Welcome to the 245th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. It's a short newsletter this week, whose highlights are a randomised controlled trial on dexmedetomidine for the prevention of delirium in elderly patients after non-cardiac surgery, plus review articles on fluid management for critically ill patients, extracorporeal blood purification for sepsis and fluid resuscitation management in patients with burns.
If you only have time for one review article this week, try this paper on echocardiography in shock management. Keeping with the ultrasound theme, this week's Topic of the Week is based on a series of articles from the Journal of Intensive Care on point-of-care ultrasound, starting with a paper on the role of upper airway ultrasound in airway management in tomorrow's Paper of the Day.
Every year the Critical Care Reviews Meeting brings the chief investigators for the biggest and best critical care trials to Belfast to discuss their work. Once again, our speakers come from across the world. Mervyn Singer (London) will explain the new sepsis 3.0 definition, which is already the most downloaded paper in the history of JAMA. Greet Van Den Burghe (Belgium) will present the PEPaNIC trial, comparing early with late initiation of parenteral nutrition in critically ill children. Gonzalo Hernandez (Madrid) will explain his study examing the role of high flow nasal oxygen in extubated patients at low risk for reintubation. Returning for the second year in a row, Anthony Gordon will speak about his latest, and yet to publish, LEOPARDS trial, investigating levosimendan in septic shock. Donat Spahn (Zurich), the lead for the new European Trauma Guideline, will deliver the second John Hinds Trauma Lecture. In addition, travelling from the world famous George Institute in Sydney, Australia, is John Myburgh, who will discuss the "Path to Truth" and from Virginia, USA, Paul Marik, who has figured out "The Cure for Sepsis". Registration is open so don't delay too long or you may just miss out!
- Abstract: Su. Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial. Lancet 2016;epublished August 16th
- Abstract: Kim. Influence of Mechanical Ventilation on the Incidence of Pneumothorax During Infraclavicular Subclavian Vein Catheterization: A Prospective Randomized Noninferiority Trial. Anesthesia & Analgesia 2016;123(3):636-640
- Full Text: McGuinness. A Multicenter, Randomized, Controlled Phase IIb Trial of Avoidance of Hyperoxemia during Cardiopulmonary Bypass. Anesthesiology 2016;12:465-473
- Abstract: Belletti. The effect of vasoactive drugs on mortality in patients with severe sepsis and septic shock. A network meta-analysis of randomized trials. J Crit Care 2016;epublished August 13th
- Full Text: Lewis. The efficacy and safety of prokinetic agents in critically ill patients receiving enteral nutrition: a systematic review and meta-analysis of randomized trials. Critical Care 2016;20:259
- Abstract: Rabiee. Depressive Symptoms After Critical Illness: A Systematic Review and Meta-Analysis. Crit Care Med 2016;44(9):1744-1753
- Full Text: Manzanares. Probiotic and synbiotic therapy in critical illness: a systematic review and meta-analysis. Critical Care 2016;20:262
- Abstract: Zhang. Recombinant human soluble thrombomodulin and short-term mortality of infection patients with DIC: a meta-analysis. Am J Emerg Med 2016;34(9):1876-1882
- Abstract: Bhattacharjee. Therapeutic hypothermia after cardiac arrest is not associated with favorable neurological outcome: a meta-analysis. J Clin Anaesth 2016;33:225-232
- Full Text: Ciaffoni. In-airway molecular flow sensing: A new technology for continuous, noninvasive monitoring of oxygen consumption in critical care. Science Advances 2016;2(8):e1600560
- Full Text: Park. Early initiation of continuous renal replacement therapy improves survival of elderly patients with acute kidney injury: a multicenter prospective cohort study. Critical Care 2016;20:260
- Abstract: Shiima. Cardiac Arrests Associated With Tracheal Intubations in PICUs: A Multicenter Cohort Study. Crit Care Med 2016;44(9):1675–1682
- Abstract: Di Muzio. Liberal Versus Conventional Glucose Targets in Critically Ill Diabetic Patients: An Exploratory Safety Cohort Assessment. Crit Care Med 2016;44(9):1683-1691
- Abstract: Kar. Liberal Glycemic Control in Critically Ill Patients With Type 2 Diabetes: An Exploratory Study. Crit Care Med 2016;44(9):1695-1703
