Welcome to the 213th Critical Care Reviews Newsletter, bringing you the major critical care research and best open access articles of the past week. The highlights of this week's edition are a fantastic series from Critical Care on the Future of Critical Care Medicine, plus guidelines on sedation, agitation and delirium, TTM post cardiac arrest and venous thromboembolism. If you only have time for one paper, try this one on limitation of care orders in patients with a diagnosis of dementia.
There are now just 2 weeks to the Critical Care Reviews Meeting, discussing the biggest studies of 2015 with their chief investigators. The post meeting dinner is almost sold out, so don't delay if you intend joining us. Meeting registration is still available at the moment, but is likely to sell out soon also.
- Full Text: Sponholz. Molecular adsorbent recirculating system and single-pass albumin dialysis in liver failure – a prospective, randomised crossover study. Critical Care Reviews 2016;epublished January 4th
- Abstract: Deem. Randomized Pilot Trial of Two Modified Endotracheal Tubes To Prevent Ventilator-associated Pneumonia. Annals of the American Thoracic Society 2016;13(1):72-80
- Abstract: Shein. Prophylactic Use of Nebulized Hypertonic Saline in Mechanically Ventilated Children: A Randomized Blinded Pilot Study. Respir Care 2016;epublished January 5th
- Full Text: Muller. Antimicrobial surfaces to prevent healthcare-associated infections: a systematic review. Journal of Hospital Infection 2016;92(1):7-13
- Abstract: Lu. The effect of early goal-directed therapy on mortality in patients with severe sepsis and septic shock: a meta-analysis. Journal of Surgical Research 2016;epublished January 4th
- Abstract: Nehme. Effect of supplemental oxygen exposure on myocardial injury in ST-elevation myocardial infarction. Heart 2016;epublished January 6th
- Full Text: Han. Dysnatremia, its correction, and mortality in patients undergoing continuous renal replacement therapy: a prospective observational study. BMC Nephrol 2016;17:2
- Full Text: Leroy. Systemic antifungal therapy for proven or suspected invasive candidiasis: the AmarCAND 2 study. Annals of Intensive Care 2016;6:2
- Full Text: Sankar. Vitamin D deficiency and length of pediatric intensive care unit stay: a prospective observational study. Annals of Intensive Care 2016;epublished January 8th
- Abstract: Semler. Impact of Initial Central Venous Pressure on Outcomes of Conservative Versus Liberal Fluid Management in Acute Respiratory Distress Syndrome. Crit Care Med 2016;epublished January 6th
- Full Text: Di mussi. Impact of prolonged assisted ventilation on diaphragmatic efficiency: NAVA versus PSV. Critical Care 2016;20:1
- Abstract: Suberviola. Microbiological Diagnosis of Sepsis: Polymerase Chain Reaction System Versus Blood Cultures. Am J Crit Care January 2016;25:68-75
- Full Text: Marshall. Disclosure of Industry Payments to Physicians. An Epidemiologic Analysis of Early Data From the Open Payments Program. Mayo Clin Proc 2016;91(1):84–96
- Full Text: Cappabianca. Safety and efficacy of prothrombin complex concentrate as first-line treatment in bleeding after cardiac surgery. Critical Care 2016;20:5
- Abstract: Tamme. Pharmacokinetics and pharmacodynamics of piperacillin/tazobactam during high volume haemodiafiltration in patients with septic shock. Acta Anaesthesiologica Scandinavica 2016;60(2):230-240
- Abstract: Boddi. Renal Resistive Index and mortality in critical patients with acute kidney injury. Eur J Clin Invest 2016;epublished January 5th
Series from Critical Care - Future of Critical Care Medicine (FCCM) 2014
- Marini. A few of our favorite unconfirmed ideas. Critical Care 2015;19(Suppl 3):S1
- Kozek-Langenecker. Intravenous fluids: should we go with the flow? Critical Care 2015;19(Suppl 3):S2
- Marini. Re-tooling critical care to become a better intensivist: something old and something new. Critical Care 2015;19(Suppl 3):S3
- Marini. Advances in the support of respiratory failure: putting all the evidence together. Critical Care 2015, 19(Suppl 3):S4
- Oshima. Parenteral nutrition: never say never. Critical Care 2015;19(Suppl 3):S5
- Wischmeyer. Winning the war against ICU-acquired weakness: new innovations in nutrition and exercise physiology. Critical Care 2015;19(Suppl 3):S6
