock. We also have Prof Andrew Rhodes, from London, exploring the latest iteration of the Surviving Sepsis Campaign, published earlier this year. There are still additional speakers to add to the programme, so the meeting will continue to grow and get even better and better.
We sold out #CCR17 and had to turn people away. At present we are way up on registrations compared to the same time-point in 2016. So, if you intend on coming, don't leave it too late to register. There is plenty of space still at present, but I expect the meeting will sell out long before its date of Friday January 19th. Don't worry if you can't make it, as the talks will be recorded and put online for free viewing as usual. However, there is nothing like being there in person and having the opportunity to chat with these chief investigators. Numbers are strictly limited to ensure this remains a small, intimate meeting. It would be a shame to miss out......
Speaking of meetings, donations to Supadel have topped $4000, paying for 7.5 delegates to attend emergency medicine conferences in Africa. 43 delegates from SMACC have contributed, as well, no doubt, as some delegates from #CCR18. If you can spare a few euros / pounds / dollars, please consider helping your colleagues in Africa to attend their local conferences. Many thanks to Stevan Bruijns for the update.
This week's Topic of the Week is thrombosis, based on a selection of review articles from the Thrombosis & Haemostasis journal, starting with a paper on venous thromboembolism in tomorrow's Paper of the Day.
- Abstract: Zhang. Efficacy and Safety of Combination Therapy of Shenfu Injection and Postresuscitation Bundle in Patients With Return of Spontaneous Circulation After In-Hospital Cardiac Arrest: A Randomized, Assessor-Blinded, Controlled Trial. Crit Care Med 2017;epublished June 28th
- Abstract: Shankaran. Effect of Depth and Duration of Cooling on Death or Disability at Age 18 Months Among Neonates With Hypoxic-Ischemic Encephalopathy. A Randomized Clinical Trial. JAMA 2017;318(1):57-67
- Full Text: Vickers. Efficacy and safety of ridinilazole compared with vancomycin for the treatment of Clostridium difficile infection: a phase 2, randomised, double-blind, active-controlled, non-inferiority study. Lancet Infect Dis 2017;17(7):735–744
- Abstract: Sellares. Discontinuing noninvasive ventilation in severe chronic obstructive pulmonary disease exacerbations: a randomised controlled trial. Eur Respir J 2017;50(1)
- Abstract: D'Aragon. Effect of corticosteroid administration on neurologically deceased organ donors and transplant recipients: a systematic review and meta-analysis. BMJ Open 2017;7:e014436
- Full Text: Muscedere. The impact of frailty on intensive care unit outcomes: a systematic review and meta-analysis. Intensive Care Med 2017;epublished July 4th
- Abstract: Putzu. Blood purification with continuous venovenous hemofiltration in patients with sepsis or acute respiratory distress syndrome. A systematic review and meta-analysis of randomized evidence. Minerva Anestesiol 2017;epublished June 12th
- Abstract: Johannes. A Technique of Awake Bronchoscopic Endotracheal Intubation for Respiratory Failure in Patients With Right Heart Failure and Pulmonary Hypertension. Crit Care Med 2017;epublished July 4th
- Abstract: Dragancea. Protocol-driven neurological prognostication and withdrawal of life-sustaining therapy after cardiac arrest and targeted temperature management. Resuscitation 2017;117:50–57
- Abstract: Leisman. Patterns and Outcomes Associated With Timeliness of Initial Crystalloid Resuscitation in a Prospective Sepsis and Septic Shock Cohort. Crit Care Med 2017;epublished June 30th
- Abstract: Lascarrou. Antibiotic Therapy in Comatose Mechanically Ventilated Patients Following Aspiration: Differentiating Pneumonia From Pneumonitis. Crit Care Med 2017;epublished June 7th
- Abstract: Smith. Delirium and Benzodiazepines Associated With Prolonged ICU Stay in Critically Ill Infants and Young Children. Crit Care Med 2017;epublished June 7th
- Abstract: Lee. Preadmission Use of Calcium Channel Blocking Agents Is Associated With Improved Outcomes in Patients With Sepsis: A Population-Based Propensity Score-Matched Cohort Study. Crit Care Med 2017;epublished June 27th
- Full Text: Endo. Open-chest versus closed-chest cardiopulmonary resuscitation in blunt trauma: analysis of a nationwide trauma registry. Critical Care 2017;21:169