- Full Text: Kamdar. The association of sleep quality, delirium, and sedation status with daily participation in physical therapy in the ICU. Critical Care 2016;20:261
- Full Text: Morita. The usability of ventilators: a comparative evaluation of use safety and user experience. Critical Care 2016;20:263
- Lammy. Intravenous heparin during ruptured abdominal aortic aneurysmal repair. Cochrane Database of Systematic Reviews 2016, Issue 8. Art. No.: CD011486
- Morag. Cycled light in the intensive care unit for preterm and low birth weight infants. Cochrane Database of Systematic Reviews 2016, Issue 8. Art. No.: CD006982
- McLean. Echocardiography in shock management. Critical Care 2016;20:275
- Frazee. Fluid Management for Critically Ill Patients: A Review of the Current State of Fluid Therapy in the Intensive Care Unit. Kidney Dis 2016;2:64-71
- Gomez. Total Artificial Heart Imaging and Complications: a Pictorial Review. The VAD Journal 2016;epublished August 16th
- Guglin. What Did We Learn about VADs in 2015? The VAD Journal 2016;2:2
- Guglin. VA-ECMO in Cardiogenic Shock in Adults: Indications and Outcomes. The VAD Journal 2016;2:8
- Samson. Incidence of Pump Thrombosis in HeartMate II during Destination Therapy. The VAD Journal 2016;2:16
- McGreal. Current Challenges in the Evaluation and Management of Hyponatremia. Kidney Dis (Basel). 2016;2(2):56-63
- Zacchia. Potassium: From Physiology to Clinical Implications. Kidney Dis 2016;2:72-79
- Levi. Management of bleeding in patients treated with direct oral anticoagulants. Critical Care 2016;20:249
- Ho. Dabigatran approaching the realm of heparin-induced thrombocytopenia. Blood Res 2016;51(2):77–87
- Guilabert. Fluid resuscitation management in patients with burns: update. Br J Anaesth 2016;117(3):284-296
- Scurlock. Telemedicine for Trauma and Emergency: the eICU. Current Trauma Reports 2016;293:132-137
- Zago. Management of Post-Traumatic Complications by Interventional Ultrasound: a Review. Current Trauma Reports 2016;2(3):151–158
- Garza-Berlanga. Interventional Radiology: Interventions and Techniques in Trauma. Current Trauma Reports 2016;2(3):159-164
- Osman. Role of upper airway ultrasound in airway management. Journal of Intensive Care 2016;4:52
- Kameda. Overview of point-of-care abdominal ultrasound in emergency and critical care. Journal of Intensive Care 2016;4:53
- Chen. An overview of point-of-care ultrasound for soft tissue and musculoskeletal applications in the emergency department. Journal of Intensive Care 2016;4:55
- Ha. Clinically integrated multi-organ point-of-care ultrasound for undifferentiated respiratory difficulty, chest pain, or shock: a critical analytic review. Journal of Intensive Care 2016;4:54
- Mok. Make it SIMPLE: enhanced shock management by focused cardiac ultrasound. Journal of Intensive Care 2016;4:51
- Whitson. Ultrasonography in the emergency department. Critical Care 2016;20:227
- Diringer. Decompressive Hemicraniectomy in the Age of Personalized Medicine. Neurocrit Care 2016;25:1
- Quenot. Intensive care unit strain should not rush physicians into making inappropriate decisions, but merely reduce the time to the right decisions being made. Ann Transl Med 2016
- Kaziani. Improving diagnostic accuracy for invasive pulmonary aspergillosis in the intensive care unit. Ann Transl Med 2016
- Russo. The hunt for fatal myocardial infarction biomarkers: predictive circulating microRNAs Ann Transl Med 2016
- Honore. Timing of renal replacement therapy in critically ill patients: where are the hands on the clock? Ann Transl Med 2016
- Sehgal. Non-invasive ventilation in acute respiratory distress syndrome: helmet use saves lives? Ann Transl Med 2016
- Rozen. Rapid response teams: how are they best used? Critical Care 2016;20:253
- Holder. Hotspotting sepsis: applying analytic tools from other disciplines to eliminate disparities. Ann Transl Med 2016;4(15):295
- Abu-Zidan. On table POCUS assessment for the IVC following abdominal packing: how I do it. World Journal of Emergency Surgery 2016;11:38
- Kopterides. Understanding the sepsis mortality belt: time to buckle down! Ann Transl Med 2016
- Zakhary. Do we really need more intensive care unit beds? Ann Transl Med 2016
- Lattanzi. Blood pressure in acute intra-cerebral hemorrhage. Ann Transl Med 2016
- Nußbaum. Does hyperoxia enhance susceptibility to secondary pulmonary infection in the ICU? Critical Care 2016;20:239
- Platt. Beneath the Furrowed Brow: A Ketamine Journey in the ER. Anesthesiology 2016;125:599-601
