Paul Marik (Norfolk, USA) describes his "Cure for Sepsis"
Welcome to the 274th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. The highlights of this week's edition are a guideline on healthcare-associated ventriculitis and meningitis, narrative reviews on status epilepticus, lactic acidosis and critical burn injuries, plus a debate on the usefulness, or not, of IVC diameter guided fluid resuscitation.
The latest talk from #CCR17 was released earlier this morning, with Paul Marik explaining why he thinks he has discovered the "Cure for Sepsis". (spoiler alert, before you reach for the lemons, the trial methodology is inadequate to allow the question to be tested.......)
This week's Topic of the Week will be out tomorrow morning as I'm out of time tonight.
- Full Text: Hao. Risk of Intracranial Hemorrhage after Endovascular Treatment for Acute Ischemic Stroke: Systematic Review and Meta-Analysis. Intervent Neurol 2017;6:57-64
- Abstract: Aleva. Prevalence and Localization of Pulmonary Embolism in Unexplained Acute Exacerbations of COPD: A Systematic Review and Meta-analysis. Chest 2017;151(3):544-554
- Abstract: Alquraini. Sucralfate versus histamine 2 receptor antagonists for stress ulcer prophylaxis in adult critically ill patients: A meta-analysis and trial sequential analysis of randomized trials. J Crit Care 2017;epublished March 8th
- Abstract: Beitler. Favorable Neurocognitive Outcome with Low Tidal Volume Ventilation After Cardiac Arrest. Am J Respir Crit Care Med 2017;epublished March 7th
- Full Text: Smith. Duration of veno-arterial extracorporeal life support (VA ECMO) and outcome: an analysis of the Extracorporeal Life Support Organization (ELSO) registry. Critical Care 2017;21:45
- Full Text: Cressoni. Opening pressures and atelectrauma in acute respiratory distress syndrome. Intensive Care Med 2017;epublished March 10th
- Full Text: van Ravenzwaaij. A simulation study of the strength of evidence in the recommendation of medications based on two trials with statistically significant results. PLoS ONE 2017;12(3): e0173184
- Full Text: Deng. Evaluation of clinically available renal biomarkers in critically ill adults: a prospective multicenter observational study. Crit Care 2017; 21:46
- Malhotra. Neuropsychological changes following coronary artery bypass surgery. Anaesth Pain & Intensive Care 2016;20(4):511-515
- Victor. 21st century nurse’s role in decreasing the rising burden of cardiovascular disease. Anaesth Pain & Intensive Care 2016;20(4):
- Dubey. Status epilepticus: Refractory and super-refractory. Neurol India 2017;65(Suppl S1):12-7
- Pillai. Traumatic tension pneumocephalus – Two cases and comprehensive review of literature. Int J Crit Illn Inj Sci 2017;7:58-64
- Nizamutdinov. Overview of Traumatic Brain Injury: An Immunological Context. Brain Sci 2017;7(1)
- Sekimoto. Local anesthetic toxicity: acute and chronic management. Acute Med Surg 2017;epublished March 6th
- Wijdicks. Guillain-Barré Syndrome. Mayo Clin Proc 2017;92(3):467-479
- Lippi. Cardiac troponins and mortality in type 1 and 2 myocardial infarction. Clin Chem Lab Med 2017; 55(2): 181–188
- Duran. Biomarkers in Heart Failure. ICU Management & Practice 2016;4:211-215
- Elwan. The haemodynamic dilemma in emergency care: Is fluid responsiveness the answer? A systematic review. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2017;25:25
- Kounis. Kounis syndrome: an update on epidemiology, pathogenesis, diagnosis and therapeutic management. Clin Chem Lab Med 2016;54(10):1545–1559
- Abdo. Hospital Management of Acute Decompensated Heart Failure. Am J Med Sci 2017;353(3):265–274
- Lichtenstein. Lung Ultrasound (in the Critically Ill) Superior to CT: the Example of Lung Sliding. Korean J Crit Care Med. 2017;32(1):1-8