- Full Text: Ceccato. Treatment with macrolides and glucocorticosteroids in severe community-acquired pneumonia: A post-hoc exploratory analysis of a randomized controlled trial. PLoS One 2017;12(6):e0178022
- Grände. Critical Evaluation of the Lund Concept for Treatment of Severe Traumatic Head Injury, 25 Years after Its Introduction. Front Neurol 2017;8:315
- Sandercock. Controversies in Thrombolysis. Curr Neurol Neurosci Rep 2017;epublished June 30th
- Kuperberg. Sepsis-Associated Encephalopathy: The Blood–Brain Barrier and the Sphingolipid Rheostat. Front Immunol 2017;8:597
- Gordon. Neonatal Meningitis: Overcoming Challenges in Diagnosis, Prognosis, and Treatment with Omics. Front Pediatr 2017;5:139
- Nordström. Aspects on the Physiological and Biochemical Foundations of Neurocritical Care. Front Neurol 2017;8:274
- Habash. Challenges in management of left ventricular thrombus. Ther Adv Cardiovasc Dis 2017;11(8):203–213–213
- Verhoeff. Cardiopulmonary physiology: why the heart and lungs are inextricably linked. Adv Physiol Educ 2017;41(3):348-353
- Xue. Current evidence for the use of C-MAC videolaryngoscope in adult airway management: a review of the literature. Therapeutics and Clinical Risk Management 2017;13:831-841
- Prakash. Acute kidney injury in pregnancy-specific disorders. Indian J Nephrol 2017;27:258-70
- Wong. The renal and cardiovascular effects of natriuretic peptides. Adv Physiol Educ 2017;41:179–185
- Dennis. Protective Role for Antioxidants in Acute Kidney Disease. Nutrients 2017;9(7)
- Chandy. Globally emerging hantaviruses: An overview. Indian J Med Microbiol 2017;35:165-75
- Cao. Overview of antimicrobial options for Mycoplasma pneumoniae pneumonia: focus on macrolide resistance. The Clinical Respiratory Journal, 11: 419–429
- Eickhoff. Tickborne diseases other than Lyme in the United States. Cleveland Clinic Journal of Medicine 2017;84(7):555-567
- Gois. Vitamin D and Infectious Diseases: Simple Bystander or Contributing Factor? Nutrients 2017;9(7):651
- Woodcock. Master Protocols to Study Multiple Therapies, Multiple Diseases, or Both. N Engl J Med 2017; 377:62-70
- Hyatt. A student guide to proofreading and writing in science. Adv Physiol Educ 2017;324-331
- Dieser. Decreasing Patient Stress and Physician/Medical Workforce Burnout Through Health Care Environments: Uncovering the Serious Leisure Perspective at Mayo Clinic's Campus in Rochester, Minnesota. Mayo Clin Proc 2017;92(7):1080-1087
- Baveja. Statistical analysis of microbiological diagnostic tests. Indian J Med Microbiol 2017;35:184-93
- Prophylaxis against venous thromboembolism in pediatric trauma: A practice management guideline from the Eastern Association for the Surgery of Trauma and the Pediatric Trauma Society. J Trauma Acute Care Surg 2017;82(3):627-636
- Dart. Expert Consensus Guidelines for Stocking of Antidotes in Hospitals That Provide Emergency Care. Ann Emerg Med 2017;epublished June 29th
- Schetz. Focus on acute kidney injury. Intensive Care Med 2017;epublished July 3rd
- Zweigart. Medium cut-off membranes - closer to the natural kidney removal function. Int J Artif Organs 2017;40(7):328-334
- Lapinsky. Maternal critical care. Obstet Med 2017;10(2):51-52
- Curran-Everett. Small steps to help improve the caliber of the reporting of statistics. Advances in Physiology Education 2017;41(3):321-323
- Bassford. Decisions regarding admission to the ICU and international initiatives to improve the decision-making process. Crit Care 2017;21(1):174
- Tyagi. Thoracic epidural block in sepsis: Looking beyond the known. J Anaesthesiol Clin Pharmacol 2017;33:148-50
- Quintel. “I feel how you feel”: reflections about empathy in the relationship between ICU physicians and relatives. Intensive Care Med 2017;epublished
- Carcillo. From febrile pancytopenia to hemophagocytic lymphohistiocytosis-associated organ dysfunction. Intensive Care Med 2017;epublished June 26th
- Trubiano. Penicillin Allergy Is Not Necessarily Forever. JAMA 2017;318(1):82-83
- Burton. Training non-physicians as neurosurgeons in sub-Saharan Africa. Lancet Neurology 2017;epublished July 5th
- Grabenkort. Acute Care Nurse Practitioners and Physician Assistants in Critical Care: Transforming Education and Practice. Crit Care Med 2017;45(7):1111–1114
- Vazire. Our obsession with eminence warps research. Nature 2017;547:7
- Yu. How to remove the grey area between ventilator-associated pneumonia and ventilator-associated tracheobronchitis? Critical Care 2017;21:165