- Gattinoni. Physiology versus evidence-based guidance for critical care practice. Critical Care 2015;19(Suppl 3):S7
- Ince. Hemodynamic coherence and the rationale for monitoring the microcirculation. Can Ince Critical Care 2015;19(Suppl 3):S8
- Mehta. Challenges and pitfalls when implementing renal replacement therapy in the ICU. Critical Care 2015, 19(Suppl 3):S9
- Vincent. Paradigm shifts in critical care medicine: the progress we have made. Critical Care 2015;19(Suppl 3):S10
- Westphal. The race against the "septic shark". Critical Care 2015;19(Suppl 3):S11
- Nair. Clinical review of non-invasive intracranial pressure measurement in medical cases. J Neuroanaesthesiol Crit Care 2016;3:9-14
- Fiehler. Mechanical Thrombectomy in Stroke. Dtsch Arztebl Int 2015;112(49):830-6
- Mohanaselvi. Neurosurgery in morbidly obese patients. J Neuroanaesthesiol Crit Care 2016;3:3-8
European Heart Journal: The Year in Cardiology 2015
- Montalescot. The year in cardiology 2015: acute coronary syndromes. Eur Heart J published 3 January 2016
- Steg. The year in cardiology 2015: coronary intervention. Eur Heart J 2016;epublished January 3rd
- Aboyans. The year in cardiology 2015: peripheral circulation. Eur Heart J 2016;epublished January 3rd
- Chapman. The year in cardiology 2015: prevention. Eur Heart J 2016;epublished January 3rd
- Steffel. The year in cardiology 2015: arrhythmias and device therapy. Eur Heart J 2016;epublished January 3rd
- Lung. The year in cardiology 2015: valvular heart disease. Eur Heart J 2016;epublished January 3rd
- Gaemperli. The year in cardiology 2015: imaging. Eur Heart J 2016;epublished January 3rd
- Komajda. The year in cardiology 2015: heart failure. Eur Heart J 2016;epublished January 3rd
- Passantino. Predicting mortality in patients with acute heart failure: Role of risk scores. World J Cardiol 2015;7(12):902-11
- Klein. Cardioversion in Non-Valvular Atrial Fibrillation. Dtsch Arztebl Int 2015;112(50):856-62
- Virgadamo. Digoxin: A systematic review in atrial fibrillation, congestive heart failure and post myocardial infarction. World J Cardiol 2015; 7(11): 808-816
- Amin. The current approach of atrial fibrillation management. Avicenna J Med 2016;6:8-16
- Radenkovic. Interventional Treatment of Abdominal Compartment Syndrome during Severe Acute Pancreatitis: Current Status and Historical Perspective. Gastroenterology Research and Practice. 2016;2016:5251806
- Donohue. Reducing transfusion requirements in liver transplantation. World J Transplant 2015;5(4):165–182
- Merhi. Role for urinary biomarkers in diagnosis of acute rejection in the transplanted kidney. World J Transplant 2015; 5(4): 251-260
- Kellum. Cell-cycle arrest and acute kidney injury: the light and the dark sides. Nephrol Dial Transplant 2016 31: 16-22
- How. Novel oral anticoagulants for atrial fibrillation. Singapore Med J 2015;56(12):657–659
- Tafur. Perioperative anticoagulant management in patients with atrial fibrillation: practical implications of recent clinical trials. Pol Arch Med Wewn 2015;125(9):666-671
- Pengo. Diagnosis and therapy of antiphospholipid syndrome. Pol Arch Med Wewn 2015;125(9):672-677
- Yuki. Sepsis Pathophysiology and Anesthetic Consideration. Cardiovasc Hematol Disord Drug Targets. 2015;15(1):57–69
- Dreger. Urosepsis—Etiology, Diagnosis, and Treatment. Dtsch Arztebl Int 2015;112(49):837-48
- Ibrahim. Limitation of care orders in patients with a diagnosis of dementia. Resuscitation 2016;98:118-124
- Antithrombotic Therapy for VTE Disease : CHEST Guideline and Expert Panel Report. Chest 2016;epublished January 7th
- Canadian Guidelines for the use of targeted temperature management (therapeutic hypothermia) after cardiac arrest: A joint statement from The Canadian Critical Care Society (CCCS), Canadian Neurocritical Care Society (CNCCS), and the Canadian Critical Care Trials Group (CCCTG). Resuscitation 2016;98:48-63
- Evidence and consensus based guideline for the management of delirium, analgesia, and sedation in intensive care medicine. Revision 2015 (DAS-Guideline 2015) - short version. Ger Med Sci 2015;12;13
- Guidelines to the Practice of Anesthesia – Revised Edition 2016. Can J Anesth 2016;63(1):86-112
- Bithal. Neurointensive Care Unit and neurointensivist: Do we need them? J Neuroanaesthesiol Crit Care 2016;3:1-2
