Chris Nutt: The Best of the Rest Critical Care Studies 2015
Welcome to the 244th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's issue are the APEX Study, on extended thromboprophylaxis with betrixaban in acutely ill medical patients, review articles on cardiogenic shock, hypotensive resuscitation in trauma and the intra-aortic balloon pump; plus the latest great series of editorials from Intensive Care Medicine on will all ARDS patients be receiving mechanical ventilation in 2035? - Yes | No | We are not sure.
This week's Topic of the Week is the last in our series on guidelines, looking at a set of miscellaneous guidelines, starting with The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition in tomorrow's Paper of the Day. If you want to hear more of this, Prof Donat Spahn, the guideline lead, will be giving the John Hinds Trauma Lecture at the Critical Care Reviews Meeting 2017. Registration is open!
Speaking of which, the latest presentation from the Critical Care Reviews Meeting 2016 is now out, featuring Chris Nutt, who stood in for me at ultra short notice when I had laryngitis. Check out this video for an amazing effort at giving a talk, without slides, and just two hours preparation!
- Abstract: Cohen. Extended Thromboprophylaxis with Betrixaban in Acutely Ill Medical Patients (APEX Study). N Engl J Med 2016;375:534-544
- Abstract: Mauri. Bedside assessment of the effects of positive end-expiratory pressure on lung inflation and recruitment by the helium dilution technique and electrical impedance tomography. Intensive Care Med 2016;epublished August 12th
- Abstract: Jeschke. Glucose Control in Severely Burned Patients Using Metformin: An Interim Safety and Efficacy Analysis of a Phase II Randomized Controlled Trial. Annals of Surgery 2016;264(3):518–527
- Abstract: Herndon. Reversal of Growth Arrest With the Combined Administration of Oxandrolone and Propranolol in Severely Burned Children. Annals of Surgery 2016;264(3):421–428
- Full Text: Cook. Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial—PROSPECT: a pilot trial. Trials 2016;17:37
- Full Text: Boumendil. Designing and conducting a cluster-randomized trial of ICU admission for the elderly patients: the ICE-CUB 2 study. Ann Intensive Care 2016;6:74
- Abstract: Lavizzari. Heated, Humidified High-Flow Nasal Cannula vs Nasal Continuous Positive Airway Pressure for Respiratory Distress Syndrome of Prematurity. A Randomized Clinical Noninferiority Trial. JAMA Pediatr 2016;epublished August 8th
- Full Text: Vincent. The value of blood lactate kinetics in critically ill patients: a systematic review. Critical Care 2016;20:257
- Abstract: Price. Neuromuscular Blocking Agents and Neuromuscular Dysfunction Acquired in Critical Illness: A Systematic Review and Meta-Analysis. Crit Care Med 2016;epublished August 2nd
- Abstract: Wang. Initiation Time of Renal Replacement Therapy on Patients with Acute Kidney Injury: A Systematic Review and Meta-analysis of 8179 participants. Nephrology (Carlton) 2016;epublished August 9th
- Abstract: French. Erythropoiesis-stimulating Agents in Critically Ill Trauma Patients: A Systematic Review and Meta Analysis. Ann Surg 2016;epublished April 8th
- Abstract: Sanfilippo. Amiodarone or lidocaine for cardiac arrest: A systematic review and meta-analysis. Resuscitation 2016;epublished August 2nd
- Abstract: Chang. Association Between Intensive Care Unit Utilization During Hospitalization and Costs, Use of Invasive Procedures, and Mortality. JAMA Intern Med 2016;epublished August 8th
- Abstract: Walkey. Practice Patterns and Outcomes Associated With Use of Anticoagulation Among Patients With Atrial Fibrillation During Sepsis. JAMA Cardiol 2016;epublished August 3rd
- Full Text: Dhabangi. Cerebral Oximetry in Ugandan Children With Severe Anemia. Clinical Categories and Response to Transfusion. JAMA Pediatr 2016;epublished August 8th
- Full Text: Ristagno. Elevated plasma heparin-binding protein is associated with early death after resuscitation from cardiac arrest. Critical Care 2016;20:251
- Full Text: Gill. Patient and Family Member-Led Research in the Intensive Care Unit: A Novel Approach to Patient-Centered Research. PLoS One 2016;11(8):e0160947