- Antonucci. Speckle tracking echocardiography: another step towards early detection of septic myocardial dysfunction? Critical Care 2016;20:236
- Bělohlávek. Mechanical chest compressions in the coronary catheterization laboratory – do not hesitate to go step further! Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2016;24:102
Once again the Critical Care Reviews Meeting will be discussing the biggest studies of the previous year with their chief investigators, asking the question "should we implement the results of this trial into our dialy practice?". We also have the John Hinds Trauma Lecture, delivered this year by Prof Donat Spahn (Zurich), lead for the new European Trauma Guideline, published a few months ago. Paul Marik thinks he has discovered "The Cure for Sepsis", while John Myburgh will explain the ins and outs of research methodology in the "Path to Truth". In addition, there is the very popular "How I Manage....." series of short talks from our speakers on conditions they are experts in, the "Year in Review" and the now famous "Informal Chat" in the bar after the main event.
Don't forget to register for dinner also, where the menu is based on an original menu from the only sailing the Titanic made. Registration for both the meeting and meal is available on the meeting webpage. The Critical Care Reviews Meeting is a not-for-profit event.
Following last year's massively successful event, the UK Intensive Care Society's State-of-the-Art Meeting is starting its build-up to 2016. The ICS completely changed its game in 2015, and relaunched SOA as a new beacon for forward-looking clinical content, open-access education, and medical social media. In keeping with the times, the podcasts and other materials from last year's meeting have been made open access.
This year the programme is looking even better, with topics ranging from the futuristic (space medicine, Formula 1 applied technology, Google Deepmind, and AI) through to the human, practical, and controversial (look out for the clinical scenarios, controversies, and the "From Ivory Tower to Desert Island" session). Speakers include Peter Brindley, Kevin Fong, Jack Iwashyna, Kath Maitland, Louise Rose, Mervyn Singer, and Jean-Louis Vincent among many others. It runs from Mon 5th - Wed 7th Dec, and I hope I'll see you there. Keep an eye on http://soa.ics.ac.uk for programme and registration, and meanwhile enjoy the comprehensive FOAM from last year.
The 1st World Sepsis Congress will take place completely online on September 8th and 9th, 2016, as a prelude and introduction to the fifth World Sepsis Day on September 13th, 2016. Participation is open to everyone with an internet connection and free of charge. In 13 distinctive sessions, over 70 speakers from over 20 countries will give 10-minute keynotes and presentations on the number one preventable cause of death worldwide: sepsis. After each talk, the speakers will answer live questions from the audience.
Highlights include the Opening Session, titled "Sepsis - A Global Health Threat", with German Minister Helge Braun, Marie-Paule Kieny, Assistant Director-General of the WHO, Achim Steiner, former Under-Secretary General UN and Director of UNEP, and Joe Kiani, Founder & CEO of the Patient Safety Movement Foundation. To read the full invitation letter from the program chairs, Simon Finfer and Konrad Reinhart, please click here.
(Image from Chensiyuan via Wikipedia)
This adult and paediatric ICM meeting is jointly organized by the Society of Intensive Care Medicine (SICM), Singapore and the Australia-New Zealand Intensive Care Society (ANZICS) and is scheduled for 20-24 April 2017 in Suntec Convention Centre, Singapore. It has grown from its humble beginnings in a small hospital venue to become one of the best ICM conference in the Asia-Pacific region. Past editions featured prominent speakers such as Jean Louis Vincent, Daniel De Backer, John J Marini, Rinaldo Bellomo amongst many others, and in this edition the list of distinguished international panel of speakers, program schedule and planned workshops look more impressive than ever. Beside the obvious educational benefits, this conference is also a great opportunity to experience the unique Singaporean culture, enjoy its famed gastronomy and visit its attractions.
Registration is yet to open so do subscribe to its newsletter at www.sg-anzics.com for updates.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week