- Champion. Do we need another prognostic score for cardiogenic shock patients with ECMO? Critical Care 2017;21:168
- Thomas-Rüddel. Limited evidence to recommend lactate kinetics-guided therapy. Critical Care 2017;21:167
It's now just 6 months until the Critical Care Reviews Meeting 2018, where the chief investigators for the best critical care trials of 2017 come to discuss their work and try to answer the question clinicians want to know - should I change my practice based on this trial? From Brisbane, Australia, Prof Bala Ventakesh will explore the ADRENAL trial, examining hydrocortisone in septic shock in the biggest sepsis trial ever undertaken. Split between Dublin and Melbourne, Prof Alistair Nichol will explain the findings of the TRANSFUSE trial, comparing transfusion of the freshest available blood with standard issued red cells. From Nantes, France, Dr Jean-Baptiste Lascarrou will consider the findings of the MACMAN trial, evaluating video laryngoscopy in the ICU. Dr Ashish Khanna, from the Cleveland Clinic, USA, will reflect on ATHOS-3, the first large clinical trial examining angiotensin II in septic shock. We also have Prof Andrew Rhodes, from London, exploring the latest iteration of the Surviving Sepsis Campaign, published earlier this year. There are still additional speakers to add to the programme, so the meeting will continue to grow and get better and better.
We sold out #CCR17 and had to turn people away. At present we are way up on registrations compared to the same time-point in 2016. So, if you intend on coming, don't leave it too late to register. There is plenty of space still at present, but I expect the meeting will sell out well before it's date of Friday January 19th. Don't worry if you can't make it, as the talks will be recorded and put online for free viewing as usual. However, there is nothing like being there in person and having the opportunity to chat with these chief investigators. Numbers are strictly limited to ensure this remains a small, intimate meeting. It would be a shame to miss out......
The ANZICS/ACCCN Annual Scientific Meeting, which incorporates the annual Paediatric and Neonatal Intensive Care Conference, will be held at the Gold Coast Convention and Exhibition Centre, 11-13 October 2017. The Annual Scientific Meeting will be the preeminent critical care conference in Australasia for the calendar year and will be an important platform that will allow doctors, nurses and allied health practitioners to meaningfully connect and discuss new developments and research in the field of intensive and critical care.
The theme of the Meeting is “Thinking Outside the Flags” and will focus upon innovative and challenging advances that lie outside the safe zone of current practice, as well as the potential dangers that they may bring. A number of highly regarded international speakers will join our distinguished national and local speakers, experts in the field of intensive care medicine, nursing and allied health, promising delegates an exciting and challenging program.
Registration and the call for abstracts will open on 20 March 2017. For further information or to express your interest in attending, please visit http://intensivecareasm2017.com.au/.
State-of-the-Art is back, for the 3rd year of its new format and an all-new venue in Liverpool for 2017. The futurism and innovation theme continues with novel topics including robotics, optical imaging of bacterial infection, new technology in patient recovery, and new device interventions in acute cardiology.
However, the focus on day-to-day care is not lost, and there are clinical updates in acute medicine, ARDS, mechanical ventilation, trauma, nutrition, rehabilitation, endocrine management in ICU, cancer patients in ICU, the difficult and altered airway, and much more. Pragmatic "how I treat..." sessions proved popular last year and will continue, along with meaningful debates on UK critical care, including the trend toward centralisation.
In addition, the trademark vibe of SOA will still be there with pop-up talks, panel debates, 'meet the expert' booths, new generation video e-posters, parent and infant facilities, two drinks evenings, and a new final night after-party. Registration and abstract submission is now open at http://soa.ics.ac.uk.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board