- Abstract: De Corte. Long-term outcome in ICU patients with acute kidney injury treated with renal replacement therapy: a prospective cohort study. Critical Care 2016;20:256
- Abstract: Kievlan. External validation of a prehospital risk score for critical illness. Critical Care 2016;20:255
- Abstract: Famous. ARDS Subphenotypes Respond Differently to Randomized Fluid Management Strategy. Am J Respir Crit Care Med 2016;epublished August 11th
- Hounsome. Nitrous oxide-based versus nitrous oxide-free general anaesthesia and accidental awareness during general anaesthesia in surgical patients. Cochrane Database of Systematic Reviews 2016, Issue 8. Art. No.: CD011052
- Wan. Normal saline versus lower-chloride solutions for kidney transplantation. Cochrane Database of Systematic Reviews 2016, Issue 8. Art. No.: CD010741
- Jaber. New method of preoxygenation for orotracheal intubation in patients with hypoxaemic acute respiratory failure in the intensive care unit, non-invasive ventilation combined with apnoeic oxygenation by high flow nasal oxygen: the randomised OPTINIV study protocol. BMJ Open 2016;6:e011298
- Meyer. Endothelial Dysfunction in Resuscitated Cardiac Arrest (ENDO-RCA): safety and efficacy of low-dose prostacyclin administration and blood pressure target in addition to standard therapy, as compared to standard therapy alone, in post-cardiac arrest syndrome patients: study protocol for a randomized controlled trial. Trials 2016;17:378
- Pettilä. Targeted tissue perfusion versus macrocirculation-guided standard care in patients with septic shock (TARTARE-2S): study protocol and statistical analysis plan for a randomized controlled trial. Trials 2016;17:384
- Willison. Guillain-Barré syndrome. Lancet 2016;388(10045):717-727
- Achrol. Personalized Medicine in Cerebrovascular Neurosurgery: Precision Neurosurgical Management of Cerebral Aneurysms and Subarachnoid Hemorrhage. Front Surg 2016;3:34
- Lim. Cardiogenic Shock: Failure of Oxygen Delivery and Oxygen Utilization. Clin Cardiol 2016;epublished August 10th
- Parissis. IABP: history-evolution-pathophysiology-indications: what we need to know. Journal of Cardiothoracic Surgery 2016;11:122
- Sinagra. Myocarditis in Clinical Practice. Mayo Clin Proc 2016;epublished July 31st
- Nighoghossian. Cyclosporine A, a Potential Therapy of Ischemic Reperfusion Injury. A Common History for Heart and Brain. Cerebrovasc Dis 2016;42:309-318
- Karthika. Rapid shallow breathing index. Ann Thorac Med 2016;11:167-76
- Hartmann. Argument against the Routine Use of Steroids for Pediatric Acute Respiratory Distress Syndrome. Front Pediatr 2016;4:79
- Cutts. Adult respiratory distress syndrome. Ann R Coll Surg Engl 2016;11:1-5
- Tonolini. Atraumatic splenic rupture, an underrated cause of acute abdomen. Insights Imaging 2016;7:641
- Carrick. Hypotensive Resuscitation among Trauma Patients. BioMed Research International 2016;2016:8901938
- Martin-Loeches. Will all ARDS patients be receiving mechanical ventilation in 2035? Yes. Intensive Care Med 2016;epublished August 11th
- Schmidt. Will all ARDS patients be receiving mechanical ventilation in 2035? No. Intensive Care Med 2016;epublished August 11th
- Quintel. Will all ARDS patients be receiving mechanical ventilation in 2035? We are not sure. Intensive Care Med 2016;epublished August 11th
- Timsit. Focus on optimization of early antimicrobial therapy in ICU-acquired infections. Intensive Care Med 2016;epublished August 11th
- Spoletini. High-flow nasal oxygen versus noninvasive ventilation for hypoxemic respiratory failure: Do we know enough? Ann Thorac Med 2016;11(3):163–166
- Hanrahan. Antibiotic dosing in obesity: a BIG challenge. Crit Care 2016;10;20(1):240
- Bagshaw. When to start renal replacement therapy in critically ill patients with acute kidney injury: comment on AKIKI and ELAIN. Critical Care 2016;20:245
- Kang. How to get away from the cold: body temperature during surgery. Korean J Anesthesiol 2016;69(4):317-318
- Vincent. Saline versus balanced solutions: are clinical trials comparing two crystalloid solutions really needed? Critical Care 2016;20:250
- Arabi. Information technology to improve patient safety: A round table discussion from the 5th International Patient Safety Forum, Riyadh, Saudi Arabia, April 14–16, 2015. Ann Thorac Med 2016;11:219-231
