Newsletter 162 / January 11th 2015


Welcome to the 162nd Critical Care Reviews Newsletter, bringing you the best critical care research published in the past week, plus a wide range of free full text review articles, guidelines, commentaries, editorials, study critiques, correspondence and case reports from hundreds of clinical and scientific journals.

The highlights of this week's newsletter are a randomized controlled trial investigating fluid responsiveness markers in sepsis, as well as a clinical review article considering the physiological effects of fluid boluses for the same pathology. If you only have time to read one article this week, try this paper from Ahmed "Furosemide in Acute Kidney Injury – A Vexed Issue". Critical Care has now moved to an open access platform, so I have included links to all 57 review articles from the past year.

This week's Topic of the Week is sepsis-induced organ dysfunction, starting with a paper on mitochondrial dysfunction in sepsis-induced multi-organ failure in tomorrow's Paper of the Day.


Review Articles:  Clinical Non-Clinical  I   Recently Made Open Access


Upcoming Meetings

Critical Care Reviews Meeting 2015

It's just two weeks to the Critical Care Reviews Meeting 2015, discussing the hottest trials of 2014. Studies being reviewed include the mechanical chest compression device studies CIRC and LINC; ALBIOS, investigating albumin in sepsis; TRISS, evaluating red cell transfusion thresholds in septic shock; OPTIMISE, looking at perioperative goal-directed haemodynamic therapy; SEPSISPAM, examining blood pressure targets in septic shock, PEITHO, exploring fibrinolysis in intermediate-risk PE, and a comparison of cerebral perfusion pressure-targeted therapy versus intracranial pressure-targeted therapy for raised intracranial pressure in paediatric CNS Infections. Chief investigators for three of the major RCTs presented at the Hot Topics Session of the European Society of Intensive Care Medicine meeting in Barcelona in October are present to discuss their work (CALORIES, HARP 2, VITdAL-ICU), as is the chief investigator for TTM. 2014 is the year of the early goal-directed sepsis therapy studies, and the chief investigator for ProMISe will be on hand to discuss the results of ProCESS & ARISE, as well as give an insight into the yet to finish UK sepsis study ProMISe. If this wasn't enough, there are also review talks from world experts on early mobilisation, ECMO, airway management, sepsis and neuroprognostication post cardiac arrest. Regardless if you're a believer in, or skeptic of, evidence-based medicine, you'll be amazed by the discussion on this recent paper exposing the fragility of the science we base our practice on.

The programme is available and online registration is open. With a global array of speakers, including the chief investigators for some of the biggest studies of the past 12 months, this is one of the most contemporary meetings around. If you've been waiting to register, time is running out, so please do so today. Please feel free to contact me if you're thinking about making the trip - it would be great to hear from you.

SMACC Chicago

The next SMACC conference will be held June 23rd to 26th, in Chicago, USA. Just like the Critical Care Reviews Meeting, this is a not-for-profit event, run by a team interested in sharing knowledge in a fun, modern way. It's a conference like no other. Further details will be out soon on the SMACC website.

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Critical Care Horizons

Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. A call for papers has been issued, so if you have something interesting to say, and can say it in an engaging manner, please get in touch. The first articles are currently being worked on.

COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.

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Randomized Controlled Trials

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Meta Analyses

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Observational Studies

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Cochrane Reviews



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Guidelines & Position Statements

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Case Reports 



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Clinical Review Articles









Non-Clinical Review Articles

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Recently Made Open Access Articles from the Major Journals

Critical Care

Review Articles

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I hope you find these links useful.

Until next week



Review Articles:  Clinical Non-Clinical  I   Recently Made Open Access