- Di Nicolò. Lung Ultrasound in Hemodialysis: A Card to be Played. Blood Purif 2017;44:1-7
- Martini. Coagulation complications following trauma. Mil Med Res 2016;3:35
- Kim. Blood Transfusion Strategies in Patients Undergoing Extracorporeal Membrane Oxygenation. Korean J Crit Care Med 2017;32(1):22-28
- Haddadi. Efficacy of corticosteroids for the treatment of septic shock. Anaesth Pain & Intensive Care 2016;20(4):488-502
- Suzuki. Sepsis-induced cardiac dysfunction and β-adrenergic blockade therapy for sepsis. Journal of Intensive Care 2017;5:22
- Inglis. Where Sepsis and Antimicrobial Resistance Countermeasures Converge. Front Public Health 2017;5:6
- Bach. The right team at the right time – Multidisciplinary approach to multi-trauma patient with orthopedic injuries. Int J Crit Illn Inj Sci 2017;7:32-7
- Stawicki. Trends in nonoperative management of traumatic injuries – A synopsis. Int J Crit Illn Inj Sci 2017;7:38-57
- Ravi. Fluid resuscitation in haemorrhagic shock in combat casualties. Disaster and Military MedicineThe Journal of Prehospital, Trauma and Emergency Care 2017;3:2
- Ma. Early prevention of trauma-related infection/sepsis. Military Medical Research 2016;3:33
- De Jong. Difficult Intubation in the ICU: Why and How to Prevent and Manage Difficult Intubation? ICU Management & Practice 2016;4:216-220
- Pichler. Cerebral Tissue Oxygenation during Immediate Neonatal Transition and Resuscitation. Front Pediatr 2017;5:29
- Mok. Airway problems in neonates – a review of the current investigation and management strategies. Front. Pediatr 2017;5:60
- Malec. Treatment of Venous Thromboembolism in Pediatric Patients. Front Pediatr 2017;5:26
- Chima. Venous Thromboembolism in Critical Illness and Trauma: Pediatric Perspectives. Front Pediatr 2017;5:47
- Dix. Monitoring cerebral oxygenation in neonates: an update. Front Pediatr 2017;5:46
- Tunkel. 2017 Infectious Diseases Society of America’s Clinical Practice Guidelines for Healthcare-Associated Ventriculitis and Meningitis. Clin Infect Dis 2017;64(6):701-706
- American College of Surgeons and Surgical Infection Society: Surgical Site Infection Guidelines, 2016 Update. Journal of the American College of Surgeons 2017;224:59-74
- Schmidt. POINT: Should Acute Fluid Resuscitation Be Guided Primarily by Inferior Vena Cava Ultrasound for Patients in Shock? Yes. Chest 2017;151(3):531-532
- Kory. COUNTERPOINT: Should Acute Fluid Resuscitation Be Guided Primarily by Inferior Vena Cava Ultrasound for Patients in Shock? No. Chest 2017;151(3):533-536
- Nair. Management of opioid induced postoperative ileus: the current scenario. Anaesth Pain & Intensive Care 2016;20(4):380-382
- Guillamet. “Does this patient have…” “Is this patient at risk for infection with multidrug resistant bacteria?”. Intensive Care Med 2017;43(3):436–439
- Rasulo. Are you Ernest Shackleton, the polar explorer? Refining the criteria for delirium and brain dysfunction in sepsis. Journal of Intensive Care 2017;5:23
- Pichler. Cerebral Tissue Oxygenation during Immediate Neonatal Transition and Resuscitation. Front Pediatr 2017;5:29
- Guidet. Quality in Practice: Towards a Patient-Centred View. ICU Management & Practice 2016;4:200-201
- Flaatten. National ICU Quality Indicators Revisited. ICU Management & Practice 2016;4:202-204
- Walther. Quality Management: The Role of Intensive Care Registries. ICU Management & Practice 2016;4:205-207
- Maggiore. Protective Ventilation: When and Why to Individualize. ICU Management & Practice 2016;4(Suppl):2-4
- Wernerman. Indirect Calorimetry to Measure Energy Requirements: From Consensus to Daily Practice. ICU Management & Practice 2016;4(Suppl):5-6
- Eriksson. Emergency Intraosseous Access: Novel Diagnostic and Therapeutic Possibilities and Limitations. ICU Management & Practice 2016;4:230-232