- WHO Ebola Response Team. After Ebola in West Africa — Unpredictable Risks, Preventable Epidemics. N Engl J Med 2016;375:587-596
- Ely. Swimming pool in the ICU. Intensive Care Med 2016;epublished August 11th
Once again the Critical Care Reviews Meeting will be discussing the biggest studies of the previous year with their chief investigators, asking the question "should we implement the results of this trial into our dialy practice?". We also have the John Hinds Trauma Lecture, delivered this year by Prof Donat Spahn (Zurich), lead for the new European Trauma Guideline, published a few months ago. Paul Marik thinks he has discovered "The Cure for Sepsis", while John Myburgh will explain the ins and outs of research methodology in the "Path to Truth". In addition, there is the very popular "How I Manage....." series of short talks from our speakers on conditions they are experts in, the "Year in Review" and the now famous "Informal Chat" in the bar after the main event.
Don't forget to register for dinner also, where the menu is based on an original menu from the only sailing the Titanic made. Registration for both the meeting and meal is available on the meeting webpage. The Critical Care Reviews Meeting is a not-for-profit event.
Following last year's massively successful event, the UK Intensive Care Society's State-of-the-Art Meeting is starting its build-up to 2016. The ICS completely changed its game in 2015, and relaunched SOA as a new beacon for forward-looking clinical content, open-access education, and medical social media. In keeping with the times, the podcasts and other materials from last year's meeting have been made open access.
This year the programme is looking even better, with topics ranging from the futuristic (space medicine, Formula 1 applied technology, Google Deepmind, and AI) through to the human, practical, and controversial (look out for the clinical scenarios, controversies, and the "From Ivory Tower to Desert Island" session). Speakers include Peter Brindley, Kevin Fong, Jack Iwashyna, Kath Maitland, Louise Rose, Mervyn Singer, and Jean-Louis Vincent among many others. It runs from Mon 5th - Wed 7th Dec, and I hope I'll see you there. Keep an eye on http://soa.ics.ac.uk for programme and registration, and meanwhile enjoy the comprehensive FOAM from last year.
The 1st World Sepsis Congress will take place completely online on September 8th and 9th, 2016, as a prelude and introduction to the fifth World Sepsis Day on September 13th, 2016. Participation is open to everyone with an internet connection and free of charge. In 13 distinctive sessions, over 70 speakers from over 20 countries will give 10-minute keynotes and presentations on the number one preventable cause of death worldwide: sepsis. After each talk, the speakers will answer live questions from the audience.
Highlights include the Opening Session, titled "Sepsis - A Global Health Threat", with German Minister Helge Braun, Marie-Paule Kieny, Assistant Director-General of the WHO, Achim Steiner, former Under-Secretary General UN and Director of UNEP, and Joe Kiani, Founder & CEO of the Patient Safety Movement Foundation. To read the full invitation letter from the program chairs, Simon Finfer and Konrad Reinhart, please click here.
(Image from Chensiyuan via Wikipedia)
This adult and paediatric ICM meeting is jointly organized by the Society of Intensive Care Medicine (SICM), Singapore and the Australia-New Zealand Intensive Care Society (ANZICS) and is scheduled for 20-24 April 2017 in Suntec Convention Centre, Singapore. It has grown from its humble beginnings in a small hospital venue to become one of the best ICM conference in the Asia-Pacific region. Past editions featured prominent speakers such as Jean Louis Vincent, Daniel De Backer, John J Marini, Rinaldo Bellomo amongst many others, and in this edition the list of distinguished international panel of speakers, program schedule and planned workshops look more impressive than ever. Beside the obvious educational benefits, this conference is also a great opportunity to experience the unique Singaporean culture, enjoy its famed gastronomy and visit its attractions.
Registration is yet to open so do subscribe to its newsletter at www.sg-anzics.com for updates.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week