- Eijgelsheim. Hypernatraemia: balancing is challenging. The Netherlands Journal of Medicine 2015;73(10):446-447
- Wernerman. Fluid management in the critically ill: science or invention?. Acta Anaesthesiologica Scandinavica 2016;60:142–143
- Brown. Deprivation of Liberty in Intensive Care: an update. JICS 2016;epublished January 8th
Due to hugely successful previous events, the Critical Care Reviews Meeting 2016 has been moved to a brand new venue, the stunning, multi-million pound Titanic Centre, birthplace of RMS Titanic, As before, the meeting theme is to review the biggest studies of the previous year, with chief investigators present where possible to discuss their work in person. From Wellington, New Zealand, Dr Paul Young will talk on his studies SPLIT (saline versus plasmalyte) and HEAT (paracetamol for pyrexia control). Dr John Holcomb (Houston, USA) will review his mega trial PROPPR, evaluating blood product transfusion ratios in traumatic haemorrhage. Dr Anthony Gordon (London, England), will review his VANISH study, a multi-centre randomized controlled trial comparing vasopressin with noradrenaline, with or without hydrocortisone, for first-line vasopressor support in septic shock. Prof Tim Walsh (Edinburgh, Scotland) will review the ABLE study, including his ABLE UK component, evaluating age of transfused red cells, as well as RECOVER, a post-ICU rehab study. In addition, two of the most eminent intensivists in global critical care, Prof Jean-Louis Vincent (Brussels, Belgium) and Prof Luciano Gattinoni (Milan, Italy) will be on hand to discuss the significance of these findings. A new feature for the meeting is the John Hinds' Trauma Lecture, with Dr Brian Burns (Sydney HEMS, Australia) travelling across the world to deliver the inaugural presentation. It won't be all study discussion, with other elements to the meeting, including the spectacularly popular "Informal Chat", taking place that evening.
If you haven't yet attended this modern, niche meeting, then put the date Friday January 29th in your diary. Both delegate and speaker feedback from previous meetings has been incredibly positive, allowing the event to grow and attract some of the biggest names in critical care. The Titanic Centre is just minutes from Belfast City Airport, with a hotel within 3 minutes walking distance, and is a 20 minute walk from the city centre, including the Cathedral Quarter, Belfast's cultural centre full of great restaurants and pubs. Further details regarding delegate rate accommodation should be available in the next week or two. Talks are given in the setting of the rebuilt famous staircase from the great ship, while both the "Informal Chat" session and dinner overlook the floodlit slipways where Titanic and Olympic were launched. Ton finish a fantastic day, we have a pre-dinner talk from a colleague of mine, Mr Chris Andrews, on "My Great Great Uncle Thomas Andrews - The Man Who Built Titanic".
With some exciting new innovations planned, this new meeting promises to delivery on its burgeoning reputation. Don't wait too long before registering, as numbers are capped to keep this an intimate event. It is as strong a one day programme as you could possibly find. If you think your colleagues would find this event interesting, please circulate this information - this is a not-for-profit event, run in association with the Northern Ireland Intensive Care Society.
The next SMACC Conference is on June 13th to 16th, in Dublin, Ireland. Registration opened on October 28th, sold out in a few hours, and closed again. Luckily, there are two further smaller batches of tickets available on Wednesday December 2nd and Wednesday February 3rd. With world leading academics and high profile clincians from the FOAMed critical care world, this conference fuses knowledge, dynamism and enthusiasm with an altruisitic desire to be the best we can be for the benefit of our patients. It's the most fun, modern critical care conference in the world. If you've been lucky enough to register for #smaccDUB, the presentations from SMACC Chicago, which are now online at Intensive Care Network, will give you an idea as to what to expect.
(Image from Wikimedia)
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week