- Puntillo. Pain Assessment and Management for Intensive Care Unit Patients: Seeking Best Practices. ICU Management & Practice 2016;4:233-236
- Su. Does Dexmedetomidine Reduce Delirium by Improving Sleep? ICU Management & Practice 2016;4:238-239
- Constantin. Early Mobilisation in ICU: From Concept to Reality - Four Steps to Change Patient Outcomes. ICU Management & Practice 2016;4:240-241
- Wade. What Can Psychologists Do in Intensive Care? ICU Management & Practice 2016;4:242-244
- Chant. Clinical Pharmacist Role in the ICU. ICU Management & Practice 2016;4:246-247
- Holste. Renal Replacement Therapy for Acute Kidney Injury: Questions Remain. ICU Management & Practice 2016;4:252-253
- Clarke. Brexit's Brutal Blow to the NHS. ICU Management & Practice 2016;4:254-255
- Andropoulos. Anesthesia and Developing Brains — Implications of the FDA Warning. N Engl J Med 2017;376:905-907
- Lippi. Serum myoglobin immunoassays: obsolete or still clinically useful? Clin Chem Lab Med 2016;54(10):1541-3
- Colombo. A Commentary on albumin in acidosis. Int J Crit Illn Inj Sci 2017;7:12-3
- Martins. Octreotide as an adjunct in the management of arterial gastrointestinal bleeding: Should it be considered in refractory cases of obscure origin?. Int J Crit Illn Inj Sci 2017;7:8-11
There are just 5 months left unit Das SMACC and all tickets have now been sold for the main conference. If you are interested in attending the workshops, there are a very small number of tickets left for the Hardcore Intensive Care workshop being organised by Steve Mathieu and Sarah Yong. With a superb international faculty, this half-day event will address your burning critical care questions.
(Image from Chensiyuan via Wikipedia)
The Critical Care Symposium (CCS) was initiated to satisfy the purpose of creating a world-class environment for medical enrichment in the North of England, particularly in Manchester. It was envisioned as a common informal platform wherein professionals from the field of critical care could provide and enhance the knowledge of delegates on current practices and related fields of interest.
Now in its 14th year, the annual conference regularly has renowned speakers from around the world and attracts more than 400 delegates. And this year is no different. In recent years a parallel course on ultrasound has been conducted alongside the conference that provides ample hand-on experience over two days. This year will host the 7th Ultrasound in Acute Care. For more information please visit http://critcaresymposium.co.uk.
The ANZICS/ACCCN Annual Scientific Meeting, which incorporates the annual Paediatric and Neonatal Intensive Care Conference, will be held at the Gold Coast Convention and Exhibition Centre, 11-13 October 2017. The Annual Scientific Meeting will be the preeminent critical care conference in Australasia for the calendar year and will be an important platform that will allow doctors, nurses and allied health practitioners to meaningfully connect and discuss new developments and research in the field of intensive and critical care.
The theme of the Meeting is “Thinking Outside the Flags” and will focus upon innovative and challenging advances that lie outside the safe zone of current practice, as well as the potential dangers that they may bring. A number of highly regarded international speakers will join our distinguished national and local speakers, experts in the field of intensive care medicine, nursing and allied health, promising delegates an exciting and challenging program.
Registration and the call for abstracts will open on 20 March 2017. For further information or to express your interest in attending, please visit http://intensivecareasm2017.com.au/.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week